emodin anthrone

1,3,8-trihydroxy-6-methylanthrone

CAS: 491-60-1 C15 H12 O4 MW: 256.25744000

Identification

Nameemodin anthrone
CAS Number491-60-1
FDA UNII77C500W1A2
Molecular FormulaC15 H12 O4
Molecular Weight256.25744000
MDL NumberMFCD09955502
Nikkaji NumberJ540.469J

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Soluble in water, 0.9813 mg/L @ 25 °C (est)

No sensory data available

Safety Information

Oral/Parenteral ToxicityNot determined
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorynatural substances and extractives
Recommendation for emodin anthrone usage levels up tonot for fragrance use.
Recommendation for emodin anthrone flavor usage levels up tonot for flavor use.

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Potential Uses

None Found

Natural Occurrence

hypericum perforatum rheum rhabarbarum leaf

Synonyms

9(10H)- anthracenone, 1,3,8-trihydroxy-6-methyl- emodinanthrone 1,3,8- trihydroxy-6-methyl-10H-anthracen-9-one 1,3,8- trihydroxy-6-methylanthrone PubMed: Occurrence and Distribution of Phytochemicals in the Leaves of 17 In vitro Cultured Hypericum spp. Adapted to Outdoor Conditions. PubMed: Effects of skeleton structure on necrosis targeting and clearance properties of radioiodinated dianthrones. PubMed: Barbaloin: a concise report of its pharmacological and analytical aspects. PubMed: In vitro formation of the anthranoid scaffold by cell-free extracts from yeast-extract-treated Cassia bicapsularis cell cultures. PubMed: Comparison of three different extraction methods and HPLC determination of the anthraquinones aloe-emodine, emodine, rheine, chrysophanol and physcione in the bark of Rhamnus alpinus L. (Rhamnaceae). PubMed: Light-independent metabolomics of endophytic Thielavia subthermophila provides insight into microbial hypericin biosynthesis. PubMed: Biosynthesis of actinorhodin and related antibiotics: discovery of alternative routes for quinone formation encoded in the act gene cluster. PubMed: [Studies on chemical constituents from rattan of Polygonum multiflorum]. PubMed: Octaketide-producing type III polyketide synthase from Hypericum perforatum is expressed in dark glands accumulating hypericins. PubMed: Aloe-emodin induced in vitro G2/M arrest of cell cycle in human promyelocytic leukemia HL-60 cells. PubMed: Rational elimination of Aspergillus terreus sulochrin production. PubMed: Signaling pathway for aloe-emodin-induced apoptosis in human H460 lung nonsmall carcinoma cell. PubMed: [Determination of six effective components in Rheum by cyclodextrin modified micellar electrokinetic chromatography]. PubMed: Permeation-enhancing effect of aloe-emodin anthrone on water-soluble and poorly permeable compounds in rat colonic mucosa. PubMed: Expression, purification, and characterization of AknX anthrone oxygenase, which is involved in aklavinone biosynthesis in Streptomyces galilaeus. PubMed: Simultaneous determination of Aloe-emodin and Rhein by synchronous fluorescence spectroscopy. PubMed: Hypotensive effect of chemical constituents from Aloe barbadensis. PubMed: Effects and mechanisms of aloe-emodin on cell death in human lung squamous cell carcinoma. PubMed: Protein kinase C involvement in aloe-emodin- and emodin-induced apoptosis in lung carcinoma cell. PubMed: Metabolism of 1,8-dihydroxy 3-hydroxy methyl anthraquinone (aloe-emodin) isolated from the leaves of Cassia tora in albino rats. PubMed: [Biologically active substances isolated from Hypericum attenuatum Choisy]. PubMed: Aloe-Emodin quinone pretreatment reduces acute liver injury induced by carbon tetrachloride. PubMed: Aloe-emodin is a new type of anticancer agent with selective activity against neuroectodermal tumors. PubMed: Synergistic effects of anthraquinones on the purgative activity of rhein anthrone in mice. PubMed: The synergistic purgative action of aloe-emodin anthrone and rhein anthrone in mice: synergism in large intestinal propulsion and water secretion. PubMed: A purgative action of barbaloin is induced by Eubacterium sp. strain BAR, a human intestinal anaerobe, capable of transforming barbaloin to aloe-emodin anthrone. PubMed: Bioactive anthraquinone glycosides from Picramnia antidesma spp. fessonia. PubMed: Studies of aloe. V. Mechanism of cathartic effect. (4). PubMed: Metabolic activation of sennoside C in mice: synergistic action of anthrones. PubMed: Evaluation of the antiviral activity of anthraquinones, anthrones and anthraquinone derivatives against human cytomegalovirus. PubMed: Identification of emodinanthrone oxygenase in fungus Aspergillus terreus. PubMed: In vitro virucidal activity of selected anthraquinones and anthraquinone derivatives. PubMed: Barbaloin stimulates growth of Eubacterium sp. strain BAR, a barbaloin-metabolizing bacterium from human feces. PubMed: Isolation of a human intestinal bacterium capable of transforming barbaloin to aloe-emodin anthrone. PubMed: Studies of aloe. III. Mechanism of cathartic effect. (2). PubMed: [Purification, glucose-6-phosphate dehydrogenase inhibition, and HPLC analysis of four 1,8-dihydroxyanthrones]. PubMed: Structure-activity relationships for epidermal ornithine decarboxylase induction and skin tumor promotion by anthrones. PubMed: Inhibition of electron transfer and uncoupling effects by emodin and emodinanthrone in Escherichia coli. PubMed: Anthraquinones, Anthrones and Dianthrones in Callus Cultures of Rhamnus frangula and Rhamnus purshiana. PubMed: In vitro biosynthesis of the C-glycosidic bond in aloin.