beta-mangostin
Identification
| Name | beta-mangostin |
| CAS Number | 20931-37-7 |
| FDA UNII | Search |
| Molecular Formula | C25 H28 O6 |
| Molecular Weight | 424.49336000 |
| Nikkaji Number | J15.918B |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Soluble in | water, 5.494e-005 mg/L @ 25 °C (est) |
No sensory data available
Safety Information
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | natural substances and extractives |
| Recommendation for beta-mangostin usage levels up to | not for fragrance use. |
| Recommendation for beta-mangostin flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
1,6-
dihydroxy-3,7-dimethoxy-2,8-bis(3-methylbut-2-enyl)xanthen-9-one
PubMed:
Garcixanthone A, a new cytotoxic xanthone from the pericarps of Garcinia mangostana.
PubMed:
Beta-mangostin from Cratoxylum arborescens activates the intrinsic apoptosis pathway through reactive oxygen species with downregulation of the HSP70 gene in the HL60 cells associated with a G
/G
cell-cycle arrest.
PubMed:
Isolation and structural modifications of ananixanthone from Calophyllum teysmannii and their cytotoxic activities.
PubMed:
β-mangostin suppresses human hepatocellular carcinoma cell invasion through inhibition of MMP-2 and MMP-9 expression and activating the ERK and JNK pathways.
PubMed:
Beta-mangostin demonstrates apoptogenesis in murine leukaemia (WEHI-3) cells in vitro and in vivo.
PubMed:
Acetyl- and O-alkyl- derivatives of β-mangostin from Garcinia mangostana and their anti-inflammatory activities.
PubMed:
New xanthones and cytotoxic constituents from Garcinia mangostana fruit hulls against human hepatocellular, breast, and colorectal cancer cell lines.
PubMed:
Mangostanaxanthones III and IV: advanced glycation end-product inhibitors from the pericarp of Garcinia mangostana.
PubMed:
Depigmentation of α-melanocyte-stimulating hormone-treated melanoma cells by β-mangostin is mediated by selective autophagy.
PubMed:
Evidence of the gastroprotective and anti- Helicobacter pylori activities of β-mangostin isolated from Cratoxylum arborescens (vahl) blume.
PubMed:
Screening of mammalian DNA polymerase and topoisomerase inhibitors from Garcinia mangostana L. and analysis of human cancer cell proliferation and apoptosis.
PubMed:
Antibacterial tetraoxygenated xanthones from the immature fruits of Garcinia cowa.
PubMed:
Metabolite footprinting of Plasmodium falciparum following exposure to Garcinia mangostana Linn. crude extract.
PubMed:
In vitro antiplasmodial activity of benzophenones and xanthones from edible fruits of Garcinia species.
PubMed:
A new coumarin from Calophyllum hosei.
PubMed:
A new furanoxanthone from Garcinia mangostana.
PubMed:
β Mangostin suppress LPS-induced inflammatory response in RAW 264.7 macrophages in vitro and carrageenan-induced peritonitis in vivo.
PubMed:
A concise and efficient total synthesis of α-mangostin and β-mangostin from Garcinia mangostana.
PubMed:
Benzophenone and xanthone derivatives from the inflorescences of Garcinia cowa.
PubMed:
Apoptosis, antimicrobial and antioxidant activities of phytochemicals from Garcinia malaccensis Hk.f.
PubMed:
Cytotoxic xanthone constituents of the stem bark of Garcinia mangostana (mangosteen).
PubMed:
Cytotoxic geranylated xanthones and O-alkylated derivatives of alpha-mangostin.
PubMed:
Anti-cancer effects of xanthones from pericarps of mangosteen.
PubMed:
Garcinia mangostana: a source of potential anti-cancer lead compounds against CEM-SS cell line.
PubMed:
HPLC analysis of selected xanthones in mangosteen fruit.
PubMed:
Antioxidant xanthones from Cratoxylum cochinchinense.
PubMed:
Quantitative and qualitative determination of six xanthones in Garcinia mangostana L. by LC-PDA and LC-ESI-MS.
PubMed:
Xanthones from Garcinia mangostana (Guttiferae).
PubMed:
Cytotoxic and antimalarial prenylated xanthones from Cratoxylum cochinchinense.
PubMed:
Xanthones induce cell-cycle arrest and apoptosis in human colon cancer DLD-1 cells.
PubMed:
A geranylated biphenyl derivative from Garcinia malvgostana.
PubMed:
Antimalarial xanthones from Garcinia cowa.