morusin
mulberrochromene
Identification
| Name | morusin |
| CAS Number | 62596-29-6 |
| FDA UNII | T4VGD5NP9B |
| Molecular Formula | C25 H24 O6 |
| Molecular Weight | 420.46148000 |
| MDL Number | MFCD09953814 |
| Nikkaji Number | J94.468H |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Soluble in | water, 0.01202 mg/L @ 25 °C (est) |
No sensory data available
Safety Information
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | natural substances and extractives |
| Recommendation for morusin usage levels up to | not for fragrance use. |
| Recommendation for morusin flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
4H,8H-
benzo(1,2-b:3,4-b')dipyran-4-one, 2-(2,4-dihydroxyphenyl)-5-hydroxy-8,8-dimethyl-3-(3-methyl-2-butenyl)-
2-(2,4-
dihydroxyphenyl)-5-hydroxy-8,8-dimethyl-3-(3-methylbut-2-enyl)pyrano[2,3-h]chromen-4-one
mulberrochromene
PubMed:
UGT-mediated metabolism plays a dominant role in the pharmacokinetic behavior and the disposition of morusin in vivo and in vitro.
PubMed:
Synergism of prenylflavonoids from Morus alba root bark against clinical MRSA isolates.
PubMed:
Morusin induces paraptosis-like cell death through mitochondrial calcium overload and dysfunction in epithelial ovarian cancer.
PubMed:
Morusin inhibits cell proliferation and tumor growth by down-regulating c-Myc in human gastric cancer.
PubMed:
Prenylated flavonoid morusin protects against TNBS-induced colitis in rats.
PubMed:
Morusin shows potent antitumor activity for human hepatocellular carcinoma in vitro and in vivo through apoptosis induction and angiogenesis inhibition.
PubMed:
Two new prenylflavonoids from Morus alba.
PubMed:
Morusin induces apoptosis by regulating expression of Bax and Survivin in human breast cancer cells.
PubMed:
Quantification of morusin using LC-MS in rat plasma: Application to a pharmacokinetic study.
PubMed:
Two novel compounds from the root bark of Morus alba L.
PubMed:
Rapid, microwave-accelerated synthesis and anti-osteoporosis activities evaluation of Morusin scaffolds and Morusignin L scaffolds.
PubMed:
Autophagy inhibits cell death induced by the anti-cancer drug morusin.
PubMed:
Anti-Melanogenic Properties of Greek Plants. A Novel Depigmenting Agent from Morus alba Wood.
PubMed:
Involvement of the antioxidative property of morusin in blocking phorbol ester-induced malignant transformation of JB6 P
mouse epidermal cells.
PubMed:
Pharmacological Evaluation of the Recuperative Effect of Morusin Against Aluminium Trichloride (AlCl3)-Induced Memory Impairment in Rats.
PubMed:
Identification of the Metabolic Enzyme Involved Morusin Metabolism and Characterization of Its Metabolites by Ultraperformance Liquid Chromatography Quadrupole Time-of-Flight Mass Spectrometry (UPLC/Q-TOF-MS/MS).
PubMed:
Morusin Induces TRAIL Sensitization by Regulating EGFR and DR5 in Human Glioblastoma Cells.
PubMed:
Blockage of STAT3 Signaling Pathway by Morusin Induces Apoptosis and Inhibits Invasion in Human Pancreatic Tumor Cells.
PubMed:
Morusin suppresses breast cancer cell growth in vitro and in vivo through C/EBPβ and PPARγ mediated lipoapoptosis.
PubMed:
The different metabolism of morusin in various species and its potent inhibition against UDP-glucuronosyltransferase (UGT) and cytochrome p450 (CYP450) enzymes.
PubMed:
[Chemical constituents from Morus notabilis and their cytotoxic effect].
PubMed:
Morusin induces cell death through inactivating STAT3 signaling in prostate cancer cells.
PubMed:
Morusin inhibits glioblastoma stem cell growth in vitro and in vivo through stemness attenuation, adipocyte transdifferentiation, and apoptosis induction.
PubMed:
Antitumor progression potential of morusin suppressing STAT3 and NFκB in human hepatoma SK-Hep1 cells.
PubMed:
Preparation of morusin from Ramulus mori and its effects on mice with transplanted H22 hepatocarcinoma.
PubMed:
Effects of Morus alba L. and Natural Products Including Morusin on In Vivo Secretion and In Vitro Production of Airway MUC5AC Mucin.
PubMed:
A new antioxidant stilbene and other constituents from the stem bark of Morus nigra L.
PubMed:
[Study on the chemical constituents of mori cortex].
PubMed:
Morusin inhibits human cervical cancer stem cell growth and migration through attenuation of NF-κB activity and apoptosis induction.
PubMed:
Virtual screening of Indonesian herbal database as HIV-1 reverse transcriptase inhibitor.
PubMed:
Protection of prenylated flavonoids from Mori Cortex Radicis (Moraceae) against nitric oxide-induced cell death in neuroblastoma SH-SY5Y cells.
PubMed:
Induction of Biologically Active Flavonoids in Cell Cultures of Morus nigra and Testing their Hypoglycemic Efficacy.
PubMed:
Inhibitory effects of constituents from Morus alba var. multicaulis on differentiation of 3T3-L1 cells and nitric oxide production in RAW264.7 cells.
PubMed:
Isolation of cholinesterase-inhibiting flavonoids from Morus lhou.
PubMed:
New isoprenylated flavonoid from Morus alba.
PubMed:
Cytotoxic prenylated flavonoids from Morus alba.
PubMed:
New isoprenylated flavonoids and cytotoxic constituents from Artocarpus tonkinensis.
PubMed:
Prenylated flavones from Artocarpus altilis.
PubMed:
[Studies on chemical constituents from twigs of Morus atropurpurea].
PubMed:
Inhibitory effects on mushroom tyrosinase by flavones from the stem barks of Morus lhou (S.) Koidz.
PubMed:
Morusin induces apoptosis and suppresses NF-kappaB activity in human colorectal cancer HT-29 cells.
PubMed:
Phenolic constituents from the wood of Morus australis with cytotoxic activity.
PubMed:
[Studies on chemical constituents from bark of Morus nigra].
PubMed:
[Determination of morusin in cortex mori].
PubMed:
Hypoglycemic effect of Egyptian Morus alba root bark extract: effect on diabetes and lipid peroxidation of streptozotocin-induced diabetic rats.
PubMed:
Antimicrobial and cytotoxic activity of 18 prenylated flavonoids isolated from medicinal plants: Morus alba L., Morus mongolica Schneider, Broussnetia papyrifera (L.) Vent, Sophora flavescens Ait and Echinosophora koreensis Nakai.
PubMed:
Antinephritis and radical scavenging activity of prenylflavonoids.
PubMed:
Root turnover: an important source of microbial substrates in rhizosphere remediation of recalcitrant contaminants.
PubMed:
Effects of naturally occurring prenylated flavonoids on enzymes metabolizing arachidonic acid: cyclooxygenases and lipoxygenases.
PubMed:
Effects of prenylated flavonoids and biflavonoids on lipopolysaccharide-induced nitric oxide production from the mouse macrophage cell line RAW 264.7.
PubMed:
Antinociceptive properties of morusin, a prenylflavonoid isolated from Morus nigra root bark.
PubMed:
Accurate mass measurement of low molecular weight compounds by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.
PubMed:
Chemistry and biological activities of constituents from Morus australis.
PubMed:
Bioactive constituents of Morus australis and Broussonetia papyrifera.
PubMed:
A prenylflavone, artonin E, as arachidonate 5-lipoxygenase inhibitor.
PubMed:
Chemistry and anti-tumor promoting activity of Morus flavonoids.
PubMed:
Components of root bark of morus lhou1 1. Structures of two new natural diels-alder adducts, kuwanons N and o.
PubMed:
[Components of Root Bark of Morus australis.].
PubMed:
Constituents of the Chinese crude drug "sÄng-bái-pÃ" (Morus root bark).
PubMed:
Constituents of the cultivated mulberry tree.