diosbulbin B
Identification
| Name | diosbulbin B |
| CAS Number | 20086-06-0 |
| FDA UNII | Search |
| Molecular Formula | C19 H20 O6 |
| Molecular Weight | 344.36360000 |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Soluble in | water, 3873 mg/L @ 25 °C (est) |
No sensory data available
Safety Information
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | natural substances and extractives |
| Recommendation for diosbulbin B usage levels up to | not for fragrance use. |
| Recommendation for diosbulbin B flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
diosbulbin B
PubMed:
Development of Polyclonal Antibodies for Detection of Diosbulbin B Derived cis-Enedial Protein Adducts.
PubMed:
Discovery of Hepatotoxic Equivalent Combinatorial Markers from Dioscorea bulbifera tuber by Fingerprint-Toxicity Relationship Modeling.
PubMed:
[Chemical constituents from fresh tubers of Dioscorea bulbifera].
PubMed:
Describing the holistic toxicokinetics of hepatotoxic Chinese herbal medicines by a novel integrated strategy: Dioscorea bulbifera rhizome as a case study.
PubMed:
Serum microRNA-122-3p, microRNA-194-5p and microRNA-5099 are potential toxicological biomarkers for the hepatotoxicity induced by Airpotato yam.
PubMed:
Chemical Identity of Interaction of Protein with Reactive Metabolite of Diosbulbin B In Vitro and In Vivo.
PubMed:
Corrigendum to "The role of Ntcp, Oatp2, Bsep and Mrp2 in liver injury induced by Dioscorea bulbifera L. and Diosbulbin B in mice" [Environ. Toxicol. Pharmacol. 51 (2017) 16-22].
PubMed:
Sensitive bromine-based screening of potential toxic furanoids in Dioscorea bulbifera L.
PubMed:
The role of Ntcp, Oatp2, Bsep and Mrp2 in liver injury induced by Dioscorea bulbifera L. and Diosbulbin B in mice.
PubMed:
Metabolic-induced cytotoxicity of diosbulbin B in CYP3A4-expressing cells.
PubMed:
Ferulic acid prevents liver injury induced by Diosbulbin B and its mechanism.
PubMed:
Metabolic activation of furan moiety makes Diosbulbin B hepatotoxic.
PubMed:
Scutellarin protects against the liver injury induced by diosbulbin B in mice and its mechanism.
PubMed:
N-acetyl lysine/glutathione-derived pyrroles as potential ex vivo biomarkers of bioactivated furan-containing compounds.
PubMed:
Protection of Angelica sinensis (Oliv) Diels against hepatotoxicity induced by Dioscorea bulbifera L. and its mechanism.
PubMed:
Metabolism of diosbulbin B in vitro and in vivo in rats: formation of reactive metabolites and human enzymes involved.
PubMed:
Cytochrome p450-mediated metabolic activation of diosbulbin B.
PubMed:
Ferulic acid prevents liver injury and increases the anti-tumor effect of diosbulbin B in vivo.
PubMed:
[Protection of Grateloupia filicina polysaccharide against hepatotoxicity induced by Dioscorea bulbifera L].
PubMed:
Diosbulbin B-induced liver injury in mice and its mechanism.
PubMed:
Gender-related pharmacokinetics and absolute bioavailability of diosbulbin B in rats determined by ultra-performance liquid chromatography-tandem mass spectrometry.
PubMed:
Determination of diosbulbin B in rat plasma and urine by LC-MS/MS and its application in pharmacokinetic and urinary excretion studies.
PubMed:
Antitumor activity of Dioscorea bulbifera L. rhizome in vivo.
PubMed:
[Evaluation on hepatotoxicity caused by Dioscorea bulbifera based on analysis of bile acids].
PubMed:
Gender-related difference in liver injury induced by Dioscorea bulbifera L. rhizome in mice.
PubMed:
[Chemical constituents from tubers of Dioscorea bulbifera].
PubMed:
Bitterness and toxicity in wild yam (Dioscorea spp.) tubers of Nepal.
PubMed:
Antitumor-promoting constituents from Dioscorea bulbifera L. in JB6 mouse epidermal cells.
PubMed:
Diosbulbin-B from the Leaves and Stems of Dioscorea bulbifera: 1H-1H and 13C-1H COSY NMR Studies.