isoliquiritin
Identification
| Name | isoliquiritin |
| CAS Number | 5041-81-6 |
| FDA UNII | 2Y348H1V4W |
| Molecular Formula | C21 H22 O9 |
| Molecular Weight | 418.39914000 |
| Nikkaji Number | J27.434H |
| XlogP3 | 1.70 (est) |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Soluble in | water, 1292 mg/L @ 25 °C (est) |
No sensory data available
Safety Information
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | natural substances and extractives |
| Recommendation for isoliquiritin usage levels up to | not for fragrance use. |
| Recommendation for isoliquiritin flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
(E)-1-(2,4-
dihydroxyphenyl)-3-[4-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]prop-2-en-1-one
2-
propen-1-one, 1-(2,4-dihydroxyphenyl)-3-(4-(beta-D-glucopyranosyloxy)phenyl)-, (2E)-
PubMed:
The effect of ethanol extract of Glycyrrhiza uralensis on the voltage-gated sodium channel subtype 1.4.
PubMed:
A Comparative Pharmacokinetic Study by UHPLC-MS/MS of Main Active Compounds after Oral Administration of Zushima-Gancao Extract in Normal and Adjuvant-Induced Arthritis Rats.
PubMed:
Simultaneous quantification of multiple components in rat plasma by UPLC-MS/MS and pharmacokinetic study after oral administration of Huangqi decoction.
PubMed:
[Study on correlation between color and effective components contents of Glycyrrhiza uralensis].
PubMed:
Neuroprotective effect of liquiritin as an antioxidant via an increase in glucose-6-phosphate dehydrogenase expression on B65 neuroblastoma cells.
PubMed:
Intestinal Absorption of Triterpenoids and Flavonoids from Glycyrrhizae radix et rhizoma in the Human Caco-2 Monolayer Cell Model.
PubMed:
Influence of Jiegeng on Pharmacokinetic Properties of Flavonoids and Saponins in Gancao.
PubMed:
Spasmolytic Mechanism of Aqueous Licorice Extract on Oxytocin-Induced Uterine Contraction through Inhibiting the Phosphorylation of Heat Shock Protein 27.
PubMed:
Simultaneous quantitation of six aconitum alkaloids and three flavonoids in the herb couple of radix aconiti lateralis-radix glycyrrhizae (Fuzi-Gancao) by UHPLC-ESI-MS/MS.
PubMed:
Simultaneous Determination of 11 Compounds in Gualou Guizhi Granule and Pharmacokinetics Study by UPLC-MS/MS.
PubMed:
Comparison of chemical constituents among licorice, roasted licorice, and roasted licorice with honey.
PubMed:
Simultaneous Determination of 8 Compounds in Gancao-Ganjiang-Tang by HPLC-DAD and Analysis of the Relations between Compatibility, Dosage, and Contents of Medicines.
PubMed:
Identification of NF-κB as Determinant of Posttraumatic Stress Disorder and Its Inhibition by the Chinese Herbal Remedy
Free and Easy Wanderer
PubMed:
Simultaneous determination of multiple active components in rat plasma using ultra-fast liquid chromatography with tandem mass spectrometry and application to a comparative pharmacokinetic study after oral administration of Suan-Zao-Ren decoction and Suan-Zao-Ren granule.
PubMed:
Protective effect of isoliquiritin against corticosterone-induced neurotoxicity in PC12 cells.
PubMed:
Development and validation of a sensitive and fast UPLC-MS/MS method for simultaneous determination of seven bioactive compounds in rat plasma after oral administration of Guizhi-gancao decoction.
PubMed:
Purification and characterization of a novel phloretin-2'-O-glycosyltransferase favoring phloridzin biosynthesis.
PubMed:
Identification and Chemical Standardization of Licorice Raw Materials and Dietary Supplements Using UHPLC-MS/MS.
PubMed:
Simultaneous Determinations of Eleven Bioactive Components in Suanzaoren Decoction Granules by High-Performance Liquid Chromatography and Its Application to the Quality Control in Productive Processes.
PubMed:
Simultaneous Determination of 18 Chemical Constituents in Traditional Chinese Medicine of Antitussive by UPLC-MS-MS.
PubMed:
Development and Validation of an UHPLC-QqQ-MS Technique for Simultaneous Determination of Ten Bioactive Components in Fangji Huangqi Tang.
PubMed:
Antifungal Activity of Isoliquiritin and Its Inhibitory Effect against Peronophythora litchi Chen through a Membrane Damage Mechanism.
PubMed:
[Effect of exogenous brassinolide on morphological characters and contents of seven chemical constituents of Glycyrrhiza uralensis].
PubMed:
Online near-infrared analysis coupled with MWPLS and SiPLS models for the multi-ingredient and multi-phase extraction of licorice (Gancao).
PubMed:
Simultaneous quantification of catechin, epicatechin, liquiritin, isoliquiritin, liquiritigenin, isoliquiritigenin, piperine and glycyrrhetinic acid in rat plasma by HPLC-MS/MS: application to a pharmacokinetic study of Longhu Rendan pills.
PubMed:
Comparison of the Spasmolytic Effects of Jakyak-Gamcho Decoctions Derived via Different Extractants.
PubMed:
Suppression of Propionibacterium acnes-Induced Dermatitis by a Traditional Japanese Medicine, Jumihaidokuto, Modifying Macrophage Functions.
PubMed:
Combination of the advantages of chromatographic methods based on active components for the quality evaluation of licorice.
PubMed:
The constituents of licorice (
Glycyrrhiza uralensis
) differentially suppress nitric oxide production in interleukin-1β-treated hepatocytes.
PubMed:
Flavonoids derived from liquorice suppress murine macrophage activation by up-regulating heme oxygenase-1 independent of Nrf2 activation.
PubMed:
Blood-brain barrier permeability of Gualou Guizhi granules and neuroprotective effects in ischemia/reperfusion injury.
PubMed:
Monitoring and evaluating the quality consistency of Compound Bismuth Aluminate tablets by a simple quantified ratio fingerprint method combined with simultaneous determination of five compounds and correlated with antioxidant activities.
PubMed:
Effect of genotype and environment on five bioactive components of cultivated licorice (Glycyrrhiza uralensis) populations in northern China.
PubMed:
Plant-derived natural medicines for the management of depression: an overview of mechanisms of action.
PubMed:
Studies on the identification of constituents in ethanol extract of Radix Glycyrrhizae and their anticancer activity.
PubMed:
Simultaneous Determination of Nine Active Compounds of the Traditional Chinese Medicinal Prescription Shaoyao-Gancao-Tang and Analysis of the Relationship between Therapeutical Effect and Compatibility of Medicines.
PubMed:
Effect of genotype and environment on five bioactive components of cultivated licorice (Glycyrrhiza uralensis F
ISCH.
) populations in northern China.
PubMed:
Chemical interaction between Paeonia lactiflora and Glycyrrhiza uralensis, the components of Jakyakgamcho-tang, using a validated high-performance liquid chromatography method: herbal combination and chemical interaction in a decoction.
PubMed:
[Studies on effects of Achyranthes bidentata on tongsaimai pellets main active ingredients chlorogenic acid, isoliquiritin, harpagoside and glycyrrhizin in vivo pharmacokinetics].
PubMed:
Distribution patterns of the contents of five active components in taproot and stolon of Glycyrrhiza uralensis.
PubMed:
Preparative isolation and analysis of alcohol dehydrogenase inhibitors from Glycyrrhiza uralensis root using ultrafiltration combined with high-performance liquid chromatography and high-speed countercurrent chromatography.
PubMed:
Simultaneous determination of 12 index components and compatibility changes in Longchai decoction by liquid chromatography-mass spectrometry.
PubMed:
[Multi-index determination and optimization of liquirtin separated from polyamide resin].
PubMed:
Antidepressant-like effects of Xiaochaihutang in a rat model of chronic unpredictable mild stress.
PubMed:
Correlation analysis between the rate of respiration in the root and the active components in licorice (
Glycyrrhiza uralensis
).
PubMed:
Combination of liquiritin, isoliquiritin and isoliquirigenin induce apoptotic cell death through upregulating p53 and p21 in the A549 non-small cell lung cancer cells.
PubMed:
Analysis of the traditional medicine YiGan San by the fragmentation patterns of cadambine indole alkaloids using HPLC coupled with high-resolution MS.
PubMed:
[Development of a rapid screening method for discovering neuroprotective components from traditional Chinese medicine].
PubMed:
Evaluation of cytotoxiciy and tumor-specificity of licorice flavonoids based on chemical structure.
PubMed:
Employing bifunctional enzymes for enhanced extraction of bioactives from plants: flavonoids as an example.
PubMed:
Pharmacokinetic comparisons of two different combinations of Shaoyao-Gancao Decoction in rats: competing mechanisms between paeoniflorin and glycyrrhetinic acid.
PubMed:
Pharmacokinetic comparisons of different combinations of Shaoyao-Gancao-Decoction in rats: simultaneous determination of ten active constituents by HPLC-MS/MS.
PubMed:
Pharmacokinetic study of four flavones of Glycyrrhiza in rat plasma using HPLC-MS.
PubMed:
HPLC method determination of isoliquiritin apioside and isoliquiritin in rat plasma for application in pharmacokinetic study after an oral administration of zhigancao extract.
PubMed:
Simultaneous quantitative determination of nine active chemical compositions in traditional Chinese medicine Glycyrrhiza by RP-HPLC with full-time five-wavelength fusion method.
PubMed:
Comparative study of bioactive constituents in crude and processed Glycyrrhizae radix and their respective metabolic profiles in gastrointestinal tract in vitro by HPLC-DAD and HPLC-ESI/MS analyses.
PubMed:
Antispasmodic effect of shakuyakukanzoto extract on experimental muscle cramps in vivo: role of the active constituents of Glycyrrhizae radix.
PubMed:
Comparative analysis of the main bioactive components of San-ao decoction and its series of formulations.
PubMed:
Analytical strategy to reveal the in vivo process of multi-component herbal medicine: a pharmacokinetic study of licorice using liquid chromatography coupled with triple quadrupole mass spectrometry.
PubMed:
The isolation of bioactive flavonoids from Jacaranda obtusifolia H. B. K. ssp. rhombifolia (G. F. W. Meijer) Gentry.
PubMed:
Influence of honey-roasting on the main pharmacological activities and the water-soluble active glycosides of licorice.
PubMed:
Simultaneous determination of five flavonoids in licorice using pressurized liquid extraction and capillary electrochromatography coupled with peak suppression diode array detection.
PubMed:
Evaluation of antigenotoxic activity of isoliquiritin apioside from Glycyrrhiza glabra L.
PubMed:
Survey of Glycyrrhizae Radix resources in Mongolia: chemical assessment of the underground part of Glycyrrhiza uralensis and comparison with Chinese Glycyrrhizea Radix.
PubMed:
Transport and metabolism of flavonoids from Chinese herbal remedy Xiaochaihu- tang across human intestinal Caco-2 cell monolayers.
PubMed:
[Selective adsorption of multi-walled carbon nanotubes with liquiritin and isoliquiritin].
PubMed:
Isoliquiritigenin isolated from the roots of Glycyrrhiza uralensis inhibits LPS-induced iNOS and COX-2 expression via the attenuation of NF-kappaB in RAW 264.7 macrophages.
PubMed:
Antidepressant-like effects of liquiritin and isoliquiritin from Glycyrrhiza uralensis in the forced swimming test and tail suspension test in mice.
PubMed:
Constituent properties of licorices derived from Glycyrrhiza uralensis, G. glabra, or G. inflata identified by genetic information.
PubMed:
In vitro and in vivo antiallergic effects of Glycyrrhiza glabra and its components.
PubMed:
Simultaneous quantification of multiple licorice flavonoids in rat plasma.
PubMed:
Isoliquiritigenin, one of the antispasmodic principles of Glycyrrhiza ularensis roots, acts in the lower part of intestine.
PubMed:
Isolation and identification of flavonoids in licorice and a study of their inhibitory effects on tyrosinase.
PubMed:
Antitussive principles of Glycyrrhizae radix, a main component of the Kampo preparations Bakumondo-to (Mai-men-dong-tang).
PubMed:
Relationship between the antidiarrhoeal effects of Hange-Shashin-To and its active components.
PubMed:
Inhibitory effect of isoliquiritin, a compound in licorice root, on angiogenesis in vivo and tube formation in vitro.
PubMed:
[Chemical components of decoction of radix Paeoniae and radix Glycyrrhizae].
PubMed:
Saponin and sapogenol. L. On the constituents of the roots of Glycyrrhiza uralensis Fischer from Xinjiang, China. Chemical structures of licorice-saponin L3 and isoliquiritin apioside.
PubMed:
[Quality evaluation of Chinese licorice].
PubMed:
[HPLC analysis of flavonoids in the root of six Glycyrrhiza species].
PubMed:
The existence of aldose reductase inhibitors in some kampo medicines (Oriental herb prescriptions).
PubMed:
[Studies on chemical constituents of Glycyrrhiza eurycarpa P. C. Li].