licochalcone B
Identification
| Name | licochalcone B |
| CAS Number | 58749-23-8 |
| FDA UNII | G7383L14F6 |
| Molecular Formula | C16 H14 O5 |
| Molecular Weight | 286.28358000 |
| Nikkaji Number | J14.699D |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Soluble in | water, 1011 mg/L @ 25 °C (est) |
No sensory data available
Safety Information
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | natural substances and extractives |
| Recommendation for licochalcone B usage levels up to | not for fragrance use. |
| Recommendation for licochalcone B flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
(E)-3-(3,4-
dihydroxy-2-methoxy-phenyl)-1-(4-hydroxy-phenyl)-propenone
(E)-3-(3,4-
dihydroxy-2-methoxyphenyl)-1-(4-hydroxyphenyl)prop-2-en-1-one
PubMed:
Natural Compound Licochalcone B Induced Extrinsic and Intrinsic Apoptosis in Human Skin Melanoma (A375) and Squamous Cell Carcinoma (A431) Cells.
PubMed:
Intestinal Absorption of Triterpenoids and Flavonoids from Glycyrrhizae radix et rhizoma in the Human Caco-2 Monolayer Cell Model.
PubMed:
Screening of hepatoprotective compounds from licorice against carbon tetrachloride and acetaminophen induced HepG2 cells injury.
PubMed:
Nrf2 activators from Glycyrrhiza inflata and their hepatoprotective activities against CCl
-induced liver injury in mice.
PubMed:
Screening for bioactive natural products from a 67-compound library of Glycyrrhiza inflata.
PubMed:
Protective role of licochalcone B against ethanol-induced hepatotoxicity through regulation of Erk signaling.
PubMed:
Hepatoprotective effects of licochalcone B on carbon tetrachloride-induced liver toxicity in mice.
PubMed:
Licochalcone B Arrests Cell Cycle Progression and Induces Apoptosis in Human Breast Cancer MCF-7 Cells.
PubMed:
Licochalcone B induces apoptosis of human oral squamous cell carcinoma through the extrinsic- and intrinsic-signaling pathways.
PubMed:
(E)-3-(3,4-dihydroxy-2-methoxyphenyl)-1-(2,4-dihydroxyphenyl)prop-2-en-1-one, a novel licochalcone B derivative compound, suppresses lipopolysaccharide-stimulated inflammatory reactions in RAW264.7 cells and endotoxin shock in mice.
PubMed:
Cardioprotection against ischemia/reperfusion by licochalcone B in isolated rat hearts.
PubMed:
Antimetastatic effects of licochalcone B on human bladder carcinoma T24 by inhibition of matrix metalloproteinases-9 and NF-кB activity.
PubMed:
Licochalcone B inhibits growth of bladder cancer cells by arresting cell cycle progression and inducing apoptosis.
PubMed:
Synthesis of licochalcone analogues with increased anti-inflammatory activity.
PubMed:
Antioxidant and anti-inflammatory activities of six flavonoids separated from licorice.
PubMed:
[Phenolic constituents from Lysimachia patungensis].
PubMed:
Glycyrrhiza inflata-derived chalcones, Licochalcone A, Licochalcone B and Licochalcone D, inhibit phosphorylation of NF-kappaB p65 in LPS signaling pathway.
PubMed:
Activity of wen-pi-tang, and purified constituents of rhei rhizoma and glycyrrhizae radix against glucose-mediated protein damage.
PubMed:
Phenolic constituents of licorice. II. Structures of licopyranocoumarin, licoarylcoumarin and glisoflavone, and inhibitory effects of licorice phenolics on xanthine oxidase.