withangulatin A

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CAS: 120824-03-5 C30 H38 O8 MW: 526.62646000
All Ingredients Aromatic Ingredients CAS Numbers Found in Nature

Identification

Namewithangulatin A
CAS Number120824-03-5
FDA UNIISearch
Molecular FormulaC30 H38 O8
Molecular Weight526.62646000
Nikkaji NumberJ619.752C

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Soluble in water, 5.448 mg/L @ 25 °C (est)

No sensory data available

Safety Information

Oral/Parenteral ToxicityNot determined
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorynatural substances and extractives
Recommendation for withangulatin A usage levels up tonot for fragrance use.
Recommendation for withangulatin A flavor usage levels up tonot for flavor use.

No supplier data available

Potential Uses

None Found

Natural Occurrence

physalis angulata

Synonyms

ergosta-2,16,24-trien-26-oic acid, 15-(acetyloxy)-5,6-epoxy-4,14,22-trihydroxy-1-oxo-, delta-lactone, (4beta,5alpha,6beta,15alpha,22R)- PubMed: Amelioration of systemic lupus erythematosus by Withangulatin A in MRL/lpr mice. PubMed: Withagulatin A inhibits hepatic stellate cell viability and procollagen I production through Akt and Smad signaling pathways. PubMed: Anti-inflammatory function of Withangulatin A by targeted inhibiting COX-2 expression via MAPK and NF-kappaB pathways. PubMed: Withangulatin I, a new cytotoxic withanolide from Physalis angulata. PubMed: Integrity of intermediate filaments is associated with the development of acquired thermotolerance in 9L rat brain tumor cells. PubMed: Induction of aggregation and augmentation of protein kinase-mediated phosphorylation of purified vimentin intermediate filaments by withangulatin A. PubMed: Induction of vimentin modification and vimentin-HSP72 association by withangulatin A in 9L rat brain tumor cells. PubMed: Enhanced phosphorylation of a 65 kDa protein is associated with rapid induction of stress proteins in 9L rat brain tumor cells. PubMed: Induction of heat-shock response and alterations of protein phosphorylation by a novel topoisomerase II inhibitor, withangulatin A, in 9L rat brain tumor cells. PubMed: A new compound, withangulatin A, promotes type II DNA topoisomerase-mediated DNA damage.