glycycoumarin
Identification
| Name | glycycoumarin |
| CAS Number | 94805-82-0 |
| FDA UNII | Search |
| Molecular Formula | C21 H20 O6 |
| Molecular Weight | 368.38560000 |
| Nikkaji Number | J253.511D |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Soluble in | water, 4.11 mg/L @ 25 °C (est) |
No sensory data available
Safety Information
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | natural substances and extractives |
| Recommendation for glycycoumarin usage levels up to | not for fragrance use. |
| Recommendation for glycycoumarin flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
3-(2,4-
dihydroxy-phenyl)-7-hydroxy-5-methoxy-6-(3-methyl-but-2-enyl)-1-benzopyran-2-one
3-(2,4-
dihydroxyphenyl)-7-hydroxy-5-methoxy-6-(3-methylbut-2-enyl)chromen-2-one
PubMed:
Glycycoumarin Sensitizes Liver Cancer Cells to ABT-737 by Targeting De Novo Lipogenesis and TOPK-Survivin Axis.
PubMed:
Cytochrome P450 inhibition by three licorice species and fourteen licorice constituents.
PubMed:
Glycycoumarin inhibits hepatocyte lipoapoptosis through activation of autophagy and inhibition of ER stress/GSK-3-mediated mitochondrial pathway.
PubMed:
Identification and Chemical Standardization of Licorice Raw Materials and Dietary Supplements Using UHPLC-MS/MS.
PubMed:
Glycycoumarin exerts anti-liver cancer activity by directly targeting T-LAK cell-originated protein kinase.
PubMed:
Licorice root components in dietary supplements are selective estrogen receptor modulators with a spectrum of estrogenic and anti-estrogenic activities.
PubMed:
Pharmacokinetic Profiles of Active Components After Oral Administration of a Kampo Medicine, Shakuyakukanzoto, to Healthy Adult Japanese Volunteers.
PubMed:
Glycycoumarin ameliorates alcohol-induced hepatotoxicity via activation of Nrf2 and autophagy.
PubMed:
[Screening of active compounds with myocardial protective effects from Tongmai Yangxin pill].
PubMed:
Prenylated polyphenolic compounds from Glycyrrhiza iconica and their antimicrobial and antioxidant activities.
PubMed:
Protective effects of glycycoumarin and procyanidin B1, active components of traditional Japanese medicine yokukansan, on amyloid β oligomer-induced neuronal death.
PubMed:
Metabolites identification of glycycoumarin, a major bioactive coumarin from licorice in rats.
PubMed:
Structures of two new flavonoids and effects of licorice phenolics on vancomycin-resistant Enterococcus species.
PubMed:
Simultaneous determination of five minor coumarins and flavonoids in Glycyrrhiza uralensis by solid-phase extraction and high-performance liquid chromatography/electrospray ionization tandem mass spectrometry.
PubMed:
Anti-hepatitis C virus compounds obtained from Glycyrrhiza uralensis and other Glycyrrhiza species.
PubMed:
Antioxidant and anti-inflammatory activities of six flavonoids separated from licorice.
PubMed:
Antispasmodic effect of shakuyakukanzoto extract on experimental muscle cramps in vivo: role of the active constituents of Glycyrrhizae radix.
PubMed:
Isoliquiritigenin is a novel NMDA receptor antagonist in kampo medicine yokukansan.
PubMed:
Prenylflavonoids from Glycyrrhiza uralensis and their protein tyrosine phosphatase-1B inhibitory activities.
PubMed:
Separation, characterization and dose-effect relationship of the PPARgamma-activating bio-active constituents in the Chinese herb formulation 'San-Ao decoction'.
PubMed:
Survey of Glycyrrhizae Radix resources in Mongolia: chemical assessment of the underground part of Glycyrrhiza uralensis and comparison with Chinese Glycyrrhizea Radix.
PubMed:
Two flavonoids extracts from Glycyrrhizae radix inhibit in vitro hepatitis C virus replication.
PubMed:
Constituent properties of licorices derived from Glycyrrhiza uralensis, G. glabra, or G. inflata identified by genetic information.
PubMed:
[Inhibitory effects of 11 coumarin compounds against growth of human bladder carcinoma cell line E-J in vitro].
PubMed:
Isoliquiritigenin, one of the antispasmodic principles of Glycyrrhiza ularensis roots, acts in the lower part of intestine.
PubMed:
Pharmaceutical evaluation of cultivated Glycyrrhiza uralensis roots in comparison of their antispasmodic activity and glycycoumarin contents with those of licorice.
PubMed:
Glycycoumarin from Glycyrrhizae Radix acts as a potent antispasmodic through inhibition of phosphodiesterase 3.
PubMed:
Comparative analysis of ten strains of Glycyrrhiza uralensis cultivated in Japan.
PubMed:
A licorice ethanolic extract with peroxisome proliferator-activated receptor-gamma ligand-binding activity affects diabetes in KK-Ay mice, abdominal obesity in diet-induced obese C57BL mice and hypertension in spontaneously hypertensive rats.
PubMed:
Field survey of Glycyrrhiza plants in Central Asia (1). Characterization of G. uralensis, G. glabra and the putative intermediate collected in Kazakhstan.
PubMed:
Antibacterial compounds of licorice against upper airway respiratory tract pathogens.
PubMed:
Phenolic constituents of licorice. VIII. Structures of glicophenone and glicoisoflavanone, and effects of licorice phenolics on methicillin-resistant Staphylococcus aureus.
PubMed:
[Phenolic constituents of licorice. IV. Correlation of phenolic constituents and licorice specimens from various sources, and inhibitory effects of licorice extracts on xanthine oxidase and monoamine oxidase].
PubMed:
[Quality evaluation of Chinese licorice].