cyclolinopeptide A

CAS: 33302-55-5 C57 H85 N9 O9 MW: 1040.36025000

Identification

Namecyclolinopeptide A
CAS Number33302-55-5
FDA UNIISearch
Molecular FormulaC57 H85 N9 O9
Molecular Weight1040.36025000

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Soluble in water, 0.0003012 mg/L @ 25 °C (est)

No sensory data available

Safety Information

Oral/Parenteral ToxicityNot determined
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorynatural substances and extractives
Recommendation for cyclolinopeptide A usage levels up tonot for fragrance use.
Recommendation for cyclolinopeptide A flavor usage levels up tonot for flavor use.

No supplier data available

Potential Uses

None Found

Natural Occurrence

flax seed oil

Synonyms

cyclo[L-isoleucyl-L-leucyl-L-leucyl-DL-prolyl-L-prolyl-L-phenylalanyl-L-phenylalanyl-L-leucyl-L-valyl] PubMed: Synthesis and biological activity of cyclolinopeptide A analogues modified with γ -bis(homo-phenylalanine). PubMed: Synthesis and biological activity of cyclolinopeptide A analogues modified with γ(3)-bis(homophenylalanine). PubMed: The structure of cyclolinopeptide A in chloroform refined by RDC measurements. PubMed: Effect of cyclolinopeptides on the oxidative stability of flaxseed oil. PubMed: Identification and quantification of cyclolinopeptides in five flaxseed cultivars. PubMed: Cyclolinopeptide derivatives modify methotrexate-induced suppression of the humoral immune response in mice. PubMed: Biomolecular interaction study of Cyclolinopeptide A with human serum albumin. PubMed: Synthesis and immunosuppressive activity of cyclolinopeptide A analogues containing homophenylalanine. PubMed: Synthesis, conformational analysis and immunological activity of beta3Phe-substituted Cyclolinopeptide A analogues. PubMed: Synthesis and immunosuppressive activity of new cyclolinopeptide A analogs modified with beta-prolines. PubMed: Cyclopeptides of Linum usitatissimum. PubMed: Structural difference between group I and group II cobra cardiotoxins: X-ray, NMR, and CD analysis of the effect of cis-proline conformation on three-fingered toxins. PubMed: Cyclolinopeptide A: inhibitor, immunosuppressor or other? PubMed: Analogues of cyclolinopeptide A containing alpha-hydroxymethyl amino acid residues. PubMed: Synthesis, conformation, and immunosuppressive activity of CLX and its analogues. PubMed: Tetrazole analogues of cyclolinopeptide A: synthesis, conformation, and biology. PubMed: Structural consequences of metal complexation of cyclo[Pro-Phe-Phe-Ala-Xaa]2 decapeptides. PubMed: Antimalarial activity of cyclolinopeptide A and its analogues. PubMed: Cyclolinopeptide: a novel immunosuppressive agent with potential anti-lipemic activity. PubMed: Solid state structural analysis of the cyclooctapeptide cyclo- (Pro1-Pro-Phe-Phe-Ac6c-Ile-D-Ala-Val8). PubMed: Cyclolinopeptides and their analogs--a new family of peptide immunosuppressants affecting the calcineurin system. PubMed: Specific interaction between bovine cyclophilin A and synthetic analogues of cyclolinopeptide A. PubMed: Cyclolinopeptide A (CLA) mediates its immunosuppressive activity through cyclophilin-dependent calcineurin inactivation. PubMed: Binding proteins for cyclic and linear oligopeptides in plasma membranes and the cytosol of rat hepatocytes. PubMed: Sulfonated analogues of cyclolinopeptide A. Synthesis, immunosuppressive activity and CD studies. PubMed: Autoradiographic distribution of bombesin/gastrin-releasing peptide receptors in fetal cortex transplants. PubMed: Effects of cyclolinopeptide A on T lymphocyte activation and peptidyl prolyl isomerase activity. PubMed: Solution and solid state structure of an aib-containing cyclodecapeptide inhibiting the cholate uptake in hepatocytes. PubMed: Bioactive peptides: conformational studies of [Tyr4] cyclolinopeptide A. PubMed: Conformational behaviour of a cyclolinopeptide A analogue: two-dimensional NMR study of cyclo(Pro1-Pro-Phe-Phe-Ac6c-Ile-ala-Val8). PubMed: Specific interaction between cyclophilin and cyclic peptides. PubMed: [Aib5,6-D-Ala8]-cyclolinopeptide A, grown from a benzene/acetonitrile mixture. PubMed: Does the edge-to-face interaction between aromatic rings occur in cyclolinopeptide A analogues? PubMed: Bioactive peptides: solid state, solution and molecular dynamics studies of a cyclolinopeptide A-related cystinyl cyclopentapeptide. PubMed: Synthesis and biological studies on analogs of cyclolinopeptide A with a shortened peptide chain. PubMed: Immunosuppressive activity in the series of cycloamanide peptides from mushrooms. PubMed: Immunosuppressive activity of alanine analogs of cyclolinopeptide A. PubMed: Synthesis and immunosuppressive activity of glycine containing linear analogs of cyclolinopeptide A. PubMed: Immunosuppressive activity of antamanide and some of its analogues. PubMed: Molecular dynamics simulation in vacuo and in solution of [Aib5,6-D-Ala8] cyclolinopeptide A: a conformational and comparative study. PubMed: Immunosuppressive activity of threonine-containing analogues of cyclolinopeptide A. PubMed: Immunosuppressive activity of tyrosine analogues of cyclolinopeptide A. PubMed: Immunosuppressive activity of cyclolinopeptide A. PubMed: Molecular dynamics simulation in vacuo and in solution of cyclolinopeptide A: a conformational study. PubMed: Ion binding of cyclolinopeptide A: an NMR and CD conformational study. PubMed: Conformational study of cyclolinopeptide A. A distance geometry and molecular dynamics approach. PubMed: Conformation of cyclolinopeptide dihydrate: an antamanide analogue. PubMed: Conformational analysis of cyclolinopeptide A, a cyclic nonapeptide: nuclear Overhauser effect and energy minimization studies. PubMed: Comparison of the conformations of cyclolinopeptide A in the solid state and in solution. PubMed: Ala analogues of the cyclolinopeptide A. PubMed: Conformations of bioactive peptides: cyclolinopeptide A. PubMed: Approximate treatment of the conformational characteristics of a cyclic nonapeptide, cyclolinopeptide a. PubMed: Conformation of cyclolinopeptide a observed by nuclear magnetic resonance spectroscopy. PubMed: Conformation of cyclolinopeptide a observed by circular dichroism.