cyclolinopeptide A
Identification
| Name | cyclolinopeptide A |
| CAS Number | 33302-55-5 |
| FDA UNII | Search |
| Molecular Formula | C57 H85 N9 O9 |
| Molecular Weight | 1040.36025000 |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Soluble in | water, 0.0003012 mg/L @ 25 °C (est) |
No sensory data available
Safety Information
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | natural substances and extractives |
| Recommendation for cyclolinopeptide A usage levels up to | not for fragrance use. |
| Recommendation for cyclolinopeptide A flavor usage levels up to | not for flavor use. |
No supplier data available
Potential Uses
Natural Occurrence
Synonyms
cyclo[L-isoleucyl-L-leucyl-L-leucyl-DL-prolyl-L-prolyl-L-phenylalanyl-L-phenylalanyl-L-leucyl-L-valyl]
PubMed:
Synthesis and biological activity of cyclolinopeptide A analogues modified with γ
-bis(homo-phenylalanine).
PubMed:
Synthesis and biological activity of cyclolinopeptide A analogues modified with γ(3)-bis(homophenylalanine).
PubMed:
The structure of cyclolinopeptide A in chloroform refined by RDC measurements.
PubMed:
Effect of cyclolinopeptides on the oxidative stability of flaxseed oil.
PubMed:
Identification and quantification of cyclolinopeptides in five flaxseed cultivars.
PubMed:
Cyclolinopeptide derivatives modify methotrexate-induced suppression of the humoral immune response in mice.
PubMed:
Biomolecular interaction study of Cyclolinopeptide A with human serum albumin.
PubMed:
Synthesis and immunosuppressive activity of cyclolinopeptide A analogues containing homophenylalanine.
PubMed:
Synthesis, conformational analysis and immunological activity of beta3Phe-substituted Cyclolinopeptide A analogues.
PubMed:
Synthesis and immunosuppressive activity of new cyclolinopeptide A analogs modified with beta-prolines.
PubMed:
Cyclopeptides of Linum usitatissimum.
PubMed:
Structural difference between group I and group II cobra cardiotoxins: X-ray, NMR, and CD analysis of the effect of cis-proline conformation on three-fingered toxins.
PubMed:
Cyclolinopeptide A: inhibitor, immunosuppressor or other?
PubMed:
Analogues of cyclolinopeptide A containing alpha-hydroxymethyl amino acid residues.
PubMed:
Synthesis, conformation, and immunosuppressive activity of CLX and its analogues.
PubMed:
Tetrazole analogues of cyclolinopeptide A: synthesis, conformation, and biology.
PubMed:
Structural consequences of metal complexation of cyclo[Pro-Phe-Phe-Ala-Xaa]2 decapeptides.
PubMed:
Antimalarial activity of cyclolinopeptide A and its analogues.
PubMed:
Cyclolinopeptide: a novel immunosuppressive agent with potential anti-lipemic activity.
PubMed:
Solid state structural analysis of the cyclooctapeptide cyclo- (Pro1-Pro-Phe-Phe-Ac6c-Ile-D-Ala-Val8).
PubMed:
Cyclolinopeptides and their analogs--a new family of peptide immunosuppressants affecting the calcineurin system.
PubMed:
Specific interaction between bovine cyclophilin A and synthetic analogues of cyclolinopeptide A.
PubMed:
Cyclolinopeptide A (CLA) mediates its immunosuppressive activity through cyclophilin-dependent calcineurin inactivation.
PubMed:
Binding proteins for cyclic and linear oligopeptides in plasma membranes and the cytosol of rat hepatocytes.
PubMed:
Sulfonated analogues of cyclolinopeptide A. Synthesis, immunosuppressive activity and CD studies.
PubMed:
Autoradiographic distribution of bombesin/gastrin-releasing peptide receptors in fetal cortex transplants.
PubMed:
Effects of cyclolinopeptide A on T lymphocyte activation and peptidyl prolyl isomerase activity.
PubMed:
Solution and solid state structure of an aib-containing cyclodecapeptide inhibiting the cholate uptake in hepatocytes.
PubMed:
Bioactive peptides: conformational studies of [Tyr4] cyclolinopeptide A.
PubMed:
Conformational behaviour of a cyclolinopeptide A analogue: two-dimensional NMR study of cyclo(Pro1-Pro-Phe-Phe-Ac6c-Ile-ala-Val8).
PubMed:
Specific interaction between cyclophilin and cyclic peptides.
PubMed:
[Aib5,6-D-Ala8]-cyclolinopeptide A, grown from a benzene/acetonitrile mixture.
PubMed:
Does the edge-to-face interaction between aromatic rings occur in cyclolinopeptide A analogues?
PubMed:
Bioactive peptides: solid state, solution and molecular dynamics studies of a cyclolinopeptide A-related cystinyl cyclopentapeptide.
PubMed:
Synthesis and biological studies on analogs of cyclolinopeptide A with a shortened peptide chain.
PubMed:
Immunosuppressive activity in the series of cycloamanide peptides from mushrooms.
PubMed:
Immunosuppressive activity of alanine analogs of cyclolinopeptide A.
PubMed:
Synthesis and immunosuppressive activity of glycine containing linear analogs of cyclolinopeptide A.
PubMed:
Immunosuppressive activity of antamanide and some of its analogues.
PubMed:
Molecular dynamics simulation in vacuo and in solution of [Aib5,6-D-Ala8] cyclolinopeptide A: a conformational and comparative study.
PubMed:
Immunosuppressive activity of threonine-containing analogues of cyclolinopeptide A.
PubMed:
Immunosuppressive activity of tyrosine analogues of cyclolinopeptide A.
PubMed:
Immunosuppressive activity of cyclolinopeptide A.
PubMed:
Molecular dynamics simulation in vacuo and in solution of cyclolinopeptide A: a conformational study.
PubMed:
Ion binding of cyclolinopeptide A: an NMR and CD conformational study.
PubMed:
Conformational study of cyclolinopeptide A. A distance geometry and molecular dynamics approach.
PubMed:
Conformation of cyclolinopeptide dihydrate: an antamanide analogue.
PubMed:
Conformational analysis of cyclolinopeptide A, a cyclic nonapeptide: nuclear Overhauser effect and energy minimization studies.
PubMed:
Comparison of the conformations of cyclolinopeptide A in the solid state and in solution.
PubMed:
Ala analogues of the cyclolinopeptide A.
PubMed:
Conformations of bioactive peptides: cyclolinopeptide A.
PubMed:
Approximate treatment of the conformational characteristics of a cyclic nonapeptide, cyclolinopeptide a.
PubMed:
Conformation of cyclolinopeptide a observed by nuclear magnetic resonance spectroscopy.
PubMed:
Conformation of cyclolinopeptide a observed by circular dichroism.