sesaminol

CAS: 74061-79-3 C20 H18 O7 MW: 370.35786000

Identification

Namesesaminol
CAS Number74061-79-3
FDA UNIISearch
Molecular FormulaC20 H18 O7
Molecular Weight370.35786000
Nikkaji NumberJ430.926J

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Soluble in water, 51.21 mg/L @ 25 °C (est)

No sensory data available

Safety Information

Oral/Parenteral ToxicityNot determined
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorynatural substances and extractives
Recommendation for sesaminol usage levels up tonot for fragrance use.
Recommendation for sesaminol flavor usage levels up tonot for flavor use.

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Potential Uses

None Found

Natural Occurrence

sesamum indicum seed

Synonyms

1,3- benzodioxol-5-ol, 6-(4-(1,3-benzodioxol-5-yl)tetrahydro-1H,3H-furo(3,4-c)furan-1-yl)-, (1S-(1alpha,3aalpha,4alpha,6aalpha))- 6-[(3S,3aR,6S,6aR)-3-(1,3- benzodioxol-5-yl)-1,3,3a,4,6,6a-hexahydrofuro[3,4-c]furan-6-yl]-1,3-benzodioxol-5-ol (1S-(1alpha,3aalpha,4alpha,6aalpha))-6-(4-(1,3- benzodioxol-5-yl)tetrahydro-1H,3H-furo(3,4-c)furan-1-yl)-1,3-benzodioxol-5-ol PubMed: Oxidative rearrangement of (+)-sesamin by CYP92B14 co-generates twin dietary lignans in sesame. PubMed: Sesame oil: An ex vivo study of properties against oxidation of plasma low-density lipoproteins and total serum lipoproteins. PubMed: The pleiotropic regulation of cyclin D1 by newly identified sesaminol-binding protein ANT2. PubMed: Discovery of a sesamin-metabolizing microorganism and a new enzyme. PubMed: Effects of Sesaminol Feeding on Brain Aβ Accumulation in a Senescence-Accelerated Mouse-Prone 8. PubMed: Water-soluble extracts from defatted sesame seed flour show antioxidant activity in vitro. PubMed: Protective effects of sesaminol on BEAS-2B cells impaired by cigarette smoke extract. PubMed: Gene expression profiling of sesaminol triglucoside and its tetrahydrofuranoid metabolites in primary rat hepatocytes. PubMed: Paenibacillus relictisesami sp. nov., isolated from sesame oil cake. PubMed: Lignans of sesame: purification methods, biological activities and biosynthesis--a review. PubMed: Purification, gene cloning, and biochemical characterization of a β-glucosidase capable of hydrolyzing sesaminol triglucoside from Paenibacillus sp. KB0549. PubMed: Effect of thermal heating on some lignans in flax seeds, sesame seeds and rye. PubMed: Purification and fermentation in vitro of sesaminol triglucoside from sesame cake by human intestinal microbiota. PubMed: Protective effect of sesaminol from Sesamum indicum Linn. against oxidative damage in PC12 cells. PubMed: Tissue distribution and cytochrome P450 inhibition of sesaminol and its tetrahydrofuranoid metabolites. PubMed: Sesaminol glucosides protect β-amyloid induced apoptotic cell death by regulating redox system in SK-N-SH cells. PubMed: Intestinal distribution and excretion of sesaminol and its tetrahydrofuranoid metabolites in rats. PubMed: Sesame seed lignans: potent physiological modulators and possible ingredients in functional foods & nutraceuticals. PubMed: Effect of sesame lignans on TNF-alpha-induced expression of adhesion molecules in endothelial cells. PubMed: Tissue distribution and elimination of estrogenic and anti-inflammatory catechol metabolites from sesaminol triglucoside in rats. PubMed: Analysis of antioxidant activities in vegetable oils and fat soluble vitamins and biofactors by the PAO-SO method. PubMed: Differential tissue distribution of sesaminol triglucoside and its metabolites in rats fed with lignan glycosides from sesame meal with or without nano/submicrosizing. PubMed: Identification and characterization of sesaminol metabolites in the liver. PubMed: Sesaminol glucosides protect beta-amyloid peptide-induced cognitive deficits in mice. PubMed: Biotransformation of sesaminol triglucoside to mammalian lignans by intestinal microbiota. PubMed: Tissue distribution and elimination of sesaminol triglucoside and its metabolites in rat. PubMed: Sequential glucosylation of a furofuran lignan, (+)-sesaminol, by Sesamum indicum UGT71A9 and UGT94D1 glucosyltransferases. PubMed: Hydroxymatairesinol and sesaminol act differently on tocopherol concentrations in rats. PubMed: Inhibitory effect of sesaminol glucosides on lipopolysaccharide-induced NF-kappaB activation and target gene expression in cultured rat astrocytes. PubMed: Nondestructive determination of lignans and lignan glycosides in sesame seeds by near infrared reflectance spectroscopy. PubMed: Modifying effect of dietary sesaminol glucosides on the formation of azoxymethane-induced premalignant lesions of rat colon. PubMed: HPLC analysis of sesaminol glucosides in sesame seeds. PubMed: Effect of sesaminol glucosides on beta-amyloid-induced PC12 cell death through antioxidant mechanisms. PubMed: Antioxidative catechol lignans converted from sesamin and sesaminol triglucoside by culturing with Aspergillus. PubMed: Free radical scavenging behavior of antioxidant compounds of sesame (sesamum indicum L.) in DPPH(*) system. PubMed: Dietary sesame lignans decrease lipid peroxidation in rats fed docosahexaenoic acid. PubMed: Increased production of antioxidative sesaminol glucosides from sesame oil cake through fermentation by Bacillus circulans strain YUS-2. PubMed: Effect of sesaminol on plasma and tissue alpha-tocopherol and alpha-tocotrienol concentrations in rats fed a vitamin E concentrate rich in tocotrienols. PubMed: Dietary sesame seed and its lignans inhibit 2,7,8-trimethyl- 2(2'-carboxyethyl)-6-hydroxychroman excretion into urine of rats fed gamma-tocopherol. PubMed: Sesaminol from sesame seed induces apoptosis in human lymphoid leukemia Molt 4B cells. PubMed: Mode of action of sesame lignans in protecting low-density lipoprotein against oxidative damage in vitro. PubMed: Dietary defatted sesame flour decreases susceptibility to oxidative stress in hypercholesterolemic rabbits. PubMed: Inhibition of 2,2'-azobis(2,4-dimethylvaleronitrile)-induced lipid peroxidation by sesaminols. PubMed: Sesamolin inhibits lipid peroxidation in rat liver and kidney. PubMed: Effects of dietary sesaminol and sesamin on eicosanoid production and immunoglobulin level in rats given ethanol. PubMed: Sesame seed and its lignans produce marked enhancement of vitamin E activity in rats fed a low alpha-tocopherol diet. PubMed: Effects of various natural antioxidants on the Cu(2+)-mediated oxidative modification of low density lipoprotein. PubMed: Sesaminol glucosides in sesame seeds. PubMed: Sesame seed lignans and gamma-tocopherol act synergistically to produce vitamin E activity in rats. PubMed: Changes of ingredients in the process of cooking of sesame oil. PubMed: Sesamin is a potent and specific inhibitor of delta 5 desaturase in polyunsaturated fatty acid biosynthesis. PubMed: Antimutagenic heat stable antioxidants.