ginsenoside F2

CAS: 62025-49-4 C42 H72 O13 MW: 785.02544000

Identification

Nameginsenoside F2
CAS Number62025-49-4
FDA UNIISearch
Molecular FormulaC42 H72 O13
Molecular Weight785.02544000
Nikkaji NumberJ38.857B

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Soluble in water, 0.0333 mg/L @ 25 °C (est)

No sensory data available

Safety Information

Oral/Parenteral ToxicityNot determined
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorynatural substances and extractives
Recommendation for ginsenoside F2 usage levels up tonot for fragrance use.
Recommendation for ginsenoside F2 flavor usage levels up tonot for flavor use.

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Potential Uses

None Found

Natural Occurrence

panax ginseng

Synonyms

(3beta,12beta)-20-(beta-D- glucopyranosyloxy)-12-hydroxydammar 3beta,20-bis(beta-D- glucopyranosyloxy)dammar-24-en-12beta-ol PubMed: Ginseng polysaccharides enhanced ginsenoside Rb1 and microbial metabolites exposure through enhancing intestinal absorption and affecting gut microbial metabolism. PubMed: Ciceribacter azotifigens sp. nov., a nitrogen-fixing bacterium isolated from activated sludge. PubMed: Comparative study on chemical components and anti-inflammatory effects of Panax notoginseng flower extracted by water and methanol. PubMed: Chryseobacterium ginsengiterrae sp. nov., with Beta-Glucosidase Activity Isolated from Soil of a Ginseng Field. PubMed: Daejeonia ginsenosidivorans gen. nov., sp. nov., a ginsenoside-transforming bacterium isolated from lake water. PubMed: Ginsenoside F2 induces the release of mediators associated with Anaphylactoid reactions. PubMed: Production of the Rare Ginsenoside Rh2-MIX (20( )-Rh2, 20( )-Rh2, Rk2, and Rh3) by Enzymatic Conversion Combined with Acid Treatment and Evaluation of Its Anti-Cancer Activity. PubMed: Fermentation of protopanaxadiol type ginsenosides (PD) with probiotic Bifidobacterium lactis and Lactobacillus rhamnosus. PubMed: iTRAQ-Based Proteomic Analysis of Ginsenoside F on Human Gastric Carcinoma Cells SGC7901. PubMed: Cloning and Characterization of Ginsenoside-Hydrolyzing β-Glucosidase from Lactobacillus brevis That Transforms Ginsenosides Rb1 and F2 into Ginsenoside Rd and Compound K. PubMed: Ginsenosides, ingredients of the root of Panax ginseng, are not substrates but inhibitors of sodium-glucose transporter 1. PubMed: Protective effects of ginsenoside F2 on 12-O-tetradecanoylphorbol-13-acetate-induced skin inflammation in mice. PubMed: Sphingobacterium jejuense sp. nov., with ginsenoside-converting activity, isolated from compost. PubMed: Biotransformation of ginsenoside Rb1 to ginsenoside C-K by endophytic fungus Arthrinium sp. GE 17-18 isolated from Panax ginseng. PubMed: Pseudobacter ginsenosidimutans gen. nov., sp. nov., isolated from ginseng cultivating soil. PubMed: The chemoattractant potential of ginsenosides in the ginseng - Pythium irregulare pathosystem. PubMed: Production of Ginsenoside F2 by Using Lactococcus lactis with Enhanced Expression of β-Glucosidase Gene from Paenibacillus mucilaginosus. PubMed: Ninjin'yoeito and ginseng extract prevent oxaliplatin-induced neurodegeneration in PC12 cells. PubMed: Effects of broad-spectrum antibiotics on the metabolism and pharmacokinetics of ginsenoside Rb1: a study on rats׳ gut microflora influenced by lincomycin. PubMed: The Bioconversion of Red Ginseng Ethanol Extract into Compound K by Saccharomyces cerevisiae HJ-014. PubMed: Characterization of recombinant β-glucosidase from Arthrobacter chlorophenolicus and biotransformation of ginsenosides Rb1, Rb 2, Rc, and Rd. PubMed: Ginsenoside F2 reduces hair loss by controlling apoptosis through the sterol regulatory element-binding protein cleavage activating protein and transforming growth factor-β pathways in a dihydrotestosterone-induced mouse model. PubMed: Ginsenoside F2 possesses anti-obesity activity via binding with PPARγ and inhibiting adipocyte differentiation in the 3T3-L1 cell line. PubMed: The inductive effect of ginsenoside F2 on hair growth by altering the WNT signal pathway in telogen mouse skin. PubMed: Highly selective hydrolysis for the outer glucose at the C-20 position in ginsenosides by β-glucosidase from Thermus thermophilus and its application to the production of ginsenoside F2 from gypenoside XVII. PubMed: [Chemical constituents from processed rhizomes of Panax notoginseng]. PubMed: Characterization of a ginsenoside-transforming β-glucosidase from Paenibacillus mucilaginosus and its application for enhanced production of minor ginsenoside F₂. PubMed: Enzyme-modified Panax ginseng inhibits UVB-induced skin aging through the regulation of procollagen type I and MMP-1 expression. PubMed: Biotransformation of ginsenoside Rb1 via the gypenoside pathway by human gut bacteria. PubMed: Ginsenoside F(2) induces apoptosis in humor gastric carcinoma cells through reactive oxygen species-mitochondria pathway and modulation of ASK-1/JNK signaling cascade in vitro and in vivo. PubMed: Biotransformation of saponins by endophytes isolated from Panax notoginseng. PubMed: Enzymatic Biotransformation of Ginsenoside Rb1 and Gypenoside XVII into Ginsenosides Rd and F2 by Recombinant β-glucosidase from Flavobacterium johnsoniae. PubMed: [Screening of pregnane X receptor activation from ginsenosides]. PubMed: Biotransformation and metabolic profile of American ginseng saponins with human intestinal microflora by liquid chromatography quadrupole time-of-flight mass spectrometry. PubMed: Microbial transformation of ginsenoside Rb1 to compound K by Lactobacillus paralimentarius. PubMed: Lactobacillus ginsenosidimutans sp. nov., isolated from kimchi with the ability to transform ginsenosides. PubMed: Purification and characterization of a ginsenoside Rb(1)-hydrolyzing β-glucosidase from Aspergillus niger KCCM 11239. PubMed: Ginsenosidases and the pathogenicity of Pythium irregulare. PubMed: Ginsenoside F2 induces apoptosis accompanied by protective autophagy in breast cancer stem cells. PubMed: Anti-Cancer Effect of Ginsenoside F2 against Glioblastoma Multiforme in Xenograft Model in SD Rats. PubMed: Biotransformation of Ginsenoside Rb1 to Prosapogenins, Gypenoside XVII, Ginsenoside Rd, Ginsenoside F2, and Compound K by Leuconostoc mesenteroides DC102. PubMed: Phycicoccus ginsenosidimutans sp. nov., isolated from soil of a ginseng field. PubMed: Partial purification and characterization of three ginsenoside-metabolizing beta-glucosidases from Pythium irregulare. PubMed: Comparative analysis on microbial and rat metabolism of ginsenoside Rb1 by high-performance liquid chromatography coupled with tandem mass spectrometry. PubMed: Development and validation of a reversed-phase HPLC method for quantitative determination of ginsenosides Rb1, Rd, F2, and compound K during the process of biotransformation of ginsenoside Rb1. PubMed: Microbial conversion of ginsenoside Rb1 to minor ginsenoside F2 and gypenoside XVII by Intrasporangium sp. GS603 isolated from soil. PubMed: Marked production of ginsenosides Rd, F2, Rg3, and compound K by enzymatic method. PubMed: Conversion of major ginsenoside Rb1 to ginsenoside F2 by Caulobacter leidyia. PubMed: In vitro metabolism of ginsenosides by the ginseng root pathogen Pythium irregulare. PubMed: [Metabolism of ginsenoside Rb1 and panaxadiol saponins by fungi]. PubMed: [Minor saponins from leaves of Panax ginseng C.A. Meyer]. PubMed: Studies on absorption, distribution, excretion and metabolism of ginseng saponins. VII. Comparison of the decomposition modes of ginsenoside-Rb1 and -Rb2 in the digestive tract of rats. PubMed: Studies on absorption, distribution, excretion and metabolism of ginseng saponins. V. The decomposition products of ginsenoside Rb2 in the large intestine of rats.