brassilexin

8H-isothiazolo(5,4-b)indole

CAS: 119752-76-0 C9 H6 N2 S MW: 174.22582000

Identification

Namebrassilexin
CAS Number119752-76-0
FDA UNIISearch
Molecular FormulaC9 H6 N2 S
Molecular Weight174.22582000
Nikkaji NumberJ985.446K

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Soluble in water, 8938 mg/L @ 25 °C (est)

No sensory data available

Safety Information

Oral/Parenteral ToxicityNot determined
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorynatural substances and extractives
Recommendation for brassilexin usage levels up tonot for fragrance use.
Recommendation for brassilexin flavor usage levels up tonot for flavor use.

No supplier data available

Potential Uses

None Found

Natural Occurrence

brassica juncea leaf brassica rapa

Synonyms

8H-iso thiazolo(5,4-b)indole 2H-[1,2] thiazolo[5,4-b]indole PubMed: The phytoalexins brassilexin and camalexin inhibit cyclobrassinin hydrolase, a unique enzyme from the fungal pathogen Alternaria brassicicola. PubMed: Detoxification of cruciferous phytoalexins in Botrytis cinerea: spontaneous dimerization of a camalexin metabolite. PubMed: Impact of cruciferous phytoalexins on the detoxification of brassilexin by the blackleg fungus pathogenic to brown mustard. PubMed: Discovery of inhibitors of brassinin oxidase based on the scaffolds of the phytoalexins brassilexin and wasalexin. PubMed: Cloning, purification and characterisation of brassinin glucosyltransferase, a phytoalexin-detoxifying enzyme from the plant pathogen Sclerotinia sclerotiorum. PubMed: Phytoalexins and polar metabolites from the oilseeds canola and rapeseed: differential metabolic responses to the biotroph Albugo candida and to abiotic stress. PubMed: Metabolism of crucifer phytoalexins in Sclerotinia sclerotiorum: detoxification of strongly antifungal compounds involves glucosylation. PubMed: Design, synthesis, and antifungal activity of inhibitors of brassilexin detoxification in the plant pathogenic fungus Leptosphaeria maculans. PubMed: Detoxification pathways of the phytoalexins brassilexin and sinalexin in Leptosphaeria maculans: isolation and synthesis of the elusive intermediate 3-formylindolyl-2-sulfonic acid. PubMed: Concise syntheses of the cruciferous phytoalexins brassilexin, sinalexin, wasalexins, and analogues: expanding the scope of the vilsmeier formylation. PubMed: Phytoalexins from the crucifer rutabaga: structures, syntheses, biosyntheses, and antifungal activity. PubMed: [Biological activity of the isothiazole derivatives]. PubMed: Antiproliferative and cancer chemopreventive activity of phytoalexins: focus on indole phytoalexins from crucifers. PubMed: Chemical defenses of crucifers: elicitation and metabolism of phytoalexins and indole-3-acetonitrile in brown mustard and turnip. PubMed: Unprecedented Vilsmeier formylation: expedient syntheses of the cruciferous phytoalexins sinalexin and brassilexin and discovery of a new heteroaromatic ring system. PubMed: Strategies of cruciferous pathogenic fungi: detoxification of the phytoalexin cyclobrassinin by mimicry. PubMed: The cruciferous phytoalexins brassinin and cyclobrassinin are intermediates in the biosynthesis of brassilexin. PubMed: Growth inhibitions on human cancer cell cultures with the indole sulphur-containing phytoalexins and their analogues. PubMed: Abiotic elicitation of indole phytoalexins and resistance to Leptosphaeria maculans within Brassiceae.