acetyl adenylate
5'-acetylphosphoadenosine
Identification
| Name | acetyl adenylate |
| CAS Number | 13015-87-7 |
| FDA UNII | Search |
| Molecular Formula | C12 H16 N5 O8 P |
| Molecular Weight | 389.26188200 |
| Nikkaji Number | J227.896K |
| XlogP3 | -2.90 (est) |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Soluble in | water, 2.738e+004 mg/L @ 25 °C (est) |
No sensory data available
Safety Information
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | natural substances and extractives |
| Recommendation for acetyl adenylate usage levels up to | not for fragrance use. |
| Recommendation for acetyl adenylate flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
5'-
acetylphosphoadenosine
5'-
adenylic acid, monoanhydride with acetic acid
[[(2R,3S,4R,5R)-5-(6-
aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] acetate
PubMed:
Acetylation of acetyl-CoA synthetase from Mycobacterium tuberculosis leads to specific inactivation of the adenylation reaction.
PubMed:
Identification of active site residues in Bradyrhizobium japonicum acetyl-CoA synthetase.
PubMed:
Molecular cloning and cell-cycle-dependent expression of the acetyl-CoA synthetase gene in Tetrahymena cells.
PubMed:
Effect of nonenzymatic histone acetylation on chromatin high-order folding.
PubMed:
Acetyladenylate or its derivative acetylates the chemotaxis protein CheY in vitro and increases its activity at the flagellar switch.
PubMed:
Relationship of histone acetylation to DNA topology and transcription.
PubMed:
High rotational mobility of DNA in animal cells and its modulation by histone acetylation.
PubMed:
Acetyladenylate plays a role in controlling the direction of flagellar rotation.
PubMed:
Measurement of positional isotope exchange rates in enzyme-catalyzed reactions by fast atom bombardment mass spectrometry: application to argininosuccinate synthetase.
PubMed:
ATPase of bovine heart mitochondria. Modulation of ITPase activity by ATP, ADP, acetyl ATP and acetyl AMP.
PubMed:
Chemically induced gene expression. Manipulation of the transforming ability of simian virus 40 minichromatin by specific chemical hyperacetylation of histones H3 and H4.
PubMed:
Analysis of binding interactions between histone core complex and simian virus 40 DNA. A comparison of acetylated versus non-acetylated histone core complexes.
PubMed:
Chemically induced gene activation: selective increase in DNAase I susceptibility in chromatin acetylated with acetyl adenylate.
PubMed:
Nonenzymatic acetylation of histones with acetyl phosphate and acetyl adenylate.
PubMed:
Nonenzymatic reactivation of des-acetyl citrate lyase by acetyl adenylate. First example of enzyme activation by chemotrophic modification.
PubMed:
Mechanism of enzymic acetylation of des-acetyl citrate lyase.
PubMed:
Studies of the acetyl coenzyme A synthetase reaction. V. The requirement for monovalent and divalent cations in partial reactions involving enzyme-bound acetyl adenylate.
PubMed:
STUDIES OF THE ACETYL COENZYME A SYNTHETASE REACTION. I. ISOLATION AND CHARACTERIZATION OF ENZYME-BOUND ACETYL ADENYLATE.