norathyriol
Identification
| Name | norathyriol |
| CAS Number | 3542-72-1 |
| FDA UNII | Search |
| Molecular Formula | C13 H8 O6 |
| Molecular Weight | 260.20196000 |
| Nikkaji Number | J13.004D |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Soluble in | water, 30.33 mg/L @ 25 °C (est) |
No sensory data available
Safety Information
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | information only not used for fragrances or flavors |
| Recommendation for norathyriol usage levels up to | not for fragrance use. |
| Recommendation for norathyriol flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
1,3,6,7-
tetrahydroxyxanthen-9-one
1,3,6,7-
tetrahydroxyxantone
9H-
xanthen-9-one, 1,3,6,7-tetrahydroxy-
PubMed:
In Vitro Comparative Study of the Inhibitory Effects of Mangiferin and Its Aglycone Norathyriol towards UDP-Glucuronosyl Transferase (UGT) Isoforms.
PubMed:
Naturally occurring xanthone and benzophenone derivatives exert significant anti-proliferative and proapoptotic effects in vitro on synovial fibroblasts and macrophages from rheumatoid arthritis patients.
PubMed:
In Vitro and In Vivo Effects of Norathyriol and Mangiferin on
α
-Glucosidase.
PubMed:
Pharmacokinetics of mangiferin and its metabolite-norathyriol, Part 2: Influence of UGT, CYP450, P-gp, and enterobacteria and the potential interaction in Rhizoma Anemarrhenae decoction with timosaponin B2 as the major contributor.
PubMed:
Pharmacokinetics of mangiferin and its metabolite-Norathyriol, Part 1: Systemic evaluation of hepatic first-pass effect in vitro and in vivo.
PubMed:
Hypouricaemic action of mangiferin results from metabolite norathyriol via inhibiting xanthine oxidase activity.
PubMed:
Estrogen modulation properties of mangiferin and quercetin and the mangiferin metabolite norathyriol.
PubMed:
Norathyriol reverses obesity- and high-fat-diet-induced insulin resistance in mice through inhibition of PTP1B.
PubMed:
Host-guest inclusion system of norathyriol with β-cyclodextrin and its derivatives: preparation, characterization, and anticancer activity.
PubMed:
Biflavonoids, main constituents from Garcinia bakeriana leaves.
PubMed:
Mangiferin and its aglycone, norathyriol, improve glucose metabolism by activation of AMP-activated protein kinase.
PubMed:
Norathyriol suppresses transformation in JB6 P+ cells by the inhibition of Akt.
PubMed:
Yeast-mediated xanthone synthesis through oxidative intramolecular cyclization.
PubMed:
Mangiferin aglycone attenuates radiation-induced damage on human intestinal epithelial cells.
PubMed:
Norathyriol suppresses skin cancers induced by solar ultraviolet radiation by targeting ERK kinases.
PubMed:
Structure elucidation of in vivo and in vitro metabolites of mangiferin.
PubMed:
Deglycosylation of puerarin and other aromatic C-glucosides by a newly isolated human intestinal bacterium.
PubMed:
The phenolic acids from bacterial degradation of the mangiferin aglycone are quantified in the feces of pigs after oral ingestion of an extract of Cyclopia genistoides (honeybush tea).
PubMed:
In vitro modulation of ABCB1/P-glycoprotein expression by polyphenols from Mangifera indica.
PubMed:
Benzophenone O-glycosides from Hypericum elegans.
PubMed:
In vitro effects of Mangifera indica and polyphenols derived on ABCB1/P-glycoprotein activity.
PubMed:
Mangiferin and hesperidin metabolites are absorbed from the gastrointestinal tract of pigs after oral ingestion of a Cyclopia genistoides (honeybush tea) extract.
PubMed:
Effects of the mango components mangiferin and quercetin and the putative mangiferin metabolite norathyriol on the transactivation of peroxisome proliferator-activated receptor isoforms.
PubMed:
Two proteins, Mn2+, and low molecular cofactor are required for C-glucosyl-cleavage of mangiferin.
PubMed:
Xanthone derivatives: new insights in biological activities.
PubMed:
Isolation of a human intestinal bacterium that transforms mangiferin to norathyriol and inducibility of the enzyme that cleaves a C-glucosyl bond.
PubMed:
Inhibition of the arachidonic acid cascade by norathyriol via blockade of cyclooxygenase and lipoxygenase activity in neutrophils.
PubMed:
Decreased protein kinase C activation mediates inhibitory effect of norathyriol on serotonin-mediated endothelial permeability.
PubMed:
Evidence for the involvement of protein kinase C inhibition by norathyriol in the reduction of phorbol ester-induced neutrophil superoxide anion generation and aggregation.
PubMed:
Examination of the inhibitory effect of norathyriol in formylmethionyl-leucyl-phenylalanine-induced respiratory burst in rat neutrophils.
PubMed:
Induction of calcium release from sarcoplasmic reticulum of skeletal muscle by xanthone and norathyriol.
PubMed:
Synthesis and antiplatelet effects of omega-aminoalkoxylxanthones.
PubMed:
Effect of norathyriol, isolated from Tripterospermum lanceolatum, on A23187-induced pleurisy and analgesia in mice.
PubMed:
gamma-Pyrone compounds. 5. Synthesis and antiplatelet effects of xanthonoxypropanolamines and related compounds.
PubMed:
Inhibitory effect of norathyriol, a xanthone from Tripterospermum lanceolatum, on cutaneous plasma extravasation.
PubMed:
Gamma-pyrone compounds. II: Synthesis and antiplatelet effects of tetraoxygenated xanthones.
PubMed:
Antihaemostatic and antithrombotic effect of some antiplatelet agents isolated from Chinese herbs.
PubMed:
Vasorelaxation of rat thoracic aorta caused by norathyriol isolated from Gentianaceae.
PubMed:
Novel inhibitory actions on platelet thromboxane and inositolphosphate formation by xanthones and their glycosides.