1,8-cineole
eucalyptol
Identification
| Name | 1,8-cineole |
| IUPAC | 4,7,7-trimethyl-8-oxabicyclo[2.2.2]octane |
| CAS Number | 470-82-6 |
| EINECS | 207-431-5 |
| FDA UNII | RV6J6604TK |
| Molecular Formula | C10 H18 O |
| Molecular Weight | 154.25266000 |
| MDL Number | MFCD00167977 |
| Nikkaji Number | J3.281F |
| Beilstein | 0105109 |
| CoE Number | 182 |
| XlogP3 | 2.50 (est) |
Regulatory
| JECFA Food Flavoring | 1234 eucalyptol |
| DG SANTE Food Flavourings | 03.001 1,8-cineole |
| FEMA Number | 2465 |
| FDA | No longer provide for the use of these seven synthetic flavoring substances |
| FDA Mainterm (SATF) | 470-82-6 ; EUCALYPTOL |
| FDA Regulation | FDA PART 172 -- FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION |
Physical Properties
| Appearance | colorless clear liquid (est) |
| Assay | 98.00 to 100.00 |
| Food Chemicals Codex Listed | Yes |
| Specific Gravity | 0.91900 to 0.92100 @ 25.00 °C. |
| Pounds per Gallon - (est). | 7.647 to 7.664 |
| Refractive Index | 1.44800 to 1.45100 @ 20.00 °C. |
| Melting Point | 1.00 to 2.00 °C. @ 760.00 mm Hg |
| Boiling Point | 176.00 to 177.00 °C. @ 760.00 mm Hg, 90.00 to 91.00 °C. @ 760.00 mm Hg |
| Vapor Pressure | 1.900000 mmHg @ 25.00 °C. |
| Flash Point | 122.00 °F. TCC ( 50.00 °C. ) |
| logP (o/w) | 2.740 |
| Soluble in | alcohol |
| Stability | bath foam |
Cosmetic Information
| CosIng | cosmetic data |
| Cosmetic Uses | denaturants |
Organoleptic Properties
| Odor Strength | high , |
| Substantivity | 4 hour(s) at 100.00 % |
| Odor Description |
at 10.00 % in dipropylene glycol. stong, fresh, camphoraceous, like eucalyptus and spike lavender oil ice, fresh, camphoraceous fresh strong eucalyptus camphoraceous minty cooling Fresh diffusive
|
| Odor sample from | Fragrance Resources Inc. |
| Taste Description |
minty camphoreous cooling eucalyptus medicinal eucalyptus, minty, fresh, cooling, herbal eucalyptol, balsamic
|
Safety Information
| Preferred SDS | View |
| European information | Most important hazard(s): |
| Human Experience | 16 % solution: no irritation or sensitization. |
| Oral/Parenteral Toxicity | oral-rat LD50 [sex: M,F] 2480 mg/kg |
| Dermal Toxicity | skin-rabbit LD50 > 5000 mg/kg |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements', 'PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE\nBEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD']
Safety in Use
| Category | flavor and fragrance agents |
| RIFM Fragrance Material Safety Assessment | Search |
| Recommendation for 1,8-cineole usage levels up to | 20.0000 % in the fragrance concentrate. |
| Maximised Survey-derived Daily Intakes (MSDI-EU) | 1200.00 (μg/capita/day) |
| Maximised Survey-derived Daily Intakes (MSDI-USA) | 1954.00 (μg/capita/day) |
| Structure Class | II |
| baked goods | 0.50000 |
| beverages(nonalcoholic) | - |
| beverages(alcoholic) | - |
| breakfast cereal | - |
| cheese | - |
| chewing gum | - |
| condiments / relishes | - |
| confectionery froastings | - |
| egg products | - |
| fats / oils | - |
| fish products | - |
| frozen dairy | - |
| fruit ices | - |
| gelatins / puddings | - |
| granulated sugar | - |
| gravies | - |
| hard candy | - |
| imitation dairy | - |
| instant coffee / tea | - |
| jams / jellies | - |
| meat products | - |
| milk products | - |
| nut products | - |
| other grains | - |
| poultry | - |
| processed fruits | - |
| processed vegetables | - |
| reconstituted vegetables | - |
| seasonings / flavors | - |
| snack foods | - |
| soft candy | - |
| soups | - |
| sugar substitutes | - |
| sweet sauces | - |
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