Identification

Nameethyl 2-methyl butyrate
IUPACethyl 2-methylbutanoate
CAS Number7452-79-1
EINECS231-225-4
FDA UNIIL1T4AB29DS
Molecular FormulaC7 H14 O2
Molecular Weight130.18698000
MDL NumberMFCD00012217
Nikkaji NumberJ124.069B
Beilstein1720887
CoE Number265

Regulatory

JECFA Food Flavoring206 ethyl 2-methylbutyrate
DG SANTE Food Flavourings09.409 ethyl 2-methylbutyrate
FEMA Number2443
FDANo longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm (SATF)7452-79-1 ; ETHYL 2-METHYLBUTYRATE
FDA RegulationFDA PART 172 -- FOOD ADDITIVES PERMITTED FOR DIRECT ADDITION TO FOOD FOR HUMAN CONSUMPTION

Physical Properties

Appearance colorless clear liquid (est)
Assay 98.00 to 100.00
Food Chemicals Codex Listed Yes
Specific Gravity 0.86300 to 0.87000 @ 25.00 °C.
Pounds per Gallon - (est). 7.181 to 7.239
Refractive Index 1.39300 to 1.40000 @ 20.00 °C.
Boiling Point 132.00 to 133.00 °C. @ 760.00 mm Hg
Acid Value 2.00 max. KOH/g
Vapor Pressure 7.853000 mmHg @ 25.00 °C. (est)
Vapor Density 4.5 ( Air = 1 )
Flash Point 79.00 °F. TCC ( 26.11 °C. )
logP (o/w) 2.158 (est)
Shelf Life 12.00 month(s) or longer if stored properly.
Storage store in cool, dry place in tightly sealed containers, protected from heat and light.
Soluble in alcohol
Insoluble in water
Stability soap
Similar Items note

Cosmetic Information

CosIngcosmetic data
Cosmetic Usesperfuming agents

Organoleptic Properties

Odor Strength medium ,
Substantivity 4 hour(s) at 100.00 %
Odor Description
at 10.00 % in dipropylene glycol.
Fruity, estry and berry with fresh tropical nuances
Fruity, Green, Apple peel, Pineapple skin
estery, very fruity, reminiscent of papaya, apple, quince, apricot and strawberry
green-fruity apple peel plums ethereal diffusive
Powerful green fruity fresh
Odor sample from SCM Glidco Organics
Taste Description
at 10.00 ppm.
fruity green berry strawberry fresh apple pineapple raspberry
estery, very fruity, juicy, sweet, apple- and strawberry-like

Safety Information

Preferred SDSView
European informationMost important hazard(s):
Oral/Parenteral ToxicityNot determined
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categoryflavor and fragrance agents
RIFM Fragrance Material Safety AssessmentSearch
Recommendation for ethyl 2-methyl butyrate usage levels up to1.0000 % in the fragrance concentrate.
Maximised Survey-derived Daily Intakes (MSDI-EU)1900.00 (μg/capita/day)
baked goods-
beverages(nonalcoholic)-
beverages(alcoholic)-
breakfast cereal-
cheese-
chewing gum-
condiments / relishes-
confectionery froastings-
egg products-
fats / oils-
fish products-
frozen dairy-
fruit ices-
gelatins / puddings-
granulated sugar-
gravies-
hard candy-
imitation dairy-
instant coffee / tea-
jams / jellies-
meat products-
milk products-
nut products-
other grains-
poultry-
processed fruits-
processed vegetables-
reconstituted vegetables-
seasonings / flavors-
snack foods-
soft candy-
soups-
sugar substitutes-
sweet sauces-

ACS International GmbH

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Potential Uses

FR apple FR apple green apple FR berry FR citrus FR fruit FL fruit tropical fruit FR grape FR honeydew FR mango FR orange peel FR pineapple FR raspberry FR strawberry topnotes

Natural Occurrence

apple juice PMC apple raw apple PMC bilberry fruit brandy PMC cantaloupe petiole chamomile flower oil germany @ 0.17% Data champaca concrete @ trace% Data cider PMC cognac PMC fig fruit grapefruit juice hazelnut laurel leaf oil turkey @ trace% Data melon PMC orange fruit pineapple fruit plum fruit rum PMC spearmint leaf spearmint oil strawberry wild strawberry fruit tagete flower oil rwanda @ trace% Data tagete oil rwanda @ 0.02% Data tagete oil turkey @ 0.08% Data vanilla wine wormwood oil annus france @ 0.00-0.17% Data

Synonyms

berry butyrate butanoic acid, 2-methyl-, ethyl ester butyric acid, 2-methyl-, ethyl ester cydrane dorintha ethyl 2 methyl butyrate ethyl 2 methyll butyrate synthetic ethyl 2-methyl butanoate ethyl 2-methyl butyrate (natural) ethyl 2-methyl butyrate FCC ethyl 2-methyl butyrate natural ethyl 2-methyl butyrate pure FCC ethyl 2-methylbutanoate ethyl 2-methylbutyrate ethyl 2-methylbutyrate (natural) ethyl 2-methylbutyrate FCC ethyl a-methylbutyrate ethyl alpha-methyl butyrate ethyl DL-2-methylbutyrate ethyl methyl butyrate-2 ethyl methyl butyrate-2 natural ethyl methyl-2-butyrate ethyl-2-methyl butyrate ethyl-2-methyl butyrate FCC ethyl-2-methyl butyrate natural ethyl-2-methyl butyrate, natural ethyl-2-methyl-butyrate nat. ethyl-2-methylbutyrate ethyl-2-methylbutyrate FCC ethyl-2-methylbutyrate natural 2- methyl butanoic acid ethyl ester 2- methyl butyric acid ethyl ester 2- methylbutanoic acid ethyl ester 2- methylbutyric acid ethyl ester DL-2- methylbutyric acid ethyl ester Info: FILBERTONE PubMed: Aroma characterization of tangerine hybrids by gas-chromatography-olfactometry and sensory evaluation. J-Stage: Odor-Active Constituents in Fresh Pineapple (Ananas comosus [L.] Merr.) by Quantitative and Sensory Evaluation Info: Volatile Flavor Components in Bogyojosaeng and Suhong Cultivars of Strawberry (Fragaria ananassa Duch.) PubMed: Comparison of fermented soybean paste (Doenjang) prepared by different methods based on profiling of volatile compounds. J-Stage: Asymmetric Reduction of Ethyl 2-methyl 3-oxobutanoate by Fungi PubMed: Changes in key aroma compounds of Criollo cocoa beans during roasting. J-Stage: Asymmetric Reduction of Ethyl 2-methyl 3-oxobutanoate by Chlorella PubMed: Characterization of aroma compounds in apple cider using solvent-assisted flavor evaporation and headspace solid-phase microextraction. J-Stage: Effects of MCPA and Other Phenoxyacid Compounds on Hepatic Xenobiotic Metabolism in Rats PubMed: Characterization of aroma-active compounds in raw and cooked pine-mushrooms (Tricholoma matsutake Sing.). 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PubMed: Selective mGluR1 antagonist EMQMCM inhibits the kainate-induced excitotoxicity in primary neuronal cultures and in the rat hippocampus. PubMed: Quality evaluation of olive oil by statistical analysis of multicomponent stable isotope dilution assay data of aroma active compounds. PubMed: Early leaf removal impact on volatile composition of Tempranillo wines. PubMed: Volatile compounds responsible for aroma of Jutrzenka liquer wine. PubMed: Characterization of odor-active compounds of various cherry wines by gas chromatography-mass spectrometry, gas chromatography-olfactometry and their correlation with sensory attributes. PubMed: Characteristic aroma compounds from different pineapple parts. PubMed: Aroma volatiles recovered in the water phase of cashew apple (Anacardium occidentale L.) juice during concentration. PubMed: Identification of fruity aroma-producing compounds from Chryseobacterium sp. isolated from the Western Ghats, India. PubMed: Effectiveness of different solid-phase microextraction fibres for differentiation of selected Madeira island fruits based on their volatile metabolite profile--identification of novel compounds. PubMed: Comparison of volatile components in Chinese traditional pickled peppers using HS-SPME-GC-MS, GC-O and multivariate analysis. PubMed: The effect of structure and a secondary carbon source on the microbial degradation of chlorophenoxy acids. PubMed: Characterisation of the most odour-active compounds of bone tainted dry-cured Iberian ham. PubMed: Influence of modified atmosphere packaging on volatile compounds and physicochemical and antioxidant attributes of fresh-cut pineapple (Ananas comosus). PubMed: The HIV-1 viral protein Tat increases glutamate and decreases GABA exocytosis from human and mouse neocortical nerve endings. PubMed: Development of a method based on on-line reversed phase liquid chromatography and gas chromatography coupled by means of an adsorption-desorption interface for the analysis of selected chiral volatile compounds in methyl jasmonate treated strawberries. PubMed: Nitrogen addition influences formation of aroma compounds, volatile acidity and ethanol in nitrogen deficient media fermented by Saccharomyces cerevisiae wine strains. PubMed: Neurochemical evidence that stimulation of CB1 cannabinoid receptors on GABAergic nerve terminals activates the dopaminergic reward system by increasing dopamine release in the rat nucleus accumbens. PubMed: Examples of perceptive interactions involved in specific "red-" and "black-berry" aromas in red wines. PubMed: Impact of thermal and nonthermal processing technologies on unfermented apple cider aroma volatiles. PubMed: Effects of elevated CO2 on grapevine (Vitis vinifera L.): volatile composition, phenolic content, and in vitro antioxidant activity of red wine. PubMed: Muscarinic modulation of synaptic transmission via endocannabinoid signalling in the rat midbrain periaqueductal gray. PubMed: Defining the typical aroma of sherry vinegar: sensory and chemical approach. PubMed: Modulation of a spinal locomotor network by metabotropic glutamate receptors. PubMed: Determination of volatile compounds in cider spirits by gas chromatography with direct injection. PubMed: High production of (2s,3s)-3-hydroxy-2-methylbutanoate by immobilized plant cells of Marchantia polymorpha. PubMed: Pathway analysis of branched-chain ester biosynthesis in apple using deuterium labeling and enantioselective gas chromatography-mass spectrometry. PubMed: Comparison of the odor-active compounds in unhopped beer and beers hopped with different hop varieties. PubMed: Metabolite production of yeasts on a strawberry-agar during storage at 7 degrees C in air and low oxygen atmosphere. PubMed: Comparison of aroma volatiles in commercial Merlot and Cabernet Sauvignon wines using gas chromatography-olfactometry and gas chromatography-mass spectrometry. PubMed: Aroma composition of red wines by different extraction methods and Gas Chromatography-SIM/MASS spectrometry analysis. PubMed: On-line reversed-phase liquid chromatography-gas chromatography coupled to mass spectrometry for enantiomeric analysis of chiral compounds in fruit beverages. PubMed: Novel secoergoline derivatives inhibit both GABA and glutamate uptake in rat brain homogenates: synthesis, in vitro pharmacology, and modeling. PubMed: Human adipocyte fatty acid-binding protein (aP2) gene promoter-driven reporter assay discriminates nonlipogenic peroxisome proliferator-activated receptor gamma ligands. PubMed: Investigation of volatiles in Charentais cantaloupe melons (Cucumis melo Var. cantalupensis). Characterization of aroma constituents in some cultivars. PubMed: Enantioselective analysis of methyl-branched alcohols and acids in rhubarb (Rheum rhabarbarum L.) stalks. PubMed: Composition of the essential oil of Mentha microphylla from the Gennargentu Mountains (Sardinia, Italy). PubMed: Group I metabotropic glutamate receptors modulate glutamate and gamma-aminobutyric acid release in the periaqueductal grey of rats. PubMed: Chemical and sensorial aroma characterization of freshly distilled Calvados. 2. Identification of volatile compounds and key odorants. PubMed: Odor-active compounds of Iberian hams with different aroma characteristics. PubMed: Studies of the constituents of Uruguayan propolis. PubMed: Character impact odorants of the apple cultivars Elstar and Cox Orange. PubMed: Biosynthesis of strawberry aroma compounds through amino acid metabolism. PubMed: Herbicide sensitivity of transgenic multiple herbicide-tolerant oilseed rape. PubMed: Characterization of the most odor-active compounds of Iberian ham headspace. PubMed: Aromatic profile of aqueous banana essence and banana fruit by gas chromatography-mass spectrometry (GC-MS) and gas chromatography-olfactometry (GC-O). PubMed: Biotransformation of MTBE, ETBE, and TAME after inhalation or ingestion in rats and humans. PubMed: Evaluation of aroma differences between hand-squeezed juices from Valencia late and Navel oranges by quantitation of key odorants and flavor reconstitution experiments. PubMed: Evaluation of key aroma compounds in hand-squeezed grapefruit juice (Citrus paradisi Macfayden) by quantitation and flavor reconstitution experiments. PubMed: Influence of Different Oxygen and Carbon Dioxide Concentrations during Storage on Production of Volatile Compounds by Starking Delicious Apples. PubMed: Characterization of Volatiles in Rambutan Fruit (Nephelium lappaceum L.). PubMed: Metabolism of ethyl tiglate in apple fruits leads to the formation of small amounts of (R)-ethyl 2-methylbutanoate. PubMed: Floral scent compounds of Amazonian Annonaceae species pollinated by small beetles and thrips. PubMed: Pharmacological characterization of chloride channels belonging to the ClC family by the use of chiral clofibric acid derivatives. PubMed: Asymmetric reduction of ethyl 2-methyl e-oxobutanoate by fungi. PubMed: Potent odorants of raw Arabica coffee. Their changes during roasting. PubMed: Activity-dependent activation of presynaptic metabotropic glutamate receptors in locus coeruleus. PubMed: Relationships between volatile production, fruit quality, and sensory evaluation in Granny Smith apples stored in different controlled-atmosphere treatments by means of multivariate analysis. PubMed: Similarities in the aroma chemistry of Gewürztraminer variety wines and lychee (Litchi chinesis sonn.) fruit. PubMed: Asymmetric reduction of ethyl 2-methyl 3-oxobutanoate by Chlorella. PubMed: Assimilation of volatiles from ripe apples by Sporidiobolus salmonicolor and Tilletiopsis washingtonensis. PubMed: Modulation of excitatory synaptic transmission in locus coeruleus by multiple presynaptic metabotropic glutamate receptors. PubMed: Activation of hippocampal adenosine A3 receptors produces a desensitization of A1 receptor-mediated responses in rat hippocampus. PubMed: Optimization of semiochemical-based trapping ofMetamasius hemipterus sericeus (Olivier) (Coleoptera: Curculionidae). PubMed: Effects of MCPA and other phenoxyacid compounds on hepatic xenobiotic metabolism in rats. PubMed: Effects of ethyl 4-chloro-2-methylphenoxyacetate on hepatic peroxisomal enzymes in rats. PubMed: Effects of physiological factors on the bioavailability of ethyl 2-chloro-3-[4-(2-methyl-2-phenylpropyloxy)phenyl]propionate in an emulsion in rats. PubMed: Effects of the physicochemical properties of the emulsion formulation on the bioavailability of ethyl 2-chloro-3-[4-(2-methyl-2-phenylpropyloxy)phenyl]propionate in rats. PubMed: Gastro-intestinal absorption of ethyl 2-chloro-3-[4-(2-methyl-2-phenylpropyloxy)phenyl]propionate from different dosage forms in rats and dogs. PubMed: In vivo and in vitro peroxisome proliferation properties of selected clofibrate analogues in the rat. Structure-activity relationships. PubMed: Volatile seed germination inhibitors from plant residues. PubMed: Spectrophotometric enzymatic assay for S-3-hydroxyisobutyrate. PubMed: Effect of peroxisome proliferators on intrachromosomal and interchromosomal recombination in yeast. PubMed: Analogues of alpha-aminoisobutyric acid with various alkyl groups as potential tumour imaging agents; effects of chain length on tumour and normal tissue specificity. PubMed: Use of alcohol oxidase to measure the methanol produced during the hydrolysis of D- and L-methyl-3-hydroxybutyric acid. PubMed: Enhanced peroxisomal beta-oxidation of fatty acids and glutathione metabolism in rats exposed to phenoxyacetic acids. PubMed: Hydroxy acid metabolites of branched-chain amino acids in amniotic fluid. PubMed: Induction of sister chromatid exchanges by the peroxisome proliferators 2,4-D, MCPA, and clofibrate in vivo and in vitro. PubMed: Effect of phenoxy acids on rat liver regeneration. PubMed: Hypolipidemia and peroxisome proliferation induced by phenoxyacetic acid herbicides in rats. PubMed: Larval osmeterial secretions of the swallowtails (Papilio). PubMed: Oxidative metabolism of 4-aminobutyrate by rat brain mitochondria: inhibition by branched-chain fatty acid. PubMed: [Chemistry of phenoxyacetic acid esters of oxyalkyltheophyllines and 1-(theophyllin-7-yl)-ethyl-2-[2-(p-chlorophenoxy)-2-methyl-propionate] (etofylline clofibrate), a novel antilipaemic agent (author's transl)]. PubMed: Comparison of hypocholesterolemic activity for cyclic analogs of clofibrate in normolipemic rats. PubMed: [On the specifity and stereospecificity of the conversion of different 2,3-unsaturated acids by Clostridium kluyveri (author's transl)]. PubMed: Effect of 2-methyl 2-ethyl caproic acid and 2-2-dimethyl valeric acid on audiogenic seizures and brain gamma aminobutyric acid. PubMed: D- and L-isoleucine metabolism and regulation of their pathways in Pseudomonas putida. PubMed: Influence of ethyl-2 [chlorophenoxy]--2--methyl propionate [atromid--s] on liposoluble vitamins.