(±)-sec-butyl amine

sec-butylamine

CAS: 13952-84-6 C4 H11 N MW: 73.13867000

Identification

Name(±)-sec-butyl amine
CAS Number13952-84-6
EINECS237-732-7
FDA UNIIQAZ452YGSG
Molecular FormulaC4 H11 N
Molecular Weight73.13867000
MDL NumberMFCD00008094
Nikkaji NumberJ8.464F
Beilstein1361345
CoE Number707

Regulatory

JECFA Food Flavoring1584 sec-butylamine
DG SANTE Food Flavourings11.005 sec-butylamine
FEMA Number4240
FDANo longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm (SATF)13952-84-6 ; SEC-BUTYLAMINE

Physical Properties

Appearance colorless to yellow clear liquid (est)
Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Specific Gravity 0.71500 to 0.72100 @ 25.00 °C.
Pounds per Gallon - (est). 5.950 to 5.999
Refractive Index 1.38700 to 1.39300 @ 20.00 °C.
Melting Point -72.00 °C. @ 760.00 mm Hg
Boiling Point 62.00 to 63.00 °C. @ 760.00 mm Hg
Vapor Pressure 178.000000 mmHg @ 25.00 °C.
Flash Point -3.00 °F. TCC ( -19.44 °C. )
logP (o/w) 0.740
Soluble in propylene glycol

Organoleptic Properties

Odor Description at 0.10 % in propylene glycol.

Safety Information

Preferred SDSView
European informationMost important hazard(s):
Oral/Parenteral Toxicityoral-rat LD50 152 mg/kg
Dermal Toxicityskin-rabbit LD50 2500 mg/kg
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categoryflavoring agents
Recommendation for (±)-sec-butyl amine usage levels up tonot for fragrance use.
Maximised Survey-derived Daily Intakes (MSDI-EU)0.012 (μg/capita/day)
Maximised Survey-derived Daily Intakes (MSDI-USA)2.00 (μg/capita/day)
Modified Theoretical Added Maximum Daily Intake (mTAMDI)340 (μg/person/day)
Threshold of Concern1800 (μg/person/day)
Structure Class1
baked goods2.00000
beverages(nonalcoholic)-
beverages(alcoholic)-
breakfast cereal0.20000
cheese0.40000
chewing gum-
condiments / relishes0.10000
confectionery froastings1.00000
egg products-
fats / oils0.10000
fish products0.20000
frozen dairy0.40000
fruit ices0.40000
gelatins / puddings-
granulated sugar-
gravies0.10000
hard candy-
imitation dairy-
instant coffee / tea-
jams / jellies-
meat products0.20000
milk products0.40000
nut products-
other grains0.20000
poultry0.20000
processed fruits0.40000
processed vegetables-
reconstituted vegetables-
seasonings / flavors0.10000
snack foods1.00000
soft candy-
soups0.10000
sugar substitutes-
sweet sauces-
Dairy products, excluding products of category 02.0 (01.0)0.40000
Fats and oils, and fat emulsions (type water-in-oil) (02.0)0.10000
Edible ices, including sherbet and sorbet (03.0)0.40000
Processed fruit (04.1)0.40000
Processed vegetables (incl. mushrooms & fungi, roots & tubers, pulses and legumes), and nuts & seeds (04.2)-
Confectionery (05.0)1.00000
Chewing gum (05.3)-
Cereals and cereal products, incl. flours & starches from roots & tubers, pulses & legumes, excluding bakery (06.0)0.20000
Bakery wares (07.0)2.00000
Meat and meat products, including poultry and game (08.0)0.20000
Fish and fish products, including molluscs, crustaceans and echinoderms (MCE) (09.0)0.20000
Eggs and egg products (10.0)-
Sweeteners, including honey (11.0)-
Salts, spices, soups, sauces, salads, protein products, etc. (12.0)0.10000
Foodstuffs intended for particular nutritional uses (13.0)0.20000
Non-alcoholic ("soft") beverages, excl. dairy products (14.1)-
Alcoholic beverages, incl. alcohol-free and low-alcoholic counterparts (14.2)1.00000
Ready-to-eat savouries (15.0)1.00000
Composite foods (e.g. casseroles, meat pies, mincemeat) - foods that could not be placed in categories 01.0 - 15.0 (16.0)0.20000

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Potential Uses

FL cereal FL cheese FL dairy FR fruit FL meat

Natural Occurrence

found in nature

Synonyms

(±)-2- aminobutane 2- aminobutane butafume butan-2-amine butan-2-yl amine (±)-2- butanamine 2- butanamine (±)-2- butyl amine (RS)-sec- butyl amine 2- butyl amine dextro,laevo-2- butyl amine dextro,laevo-sec- butyl amine (±)-2- butylamine (±)-sec- butylamine (RS)-sec- butylamine ±-sec- butylamine 2- butylamine D,L-2- butylamine D,L-sec- butylamine sec- butylamine 1- methyl propanamine 1- methyl propyl amine 1- methylpropanamine 1- methylpropylamine propylamine, 1-methyl propylamine, 1-methyl- tutane Info: aliphatic and aromatic amines and amides PubMed: [Synthesis of particle-free silver conductive ink and investigation of fabrication of conductive film by printing]. PubMed: Enantioselective supramolecular carriers for nucleoside drugs. A thermodynamic and kinetic gas phase investigation. PubMed: Unprecedented gas-phase chiroselective logic gates. PubMed: Transition metal catalysed dehydrogenation of amine-borane fuel blends. PubMed: Interaction of antitumor platinum complexes with human liver microsomal cytochromes P450. PubMed: Protonation and silver(I) complex-formation equilibria of some amino-alcohols. PubMed: A kinetic study of guest displacement reactions on a host-guest complex with a photoswitchable calixarene. PubMed: Modelling amphetamine/receptor interactions: a gas-phase study of complexes formed between amphetamine and Some chiral amido[4]resorcinarenes. PubMed: Induced-fit in the gas phase: conformational effects on the enantioselectivity of chiral tetra-amide macrocycles. PubMed: Monosolvation of R-1-phenyl-2,2,2-trifluoroethanol with amines: configurational effects on the excitation, ionization, and fragmentation of diastereomeric complexes. PubMed: Pharmacokinetics and metabolism of 3,4-dichlorophenyl-propenoyl-sec.-butylamine in rats by high performance liquid chromatography-ion trap mass spectrometry. PubMed: Gas-phase enantioselectivity of chiral amido[4]resorcinarene receptors. PubMed: Purification and characterization of a novel cyclohexylamine oxidase from the cyclohexylamine-degrading Brevibacterium oxydans IH-35A. PubMed: Microbial synthesis of chiral amines by (R)-specific transamination with Arthrobacter sp. KNK168. PubMed: Elementary supramolecular chemistry in the gas phase: ligand exchange reactions of proton-bound clusters of aliphatic amides and diamides with amines. PubMed: Effect of chelating vs. bridging coordination of chiral short-bite P-X-P (X=C, N, O) ligands in enantioselective palladium-catalysed allylic substitution reactions. PubMed: Chiral recognition by resorcin[4]arene receptors: intrinsic kinetics and dynamics. PubMed: Kinetic resolution of (R,S)-sec-butylamine using omega-transaminase from Vibrio fluvialis JS17 under reduced pressure. PubMed: The Direct catalytic asymmetric cross-Mannich reaction: a highly enantioselective route to 3-amino alcohols and alpha-amino acid derivatives. PubMed: DNA interactions of new antitumor platinum complexes with trans geometry activated by a 2-metylbutylamine or sec-butylamine ligand. PubMed: Microbial synthesis of (R)- and (S)-3,4-dimethoxyamphetamines through stereoselective transamination. PubMed: The effect of ligand charge on the coordination geometry of an Fe(III)ion: five- and six-coordinate Fe(III) complexes of tris(2-benzimidazolylmethyl)amine. PubMed: Comparison of the omega-transaminases from different microorganisms and application to production of chiral amines. PubMed: PMMA-stimulus generalization to the optical isomers of MBDB and 3,4-DMA. PubMed: N-methyl-1-(1,3-benzodioxol-5-yl)-2-butanamine (MBDB): its properties and possible risks. PubMed: Effect of common food preservatives on mycelial growth and spore germination of Fusarium oxysporum. PubMed: [The degradation of glycoproteins with lithium borohydride. Isolation and analysis of O-glycopeptides with reduced C-terminal amino acid residue]. PubMed: Indan analogs of fenfluramine and norfenfluramine have reduced neurotoxic potential. PubMed: [Study on ion chromatography (IC) for the low-molecular weight amines]. PubMed: Thermometric titrations of amines with nitrosyl perchlorate in acetonitrile solvent. PubMed: High-performance liquid chromatographic method for the simultaneous determination of pentisomide and its major metabolite N-desisopropylpentisomide in plasma, urine and tissues using solid-phase extraction. PubMed: Stereoselective LSD-like activity in d-lysergic acid amides of (R)- and (S)-2-aminobutane. PubMed: Postharvest-applied agrochemicals and their residues in fresh fruits and vegetables. PubMed: [3H]monoamine releasing and uptake inhibition properties of 3,4-methylenedioxymethamphetamine and p-chloroamphetamine analogues. PubMed: Behavioral, biochemical and neurotoxicological actions of the alpha-ethyl homologue of p-chloroamphetamine. PubMed: Resolution of enantiomeric amides on a Pirkle-type chiral stationary phase. A comparison of subcritical fluid and liquid chromatographic approaches. PubMed: Evaluation of the genetic activity profiles of 65 pesticides. PubMed: Determination of coumarin anticoagulant rodenticide residues in animal tissue by high-performance liquid chromatography. I. Fluorescence detection using post-column techniques. PubMed: Carcinogenicity of methylated derivatives of N-nitrosodiethylamine and related compounds in Sprague-Dawley rats. PubMed: Synthesis and body distribution of several iodine-131 labeled centrally acting drugs. PubMed: Approach to the quantitative analysis of di-sec.butylamine stereoisomeric mixtures by means of N.M.R. PubMed: An evaluation of 1-(4-methyl) 2, 5-dimethoxyphenyl-2-aminobutane (MDPA-1) as an enhancer of memory and learning. PubMed: Control of potato gangrene and skin spot diseases by fumigation of tubers with sec-butylamine.