4-O-alpha-D-glucopyranosyl-D-glucitol

CAS: 585-88-6 C12 H24 O11 MW: 344.31448000 sweet

Identification

Namemaltitol
IUPAC4-[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyhexane-1,2,3,5,6-pentol
CAS Number585-88-6
EINECS209-567-0
FDA UNIID65DG142WK
Molecular FormulaC12 H24 O11
Molecular Weight344.31448000
MDL NumberMFCD00006600
Beilstein0089983

Regulatory

JECFA Food AdditiveMaltitol
GSFA CodexMaltitol (965(i))
DG SANTE Food Additivesmaltitol
DG SANTE Food Contact Materialsmaltitol

Physical Properties

Appearance white crystalline powder (est)
Assay 98.00 to 100.00
Food Chemicals Codex Listed No
Specific Gravity 0.90000 @ 75.00 °C.
Melting Point 148.00 to 151.00 °C. @ 760.00 mm Hg
Boiling Point 788.53 °C. @ 760.00 mm Hg (est)
Flash Point 807.00 °F. TCC ( 430.70 °C. ) (est)
logP (o/w) -4.679 (est)
Soluble in chlorinated solvents
Insoluble in acetone

Cosmetic Information

CosIngcosmetic data
Cosmetic Usesfragrance

Organoleptic Properties

Taste Description sweet

Safety Information

Preferred SDSView
Oral/Parenteral ToxicityNot determined
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorysweeteners, flavor enhancers
Recommendation for maltitol usage levels up tonot for fragrance use.

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Potential Uses

humectants

Natural Occurrence

not found in nature

Synonyms

amalti syrup amalty MR 100 4-O-alpha-D- glucopyranosyl-D-glucitol D- glucopyranosyl-D-glucitol 4-O-alpha-dextro- glucopyranosyl-dextro-glucitol hexitol, 3-O-hexopyranosyl- 3-o- hexopyranosylhexitol D- maltitol dextro- maltitol rightsweet maltitol powder 4-[3,4,5- trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyhexane-1,2,3,5,6-pentol PubMed: [Malabsorption of fermentable oligo-, di-, or monosaccharides and polyols (FODMAP) as a common cause of unclear abdominal discomfort]. PubMed: Effects of sugar-free chewing gum sweetened with xylitol or maltitol on the development of gingivitis and plaque: a randomized clinical trial. PubMed: Digestive tolerance and postprandial glycaemic and insulinaemic responses after consumption of dairy desserts containing maltitol and fructo-oligosaccharides in adults. PubMed: [Determination of alditols in foods by ion chromatography-mass spectrometry]. PubMed: Metabolomic response of Calotropis procera growing in the desert to changes in water availability. PubMed: Potential intakes of total polyols based on UK usage survey data. PubMed: Interpretation of psychophysics response curves using statistical physics. PubMed: [Simultaneous determination of monosaccharides, disaccharides, oligosaccharides and sugar alcohols in foods by high performance liquid chromatography with evaporative light-scattering detection]. PubMed: Effects of maltitol and xylitol chewing-gums on parameters involved in dental caries development. PubMed: Storage stability of a commercial hen egg yolk powder in dry and intermediate-moisture food matrices. PubMed: Aqueous and hydro-alcoholic media effects on polyols. PubMed: The thuEFGKAB operon of rhizobia and agrobacterium tumefaciens codes for transport of trehalose, maltitol, and isomers of sucrose and their assimilation through the formation of their 3-keto derivatives. PubMed: Preparation of D-gulose from disaccharide lactitol using microbial and chemical methods. PubMed: Dissolution rate enhancement of piroxicam by ordered mixing. PubMed: The genotoxic and teratogenic effects of maltitol in rats. PubMed: Influence of sugar type on the bioavailability of cocoa flavanols. PubMed: No evidence of caries reduction found in a school xylitol and erythritol lozenge programme. PubMed: Metabolite profiling of the moss Physcomitrella patens reveals evolutionary conservation of osmoprotective substances. PubMed: The caries-preventive effect of xylitol/maltitol and erythritol/maltitol lozenges: results of a double-blinded, cluster-randomized clinical trial in an area of natural fluoridation. PubMed: Dissolution rate enhancement of gliclazide by ordered mixing. PubMed: The effect of alternative sweeteners on batter rheology and cake properties. PubMed: No observable differences in glycemic response to maltitol in human subjects from 3 ethnically diverse groups. PubMed: The effect of xylitol on the composition of the oral flora: a pilot study. PubMed: [Comparative effects of the maltitol chewing gums on reducing plaque]. PubMed: [Preparation and evaluation of taste masked orally disintegrating tablets with granules made by the wet granulation method]. PubMed: Influences of casein hydrolysate ingestion on cerebral activity, autonomic nerve activity, and anxiety. PubMed: A randomized cross-over study to evaluate the swallow-enhancing and taste-masking properties of a novel coating for oral tablets. PubMed: Short-term digestive tolerance of chocolate formulated with maltitol in children. PubMed: Preparation and evaluation of medicinal carbon oral films. PubMed: A human volunteer study to assess the impact of confectionery sweeteners on the gut microbiota composition. PubMed: Co-ordinated synthesis of gentiobiitol and sorbitol, evidence of sorbitol glycosylation in transgenic sugarcane. PubMed: Freeze-drying of proteins with glass-forming oligosaccharide-derived sugar alcohols. PubMed: Preparation of orally disintegrating tablets with taste-masking function: masking effect in granules prepared with correctives using the dry granulation method and evaluation of tablets prepared using the taste-masked granules. PubMed: [Preparation of orally disintegrating tablets for masking of unpleasant taste: comparison with corrective-adding methods]. PubMed: Selective heteronuclear Hartmann-Hahn: a multiple-pulse sequence for selective magnetization transfer in the structural elucidation of "isotagged" oligosaccharides. PubMed: Preparation and evaluation of medicinal carbon tablets with different saccharides as binders. PubMed: Near-infrared analysis of hydrogen-bonding in glass- and rubber-state amorphous saccharide solids. PubMed: Consistent evidence to support the use of xylitol- and sorbitol-containing chewing gum to prevent dental caries. PubMed: Isoconversional kinetics of glass aging. PubMed: Effects of polyols on the stability of whey proteins in intermediate-moisture food model systems. PubMed: High pressure study on molecular mobility of leucrose. PubMed: Suppressive effect of cellulose on osmotic diarrhea caused by maltitol in healthy female subjects. PubMed: Xylitol gummy bear snacks: a school-based randomized clinical trial. PubMed: Hydrophilic interaction chromatography/electrospray mass spectrometry analysis of carbohydrate-related metabolites from Arabidopsis thaliana leaf tissue. PubMed: Impact of sugar replacers on cognitive performance and function in rats. PubMed: Decreased salivary uptake of [14C]-xylitol after a four-week xylitol chewing gum regimen. PubMed: Improved postprandial response and feeling of satiety after consumption of low-calorie muffins with maltitol and high-amylose corn starch. PubMed: Stability of low concentrations of guanine-based antivirals in sucrose or maltitol solutions. PubMed: Long-term effect of xylitol gum use on mutans streptococci in adults. PubMed: Dental plaque formation and salivary mutans streptococci in schoolchildren after use of xylitol-containing chewing gum. PubMed: Suppressive effect of partially hydrolyzed guar gum on transitory diarrhea induced by ingestion of maltitol and lactitol in healthy humans. PubMed: Influence of carrier on the performance of dry powder inhalers. PubMed: Comparative relaxation dynamics of glucose and maltitol. PubMed: In vitro and in vivo evaluation of medicinal carbon granules and tablet on the adsorption of acetaminophen. PubMed: Considerations about the theoretically expected crushing strength of tablets from binary powder mixtures: double layer tablets versus arithmetic additivity rule. PubMed: Molecular mobility in amorphous maltose and maltitol from phosphorescence of erythrosin B. PubMed: Combined NMR and quantum chemical studies on the interaction between trehalose and dienes relevant to the antioxidant function of trehalose. PubMed: The cytogenetic effects of food sweetener maltitol in human peripheral lymphocytes. PubMed: Genetic requirements for growth of Escherichia coli K12 on methyl-alpha-D-glucopyranoside and the five alpha-D-glucosyl-D-fructose isomers of sucrose. PubMed: Evaluation of binders in the preparation of medicinal carbon tablets by wet granule compression. PubMed: Linear response of mutans streptococci to increasing frequency of xylitol chewing gum use: a randomized controlled trial [ISRCTN43479664]. PubMed: The effect of liquorice extract-containing starch gel on the amount and microbial composition of plaque. PubMed: Medicinal carbon tablets for treatment of acetaminophen intoxication: adsorption characteristics of medicinal carbon powder and its tablets. PubMed: Mutans streptococci dose response to xylitol chewing gum. PubMed: Human gut microbiota does not ferment erythritol. PubMed: Dynamic site heterogeneity in amorphous maltose and maltitol from spectral heterogeneity in erythrosin B phosphorescence. PubMed: Characteristics of transxylosylation by beta-xylosidase from Aspergillus awamori K4. PubMed: Promotive effects of non-digestible disaccharides on rat mineral absorption depend on the type of saccharide. PubMed: Oxygen solubility and permeability of carbohydrates. PubMed: The difficulty in the assessment of the compression behaviour of powder mixtures: Double layer tablets versus arithmetic additivity rule. PubMed: Various non-digestible saccharides increase intracellular calcium ion concentration in rat small-intestinal enterocytes. PubMed: Enzymatic, spectrophotometric determination of glucose, fructose, sucrose, and inulin/oligofructose in foods. PubMed: Two approaches to the synthesis of 3-beta-D-glucopyranosyl-D-glucitol. PubMed: Characteristics of erythritol and formulation of a novel coating with erythritol termed thin-layer sugarless coating. PubMed: Sugar alcohols: what is the evidence for caries-preventive and caries-therapeutic effects? PubMed: Two additional carbohydrate-binding sites of beta-amylase from Bacillus cereus var. mycoides are involved in hydrolysis and raw starch-binding. PubMed: Orientated growth of crystalline anhydrous maltitol (4-O-alpha-D-glucopyranosyl-D-glucitol). PubMed: Alternative sugars as potential carriers for dry powder inhalations. PubMed: Health potential of polyols as sugar replacers, with emphasis on low glycaemic properties. PubMed: Evaluation of critical formulation factors in the development of a rapidly dispersing captopril oral dosage form. PubMed: NMR and quantum chemical study on the OH...pi and CH...O interactions between trehalose and unsaturated fatty acids: implication for the mechanism of antioxidant function of trehalose. PubMed: Cloning and characterization of two alpha-glucosidases from Bifidobacterium adolescentis DSM20083. PubMed: Chemoenzymatically synthesized glycoconjugate polymers. PubMed: [Purification and characterization of cyclomaltodextrin glucanotransferase from alkaliphilic bacteria]. PubMed: A digestive tolerance study of maltitol after occasional and regular consumption in healthy humans. PubMed: Plasticized waxy maize starch: effect of polyols and relative humidity on material properties. PubMed: Interaction of methylparaben preservative with selected sugars and sugar alcohols. PubMed: Sugar alcohols enhance calcium transport from rat small and large intestine epithelium in vitro. PubMed: Various indigestible saccharides enhance net calcium transport from the epithelium of the small and large intestine of rats in vitro. PubMed: Metabolism of sucrose and its five linkage-isomeric alpha-D-glucosyl-D-fructoses by Klebsiella pneumoniae. Participation and properties of sucrose-6-phosphate hydrolase and phospho-alpha-glucosidase. PubMed: Phosphorylation and metabolism of sucrose and its five linkage-isomeric alpha-D-glucosyl-D-fructoses by Klebsiella pneumoniae. PubMed: Responses of the ant Lasius niger to various compounds perceived as sweet in humans: a structure-activity relationship study. PubMed: Evaluation of several saccharides as osmotic agent for peritoneal dialysate. PubMed: Erratum to "Adaptation of dental plaque to metabolise maltitol with other sweeteners". PubMed: Determination of sugar alcohols in confectioneries by high-performance liquid chromatography after nitrobenzoylation. PubMed: Paralytic ileus accompanied by pneumatosis cystoides intestinalis after acarbose treatment in an elderly diabetic patient with a history of heavy intake of maltitol. PubMed: Enzyme kinetics and chemical modification of alpha-1,4-glucan lyase from Gracilariopsis sp. PubMed: What clients need to know about sugar replacers. PubMed: Adaptation of dental plaque to metabolise maltitol compared with other sweeteners. PubMed: Digestibility of the hydrogenated derivative of an isomaltooligosaccharide mixture by rats. PubMed: Solution properties and sweetness response of selected bulk and intense sweeteners. PubMed: Determination of maltitol, isomaltitol, and lactitol by high-pH anion-exchange chromatography with pulsed amperometric detection. PubMed: Transglycosylation reactions of Bacillus stearothermophilus maltogenic amylase with acarbose and various acceptors. PubMed: Evaluation of certain food additives and contaminants. Forty-ninth report of the Joint FAO/WHO Expert Committee on Food Additives. PubMed: Enhanced absorption of calcium after oral administration of maltitol in the rat intestine. PubMed: The maltitol-induced increase in intestinal calcium transport increases the calcium content and breaking force of femoral bone in weanling rats. PubMed: Polyol-combinant saliva stimulants: a 4-month pilot study in young adults. PubMed: Di- and oligosaccharide substrate specificities and subsite binding energies of pig intestinal glucoamylase-maltase. PubMed: Disaccharidase activity in rat cecum and colon with hyperplasia induced by maltitol or glucomannan. PubMed: Sensory evaluation of mixtures of maltitol or aspartame, sucrose and an orange aroma. PubMed: Tolerance and breath hydrogen excretion following ingestion of maltitol incorporated at two levels into milk chocolate consumed by healthy young adults with and without fasting. PubMed: Dietary maltitol decreases the incidence of 1,2-dimethylhydrazine-induced cecum and proximal colon tumors in rats. PubMed: Separation of alditols of interest in food products by high-performance anion-exchange chromatography with pulsed amperometric detection. PubMed: Acarbose and 1-deoxynojirimycin inhibit maltose and maltooligosaccharide hydrolysis of human small intestinal glucoamylase-maltase in two different substrate-induced modes. PubMed: Efficient purification, characterization and partial amino acid sequencing of two alpha-1,4-glucan lyases from fungi. PubMed: Maltitol and maltobionate act differently on maltose- and maltooligosaccharide hydrolysis by human small intestinal glucoamylase-maltase indicating two different enzyme binding modes. PubMed: Influence of the nature of carbohydrate intake on the absorption chronology of reducing sugars and volatile fatty acids in the pig. PubMed: Maltitol increases transepithelial diffusional transfer of calcium in rat ileum. PubMed: Dose-related gastrointestinal response to the ingestion of either isomalt, lactitol or maltitol in milk chocolate. PubMed: Methods available to estimate the energy values of sugar alcohols. PubMed: Dietary maltitol increases calcium content and breaking force of femoral bone in ovariectomized rats. PubMed: Inhibition of dextran and mutan synthesis by cycloisomaltooligosaccharides. PubMed: Digestibility characteristics of isomaltooligosaccharides in comparison with several saccharides using the rat jejunum loop method. PubMed: Transgalactosylation catalyzed by alpha-galactosidase from Candida guilliermondii H-404. PubMed: Evaluation of acidogenicity of commercial isomaltooligosaccharides mixture and its hydrogenated derivative by measurement of pH response under human dental plaque. PubMed: Bitterness of sweeteners as a function of concentration. PubMed: Digestion and absorption of sorbitol, maltitol and isomalt from the small bowel. A study in ileostomy subjects. PubMed: A new enzyme, maltobionate alpha-D-glucohydrolase, from alkalophilic Bacillus sp. N-1053. PubMed: Further characterization of the sorbitol permease in PAP-HT25 cells. PubMed: Effect of modulators of the adenylate cyclase system on sweet electrophysiological taste responses in gerbil. PubMed: NMR spectroscopy of exchangeable protons of glucoamylase and of complexes with inhibitors in the 9-15-ppm range. PubMed: Phosphoenolpyruvate-dependent maltose:phosphotransferase activity in Fusobacterium mortiferum ATCC 25557: specificity, inducibility, and product analysis. PubMed: Glycaemic and insulinaemic responses in healthy volunteers upon ingestion of maltitol and hydrogenated glucose syrups. PubMed: Clinical caries studies with polyalcohols. A literature review. PubMed: Maltitol-induced increase of transepithelial transport of calcium in rat small intestine. PubMed: Absorption balances and kinetics of nutrients and bacterial metabolites in conscious pigs after intake of maltose- or maltitol-rich diets. PubMed: Safety assessment of hydrogenated starch hydrolysates. PubMed: 'Determination' of sugar alcohol and Polydextrose absorption in humans by the breath hydrogen (H2) technique: the stoichiometry of hydrogen production and the interaction between carbohydrates assessed in vivo and in vitro. PubMed: Isolation and attempted introduction of sugar alcohol-utilizing bacteria in the sheep rumen. PubMed: Stability of procainamide hydrochloride syrups compounded from capsules. PubMed: Stability of hydralazine hydrochloride syrup compounded from tablets. PubMed: Efficacy of sweeteners and sugar substitutes in caries prevention. PubMed: Gastrointestinal transit and digestibility of maltitol, sucrose and sorbitol in rats: a multicompartmental model and recovery study. PubMed: Effect of maltitol intake on intestinal calcium absorption in the rat. PubMed: Roles of the aromatic side chains in the binding of substrates, inhibitors, and cyclomalto-oligosaccharides to the glucoamylase from Aspergillus niger probed by perturbation difference spectroscopy, chemical modification, and mutagenesis. PubMed: Noncariogenicity of maltitol in specific pathogen-free rats infected with mutans streptococci. PubMed: Metabolic fate of ingested [14C]-maltitol in man. PubMed: Feeding behavior in growing rats fed diets containing sorbose. PubMed: Comparative digestion of maltitol and maltose in unanesthetized pigs. PubMed: Effects of chemically modified starches in suspensions and lozenges on pH of human dental plaque. PubMed: [Clinical tolerance, intestinal absorption, and energy value of four sugar alcohols taken on an empty stomach]. PubMed: Relationship between molecular structures of sugars and their ability to stimulate the release of glucagon-like peptide-1 from canine ileal loops. PubMed: Digestion and absorption in the human intestine of three sugar alcohols. PubMed: Metabolic response to oral challenge of hydrogenated starch hydrolysate versus glucose in diabetes. PubMed: Effects of reduced malto-oligosaccharides on the thermal stability of pullulanase from Bacillus acidopullulyticus. PubMed: Dietary maltitol causes increased serum and liver cholesterol concentrations in rats. PubMed: Metabolism of maltitol by conventional rats and mice and germ-free mice, and comparative digestibility between maltitol and sorbitol in germ-free mice. PubMed: Hydrogen excretion after ingestion of five different sugar alcohols and lactulose. PubMed: Carbohydrate-controlled precipitation of apatite with coprecipitation of organic molecules in human saliva: stabilizing role of polyols. PubMed: The effect of hydrogenated starch hydrolysates on plaque pH in vivo. PubMed: [Non-cariogenicity of maltitol in vitro and animal experiments]. PubMed: Relationship between carbohydrate sweeteners and oral diseases. PubMed: Sugar substitutes and their energy value for the human body. PubMed: Hydrolysis of lactitol, maltitol and Palatinit by human intestinal biopsies. PubMed: Purification and characterization of extracellular alpha-amylase and glucoamylase from the yeast Candida antarctica CBS 6678. PubMed: Comparative study of maltitol and sucrose by means of continuous indirect calorimetry. PubMed: [Digestion of a maltitol-rich hydrogenated syrup in conscious pigs]. PubMed: Effects of oral administration of maltitol on plasma glucose, plasma sorbitol, and serum insulin levels in man. PubMed: Digestion and absorption of sugars and sugar substitutes in rat small intestine. PubMed: [Biochemical and organoleptic characteristics of maltitol. A non-cariogenic sweetener]. PubMed: Inhibition of glucoamylases from a Rhizopus sp. and Aspergillus saitoi by aminoalcohol derivatives. PubMed: [Malbit, a dentally harmless sugar substitute]. PubMed: Microbiological aspects of some caloric sugar substitutes. PubMed: The effect of sweeteners on acid production in plaque. PubMed: New approach to the metabolism of hydrogenated starch hydrolysate: hydrolysis by the maltase/glucoamylase complex of the rat intestinal mucosa. PubMed: [Caries-inducing activity of a maltitol-rich sweetener in the experimental dental caries of rats]. PubMed: [Influence of maltitol on lipid metabolism: fatty acid composition of the heart and brain of the rat]. PubMed: Comparison of the structures and elicitor activities of a synthetic and a mycelial-wall-derived hexa(beta-D-glucopyranosyl)-D-glucitol. PubMed: Purification and partial characterization of a beta-glucan fragment that elicits phytoalexin accumulation in soybean. PubMed: The primary structures of one elicitor-active and seven elicitor-inactive hexa(beta-D-glucopyranosyl)-D-glucitols isolated from the mycelial walls of Phytophthora megasperma f. sp. glycinea. PubMed: Bacterial reversion assay and micronucleus test carried out on hydrogenated glucose syrups 'Malti-Towa' (powder) and maltitol crystal. PubMed: Differential assay of human pancreatic and salivary alpha-amylases in serum using a new fluorogenic substrate. PubMed: Nutritional studies on maltitol. Part 1: Acceptability, energetic yield, effects on growth and blood biochemical parameters. PubMed: Nutritional studies on maltitol. Part 2: Effect on lipid metabolism and fatty acid composition of different rat tissues. PubMed: Digestion of maltitol in man, rat, and rabbit. PubMed: Special bacterial polysaccharides and polysaccharases. PubMed: The metabolism of maltitol in the rat. PubMed: Taste aversion to sugars by the gerbil. PubMed: N-bromosuccinimide oxidation of a glucoamylase from Aspergillus saitoi. PubMed: Sugar substitutes: reasons and indications for their use. PubMed: Identity of alpha-glucosidase of human kidney with urine F-1 alpha-glucosidase. PubMed: Maltitol and maltotriitol as inhibitors of acid production in human dental plaque. PubMed: Controlled clinical trial of a new non-calorigenic sweetening agent. PubMed: Inhibition of human digestive enzymes by hydrogenated malto-oligosaccharides. PubMed: [Effects of maltitol or mannitol on gastrointestinal absorption of drugs (author's transl)]. PubMed: Contribution of maltitol and lycasin to experimental enamel demineralization in the human mouth. PubMed: Effects of 3 months frequent consumption of hydrogenated starch hydrolysate (Lycasin), maltitol, sorbitol and xylitol on human dental plaque. PubMed: Chemical modification of 1,4-diamino-1,4-dideoxy-3-O-(4-deoxy-4-propionamido-alpha-D-glucopyranosyl)-D-glucitol. PubMed: Effect of various sugars on the induction of chick embryonic intestinal disaccharidases in the organ culture system. PubMed: Nutritional and toxicological properties of some raw and modified starches. PubMed: Acid production from Lycasin, maltitol, sorbitol and xylitol by oral streptococci and lactobacilli. PubMed: Metabolism and caloric utilization of orally administered maltitol-14C in rat, dog, and man. PubMed: The effects of maltitol on rat intestinal disaccharidases. PubMed: [Influence of maltitol on intestinal absorption hepatic coma]. PubMed: [Lactic acid production from sugar alcohol, maltitol and lactitol, in human whole saliva]. PubMed: [pH analysis of the bacterial fermentation of sugar alcohol, maltitol and lactitol, in human whole saliva]. PubMed: 1,5-Anhydro-4-(beta-D-glucopyranosyl)-D-glucitol,1,5-anhydro-6-(beta-D-glucopyranosyl)-D-glucitol and 1,5-anhydro-D-galactitol.