miltirone
3,4-phenanthrenedione, 5,6,7,8-tetrahydro-8,8-dimethyl-2-(1-methylethyl)-
Identification
| Name | miltirone |
| IUPAC | 8,8-dimethyl-2-propan-2-yl-6,7-dihydro-5H-phenanthrene-3,4-dione |
| CAS Number | 27210-57-7 |
| FDA UNII | Search |
| Molecular Formula | C19 H22 O2 |
| Molecular Weight | 282.38274000 |
| Nikkaji Number | J17.268E |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Boiling Point | 421.00 to 422.00 °C. @ 760.00 mm Hg |
| Flash Point | 354.00 °F. TCC ( 178.89 °C. ) |
| logP (o/w) | 4.916 (est) |
| Soluble in | water, 0.05297 mg/L @ 25 °C (est) |
No sensory data available
Safety Information
| European information | Most important hazard(s): |
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | natural substances and extractives |
| Recommendation for miltirone usage levels up to | not for fragrance use. |
| Recommendation for miltirone flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
8,8-
dimethyl-2-propan-2-yl-6,7-dihydro-5H-phenanthrene-3,4-dione
3,4-
phenanthrenedione, 5,6,7,8-tetrahydro-8,8-dimethyl-2-(1-methylethyl)-
2-iso
propyl-8,8-dimethyl-5,6,7,8-tetrahydro-3,4-phenanthrenedione
2-iso
propyl-8,8-dimethyl-5,6,7,8-tetrahydro-phenanthrene-3,4-dione
2-iso
propyl-8,8-dimethyl-5,6,7,8-tetrahydrophenanthrene-3,4-dione
rosmariquinone
5,6,7,8-
tetrahydro-8,8-dimethyl-2-(1-methyl ethyl)-3,4-phenanthrene dione
PubMed:
Effects of tanshinones from Salvia miltiorrhiza on CYP2C19 activity in human liver microsomes: Enzyme kinetic and molecular docking studies.
PubMed:
Metabolic profile of miltirone in rats by high performance liquid chromatography/quadrupole time-of-flight mass spectrometry.
PubMed:
A simple and sensitive LC-MS/MS method for determination of miltirone in rat plasma and its application to pharmacokinetic studies.
PubMed:
Reversal of P-glycoprotein (P-gp) mediated multidrug resistance in colon cancer cells by cryptotanshinone and dihydrotanshinone of Salvia miltiorrhiza.
PubMed:
Enzyme kinetic and molecular docking studies for the inhibitions of miltirone on major human cytochrome P450 isozymes.
PubMed:
Tanshinones as selective and slow-binding inhibitors for SARS-CoV cysteine proteases.
PubMed:
[Chemical constituents from Salvia przewalskii Maxim].
PubMed:
Extraction and preparative purification of tanshinones from Salvia miltiorrhiza Bunge by high-speed counter-current chromatography.
PubMed:
Antiplasmodial and antitrypanosomal activity of tanshinone-type diterpenoids from Salvia miltiorrhiza.
PubMed:
[Advances in studies on antitumor activities of compounds in Salvia miltiorrhiza].
PubMed:
Characterization of tanshinones with quinone reductase induction activity from Radix Salvia miltiorrhiza by liquid chromatography/tandem mass spectrometry.
PubMed:
Phytochemistry and pharmacogenomics of natural products derived from traditional Chinese medicine and Chinese materia medica with activity against tumor cells.
PubMed:
Optimizing ultraperformance liquid chromatographic analysis of 10 diterpenoid compounds in Salvia miltiorrhiza using central composite design.
PubMed:
Determination of fifteen bioactive components in Radix et Rhizoma Salviae Miltiorrhizae by high-performance liquid chromatography with ultraviolet and mass spectrometric detection.
PubMed:
Identification of miltirone as active ingredient of Salvia miltiorrhiza responsible for the reducing effect of root extracts on alcohol intake in rats.
PubMed:
Synthesis of miltirone analogues as inhibitors of Cdc25 phosphatases.
PubMed:
Inhibition by miltirone of up-regulation of GABAA receptor alpha4 subunit mRNA by ethanol withdrawal in hippocampal neurons.
PubMed:
Antioxidant activity of chemical components from sage (Salvia officinalis L.) and thyme (Thymus vulgaris L.) measured by the oil stability index method.
PubMed:
Apianane terpenoids from Salvia officinalis.
PubMed:
Miltirone, a central benzodiazepine receptor partial agonist from a Chinese medicinal herb Salvia miltiorrhiza.
PubMed:
Structure-activity relationship of miltirone, an active central benzodiazepine receptor ligand isolated from Salvia miltiorrhiza Bunge (Danshen).
PubMed:
[Chemical studies of Salvia miltiorrhiza f. alba].