(+)-taxodione
podocarpa-7,9(11),13-triene-6,12-dione, 11-hydroxy-13-isopropyl- (8CI)
Identification
| Name | (+)-taxodione |
| IUPAC | (4bS,8aS)-4-hydroxy-4b,8,8-trimethyl-2-propan-2-yl-5,6,7,8a-tetrahydrophenanthrene-3,9-dione |
| CAS Number | 19026-31-4 |
| FDA UNII | W96G420HJX |
| Molecular Formula | C20 H26 O3 |
| Molecular Weight | 314.42482000 |
| Nikkaji Number | J245.694J |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Soluble in | water, 2.367 mg/L @ 25 °C (est) |
No sensory data available
Safety Information
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | natural substances and extractives |
| Recommendation for (+)-taxodione usage levels up to | not for fragrance use. |
| Recommendation for (+)-taxodione flavor usage levels up to | not for flavor use. |
BOC Sciences
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Potential Uses
Natural Occurrence
Synonyms
(4bS,8aS)-4-
hydroxy-4b,8,8-trimethyl-2-propan-2-yl-5,6,7,8a-tetrahydrophenanthrene-3,9-dione
3,9-
phenanthrenedione, 4b,5,6,7,8,8a-hexahydro-4-hydroxy-4b,8,8-trimethyl-2-(1-methylethyl)-, (4bS-trans)- (9CI)
podocarpa-7,9(11),13-triene-6,12-dione, 11-hydroxy-13-isopropyl- (8CI)
PubMed:
The production and antiprotozoal activity of abietane diterpenes in Salvia austriaca hairy roots grown in shake-flasks and bioreactor.
PubMed:
Taxodione and Extracts from Salvia austriaca Roots as Human Cholinesterase Inhibitors.
PubMed:
Antimicrobial and Antileishmanial Activities of Diterpenoids Isolated from the Roots of Salvia deserta.
PubMed:
A bioguided identification of the active compounds that contribute to the antiproliferative/cytotoxic effects of rosemary extract on colon cancer cells.
PubMed:
Anti-apoptotic effect of taxodione on serum/glucose deprivation-induced PC12 cells death.
PubMed:
Taxodione and arenarone inhibit farnesyl diphosphate synthase by binding to the isopentenyl diphosphate site.
PubMed:
In vitro antiprotozoal activity of abietane diterpenoids isolated from Plectranthus barbatus Andr.
PubMed:
Antiproliferative activity of abietane diterpenoids against human tumor cells.
PubMed:
Cytotoxic and apoptogenic properties of three isolated diterpenoids from Salvia chorassanica through bioassay-guided fractionation.
PubMed:
Antimicrobial and anti-biofilm properties of new taxodione derivative from hairy roots of Salvia austriaca.
PubMed:
An unusual taxodione derivative from hairy roots of Salvia austriaca.
PubMed:
Genetic transformation of Salvia austriaca by Agrobacterium rhizogenes and diterpenoid isolation.
PubMed:
A new highly hydroxylated triterpene from Salvia atropatana Bunge.
PubMed:
A new triterpene from Salvia xanthocheila Boiss.
PubMed:
Antifungal abietane-type diterpenes from the cones of Taxodium distichum Rich.
PubMed:
Syntheses and antibacterial activities of diterpene catechol derivatives with abietane, totarane and podocarpane skeletons against methicillin-resistant Staphylococcus aureus and Propionibacterium acnes.
PubMed:
Antitermitic activities of abietane-type diterpenes from Taxodium distichum cones.
PubMed:
Antioxidant diterpenoids from the roots of Salvia barrelieri.
PubMed:
Taxodione, a DNA-binding compound from Taxodium distichum L. (Rich.).
PubMed:
Diterpenes from Salvia broussonetii transformed roots and their insecticidal activity.
PubMed:
Structural and spectral assignment by two-dimensional NMR of two new derivatives of the abietane diterpenoid taxodione.
PubMed:
Studies on di- and triterpenoids from Salvia staminea with cytotoxic activity.
PubMed:
Synthesis of variously oxidized abietane diterpenes and their antibacterial activities against MRSA and VRE.
PubMed:
Constituents of the roots of Salvia prionitis.
PubMed:
Effects of plant diterpenes on the neuronal GABAA receptor-operated chloride current.
PubMed:
Diterpenoid total synthesis. 13. Taxodione, a quinone methide tumor inhibitor.
PubMed:
Inhibition of phosphofructokinase by quinone methide and alpha-methylene lactone tumor inhibitors.
PubMed:
Tumor inhibitors. 48. Taxodione and taxodone, two novel diterpenoid quinone methide tumor inhibitors from Taxodium distichum.
PubMed:
Taxodione and taxodone, two novel diterpenoid quinone methide tumor inhibitors from Taxodium distichum.