(+)-taxodione

podocarpa-7,9(11),13-triene-6,12-dione, 11-hydroxy-13-isopropyl- (8CI)

CAS: 19026-31-4 C20 H26 O3 MW: 314.42482000

Identification

Name(+)-taxodione
IUPAC(4bS,8aS)-4-hydroxy-4b,8,8-trimethyl-2-propan-2-yl-5,6,7,8a-tetrahydrophenanthrene-3,9-dione
CAS Number19026-31-4
FDA UNIIW96G420HJX
Molecular FormulaC20 H26 O3
Molecular Weight314.42482000
Nikkaji NumberJ245.694J

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Soluble in water, 2.367 mg/L @ 25 °C (est)

No sensory data available

Safety Information

Oral/Parenteral ToxicityNot determined
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorynatural substances and extractives
Recommendation for (+)-taxodione usage levels up tonot for fragrance use.
Recommendation for (+)-taxodione flavor usage levels up tonot for flavor use.

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Potential Uses

None Found

Natural Occurrence

salvia austriaca root

Synonyms

(4bS,8aS)-4- hydroxy-4b,8,8-trimethyl-2-propan-2-yl-5,6,7,8a-tetrahydrophenanthrene-3,9-dione 3,9- phenanthrenedione, 4b,5,6,7,8,8a-hexahydro-4-hydroxy-4b,8,8-trimethyl-2-(1-methylethyl)-, (4bS-trans)- (9CI) podocarpa-7,9(11),13-triene-6,12-dione, 11-hydroxy-13-isopropyl- (8CI) PubMed: The production and antiprotozoal activity of abietane diterpenes in Salvia austriaca hairy roots grown in shake-flasks and bioreactor. PubMed: Taxodione and Extracts from Salvia austriaca Roots as Human Cholinesterase Inhibitors. PubMed: Antimicrobial and Antileishmanial Activities of Diterpenoids Isolated from the Roots of Salvia deserta. PubMed: A bioguided identification of the active compounds that contribute to the antiproliferative/cytotoxic effects of rosemary extract on colon cancer cells. PubMed: Anti-apoptotic effect of taxodione on serum/glucose deprivation-induced PC12 cells death. PubMed: Taxodione and arenarone inhibit farnesyl diphosphate synthase by binding to the isopentenyl diphosphate site. PubMed: In vitro antiprotozoal activity of abietane diterpenoids isolated from Plectranthus barbatus Andr. PubMed: Antiproliferative activity of abietane diterpenoids against human tumor cells. PubMed: Cytotoxic and apoptogenic properties of three isolated diterpenoids from Salvia chorassanica through bioassay-guided fractionation. PubMed: Antimicrobial and anti-biofilm properties of new taxodione derivative from hairy roots of Salvia austriaca. PubMed: An unusual taxodione derivative from hairy roots of Salvia austriaca. PubMed: Genetic transformation of Salvia austriaca by Agrobacterium rhizogenes and diterpenoid isolation. PubMed: A new highly hydroxylated triterpene from Salvia atropatana Bunge. PubMed: A new triterpene from Salvia xanthocheila Boiss. PubMed: Antifungal abietane-type diterpenes from the cones of Taxodium distichum Rich. PubMed: Syntheses and antibacterial activities of diterpene catechol derivatives with abietane, totarane and podocarpane skeletons against methicillin-resistant Staphylococcus aureus and Propionibacterium acnes. PubMed: Antitermitic activities of abietane-type diterpenes from Taxodium distichum cones. PubMed: Antioxidant diterpenoids from the roots of Salvia barrelieri. PubMed: Taxodione, a DNA-binding compound from Taxodium distichum L. (Rich.). PubMed: Diterpenes from Salvia broussonetii transformed roots and their insecticidal activity. PubMed: Structural and spectral assignment by two-dimensional NMR of two new derivatives of the abietane diterpenoid taxodione. PubMed: Studies on di- and triterpenoids from Salvia staminea with cytotoxic activity. PubMed: Synthesis of variously oxidized abietane diterpenes and their antibacterial activities against MRSA and VRE. PubMed: Constituents of the roots of Salvia prionitis. PubMed: Effects of plant diterpenes on the neuronal GABAA receptor-operated chloride current. PubMed: Diterpenoid total synthesis. 13. Taxodione, a quinone methide tumor inhibitor. PubMed: Inhibition of phosphofructokinase by quinone methide and alpha-methylene lactone tumor inhibitors. PubMed: Tumor inhibitors. 48. Taxodione and taxodone, two novel diterpenoid quinone methide tumor inhibitors from Taxodium distichum. PubMed: Taxodione and taxodone, two novel diterpenoid quinone methide tumor inhibitors from Taxodium distichum.