Identification

Namemethyl palmitate
IUPACmethyl hexadecanoate
CAS Number112-39-0
EINECS203-966-3
FDA UNIIDPY8VCM98I
Molecular FormulaC17 H34 O2
Molecular Weight270.45638000
MDL NumberMFCD00008994
Nikkaji NumberJ1.994A
Beilstein1780973
CoE Number581
XlogP37.90 (est)

Regulatory

DG SANTE Food Flavourings09.180 methyl hexadecanoate
FDA Mainterm (IAUFC)112-39-0 ; METHYL PALMITATE

Physical Properties

Appearance white solid (est)
Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Melting Point 32.00 to 35.00 °C. @ 760.00 mm Hg
Boiling Point 163.00 to 164.00 °C. @ 4.00 mm Hg, 185.00 °C. @ 10.00 mm Hg
Vapor Pressure 0.000149 mmHg @ 25.00 °C. (est)
Flash Point > 230.00 °F. TCC ( > 110.00 °C. )
logP (o/w) 7.380
Soluble in alcohol
Insoluble in water
Similar Items note

Cosmetic Information

CosIngcosmetic data
Cosmetic Usesperfuming agents

Organoleptic Properties

Odor Strength low
Odor Description
at 100.00 %.
WAXY, FAT, CANDLE

Safety Information

Preferred SDSView
European informationMost important hazard(s):
Oral/Parenteral ToxicityNot determined
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorycosmetic, flavor and fragrance agents
RIFM Fragrance Material Safety AssessmentSearch
Recommendation for methyl palmitate usage levels up to8.0000 % in the fragrance concentrate.
Maximised Survey-derived Daily Intakes (MSDI-EU)2.80 (μg/capita/day)
Modified Theoretical Added Maximum Daily Intake (mTAMDI)3900 (μg/person/day)
Threshold of Concern1800 (μg/person/day)
Structure ClassI
Dairy products, excluding products of category 02.0 (01.0)7.00000
Fats and oils, and fat emulsions (type water-in-oil) (02.0)5.00000
Edible ices, including sherbet and sorbet (03.0)10.00000
Processed fruit (04.1)7.00000
Processed vegetables (incl. mushrooms & fungi, roots & tubers, pulses and legumes), and nuts & seeds (04.2)-
Confectionery (05.0)10.00000
Chewing gum (05.3)-
Cereals and cereal products, incl. flours & starches from roots & tubers, pulses & legumes, excluding bakery (06.0)5.00000
Bakery wares (07.0)10.00000
Meat and meat products, including poultry and game (08.0)2.00000
Fish and fish products, including molluscs, crustaceans and echinoderms (MCE) (09.0)2.00000
Eggs and egg products (10.0)-
Sweeteners, including honey (11.0)-
Salts, spices, soups, sauces, salads, protein products, etc. (12.0)5.00000
Foodstuffs intended for particular nutritional uses (13.0)10.00000
Non-alcoholic ("soft") beverages, excl. dairy products (14.1)5.00000
Alcoholic beverages, incl. alcohol-free and low-alcoholic counterparts (14.2)10.00000
Ready-to-eat savouries (15.0)20.00000
Composite foods (e.g. casseroles, meat pies, mincemeat) - foods that could not be placed in categories 01.0 - 15.0 (16.0)5.00000

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Potential Uses

emollients FR fruit skin conditioning

Natural Occurrence

boronia absolute @ 0.02% Data champaca absolute @ 3.00% Data champaca concrete @ 0.20% Data cichorium intybus l. root extract @ 1.85% Data cinnamon fruit oil india @ 0.0-0.3% Data clove bud clove fruit elderberry fruit - 5.3 mg/kg fennel absolute sweet @ 0.10% Data genet absolute @ 0.40% Data helichrysum arenarium (l.) moench oil hungary @ 28.50% Data herniaria incana lam. oil greece @ 0.30% Data jambu flower oil brazil @ 0.10% Data jasmin absolute china @ 5.51% Data jasmin absolute concrete egypt @ 1.56% Data jasmin sambac absolute egypt @ 0.95% Data lavender oil spike spain @ 0.017% Data mushrooms - up to 20 mg/kg PMC osmanthus absolute @ 0.07% Data sage oil cuba @ 0.26% Data salvia officinalis oil cuba @ 0.26% Data star fruit oil cuba @ trace% Data tea green tea - up to 1.1 mg/kg thevetia peruviana (pers.) k. schum. flower oil brazil @ 0.20% Data valerian root oil @ 0.1-0.9% Data witch hazel leaf oil @ 0.33% Data

Synonyms

formyl hexadecanoate hexadecanoic acid methyl ester N- hexadecanoic acid methyl ester hexadecanoic acid, methyl ester metholene 2216 methyl hexadecanoate methyl N-hexadecanoate palmitic acid methyl ester palmitic acid, methyl ester (8CI) uniphat A60 PubMed: Chemical Composition and Biological Activities of Gerbera anandria. PubMed: Androgenic effect of honeybee drone milk in castrated rats: Roles of methyl palmitate and methyl oleate. PubMed: Perivascular Adipose Tissue, Vascular Reactivity and Hypertension. PubMed: Methyl palmitate attenuates lipopolysaccharide-induced acute lung injury in mice. PubMed: Stimulation of nitrogen removal in the rhizosphere of aquatic duckweed by root exudate components. PubMed: Cytotoxic effect of Alpinia scabra (Blume) Náves extracts on human breast and ovarian cancer cells. PubMed: Scenedesmus incrassatulus CLHE-Si01: a potential source of renewable lipid for high quality biodiesel production. PubMed: Protective effects of methyl palmitate against silica-induced pulmonary fibrosis in rats. PubMed: Insecticidal and genotoxic activity of Psoralea corylifolia Linn. (Fabaceae) against Culex quinquefasciatus Say, 1823. PubMed: Lipase-catalyzed synthesis of starch palmitate in mixed ionic liquids. PubMed: Antioxidant and antimicrobial activities of essential oil and extracts of Saurauia lantsangensis hu root. PubMed: Diatomite-supported Pd-M (M=Cu, Co, Ni) bimetal nanocatalysts for selective hydrogenation of long-chain aliphatic esters. PubMed: Analysis of lipids: metal oxide laser ionization mass spectrometry. PubMed: Anti-inflammatory activity of methyl palmitate and ethyl palmitate in different experimental rat models. PubMed: Transferable force field for carboxylate esters: application to fatty acid methylic ester phase equilibria prediction. PubMed: Antimicrobial and antioxidant activities of the flower essential oil of Halimodendron halodendron. PubMed: [Bioactivity of the metabolites from endophytic actinomycete Fq24 against Tetranychus cinnabarinus]. PubMed: Insights antifibrotic mechanism of methyl palmitate: impact on nuclear factor kappa B and proinflammatory cytokines. PubMed: Characterization of volatile components of tea flowers (Camellia sinensis) growing in Kangra by GC/MS. PubMed: Role of perivascular adipose tissue-derived methyl palmitate in vascular tone regulation and pathogenesis of hypertension. PubMed: [Chemical composition of essential oils from leaves of Helicteres guazumifolia (Sterculiaceae), Piper tuberculatum (Piperaceae), Scoparia dulcis (Arecaceae) and Solanum subinerme (Solanaceae) from Sucre, Venezuela]. PubMed: Anti-inflammatory and antifibrotic effects of methyl palmitate. PubMed: Culture of microalgae Chlorella minutissima for biodiesel feedstock production. PubMed: Retina evokes biphasic relaxations in retinal artery unrelated to endothelium, K(V), K(ATP), K(Ca) channels and methyl palmitate. PubMed: Cinnamyl alcohols and methyl esters of fatty acids from Wedelia prostrata callus cultures. PubMed: Modeling Study of the Low-Temperature Oxidation of Large Methyl Esters from C11 to C19. PubMed: Assessment of the contact toxicity of methyl palmitate on Tetranychus viennensis (Acari: Tetranychidae). PubMed: Experimental study of the oxidation of methyl oleate in a jet-stirred reactor. PubMed: Methyl palmitate: a potent vasodilator released in the retina. PubMed: Antimicrobial activities of essential oil and hexane extract of Florence fennel [Foeniculum vulgare var. azoricum (Mill.) Thell.] against foodborne microorganisms. PubMed: Marine diatom, Navicula sp. strain JPCC DA0580 and marine green alga, Chlorella sp. strain NKG400014 as potential sources for biodiesel production. PubMed: Construction of combustion models for rapeseed methyl ester bio-diesel fuel for internal combustion engine applications. PubMed: Methyl palmitate, an acaricidal compound occurring in green walnut husks. PubMed: Effect of additives in aqueous formulation on the foliar uptake of dimethomorph by cucumbers. PubMed: Endogenous methyl palmitate modulates nicotinic receptor-mediated transmission in the superior cervical ganglion. PubMed: [Determination of 11 fatty acids and fatty acids methyl esters in biodiesel using ultra performance liquid chromatography]. PubMed: Methyl palmitate prevents CCl(4)-induced liver fibrosis. PubMed: 16-Cyclopentadienyl tricarbonyl 99mTc 16-oxo-hexadecanoic acid: synthesis and evaluation of fatty acid metabolism in mouse myocardium. PubMed: Cyclooxygenase-2 inhibitory effects and composition of the volatile oil from the dried roots of Lithospermum erythrorhizon. PubMed: Characterization of chemical components in extracts from Si-wu decoction with proliferation-promoting effects on rat mesenchymal stem cells. PubMed: Lipase-catalyzed regioselective synthesis of steryl (6'-O-acyl)glucosides. PubMed: Gas chromatographic/mass spectrometric analysis of the essential oil of Houttuynia cordata Thunb by using on-column methylation with tetramethylammonium acetate. PubMed: Antileukemic effects of Didemnum psammatodes (Tunicata: Ascidiacea) constituents. PubMed: Does lipophilicity per se induce adjuvant effects? Methyl palmitate as model substance does not affect ovalbumin sensitization. PubMed: Fatty acid composition of Abies pindrow (West Himalayan fir). PubMed: Methyl palmitate inhibits lipopolysaccharide-stimulated phagocytic activity of rat peritoneal macrophages. PubMed: New amphiphilic diblock copolymers: surfactant properties and solubilization in their micelles. PubMed: Purification and characterization of lipase from Rhizopus chinensis cells. PubMed: An infrared spectroscopic method for quantitative analysis of fatty alcohols and fatty acid esters in machinery oils. PubMed: Benefit of Kupffer cell modulation with glycine versus Kupffer cell depletion after liver transplantation in the rat: effects on postischemic reperfusion injury, apoptotic cell death graft regeneration and survival. PubMed: Enhanced reactivity of Rhizopus oryzae lipase displayed on yeast cell surfaces in organic solvents: potential as a whole-cell biocatalyst in organic solvents. PubMed: Presence and titer of methyl palmitate in the Medfly (Ceratitis capitata) during reproductive maturation. PubMed: Methyl palmitate: inhibitor of phagocytosis in primary rat Kupffer cells. PubMed: Comparison of fatty acid and polar lipid contents of tubers from two potato species, Solanum tuberosum and Solanum phureja. PubMed: Mono-thioesters and di-thioesters by lipase-catalyzed reactions of alpha,omega-alkanedithiols with palmitic acid or its methyl ester. PubMed: Methyl palmitate: a novel product of the Medfly (Ceratitis capitata) corpus allatum. PubMed: Palmitate potentiation of glucose-induced insulin release: a study using 2-bromopalmitate. PubMed: Fatty acid composition of seeds of Satureja thymbra and S. cuneifolia. PubMed: A cytotoxic butenolide, two new dolabellane diterpenoids, a chroman and a benzoquinol derivative formosan Casearia membranacea. PubMed: Feeding stimulants eliciting the probing behavior for Peregrinator blannulipes Montrouzier et Signore (Hemiptera: Ruduviidae) from Tribolium confusum (Jacquelin du Val). PubMed: Normal mode analyses of methyl palmitate all-trans and disordered forms in wagging progressive region. PubMed: Glycine but not gadolinium chloride or methyl palmitate reduces postischemic white blood cell accumulation and early graft nonfunction after liver transplantation in the rat. PubMed: Straightforward synthesis of two pairs of enantiomeric butenolides 3-tetradecyl- and 3-hexadecyl-5-methyl-2(5H)-furanone. PubMed: [New data on composition of esssential oil from inflorescence of everlasting (Helichrysum arenarium(L.) Moench.)]. PubMed: Single chain antibodies specific for fatty acids derived from a semi-synthetic phage display library. PubMed: Critical micelle concentrations of allelopathic substances produced by Nannochloris oculata which affect a red tide organism, Gymnodinium breve. PubMed: Elimination of the concentration dependence in mass isotopomer abundance mass spectrometry of methyl palmitate using metastable atom bombardment. PubMed: Novel role of oxidants in the molecular mechanism of action of peroxisome proliferators. PubMed: A kinetic study of the synthesis of ascorbate fatty acid esters catalysed by immobilized lipase in organic media. PubMed: Bioassays of APONIN-3 and -4 with rabbit erythrocytes. PubMed: Use of stable isotope labeling technique and mass isotopomer distribution analysis of [(13)C]palmitate isolated from surfactant disaturated phospholipids to study surfactant in vivo kinetics in a premature infant. PubMed: Role of Kupffer cells and oxidants in signaling peroxisome proliferator-induced hepatocyte proliferation. PubMed: Requirement for omega and (omega;-1)-hydroxylations of fatty acids by human cytochromes P450 2E1 and 4A11. PubMed: Chemical components of shredded paper insulation: a preliminary study. PubMed: Antinociceptive and uterine relaxant activities of Viburnum toronis alive (Caprifoliaceae). PubMed: Molecular ion fragmentation and its effects on mass isotopomer abundances of fatty acid methyl esters ionized by electron impact. PubMed: Reduction of fatty acid methyl esters to fatty alcohols to improve volatility for isotopic analysis without extraneous carbon. PubMed: Kupffer cells are causally responsible for the mitogenic effect of peroxisome proliferators. PubMed: A two-component system in Ralstonia (Pseudomonas) solanacearum modulates production of PhcA-regulated virulence factors in response to 3-hydroxypalmitic acid methyl ester. PubMed: High-precision position-specific isotope analysis. PubMed: Quantitative evaluation of carbon isotopic fractionation during reversed-phase high-performance liquid chromatography. PubMed: Immune dysfunction in patients with obstructive jaundice, mediators and implications for treatments. PubMed: Effects of methyl palmitate on cytokine release, liver injury and survival in mice with sepsis. PubMed: Identification of fatty acid methyl ester as naturally occurring transcriptional regulators of the members of the peroxisome proliferator-activated receptor family. PubMed: Effect of a brood pheromone on honeybee hypopharyngeal glands. PubMed: [Chemical constituents of the essential oil from the pericarp of Trichosanthes rosthornii Harms]. PubMed: Oviposition response ofLobesia botrana females to long-chain free fatty acids and esters from its eggs. PubMed: Effect of agents which modify reticuloendothelial system function on acute phalloidin-induced lethality and hepatotoxicity in mice. PubMed: Egg dispersion in codling moth: Influence of egg extract and of its fatty acid constituents. PubMed: The immuno-stimulant OK-432 enhances liver regeneration after 70% hepatectomy. PubMed: Effect of agents which modify reticuloendothelial system function on acute phalloidin-induced lethality and hepatotoxicity in mice. PubMed: An unusual polar lipid from the cell membrane of Mycoplasma fermentans. PubMed: In vivo magnetic resonance imaging study of Kupffer cell involvement in CCl4-induced hepatotoxicity in rats. PubMed: Cellular expression of a cloned, hydrophilic, murine acetylcholinesterase. Evidence of palmitoylated membrane-bound forms. PubMed: The reaction of low levels of nitrogen dioxide with methyl linoleate in the presence and absence of oxygen. PubMed: Concentration dependence of methyl palmitate isotope ratios by electron impact ionization gas chromatography/mass spectrometry. PubMed: Vitamin A potentiation of carbon tetrachloride hepatotoxicity: role of liver macrophages and active oxygen species. PubMed: Modulation of 1,2-dichlorobenzene hepatotoxicity in the Fischer-344 rat by a scavenger of superoxide anions and an inhibitor of Kupffer cells. PubMed: The deficient degradation of synthetic 2- and 3-methyl-branched fatty acids in fibroblasts from patients with peroxisomal disorders. PubMed: Semiochemical basis of infestation of honey bee brood byVarroa jacobsoni. PubMed: Comparison of anacardic acid biosynthetic capability between insect-resistant and-susceptible geraniums. PubMed: The origin of palmitic acid in brain of the developing rat. PubMed: Activation of Kupffer cells on reperfusion following hypoxia: particle phagocytosis in a low-flow, reflow model. PubMed: The role of Kupffer cells in the development of hepatic dysfunction during sepsis. PubMed: Mitochondrial and peroxisomal beta oxidation of the branched chain fatty acid 2-methylpalmitate in rat liver. PubMed: Effect of variation in infusion time and macrophage blockade on organ uptake of amphotericin B-deoxycholate. PubMed: Methyl palmitate prevents Kupffer cell activation and improves survival after orthotopic liver transplantation in the rat. PubMed: An improved synthesis of trehalose 6-mono- and 6,6'-di-corynomycolates and related esters. PubMed: [Chemical constituents of anticancer plant Nyssa sinensis Oliv]. PubMed: Orientation of specifically 13C=O labeled phosphatidylcholine multilayers from polarized attenuated total reflection FT-IR spectroscopy. PubMed: Neutrophil and Kupffer cell-induced oxidant stress and ischemia-reperfusion injury in rat liver. PubMed: Reactive oxygen species in the progression of CCl4-induced liver injury. PubMed: Relation of the reticuloendothelial function to endotoxin hepatotoxicity. PubMed: Prevention of early graft failure by the calcium channel blocker nisoldipine: involvement of Kupffer cells. PubMed: 2',3'-cyclic nucleotide-3'-phosphodiesterase in the central nervous system is fatty-acylated by thioester linkage. PubMed: Cell mass of Mycobacterium bovis BCG estimated by gas chromatography. PubMed: A new method to monitor Kupffer-cell function continuously in the perfused rat liver. Dissociation of glycogenolysis from particle phagocytosis. PubMed: Unesterified fatty acids inhibit the binding of low density lipoproteins to the human fibroblast low density lipoprotein receptor. PubMed: Attraction of the parasitic mite varroa to the drone larvae of honey bees by simple aliphatic esters. PubMed: Agonist-enhanced palmitoylation of platelet proteins. PubMed: [Studies on the constituents of trichosanthes root. III. Constituents of roots of Trichosanthes bracteata Voigt]. PubMed: [Studies on the constituents of trichosanthes root. II. Constituents of roots of Trichosanthes cucumeroides Maxim]. PubMed: [Studies on the constituents of trichosanthes root. I. Constituents of roots of Trichosanthes kirilowii Maxim. var. japonicum Kitam]. PubMed: Acylation of keratinocyte transglutaminase by palmitic and myristic acids in the membrane Anchorage region. PubMed: Kinetics of radioiodinated monoclonal antibodies in the rat. Influence of tumour growth and reticuloendothelial system host modulation. PubMed: Lipid-modified surface protein antigens expressing size variation within the species Mycoplasma hyorhinis. PubMed: Lipoproteins of Haemophilus influenzae type b. PubMed: Identification of thoracic gland constituents from maleXylocopa spp. latreille (Hymenoptera: Anthophoridae) from arizona. PubMed: Release of sodium diclofenac from vehicles prepared with hydrogenated soya lecithin and methyl palmitate. PubMed: Major membrane surface proteins of Mycoplasma hyopneumoniae selectively modified by covalently bound lipid. PubMed: RES function and tumour take and tumour growth in the liver and in the kidney--an experimental study in rats. PubMed: Passive protection across subgroups of alphaviruses by hyperimmune non-cross-neutralizing anti-Sindbis serum. PubMed: Simple diagnosis of the Zellweger syndrome by gas-liquid chromatography of dimethylacetals. PubMed: Identification of ant repellent allomone produced by social waspPolistes fuscatus (Hymenoptera: Vespidae). PubMed: Evidence for the presence of fatty acid methyl esters in human hepatoma tissue from a patient with hypercholesterolemia. PubMed: Influence of a reticuloendothelial-suppressing agent on liver tumor growth in the rat. PubMed: Cysteines in the transmembrane region of major histocompatibility complex antigens are fatty acylated via thioester bonds. PubMed: Influence on plasma beta-N-acetyl-D-glucosaminidase of reticuloendothelial stimulation and depression: an experimental study in rats. PubMed: In vitro synthesis of mycolic acids by the fluffy layer fraction of Bacterionema matruchotii. PubMed: Immunotherapeutic modification of Escherichia coli--induced experimental peritonitis and bacteremia by glucan. PubMed: Experimental elimination of the splenic function by ethyl and methyl palmitate and significance of these substances from an immunological point of view. PubMed: Radiolysis of alpha, alpha-trehalose in concentrated aqueous solution; the effect of co-irradiated proteins and lipids. PubMed: In vivo acylation of rat brain myelin proteolipid protein. PubMed: Erythrocyte survival and haematocrit values in rats after i.v. application of ethyl palmitate and methyl palmitate emulsions. PubMed: Modification of galactosamine-induced liver injury in rats by reticuloendothelial system stimulation or depression. PubMed: Separation of partially deuterated methyl palmitate from nondeuterated methyl palmitate by high-pressure liquid chromatography. PubMed: Effect of substrates on the malonate inhibitory pattern and brefeldin A formation in Curvularia lunata. PubMed: [Incorporation of I14c-leucine into hepatic and splenic tissue of rats during an experimental study of the effect of methyl palmitate on the RES (author's transl)]. PubMed: Fatty acid composition of the lipids of Pseudomonas mildenbergii. Presence of a fatty acid containing two conjugated double bonds. PubMed: Modulation of experimental allergic encephalomyelitis with yeast glucan and methyl palmitate to alter the activity of the reticuloendothelial system. PubMed: Effect of polyunsaturated fatty acids of the alpha-linolenic series in the lipid composition of rat testicles during development. PubMed: Sequestration of heat damaged rat erythrocytes during experimental action of methyl palmitate on RES. PubMed: Quantitation of 1,4-Benzoxazin-3-ones in Maize by Gas-Liquid Chromatography. PubMed: Cellular fatty acids of Flavobacterium meningosepticum and Flavobacterium species group IIb. PubMed: Decreased activity of peptide-elongation factors after treatment with cholesterol esterase. PubMed: Effect of polyunsaturated fatty acids of the alpha-linolenic series on the development of rat testicles. PubMed: Effect of methyl palmitate on the survival of skin semi-allografts in rats. PubMed: The inhibitory effect of methyl palmitate on heteroagglutinin formation in rats. PubMed: Hydrolysis of plant cuticle by plant pathogens. Properties of cutinase I, cutinase II, and a nonspecific esterase isolated from Fusarium solani pisi. PubMed: Quantitative determination of cholesteryl 14-methyl-hexadecanoate by radio-gas chromatography. PubMed: Oxidative desaturation of eicosa-8,11-dienoic acid to eicosa-5,8,11-trienoic acid: comparison of different diets on oxidative desaturation at the 5,6 and 6,7 positions. PubMed: Four-directional-development thin-layer chromatography of lipids using trimethyl borate. PubMed: The enzymic deacylation of phospholipids and galactolipids in plants. Purification and properties of a lipolytic acyl-hydrolase from potato tubers. PubMed: Binding of long-chain fatty acids to bovine serum albumin. PubMed: Suppression of antibody formation by the res-blockade. 3. Effects of the res-blockade with methyl palmitate. PubMed: Evaluation of humoral and cellular mechanisms of methyl palmitate induced reticuloendothelial depression. PubMed: Autoxidation of saturated fatty acids. II. The determination of the site of hydroperoxide groups in autoxidizing methyl palmitate. PubMed: Autoxidation of saturated fatty acids. I. The initial products of autoxidation of methyl palmitate. PubMed: Synthesis of saturated long chain fatty acids from sodium acetate-1-C14 by Mycoplasma. PubMed: Failure of methyl palmitate induced reticuloendothelial blockade to affect plasma levels of factor 8. PubMed: DEPRESSION OF PHAGOCYTIC ACTIVITY AND IMMUNE RESPONSE BY METHYL PALMITATE.