hydrangenol
1H-2-benzopyran-1-one, 3,4-dihydro-8-hydroxy-3-(4-hydroxyphenyl)-
Identification
| Name | hydrangenol |
| CAS Number | 480-47-7 |
| FDA UNII | TL8PI7PHV1 |
| Molecular Formula | C15 H12 O4 |
| Molecular Weight | 256.25744000 |
| MDL Number | MFCD01570286 |
| Nikkaji Number | J12.398F |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Boiling Point | 528.00 to 529.00 °C. @ 760.00 mm Hg (est) |
| Flash Point | 404.00 °F. TCC ( 206.40 °C. ) (est) |
| logP (o/w) | 2.339 (est) |
| Soluble in | water, 174.5 mg/L @ 25 °C (est) |
No sensory data available
Safety Information
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | natural substances and extractives |
| Recommendation for hydrangenol usage levels up to | not for fragrance use. |
| Recommendation for hydrangenol flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
1H-2-
benzopyran-1-one, 3,4-dihydro-8-hydroxy-3-(4-hydroxyphenyl)-
3,4-
dihydro-8-hydroxy-3-(4-hydroxyphenyl)-1h-2-benzopyran-1-one
8-
hydroxy-3-(4-hydroxyphenyl)-3,4-dihydroisochromen-1-one
PubMed:
Search for new type of PPARγ agonist-like anti-diabetic compounds from medicinal plants.
PubMed:
[Chemical constituents from Hydrangea macrophylla].
PubMed:
Phenolic compounds from the roots of Jordanian viper's grass, Scorzonera judaica.
PubMed:
Three new glycosides from the leaves of Hydrangea macrophylla subsp. serrata (THUNB.) MAKINO.
PubMed:
New type of anti-diabetic compounds from the processed leaves of Hydrangea macrophylla var. thunbergii (Hydrangeae Dulcis Folium).
PubMed:
Inhibitory effects of thunberginols A, B, and F on degranulations and releases of TNF-alpha and IL-4 in RBL-2H3 cells.
PubMed:
Metabolic fate of orally administered phyllodulcin in rats.
PubMed:
Stilbenecarboxylate biosynthesis: a new function in the family of chalcone synthase-related proteins.
PubMed:
Allergic contact dermatitis from hydrangea--is it so rare?
PubMed:
Effects of phyllodulcin, hydrangenol, and their 8-O-glucosides, and thunberginols A and F from Hydrangea macrophylla SERINGE var. thunbergii MAKINO on passive cutaneous anaphylaxis reaction in rats.
PubMed:
Structure-requirements of isocoumarins, phthalides, and stilbenes from Hydrangeae Dulcis Folium for inhibitory activity on histamine release from rat peritoneal mast cells.
PubMed:
Immunomodulatory activity of thunberginol A and related compounds isolated from Hydrangeae Dulcis Folium on splenocyte proliferation activated by mitogens.
PubMed:
Development of bioactive functions in Hydrangeae Dulcis Folium. VII. Immunomodulatory activities of thunberginol A and related compounds on lymphocyte proliferation.
PubMed:
Inhibitory effects of plumbagin and juglone on azoxymethane-induced intestinal carcinogenesis in rats.
PubMed:
Development of bioactive functions in Hydrangeae dulcis folium. VI. Syntheses of thunberginols A and F and their 3'-deoxy-derivatives using regiospecific lactonization of stilbene carboxylic acid: structures and inhibitory activity on histamine release of hydramacrophyllols A and B.
PubMed:
Development of bioactive functions in hydrangeae dulcis folium. V. On the antiallergic and antimicrobial principles of hydrangeae dulcis folium. (2). Thunberginols C, D, and E, thunberginol G 3'-O-glucoside, (-)-hydrangenol 4'-o-glucoside, and (+)-hydrangenol 4'-O-glucoside.
PubMed:
Modifying effects of naturally occurring products on the development of colonic aberrant crypt foci induced by azoxymethane in F344 rats.
PubMed:
Development of bioactive functions in hydrangeae dulcis folium. III. On the antiallergic and antimicrobial principles of hydrangeae dulcis folium. (1). Thunberginols A, B, and F.
PubMed:
[Development of bioactive functions in hydrangeae dulcis folium. II. Antiulcer, antiallergy, and cholagoic effects of the extract from hydrangeae dulcis folium].
PubMed:
[Chemical constituents of Hydrangea macrophylla (Thunb.) Ser].
PubMed:
[Quantitative analysis of dihydroisocoumarin constituents of Hydrangeae Dulcis Folium by means of high performance liquid chromatography. Chemical characterization of the processing, distribution in plant, and seasonal fluctuation].
PubMed:
Thunberginols C, D, and E, new antiallergic and antimicrobial dihydroisocoumarins, and thunberginol G 3'-O-glucoside and (-)-hydrangenol 4'-O-glucoside, new dihydroisocoumarin glycosides, from Hydrangeae Dulcis Folium.
PubMed:
Thunberginols A, B, and F, new antiallergic and antimicrobial principles from hydrangeae dulcis folium.
PubMed:
Hydrangenol, a strong contact sensitizer found in hydrangea (Hydrangea sp.; Hydrangeaceae).
PubMed:
Inhibitory effects of hydrangenol derivatives on the activation of hyaluronidase and their antiallergic activities.
PubMed:
Allergic contact dermatitis to hydrangea.
PubMed:
Antifungal activity of oosponol, oospolactone, phyllodulcin, hydrangenol, and some other related compounds.
PubMed:
[High-speed liquid chromatographic analysis of drugs. IV. Speration analysis of phyllodulcin and hydrangenol in sweet hydrangea (author's transl)].
PubMed:
Studies of hydrangenol in Hydrangea macrophylla Ser. II. Biosynthesis of hydrangenol from C14-labelled compounds.
PubMed:
Enhancement of Gibberellin Growth-Promoting Activity by Hydrangenol Isolated from Leaves of Hydrangea Macrophylla.
PubMed:
Studies of hydrangenol in hydrangea macrophylla Ser. I. Isolation, identification, and biosynthesis from C 14-labelled compounds.