hydrangenol

1H-2-benzopyran-1-one, 3,4-dihydro-8-hydroxy-3-(4-hydroxyphenyl)-

CAS: 480-47-7 C15 H12 O4 MW: 256.25744000

Identification

Namehydrangenol
CAS Number480-47-7
FDA UNIITL8PI7PHV1
Molecular FormulaC15 H12 O4
Molecular Weight256.25744000
MDL NumberMFCD01570286
Nikkaji NumberJ12.398F

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Boiling Point 528.00 to 529.00 °C. @ 760.00 mm Hg (est)
Flash Point 404.00 °F. TCC ( 206.40 °C. ) (est)
logP (o/w) 2.339 (est)
Soluble in water, 174.5 mg/L @ 25 °C (est)

No sensory data available

Safety Information

Oral/Parenteral ToxicityNot determined
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorynatural substances and extractives
Recommendation for hydrangenol usage levels up tonot for fragrance use.
Recommendation for hydrangenol flavor usage levels up tonot for flavor use.

BOC Sciences

Best of Chemicals Supplier

Quality supplier of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecul...

View All Website 1-631-485-4226 account@bocsci.com

Potential Uses

antifungal

Natural Occurrence

hydrangea serrata

Synonyms

1H-2- benzopyran-1-one, 3,4-dihydro-8-hydroxy-3-(4-hydroxyphenyl)- 3,4- dihydro-8-hydroxy-3-(4-hydroxyphenyl)-1h-2-benzopyran-1-one 8- hydroxy-3-(4-hydroxyphenyl)-3,4-dihydroisochromen-1-one PubMed: Search for new type of PPARγ agonist-like anti-diabetic compounds from medicinal plants. PubMed: [Chemical constituents from Hydrangea macrophylla]. PubMed: Phenolic compounds from the roots of Jordanian viper's grass, Scorzonera judaica. PubMed: Three new glycosides from the leaves of Hydrangea macrophylla subsp. serrata (THUNB.) MAKINO. PubMed: New type of anti-diabetic compounds from the processed leaves of Hydrangea macrophylla var. thunbergii (Hydrangeae Dulcis Folium). PubMed: Inhibitory effects of thunberginols A, B, and F on degranulations and releases of TNF-alpha and IL-4 in RBL-2H3 cells. PubMed: Metabolic fate of orally administered phyllodulcin in rats. PubMed: Stilbenecarboxylate biosynthesis: a new function in the family of chalcone synthase-related proteins. PubMed: Allergic contact dermatitis from hydrangea--is it so rare? PubMed: Effects of phyllodulcin, hydrangenol, and their 8-O-glucosides, and thunberginols A and F from Hydrangea macrophylla SERINGE var. thunbergii MAKINO on passive cutaneous anaphylaxis reaction in rats. PubMed: Structure-requirements of isocoumarins, phthalides, and stilbenes from Hydrangeae Dulcis Folium for inhibitory activity on histamine release from rat peritoneal mast cells. PubMed: Immunomodulatory activity of thunberginol A and related compounds isolated from Hydrangeae Dulcis Folium on splenocyte proliferation activated by mitogens. PubMed: Development of bioactive functions in Hydrangeae Dulcis Folium. VII. Immunomodulatory activities of thunberginol A and related compounds on lymphocyte proliferation. PubMed: Inhibitory effects of plumbagin and juglone on azoxymethane-induced intestinal carcinogenesis in rats. PubMed: Development of bioactive functions in Hydrangeae dulcis folium. VI. Syntheses of thunberginols A and F and their 3'-deoxy-derivatives using regiospecific lactonization of stilbene carboxylic acid: structures and inhibitory activity on histamine release of hydramacrophyllols A and B. PubMed: Development of bioactive functions in hydrangeae dulcis folium. V. On the antiallergic and antimicrobial principles of hydrangeae dulcis folium. (2). Thunberginols C, D, and E, thunberginol G 3'-O-glucoside, (-)-hydrangenol 4'-o-glucoside, and (+)-hydrangenol 4'-O-glucoside. PubMed: Modifying effects of naturally occurring products on the development of colonic aberrant crypt foci induced by azoxymethane in F344 rats. PubMed: Development of bioactive functions in hydrangeae dulcis folium. III. On the antiallergic and antimicrobial principles of hydrangeae dulcis folium. (1). Thunberginols A, B, and F. PubMed: [Development of bioactive functions in hydrangeae dulcis folium. II. Antiulcer, antiallergy, and cholagoic effects of the extract from hydrangeae dulcis folium]. PubMed: [Chemical constituents of Hydrangea macrophylla (Thunb.) Ser]. PubMed: [Quantitative analysis of dihydroisocoumarin constituents of Hydrangeae Dulcis Folium by means of high performance liquid chromatography. Chemical characterization of the processing, distribution in plant, and seasonal fluctuation]. PubMed: Thunberginols C, D, and E, new antiallergic and antimicrobial dihydroisocoumarins, and thunberginol G 3'-O-glucoside and (-)-hydrangenol 4'-O-glucoside, new dihydroisocoumarin glycosides, from Hydrangeae Dulcis Folium. PubMed: Thunberginols A, B, and F, new antiallergic and antimicrobial principles from hydrangeae dulcis folium. PubMed: Hydrangenol, a strong contact sensitizer found in hydrangea (Hydrangea sp.; Hydrangeaceae). PubMed: Inhibitory effects of hydrangenol derivatives on the activation of hyaluronidase and their antiallergic activities. PubMed: Allergic contact dermatitis to hydrangea. PubMed: Antifungal activity of oosponol, oospolactone, phyllodulcin, hydrangenol, and some other related compounds. PubMed: [High-speed liquid chromatographic analysis of drugs. IV. Speration analysis of phyllodulcin and hydrangenol in sweet hydrangea (author's transl)]. PubMed: Studies of hydrangenol in Hydrangea macrophylla Ser. II. Biosynthesis of hydrangenol from C14-labelled compounds. PubMed: Enhancement of Gibberellin Growth-Promoting Activity by Hydrangenol Isolated from Leaves of Hydrangea Macrophylla. PubMed: Studies of hydrangenol in hydrangea macrophylla Ser. I. Isolation, identification, and biosynthesis from C 14-labelled compounds.