rosmanol
Identification
| Name | rosmanol |
| CAS Number | 80225-53-2 |
| FDA UNII | F25TV383OC |
| Molecular Formula | C20 H26 O5 |
| Molecular Weight | 346.42322000 |
| Nikkaji Number | J56.290D |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Soluble in | water, 828.2 mg/L @ 25 °C (est) |
No sensory data available
Safety Information
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | natural substances and extractives |
| Recommendation for rosmanol usage levels up to | not for fragrance use. |
| Recommendation for rosmanol flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
2H-10,4a-(
epoxymethano)phenanthren-12-one, 1,3,4,9,10,10a-hexahydro-5,6,9-trihydroxy-1,1-dimethyl-7-(1-methylethyl)-, (4aR,9S,10S,10aS)-
(4bR,8aS,9S,10S)-3,4,10-
trihydroxy-2-isopropyl-8,8-dimethyl-6,7,8,8a,9,10-hexahydro-5H-9,4b-(epoxymethano)phenanthren-12-one
PubMed:
NMR, HS-SPME-GC-MS and HPLC-MS(n) analyses of phytoconstituents and aroma profile of Rosmarinus eriocalyx L.
PubMed:
Determination and Pharmacokinetic Study of Three Diterpenes in Rat Plasma by UHPLC-ESI-MS/MS after Oral Administration of Rosmarinus officinalis L. Extract.
PubMed:
Phytochemical Profiling of Flavonoids, Phenolic Acids, Terpenoids, and Volatile Fraction of a Rosemary (Rosmarinus officinalis L.) Extract.
PubMed:
Antidepressant, Anxiolytic and Antinociceptive Activities of Constituents from Rosmarinus Officinalis.
PubMed:
Diterpenes from rosemary (Rosmarinus officinalis): Defining their potential for anti-cancer activity.
PubMed:
New terpenoid glycosides obtained from Rosmarinus officinalis L. aerial parts.
PubMed:
Relevance of the carnosic acid/carnosol ratio for the level of rosemary diterpene transfer and for improving lamb meat antioxidant status.
PubMed:
Bioavailability of the major bioactive diterpenoids in a rosemary extract: metabolic profile in the intestine, liver, plasma, and brain of Zucker rats.
PubMed:
Structure activity relationship of phenolic diterpenes from Salvia officinalis as activators of the nuclear factor E2-related factor 2 pathway.
PubMed:
Phenolic diterpenes derived from Hyptis incana induce apoptosis and G(2)/M arrest of neuroblastoma cells.
PubMed:
Role of macrophage CCAAT/enhancer binding protein delta in the pathogenesis of rheumatoid arthritis in collagen-induced arthritic mice.
PubMed:
Comparison of different extraction procedures for the comprehensive characterization of bioactive phenolic compounds in Rosmarinus officinalis by reversed-phase high-performance liquid chromatography with diode array detection coupled to electrospray time-of-flight mass spectrometry.
PubMed:
Rosmanol potently induces apoptosis through both the mitochondrial apoptotic pathway and death receptor pathway in human colon adenocarcinoma COLO 205 cells.
PubMed:
Rosmanol potently inhibits lipopolysaccharide-induced iNOS and COX-2 expression through downregulating MAPK, NF-kappaB, STAT3 and C/EBP signaling pathways.
PubMed:
Semisynthesis and biological evaluation of abietane-type diterpenes. Revision of the structure of rosmaquinone.
PubMed:
Neuroprotective and neurotrophic effects of isorosmanol.
PubMed:
Characterization of two unknown compounds in methanol extracts of rosemary oil.
PubMed:
[Chemical diversity of the biological active ingredients of salvia officinalis and some closely related species].
PubMed:
Abietane diterpenoids from Salvia pachyphylla and S. clevelandii with cytotoxic activity against human cancer cell lines.
PubMed:
Recovery of antioxidant activity from carnosol quinone: antioxidants obtained from a water-promoted conversion of carnosol quinone.
PubMed:
Antioxidant activity of organic extracts from aqueous infusions of sage.
PubMed:
Subcritical water extraction of antioxidant compounds from rosemary plants.
PubMed:
Recovery mechanism of the antioxidant activity from carnosic acid quinone, an oxidized sage and rosemary antioxidant.
PubMed:
Antioxidant capacity of abietanes from Sphacele salviae.
PubMed:
Semisynthesis of rosmanol and its derivatives. Easy access to abietatriene diterpenes isolated from the genus Salvia with biological activities.
PubMed:
Antioxidant activity of chemical components from sage (Salvia officinalis L.) and thyme (Thymus vulgaris L.) measured by the oil stability index method.
PubMed:
Antioxidant properties of phenolic diterpenes from Rosmarinus officinalis.
PubMed:
Apianane terpenoids from Salvia officinalis.
PubMed:
Response of abietane diterpenes to stress in Rosmarinus officinalis L.: new insights into the function of diterpenes in plants.
PubMed:
Atmospheric pressure chemical ionization (APcI) liquid chromatography-mass spectrometry: characterization of natural antioxidants.
PubMed:
Inhibition of lipid peroxidation and superoxide generation by diterpenoids from Rosmarinus officinalis.
PubMed:
Inhibitory effect of carnosic acid on HIV-1 protease in cell-free assays [corrected].