ailanthone
picrasa-3,13(21)-dien-2,16-dione, 11,20-epoxy-1,11,12-trihydroxy-, (1b,11b,12a)
Identification
| Name | ailanthone |
| CAS Number | 981-15-7 |
| FDA UNII | Search |
| Molecular Formula | C20 H24 O7 |
| Molecular Weight | 376.40568000 |
| Nikkaji Number | J21.167B |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Boiling Point | 641.00 °C. @ 760.00 mm Hg (est) |
| Flash Point | 449.00 °F. TCC ( 231.60 °C. ) (est) |
| logP (o/w) | -0.760 (est) |
| Soluble in | water, 2637 mg/L @ 25 °C (est) |
No sensory data available
Safety Information
| Oral/Parenteral Toxicity | intraperitoneal-mouse LD50 31400 ug/kg |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | natural substances and extractives |
| Recommendation for ailanthone usage levels up to | not for fragrance use. |
| Recommendation for ailanthone flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
ailantone
(1-beta,11-beta,12-alpha)-11,20-
epoxy-1,11,12-trihydroxypicrasa-3,13(21)-diene-2,16-dione
2H-1,11c-(
epoxymethano)phenanthro(10,1-bc)pyran-5,10(3H,6ah)-dione, 1,3a,4,7,7a,11,11a,11b-octahydro-8,11a-b-dimethyl-3-methylene-1-a,2-b,11-b-trihydroxy-
picrasa-3,13(21)-dien-2,16-dione, 11,20-epoxy-1,11,12-trihydroxy-, (1b,11b,12a)
PubMed:
Herbicide activity of extracts from Ailanthus altissima (Simaroubaceae).
PubMed:
Quassinoids can induce mitochondrial membrane depolarisation and caspase 3 activation in human cells.
PubMed:
Antiplasmodial activity of extracts and quassinoids isolated from seedlings of Ailanthus altissima (Simaroubaceae).
PubMed:
Isolation of phytotoxic compounds from tree-of-heaven (Ailanthus altissima swingle).
PubMed:
Anti-tuberculosis activity of quassinoids.
PubMed:
Quassinoids as inhibitors of Epstein-Barr virus early antigen activation.
PubMed:
Antitumor activity of novel ailanthone derivatives in vitro and in vivo.
PubMed:
[Antiamebic properties of some derivatives of ailantone and quassin].