allantoin

urea, N-(2,5-dioxo-4-imidazolidinyl)-

CAS: 97-59-6 C4 H6 N4 O3 MW: 158.11742000

Identification

Nameallantoin
CAS Number97-59-6
EINECS202-592-8
FDA UNII344S277G0Z
Molecular FormulaC4 H6 N4 O3
Molecular Weight158.11742000
MDL NumberMFCD00005260
Nikkaji NumberJ3.978K
Beilstein102364

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Melting Point 239.00 °C. @ 760.00 mm Hg
Flash Point 32.00 °F. TCC ( 0.00 °C. ) (est)
logP (o/w) -1.523 (est)
Soluble in water, 5260 mg/L @ 25 °C (exp)

Cosmetic Information

CosIngcosmetic data
Cosmetic Usesskin conditioning

No sensory data available

Safety Information

Oral/Parenteral ToxicityNot determined
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorycosmetic agents
Recommendation for allantoin usage levels up tonot for fragrance use.
Recommendation for allantoin flavor usage levels up tonot for flavor use.

American International Chemical, Inc.

Consistent sources

North American supplier for globally sourced ingredients.

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ECSA Chemicals

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Glentham Life Sciences Ltd

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Glentham Life Sciences is a supplier of fine chemicals and raw materials with warehousing, laboratories and packaging facilities in the UK.

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Penta International Corporation

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At Penta, our products and services help businesses do business better.

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Potential Uses

oral care agents

Natural Occurrence

beet root black gram seed borage embryo borage leaf borage rhizome borage root borage seed borage sprout butternut seed cherry sour cherry stem coffee leaf comfrey corn embryo corn seed lupine white lupine sprout pea shoot potato plant rice seed shea tree seed soybean leaf soybean seed soybean shoot tea plant watermelon seed wheat embryo

Synonyms

(±)- allantoin DL- allantoin allantoin powder allantoin powder USP allantoin USP brookosome A cordianin cutemol emollient 2,5- dioxo-4-imidazolidinyl-urea (2,5- dioxo-4-imidazolidinyl)-urea (2,5- dioxo-4-imidazolidinyl)urea 1-(2,5- dioxo-4-imidazolidinyl)urea N-(2,5- dioxo-4-imidazolidinyl)urea (2,5- dioxo-imidazolidin-4-yl)-urea (2,5- dioxoimidazolidin-4-yl)urea 1-(2,5- dioxoimidazolidin-4-yl)urea fancol TOIN glyoxyldiureid glyoxylic diureide hemocane 4H- imidazole-2,5-diol, 4-[(hydroxyiminomethyl)amino]- paxyl psoralon sebical septalan uniderm A urea, (2,5-dioxo-4-imidazolidinyl)- urea, N-(2,5-dioxo-4-imidazolidinyl)- 5- ureidohydantoin 5- ureidohydrantoin PubMed: Characterization of imidazoline receptors in blood vessels for the development of antihypertensive agents. PubMed: Antihypertensive action of allantoin in animals. PubMed: Effects of allantoin on cognitive function and hippocampal neurogenesis. PubMed: Biological system responses to zearalenone mycotoxin exposure by integrated metabolomic studies. PubMed: Rapid detection of economic adulterants in fresh milk by liquid chromatography-tandem mass spectrometry. PubMed: Diet-induced hyperinsulinemia differentially affects glucose and protein metabolism: a high-throughput metabolomic approach in rats. PubMed: Nanoparticulate silver increases uric acid and allantoin excretion in rats, as identified by metabolomics. PubMed: Pegloticase: a novel agent for treatment-refractory gout. PubMed: Distribution and function of allantoin (5-ureidohydantoin) in rice grains. PubMed: Effect of Dioscorea opposita Thunb. (yam) supplementation on physicochemical and sensory characteristics of yogurt. PubMed: Decrease of plasma glucose by allantoin, an active principle of yam ( Dioscorea spp.), in streptozotocin-induced diabetic rats. PubMed: Toxicometabolomics approach to urinary biomarkers for mercuric chloride (HgCl₂)-induced nephrotoxicity using proton nuclear magnetic resonance (¹H NMR) in rats. PubMed: Intake, digestibility and rumen dynamics of neutral detergent fibre in cattle fed low-quality tropical forage and supplemented with nitrogen and/or starch. PubMed: Pattern recognition analysis for the prediction of adverse effects by nonsteroidal anti-inflammatory drugs using 1H NMR-based metabolomics in rats. PubMed: Improved high-performance liquid chromatography (HPLC) method for qualitative and quantitative analysis of allantoin in Zea mays. PubMed: Uric acid recycling in the shield bug, Parastrachia japonensis (Hemiptera: Parastrachiidae), during diapause. PubMed: Urinary excretion of purine derivatives as an index of microbial protein synthesis in the camel (Camelus dromedarius). PubMed: Suppressive effect of viscous dietary fiber on elevations of uric acid in serum and urine induced by dietary RNA in rats is associated with strength of viscosity. PubMed: Rasburicase: potential role in managing tumor lysis in patients with hematological malignancies. PubMed: Aspects of excretion of antlion larvae (Neuroptera: myrmeleontidae) during feeding and non-feeding periods. PubMed: Major constituents, leptin, and non-protein nitrogen compounds in mares' colostrum and milk. PubMed: Ultrastructural localization of xanthine oxidoreductase activity in isolated rat liver cells. PubMed: High versus low protein diets to mink--postprandial plasma urea and creatinine response, osmotic load and pattern of nitrogen and electrolyte excretion. PubMed: Effectiveness of a nonrinse, alcohol-free antiseptic hand wash. PubMed: Identification of allantoin, uric acid, and indoxyl sulfate as biochemical indicators of filth in food packaging by LC. PubMed: Effects of corn particle size and source on performance of lactating cows fed direct-cut grass-legume forage. PubMed: A modified HET-CAM assay approach to the assessment of anti-irritant properties of plant extracts. PubMed: Intraruminal supplementation with increasing levels of exogenous polysaccharide-degrading enzymes: effects on nutrient digestion in cattle fed a barley grain diet. PubMed: Biosynthesis and catabolism of caffeine in low-caffeine-containing species of Coffea. PubMed: Xanthine degradation and related enzyme activities in leaves and fruits of two coffea species differing in caffeine catabolism. PubMed: Synergistic operation of the CAR2 (Ornithine transaminase) promoter elements in Saccharomyces cerevisiae. PubMed: Effect of dietary or abomasal supplementation of exogenous polysaccharide-degrading enzymes on rumen fermentation and nutrient digestibility. PubMed: Food intake, nutrient utilization and water turnover in the lesser mouse-deer (Tragulus javanicus) given lundai (Sapium baccatum). PubMed: Compositional and toxicological evaluation of the diazotrophic cyanobacterium, Cyanothece sp. strain ATCC 51142. PubMed: Winter evaluation of a postmilking powdered teat dip. PubMed: [Purine and pyrimidine metabolites for the estimation of rumen metabolism: HPLC analysis in milk and blood plasma]. PubMed: [The effect of aldioxa on the formation of gastritis induced with sodium hydroxide]. PubMed: Uricogenic potential of selected cooked foods in rats. PubMed: Improved reagent for detection of allantoin in thin-layer chromatographic method for urine stains on foods and packaging. PubMed: Effects of intraruminal sodium chloride infusion on rumen and renal nitrogen and electrolyte dynamics in sheep. PubMed: [Allantoin excretion of wethers in variations of raw protein and energy administration]. PubMed: Induction of tumours in rats by feeding nitrosatable amines together with sodium nitrite. PubMed: Extraction and thin layer chromatographic confirmation of urine residues: new plate development. PubMed: Food additives. PubMed: Nitrogen retention in rats fed on diets enriched with arginine and glycine. 1. Improved N retention after trauma. PubMed: Utilization of dried microbial cells grown on methanol in a semi-purified diet for growing pigs. PubMed: Long-term feeding study on disodium 5-ribonucleotide in dogs. PubMed: Extraction and thin layer chromatographic confirmation of urine residues from food packaging materials. PubMed: Thin layer chromatographic test for mammalian urine on wheat. PubMed: Observations on the regulation of uricase activity during development of Drosophila melanogaster. PubMed: Decomposition of nucleic acids and some of their degradation products by microorganisms. PubMed: PROTEINURIA IN NEW-BORN CALVES FOLLOWING THE FEEDING OF COLOSTRUM.