imidazolidinyl urea

urea, N,N''-methylenebis[N'-[3-(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl]-

CAS: 39236-46-9 C11 H16 N8 O8 MW: 388.29812000

Identification

Nameimidazolidinyl urea
IUPAC1-[3-(hydroxymethyl)-2,5-dioxoimidazolidin-4-yl]-3-[[[3-(hydroxymethyl)-2,5-dioxoimidazolidin-4-yl]carbamoylamino]methyl]urea
CAS Number39236-46-9
EINECS254-372-6
FDA UNIIM629807ATL
Molecular FormulaC11 H16 N8 O8
Molecular Weight388.29812000
MDL NumberMFCD00221482
Nikkaji NumberJ236.023C
Beilstein8731946

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Flash Point 32.00 °F. TCC ( 0.00 °C. ) (est)
logP (o/w) -4.930 (est)
Soluble in water, 1e+006 mg/L @ 25 °C (est)

Cosmetic Information

CosIngcosmetic data
Cosmetic Usespreservatives

No sensory data available

Safety Information

Preferred SDSView
Oral/Parenteral Toxicityoral-rat LD50 11300 mg/kg
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorypreservatives
Recommendation for imidazolidinyl urea usage levels up tonot for fragrance use.
Recommendation for imidazolidinyl urea flavor usage levels up tonot for flavor use.

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Potential Uses

preservatives

Natural Occurrence

not found in nature

Synonyms

abiol germall 115 imidazolinidyl urea imidurea 1,1'- methanediylbis{3-[3-(hydroxymethyl)-2,5-dioxoimidazolidin-4-yl]urea} N,N''- methylene bis(N'-(3-(hydroxymethyl)-2,5-dioxoimidazolidin-4-yl)urea) 1,1'- methylenebis(3-(3-(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl)urea) N,N"- methylenebis(N'-(1-(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl)urea) N,N''- methylenebis(N'-(3-(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl)urea) N,N''- methylenebis(N'-(3-(hydroxymethyl)-2,5-dioxoimidazolidin-4-yl)urea) N,N`- methylenebis[N`-3-(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl] urea N,N''- methylenebis[N'-[3-(hydroxymethyl)-2,5-dioxoimidazolidin-4-yl]urea] N,N"- methylenebis[N"-[3-(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl]urea] 1,1'- methylenebis{3-[3-(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl]urea} 1,1'- methylenebis{3-[3-(hydroxymethyl)-2,5-dioxoimidazolidin-4-yl]urea} N,N- methylenebisN'-1- -2,5-dioxo-4-imidazolidinylurea urea, N,N''-methylenebis(N'-(3-(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl)- urea, N,N''-methylenebis[N'-[3-(hydroxymethyl)-2,5-dioxo-4-imidazolidinyl]- PubMed: Contact sensitivity to preservatives in Singapore: frequency of sensitization to 11 common preservatives 2006-2011. PubMed: Cutaneous delayed-type hypersensitivity in patients with atopic dermatitis: reactivity to topical preservatives. PubMed: Allantoin as a solid phase adsorbent for removing endotoxins. PubMed: Characterization and removal of aggregates formed by nonspecific interaction of IgM monoclonal antibodies with chromatin catabolites during cell culture production. PubMed: Frequency of positive patch test reactions to preservatives: The Australian experience. PubMed: Follow-up of the monitored levels of preservative sensitivity in Europe: overview of the years 2001-2008. PubMed: Simultaneous determination of eleven preservatives in cosmetics by micellar electrokinetic chromatography. PubMed: Cell chip-based monitoring of toxic effects of cosmetic compounds on skin fibroblast cells. PubMed: Formalehyde in personal care products. PubMed: Characterization of the decomposition of compounds derived from imidazolidinyl urea in cosmetics and patch test materials. 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PubMed: Positive concomitant test reactions to allergens in the standard patch test series. PubMed: Formaldehyde-releasers in cosmetics in the USA and in Europe. PubMed: Temporal trends of preservative allergy in Denmark (1985-2008). PubMed: Formaldehyde-releasers in cosmetics: relationship to formaldehyde contact allergy. Part 2. Patch test relationship to formaldehyde contact allergy, experimental provocation tests, amount of formaldehyde released, and assessment of risk to consumers allergic to formaldehyde. PubMed: Formaldehyde-releasers in cosmetics: relationship to formaldehyde contact allergy. Part 1. Characterization, frequency and relevance of sensitization, and frequency of use in cosmetics. PubMed: In vitro synergistic activities of essential oils and surfactants in combination with cosmetic preservatives against Pseudomonas aeruginosa and Staphylococcus aureus. PubMed: Hand dermatitis: a focus on allergic contact dermatitis to biocides. PubMed: Long-term trend in patch test reactions: a 32-year statistical overview (1970-2002), part II. PubMed: Contact hypersensitivity to selected excipients of dermatological topical preparations and cosmetics in patients with chronic eczema. PubMed: Sensitivity of petrolatum and aqueous vehicles for detecting allergy to imidazolidinylurea, diazolidinylurea, and DMDM hydantoin: a retrospective analysis from the North American Contact Dermatitis Group. PubMed: Contact sensitivity to preservatives in the UK, 2004-2005: results of multicentre study. PubMed: [Contact allergy to preservatives contained in cosmetics]. PubMed: The relationship of vehicle and concentration for imidazolidinylurea, with attention to formaldehyde allergy status. PubMed: The relationship of vehicle and concentration of imidazolidinylurea, with attention to formaldehyde allergy status. PubMed: Characterization and chemistry of imidazolidinyl urea and diazolidinyl urea. PubMed: Can an imidazolidinyl urea-preserved corticosteroid cream be safely used in individuals hypersensitive to formaldehyde? PubMed: Cosmetic dermatitis in Chinese eczema patients patch tested with a modified European standard series of allergens. PubMed: [Allergy to diazolidinyl urea (Germall II) and imidazolidinyl urea (Germall 115)]. PubMed: Contact sensitivity to preservatives in Turkey. PubMed: Evaluation of phototoxic properties of antimicrobials used in topical preparations by a photohaemolysis test. PubMed: [Contact sensitization to pharmaceutic aids in dermatologic cosmetic and external use preparations]. PubMed: The British standard series of contact dermatitis allergens: validation in clinical practice and value for clinical governance. PubMed: In vitro induction of apoptosis vs. necrosis by widely used preservatives: 2-phenoxyethanol, a mixture of isothiazolinones, imidazolidinyl urea and 1,2-pentanediol. PubMed: Synthesis and pharmacological activity of new carbonyl derivatives of 1-aryl-2-iminoimidazolidine. Part 1. Synthesis and pharmacological activity of chain derivatives of 1-aryl-2-iminoimidazolidine containing urea moiety. PubMed: Standardization of the TRUE Test imidazolidinyl urea and diazolidinyl urea patches. PubMed: Comparison of patch test results with a standard series among white and black racial groups. PubMed: Contact sensitization to corticosteroids: increased risk in long term dermatoses. PubMed: Allergic contact dermatitis from imidazolidinyl urea in an ultrasonic gel. PubMed: Concomitant positive reactions to allergens in a patch testing standard series from 1988-1997. PubMed: Significance-prevalence index number: a reinterpretation and enhancement of data from the North American contact dermatitis group. PubMed: Physician, heed thy shelf. PubMed: Simultaneous HPLC determination of multiple components in a commercial cosmetic cream. PubMed: Mechanisms of cytotoxicity by cosmetic ingredients in sea urchin eggs. PubMed: A method for quantification of formaldehyde in the presence of formaldehyde donors in skin-care products. PubMed: Flow-cytometric screening for the modulation of receptor-mediated endocytosis in human dendritic cells: implications for the development of an in vitro technique for predictive testing of contact sensitizers. PubMed: Utilization of electrochemical silver ions as preservative agent in cosmetic dispersions. PubMed: Comparison of automated and traditional minimum inhibitory concentration procedures for microbiological cosmetic preservatives. PubMed: Reactions to formaldehyde and formaldehyde releasers in a standard series. PubMed: Patch testing with preservatives at St John's from 1982 to 1993. PubMed: Chloromethylisothiazolone/methylisothiazolone (CMI/MI) use test with a shampoo on patch-test-positive subjects. Results of a multicentre double-blind crossover trial. PubMed: Cytotoxicity tests of antibacterial agents on human fibroblasts cultures. PubMed: [Sensitization to hypoallergenic cosmetics]. PubMed: Frequency of sensitization to 13 common preservatives in Switzerland. Swiss Contact Dermatitis Research Group. PubMed: Diazolidinyl urea: incidence of sensitivity, patterns of cross-reactivity and clinical relevance. PubMed: [Antimicrobial conservation of some cosmetics]. PubMed: Direct contact membrane inoculation of yeasts and moulds for evaluating preservative efficacy in solid cosmetics. PubMed: Imidazolidinyl urea (Germall 115) should be patch tested in water. PubMed: Direct contact membrane method for evaluating preservative efficacy in solid cosmetics. PubMed: Water versus petrolatum for testing imidazolidinyl urea. PubMed: Chemical stability and microbiological reply of preservative systems in cosmetics: a direct correlation. PubMed: Dose-response sensitization experiments with imidazolidinyl urea. PubMed: Contact allergy to diazolidinyl urea (Germall II). PubMed: Dehydroacetic acid sodium salt stability in cosmetic preservative mixtures. PubMed: Correlation of in vitro challenge testing with consumer use testing for cosmetic products. PubMed: Hidden contact allergy to formaldehyde in imidazolidinyl urea. PubMed: Imidazolidinyl urea (germall 115) causing cosmetic dermatitis. PubMed: Experimental delayed contact sensitization to diazolidinyl urea (Germall II) in guinea pigs. PubMed: Imidazolidinyl urea dermatitis. PubMed: Reactions to Quaternium 15, Bronopol and Germall 115 in a standard series. PubMed: A five-year study of cosmetic reactions. PubMed: Guinea pig maximization tests with formaldehyde releasers. Results from two laboratories. PubMed: Concentrated solutions of preservatives: their technological and analytical advantages in cosmetic products. PubMed: [Allergy to preservatives]. PubMed: Iatrogenic dermatitis. PubMed: Cosmetic ingredients and their safety assessment. Reports issued by the Cosmetic Ingredient Review. PubMed: Cosmetic dermatitis. Part II. Reactions to some commonly used preservatives. PubMed: Allergic contact dermatitis from Germall 115, a new cosmetic preservative. PubMed: Letter: Contact dermatitis to substituted imidazolidinyl urea--a common preservative in cosmetics.