musk tibetene (Givaudan)
benzene, 1-(1,1-dimethylethyl)-3,4,5-trimethyl-2,6-dinitro-
Identification
| Name | musk tibetene (Givaudan) |
| IUPAC | 1-tert-butyl-3,4,5-trimethyl-2,6-dinitrobenzene |
| CAS Number | 145-39-1 |
| EINECS | 205-651-6 |
| FDA UNII | CMN65165X5 |
| Molecular Formula | C13 H18 N2 O4 |
| Molecular Weight | 266.29726000 |
| MDL Number | MFCD00024266 |
| Nikkaji Number | J12.977A |
| Beilstein | 2000732 |
Regulatory
Physical Properties
| Appearance | pale yellow crystals (est) |
| Assay | 98.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Boiling Point | 391.01 °C. @ 760.00 mm Hg (est) |
| Congealing Point | 135.00 °C. |
| Vapor Pressure | 0.000005 mmHg @ 25.00 °C. (est) |
| Flash Point | > 200.00 °F. TCC ( > 93.33 °C. ) |
| logP (o/w) | 4.931 (est) |
| Soluble in | benzyl benzoate, 27.4:100 |
| Insoluble in | water |
Cosmetic Information
| CosIng | cosmetic data |
| Cosmetic Uses | not used anymore |
Organoleptic Properties
| Odor Strength | medium , |
| Substantivity | 348 hour(s) at 20.00 % in benzyl benzoate |
| Odor Description | at 10.00 % in benzyl benzoate. |
| Odor sample from | Givaudan Corporation |
Safety Information
| Preferred SDS | View |
| Oral/Parenteral Toxicity | oral-rat LD50 > 6000 mg/kg |
| Dermal Toxicity | skin-rabbit LD50 > 5000 mg/kg |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | information only not used for fragrances or flavors |
| IFRA Critical Effect | Insufficient data |
| Recommendation for musk tibetene (Givaudan) usage levels up to | PROHIBITED: Should not be used as a fragrance ingredient. |
| Recommendation for musk tibetene (Givaudan) flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
benzene, 1- (1,1-dimethylethyl)-3,4,5-trimethyl-2,6-dinitro-
benzene, 1-(1,1-dimethylethyl)-2,6-dinitro-3,4,5-trimethyl-
benzene, 1-(1,1-dimethylethyl)-3,4,5-trimethyl-2,6-dinitro-
benzene, 1-tert-butyl-2,6-dinitro-3,4,5-trimethyl-
benzene, 1-tert-butyl-3,4,5-trimethyl-2,6-dinitro-
5-tert-
butyl-1,2,3-trimethyl-4,6-dinitrobenzene
2-tert-
butyl-1,3-dinitro-4,5,6-trimethylbenzene
1-tert-
butyl-3,4,5-trimethyl-2,6-dinitrobenzene
5-tert-
butyl-4,6-dinitro-1,2,3-trimethyl benzene
5-tert-
butyl-4,6-dinitro-1,2,3-trimethylbenzene
1-(tert-
butyl)-3,4,5-trimethyl-2,6-dinitrobenzene
1-(1,1-
dimethyl ethyl)-3,4,5-trimethyl-2,6-dinitrobenzene
1-(1,1-
dimethylethyl)-3,4,5-trimethyl-2,6-dinitrobenzene
musk tibetene (Givaudan)
musk tibetine
tibetene musk
PubMed:
Analysis of 7 synthetic musks in cream by supported liquid extraction and solid phase extraction followed by GC-MS/MS.
PubMed:
Analysis of plasticizers and synthetic musks in cosmetic and personal care products by matrix solid-phase dispersion gas chromatography-mass spectrometry.
PubMed:
Photochemical behaviour of musk tibetene. A chemical and kinetic investigation.
PubMed:
Optimization of a sensitive method for the determination of nitro musk fragrances in waters by solid-phase microextraction and gas chromatography with micro electron capture detection using factorial experimental design.
PubMed:
Further solid-phase microextraction-gas chromatography-mass spectrometry applications: "on-fibre" and aqueous photodegradation of nitro musks.
PubMed:
Determination of musk compounds in sewage treatment plant sludge samples by solid-phase microextraction.
PubMed:
Evaluation of carcinogenic potential of two nitro-musk derivatives, musk xylene and musk tibetene in a host-mediated in vivo/in vitro assay system.
PubMed:
Nitromusk compounds in women with gynecological and endocrine dysfunction.
PubMed:
Kinetics of nitromusk compounds degradation in water by ultraviolet radiation and hydrogen peroxide.
PubMed:
Genotoxicity of nitro musks in the micronucleus test with human lymphocytes in vitro and the human hepatoma cell line Hep G2.
PubMed:
Nitro musk compounds genotoxic activity : Genotoxicity testing of nitro musks with the SOS-chromotest and the sister-chromatid exchange test.
PubMed:
Occurrence of nitro and non-nitro benzenoid musk compounds in human adipose tissue.
PubMed:
A comparative study of five nitro musk compounds for genotoxicity in the SOS chromotest and Salmonella mutagenicity.
PubMed:
[Mutagenicity, genotoxicity and cogenotoxicity of environmentally relevant nitro musk compounds].
PubMed:
Determination of musk ambrette in fragrance products by capillary gas chromatography with electron capture detection: interlaboratory study.
PubMed:
90-day dermal toxicity study and neurotoxicity evaluation of nitromusks in the albino rat.
PubMed:
Photoallergic potential in the guinea-pig of the nitromusk perfume ingredients musk ambrette, musk moskene, musk xylene, musk ketone, and musk tibetene.
PubMed:
Phototoxicity, photoallergy, and contact sensitization of nitro musk perfume raw materials.
PubMed:
The structure of musk ketone and musk tibetene.