musk tibetene (Givaudan)

benzene, 1-(1,1-dimethylethyl)-3,4,5-trimethyl-2,6-dinitro-

CAS: 145-39-1 C13 H18 N2 O4 MW: 266.29726000 musk

Identification

Namemusk tibetene (Givaudan)
IUPAC1-tert-butyl-3,4,5-trimethyl-2,6-dinitrobenzene
CAS Number145-39-1
EINECS205-651-6
FDA UNIICMN65165X5
Molecular FormulaC13 H18 N2 O4
Molecular Weight266.29726000
MDL NumberMFCD00024266
Nikkaji NumberJ12.977A
Beilstein2000732

Regulatory

Physical Properties

Appearance pale yellow crystals (est)
Assay 98.00 to 100.00
Food Chemicals Codex Listed No
Boiling Point 391.01 °C. @ 760.00 mm Hg (est)
Congealing Point 135.00 °C.
Vapor Pressure 0.000005 mmHg @ 25.00 °C. (est)
Flash Point > 200.00 °F. TCC ( > 93.33 °C. )
logP (o/w) 4.931 (est)
Soluble in benzyl benzoate, 27.4:100
Insoluble in water

Cosmetic Information

CosIngcosmetic data
Cosmetic Usesnot used anymore

Organoleptic Properties

Odor Strength medium ,
Substantivity 348 hour(s) at 20.00 % in benzyl benzoate
Odor Description at 10.00 % in benzyl benzoate.
Odor sample from Givaudan Corporation

Safety Information

Preferred SDSView
Oral/Parenteral Toxicityoral-rat LD50 > 6000 mg/kg
Dermal Toxicityskin-rabbit LD50 > 5000 mg/kg
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categoryinformation only not used for fragrances or flavors
IFRA Critical EffectInsufficient data
Recommendation for musk tibetene (Givaudan) usage levels up toPROHIBITED: Should not be used as a fragrance ingredient.
Recommendation for musk tibetene (Givaudan) flavor usage levels up tonot for flavor use.

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Potential Uses

FR amber FR animal clean depth fixer FR moss FR musk FR woody

Natural Occurrence

not found in nature

Synonyms

benzene, 1- (1,1-dimethylethyl)-3,4,5-trimethyl-2,6-dinitro- benzene, 1-(1,1-dimethylethyl)-2,6-dinitro-3,4,5-trimethyl- benzene, 1-(1,1-dimethylethyl)-3,4,5-trimethyl-2,6-dinitro- benzene, 1-tert-butyl-2,6-dinitro-3,4,5-trimethyl- benzene, 1-tert-butyl-3,4,5-trimethyl-2,6-dinitro- 5-tert- butyl-1,2,3-trimethyl-4,6-dinitrobenzene 2-tert- butyl-1,3-dinitro-4,5,6-trimethylbenzene 1-tert- butyl-3,4,5-trimethyl-2,6-dinitrobenzene 5-tert- butyl-4,6-dinitro-1,2,3-trimethyl benzene 5-tert- butyl-4,6-dinitro-1,2,3-trimethylbenzene 1-(tert- butyl)-3,4,5-trimethyl-2,6-dinitrobenzene 1-(1,1- dimethyl ethyl)-3,4,5-trimethyl-2,6-dinitrobenzene 1-(1,1- dimethylethyl)-3,4,5-trimethyl-2,6-dinitrobenzene musk tibetene (Givaudan) musk tibetine tibetene musk PubMed: Analysis of 7 synthetic musks in cream by supported liquid extraction and solid phase extraction followed by GC-MS/MS. PubMed: Analysis of plasticizers and synthetic musks in cosmetic and personal care products by matrix solid-phase dispersion gas chromatography-mass spectrometry. PubMed: Photochemical behaviour of musk tibetene. A chemical and kinetic investigation. PubMed: Optimization of a sensitive method for the determination of nitro musk fragrances in waters by solid-phase microextraction and gas chromatography with micro electron capture detection using factorial experimental design. PubMed: Further solid-phase microextraction-gas chromatography-mass spectrometry applications: "on-fibre" and aqueous photodegradation of nitro musks. PubMed: Determination of musk compounds in sewage treatment plant sludge samples by solid-phase microextraction. PubMed: Evaluation of carcinogenic potential of two nitro-musk derivatives, musk xylene and musk tibetene in a host-mediated in vivo/in vitro assay system. PubMed: Nitromusk compounds in women with gynecological and endocrine dysfunction. PubMed: Kinetics of nitromusk compounds degradation in water by ultraviolet radiation and hydrogen peroxide. PubMed: Genotoxicity of nitro musks in the micronucleus test with human lymphocytes in vitro and the human hepatoma cell line Hep G2. PubMed: Nitro musk compounds genotoxic activity : Genotoxicity testing of nitro musks with the SOS-chromotest and the sister-chromatid exchange test. PubMed: Occurrence of nitro and non-nitro benzenoid musk compounds in human adipose tissue. PubMed: A comparative study of five nitro musk compounds for genotoxicity in the SOS chromotest and Salmonella mutagenicity. PubMed: [Mutagenicity, genotoxicity and cogenotoxicity of environmentally relevant nitro musk compounds]. PubMed: Determination of musk ambrette in fragrance products by capillary gas chromatography with electron capture detection: interlaboratory study. PubMed: 90-day dermal toxicity study and neurotoxicity evaluation of nitromusks in the albino rat. PubMed: Photoallergic potential in the guinea-pig of the nitromusk perfume ingredients musk ambrette, musk moskene, musk xylene, musk ketone, and musk tibetene. PubMed: Phototoxicity, photoallergy, and contact sensitization of nitro musk perfume raw materials. PubMed: The structure of musk ketone and musk tibetene.