Identification

Nameheliotropin
IUPAC1,3-benzodioxole-5-carbaldehyde
CAS Number120-57-0
EINECS204-409-7
FDA UNIIKE109YAK00
Molecular FormulaC8 H6 O3
Molecular Weight150.13342000
MDL NumberMFCD00005828
Nikkaji NumberJ2.919J
Beilstein131691
CoE Number104
XlogP31.10 (est)

Regulatory

JECFA Food Flavoring896 piperonal
DG SANTE Food Flavourings05.016 piperonal
FEMA Number2911
FDANo longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm (SATF)120-57-0 ; PIPERONAL
FDA RegulationFDA PART 182 -- SUBSTANCES GENERALLY RECOGNIZED AS SAFE

Physical Properties

Appearance white crystalline powder (est)
Assay 98.00 to 100.00
Heavey Metals <40.00 ppm
Food Chemicals Codex Listed Yes
Melting Point 37.00 to 39.00 °C. @ 760.00 mm Hg
Boiling Point 263.00 to 265.00 °C. @ 760.00 mm Hg, 144.00 to 145.00 °C. @ 15.00 mm Hg
Congealing Point 35.30 °C.
Acid Value 3.00 max. KOH/g
Vapor Pressure 0.003000 mmHg @ 25.00 °C.
Flash Point > 230.00 °F. TCC ( > 110.00 °C. )
logP (o/w) 1.050
Shelf Life 24.00 month(s) or longer if stored properly.
Storage store in cool, dry place in tightly sealed containers, protected from heat and light.
Soluble in alcohol
Insoluble in paraffin oil
Stability bath foam

Cosmetic Information

CosIngcosmetic data
Cosmetic Usesfragrance

Organoleptic Properties

Odor Strength medium
Substantivity 212 hour(s) at 100.00 %
Odor Description
at 100.00 %.
Cherry, vanilla, sweet cherry pit notes and creamy with cinnamic nuances
Cherry-like
almond; anise; balsam; berry; cherry; creamy; floral; raspberry; sweet; vanilla; violet; woody; wine-like; herbaceous
sweet, vanilla
Heliotrope Flower Sweet Coconut
Odor sample from Berje Inc.
Taste Description
at 15.00 ppm.
sweet creamy nutty benzaldehyde vanilla spice
sweet creamy nutty benzaldehyde vanilla spice
sweet, aromatic, vanilla, benzaldehyde

Safety Information

Preferred SDSView
European informationMost important hazard(s):
Human Experience6 % solution: no irritation or sensitization.
Oral/Parenteral Toxicitygavage-rat LD50 [sex: M,F] 2700 mg/kg
Dermal Toxicityskin-rabbit LD50 > 5000 mg/kg
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorycosmetic, flavor and fragrance agents
RIFM Fragrance Material Safety AssessmentSearch
Recommendation for heliotropin usage levels up to8.0000 % in the fragrance concentrate.
Maximised Survey-derived Daily Intakes (MSDI-EU)1500.00 (μg/capita/day)
Maximised Survey-derived Daily Intakes (MSDI-USA)3200.00 (μg/capita/day)
baked goods-
beverages(nonalcoholic)-
beverages(alcoholic)-
breakfast cereal-
cheese-
chewing gum-
condiments / relishes-
confectionery froastings-
egg products-
fats / oils-
fish products-
frozen dairy-
fruit ices-
gelatins / puddings-
granulated sugar-
gravies-
hard candy-
imitation dairy-
instant coffee / tea-
jams / jellies-
meat products-
milk products-
nut products-
other grains-
poultry-
processed fruits-
processed vegetables-
reconstituted vegetables-
seasonings / flavors-
snack foods-
soft candy-
soups-
sugar substitutes-
sweet sauces-

Advanced Biotech. Inc.

Inspired by Nature

A diverse range of products, all meeting our stringent commitment to quality.

View All Website 973-339-6242 info@adv-bio.com

Alfrebro LLC/ Archer Daniels Midland Company

Let's get reacquainted

Building great taste with aroma chemicals, extracts, and distillates

View All Website 513-539-7373 sforbis@alfrebro.com

Associate Allied Chemicals

Quality, Service and Values

Our aim is to become a reliable one-stop shop for our customers.

View All Website +91 22 2419 8800 aacipl@aacipl.com

Augustus Oils Ltd

The Premier Supplier

Augustus Oils Ltd, in harmony with nature - to present it at its best...

View All Website +44 (0)1420 590555 essentials@augustus-oils.ltd.uk

Axxence Aromatic GmbH

We bring nature to your flavour

Dedicated to provide the best possible quality and supply service of natural aroma ingredients.

View All Website +49.2822.68561.0 service@axxence.com

Berje Inc.

Where the world comes to its senses

Where the world comes to its senses - Berjé is a global distributor of Essential Oils and Aromatic Chemicals.

View All Website 973-748-8980 tlauzurica@berjeinc.com

BOC Sciences

Best of Chemicals Supplier

Quality supplier of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecul...

View All Website 1-631-485-4226 account@bocsci.com

Bontoux SAS

Major international supplier

Major international Producer of aromatic ingredients for the production of fragrances, flavors, cosmetics, pharmaceuticals and Aromatherapy.

View All Website + 1.908.755.4800 contact@bontoux.com

Charkit Chemical Corporation

The Specialty Chemical Specialists

Explore this website to discover the products and services that Charkit provides for your industry and please contact us directly to find out how we can be of service to you.

View All Website 203-299-3220 sales@charkit.com

ECSA Chemicals

Human Chemistry

ECSA Chemicals has been active since 1913 in the trading and international commerce of raw materials. With an organisation divided into industrial segments managed by specialists, it has become one of...

View All Website +41 91 695 88 00 marketing@ecsa.ch

Excellentia International

Ingredients by Nature

Exceptional quality and excellence in meeting our customers requirements.

View All Website 732.749.9840 info@excellentiaint.com

Fleurchem, Inc.

Have A Flavorful Day

A leading global manufacturer and supplier of ingredients for Flavors, Fragrances, AromaTherapy, Foods, Beverages, Personal Care Products, and other uses.

View All Website 845-341-2100 info@fleurchem.com

Foreverest Resources Ltd.

Leading pine based chemicals supplier

Supplying turpentine based and natural/extracted flavor & fragrance ingredients.

View All Website +86 (0)592 5105533 info@foreverest.cn

Global Essence Inc.

Preferred Partner

Accommodate each customers unique needs.

View All Website 001 732 677 1100 info@globalessenceuk.com

Indukern, S.A. F&F Ingredients Division

Commitment to quality

Idukern F&F Ingredients is your partner for the fragrance and flavor ingredients.

View All Website +34 93 506 91 00 info@indukern.es

Lluch Essence S.L.

A family company dedicated to sales and distribution

Flexibility, availability, price and quality.

View All Website 34 93 379 38 49 web@lluche.com

M&U International LLC

Steady supply & demand

Meeting customers increasing demands at home as well as abroad.

View All Website 908-359-9000 sales@mu-intel.com

Moellhausen S.P.A.

THE CHEMISTRY OF EMOTIONS

Innovation and commitment in the name of excellence.

View All Website +39 039.685.6262

O'Laughlin Industries Inc.

Manufacturer of chemicals and ingredients used in flavors, fragrances, food, beverages and cosmetics

Leading the Flavor and Fragrance Industry since 1980.

View All Website (973) 376-4600 olcorphk@hkstar.com

OQEMA

With a focus on providing the highest level of service

OQEMA has established itself at the forefront of the global chemical industry.

View All Website +1 973 886 3778 fandf@oqema.co.uk

Penta International Corporation

Chemistry innovation

At Penta, our products and services help businesses do business better.

View All Website (973) 740-2300 lisaa@pentamfg.com

Sigma-Aldrich

Complete Supply Chain

The perfect blend of products and services that bring your creativity to life.

View All Website 800-244-1173 ff@sial.com

SRS Aromatics Ltd

For over 25 years

Bringing flavour and fragrance into your world.

View All Website +44 (0) 1284 704076 info@srsaromatics.co.uk

The John D. Walsh Company, Inc

Suppliers Since 1942

Supplying the fragrance and flavor industry with high quality products.

View All Website 973-962-1400 info@johndwalsh.com

The Lermond Company

Your Sourcing Resource

The Lermond family has been sourcing raw materials for the flavor and fragrance industry for nearly 7 decades.

View All Website 201-896-3300 info@lermond.com

R C Treatt and Co Ltd

Innovative ingredient solutions

World-leading innovative ingredient solutions provider for the flavour, fragrance and FMCG industries.

View All Website +1 863 668 9500 enquiries@treatt.com

Ernesto Ventós S.A.

Leaders in essence

We employ our five senses to do our job well.

View All Website +1 856 226 7501 info@ventos.com

Vigon International

Passion for Simplicity

Manufacturer and supplier of high quality flavor and fragrance ingredients.

View All Website 570-476-6300 sales@vigon.com

Potential Uses

FR abronia FR acacia aimant FR aldehydic FR amber FR ambrene amour-amour FR angel essence FR apple blossom arpege FL arrack FR baby powder FR balsam FR banana FR bayberry FR blackberry FR bluebell FR blueberry FR bouquet FR carnation FR cherry FR cherry blossom FR clover FR coconut FR coconut tropical coconut FR country meadow FR crabapple blossom FR cream FR decumaria FR dillenia FR fern FR fetes FR fir needle oil replacer fixer FR floral FR florida breeze FR fresh and clean FR gardenia FR genet FR ginger white ginger FR gingerbread FR habuba FR hawthorn FR hay new mown hay FR heliotrope FR honeysuckle FR hop FR hugonia FR hyacinth FR japan flowers je reviens FR leather russian leather FR lemon FR lilac FR lily FR lily of the valley FR linden flower FR lotus FR magnolia FR mimosa FR mint monimia FR musk my sin FR narcissus nemesia FR neroli FR ophira FR orchid FR oriental FR orris FR passion blossom FR patchouli FR peach FR pina colada FR pine forest FL pistachio FR powder FR pumpkin pie FR rain FR rose FR sandalwood scandal FR spice FR sweet pea tide FR tobacco FR tonka bean FR tuberose FR vanilla FR violet FR wallflower FR wisteria FR woody

Natural Occurrence

blueberry fruit blueberry plant camphor wood chicken PMC dill melon PMC pepper black pepper fruit pepper black pepper oil pepper black pepper seed sherry PMC spirea ulmaria tobacco burley tobacco vanilla spp. vanilla tahiti vanilla violet flower

Synonyms

benzo[1,3]dioxole-5-carbaldehyde benzo[d][1,3]dioxole-5-carbaldehyde 2H- benzo[d]1,3-dioxolene-5-carbaldehyde 1,3- benzodioxole-5-carbaldehyde 2H-1,3- benzodioxole-5-carbaldehyde 1,3- benzodioxole-5-carboxaldehyde 3,4- dihydroxybenzaldehyde methylene ketal 3,4- dimethylene dioxybenzaldehyde dioxymethylene procatechuic aldehyde dioxymethylene protocatechuic aldehyde formaldehyde protechualdehyde-3,4-cyclic acetal 5- formyl-1,3-benzodioxole geliotropin heliobase heliotropin natural heliotropin recrystallized extra FCC heliotropine heliotropine crystals heliotropine crystals FCC heliotropine natural heliotropine synthetic 3,4- methylene dioxy) benzaldehyde 3,4-bis( methylene dioxy) benzaldehyde 3,4-( methylene dioxy)-1,3-benzodioxole-5-benzaldehyde 3,4- methylene dioxybenzaldehyde 3,4- methylene protocatechuic aldehyde 3,4-( methylenedioxy)benzaldehyde 3,4- methylenedioxybenzaldehyde piperonal piperonal nat. piperonaldehyde piperonyl aldehyde piperonylaldehyde protocatechuic aldehyde methylene ether Google Patents: Process for preparing piperonal PubMed: Can head louse repellents really work? Field studies of piperonal 2% spray. J-Stage: First Total Synthesis of Justicidone, a p-Quinone-Lignan Derivative from Justicia hyssopifolia PubMed: Piperonal prevents high-fat diet-induced hepatic steatosis and insulin resistance in mice via activation of adiponectin/AMPK pathway. J-Stage: Synthesis of Optically Active Olivil Type of Lignan from L-Arabinose Using threo-Selective Aldol Condensation as a Key Reaction PubMed: Forensic profiling of sassafras oils based on comprehensive two-dimensional gas chromatography. PubMed: Anticancer activity and biophysical reactivity of copper complexes of 2-(benzo[d][1,3]dioxol-5-ylmethylene)-N-alkylhydrazinecarbothioamides. PubMed: Enantiomeric HPLC resolution and absolute stereochemistry assignment of a new poligamain derivative. PubMed: Production of natural fragrance aromatic acids by coexpression of trans-anethole oxygenase and p-anisaldehyde dehydrogenase genes of Pseudomonas putida JYR-1 in Escherichia coli. PubMed: Synthesis and impurity profiling of MDMA prepared from commonly available starting materials. PubMed: Synthesis and GC-MS analysis of a series of homologs and regioisomers of 3,4-methylenedioxypyrovalerone (MDPV). PubMed: Piperonal ciprofloxacin hydrazone induces growth arrest and apoptosis of human hepatocarcinoma SMMC-7721 cells. PubMed: Selective recognition of sesamol using molecularly imprinted polymers containing magnetic wollastonite. PubMed: Simultaneous determination of bioactive compounds in Piper nigrum L. and a species comparison study using HPLC-PDA. PubMed: Availability of target odor compounds from seized ecstasy tablets for canine detection. PubMed: Half-sandwich ruthenium–arene complexes with thiosemicarbazones: synthesis and biological evaluation of [(η⁶-p-cymene)Ru(piperonal thiosemicarbazones)Cl]Cl complexes. PubMed: Synthesis and characterization of mixed-ligand diimine-piperonal thiosemicarbazone complexes of ruthenium(II): Biophysical investigations and biological evaluation as anticancer and antibacterial agents. PubMed: S-selective hydroxynitrile lyase from a plant Baliospermum montanum: molecular characterization of recombinant enzyme. PubMed: Total synthesis of (+)-virgatusin via AlCl3-catalyzed [3+2] cycloaddition. PubMed: In vitro biological studies and structural elucidation of fluoro-substituted phenyl acrylic acids. PubMed: Enhancement in sample collection for the detection of MDMA using a novel planar SPME (PSPME) device coupled to ion mobility spectrometry (IMS). PubMed: Toxicological methods for tracing drug abuse: chromatographic, spectroscopic and biological characterisation of ecstasy derivatives. PubMed: Dynamic planar solid phase microextraction-ion mobility spectrometry for rapid field air sampling and analysis of illicit drugs and explosives. PubMed: Detection of piperonal emitted from polymer controlled odor mimic permeation systems utilizing Canis familiaris and solid phase microextraction-ion mobility spectrometry. PubMed: N-[(E)-1,3-Benzodioxol-5-yl-methyl-idene]-4-methyl-aniline. PubMed: Titanium imido complexes utilizing orthometallated derivatized acetophenone and piperonal imine ligands: synthesis, isolation, and characterization. PubMed: A combined experimental and theoretical study of the polar [3 + 2] cycloaddition of electrophilically activated carbonyl ylides with aldehydes and imines. PubMed: Adsorbed resin phase spectrophotometric determination of vanillin or/and its derivatives. PubMed: [Synthesis of pyridine-containing diacylhydrazones and study on their spectral properties]. PubMed: Design, synthesis, and biological evaluation of platensimycin analogues with varying degrees of molecular complexity. PubMed: Headspace sampling and detection of cocaine, MDMA, and marijuana via volatile markers in the presence of potential interferences by solid phase microextraction-ion mobility spectrometry (SPME-IMS). PubMed: Synthesis and use of 4-peptidylhydrazido-N-hexyl-1,8-naphthalimides as fluorogenic histochemical substrates for dipeptidyl peptidase IV and tripeptidyl peptidase I. PubMed: Silenes in organic synthesis: a concise synthesis of (+/-) -epi-picropodophyllin. PubMed: Electrochemical and spectroscopic characterisation of amphetamine-like drugs: application to the screening of 3,4-methylenedioxymethamphetamine (MDMA) and its synthetic precursors. PubMed: Alpha-phenyl-N-tert-butyl nitrone (PBN) derivatives: synthesis and protective action against microvascular damages induced by ischemia/reperfusion. PubMed: Development and validation of an RP-HPLC method for quantitative determination of vanillin and related phenolic compounds in Vanilla planifolia. PubMed: The fumigant and repellent activity of aliphatic lactones against Pediculus humanus capitis (Anoplura: Pediculidae). PubMed: Synthesis of 7-deoxypancratistatin from carbohydrates by the use of olefin metathesis. PubMed: A study of impurities in intermediates and 3,4-methylenedioxymethamphetamine (MDMA) samples produced via reductive amination routes. PubMed: First total synthesis of justicidone, a p-quinone-lignan derivative from Justicia hyssopifolia. PubMed: Determination of synthesis method of ecstasy based on the basic impurities. PubMed: Chemical profiling of 3,4-methylenedioxymethamphetamine (MDMA) tablets seized in Hong Kong. PubMed: [Succivil efficacy in endogenous intoxication]. PubMed: [Study on the spectrophotometric determination of vanadium with piperonal fluorone by atomic absorption spectrophotometer]. PubMed: [Study on the determination of iron by silica gel H phase-diffuse reflectance spectrometry]. PubMed: Bhc-diol as a photolabile protecting group for aldehydes and ketones. PubMed: Microbiologic oxidation of isosafrole into piperonal. PubMed: Concentrations of nine alkenylbenzenes, coumarin, piperonal and pulegone in Indian bidi cigarette tobacco. PubMed: [Comparative evaluation of antioxidant properties of neoselen and berberin in chronic heliotrinal hepatitis]. PubMed: [Morphological features of the thymus in heliotrin hepatitis upon administration of immunostimulators]. PubMed: A short synthesis of (+/-)-epiasarinin. PubMed: Antioxidant properties of 8.0.4'-neolignans. PubMed: Asymmetric Synthesis of Sesaminone: Confirmation of Its Structure and Determination of Its Absolute Configuration. PubMed: Synthesis of optically active olivil type of lignan from L-arabinose using threo-selective aldol condensation as a key reaction. PubMed: Histochemical method for dipeptidyl aminopeptidase II with a new anthraquinonyl hydrazide substrate. PubMed: [The effect of perftoran on the biochemical detoxication parameters in rats with an acute toxic lesion of the liver]. PubMed: Enzyme-assisted asymmetric total synthesis of (-)-podophyllotoxin and (-)-picropodophyllin. PubMed: Quantitation of flavor-related alkenylbenzenes in tobacco smoke particulate by selected ion monitoring gas chromatography-mass spectrometry. PubMed: [The effect of immunomudulin on the structural-functional status of the organs of the immune and hematopoietic systems in chronic toxic hepatitis]. PubMed: Solid phase microextraction of alkenylbenzenes and other flavor-related compounds from tobacco for analysis by selected ion monitoring gas chromatography-mass spectrometry. PubMed: Specificity and sensitivity of a human olfactory receptor functionally expressed in human embryonic kidney 293 cells and Xenopus Laevis oocytes. PubMed: Cloning, functional expression and characterization of a human olfactory receptor. PubMed: An Asymmetric Synthesis of L-694,458, a Human Leukocyte Elastase Inhibitor, via Novel Enzyme Resolution of beta-Lactam Esters. PubMed: Antimutagenic and anticarcinogenic activity of natural and synthetic curcuminoids. PubMed: Synthesis, anti-GABA activity and preferred conformation of bicuculline and norbicuculline enantiomers. PubMed: Fragrance administration to reduce anxiety during MR imaging. PubMed: Head louse repellents. PubMed: Arena tests with piperonal, a new louse repellent. PubMed: New head louse repellent. PubMed: [Contamination in illegal amphetamine. Contaminants resulting from the synthesis of 3,4-(methylenedioxy)amphetamine (MDA) via condensation between nitroethane and piperonal]. PubMed: [Synthesis of derivatives of 2,4-bis(arylmethino)-8-butyl-8- azabicyclo[3.2.1]octan-3-one]. PubMed: Determination of coumarin as an adulterant in vanilla flavoring products by high-performance liquid chromatography. PubMed: Metabolic disposition of piperine in the rat. PubMed: Inhibition of rabbit nasal and hepatic cytochrome P-450-dependent hexamethylphosphoramide (HMPA) N-demethylase by methylenedioxyphenyl compounds. PubMed: Chemosensitivity of lobster,Homarus americanus, to secondary plant compounds: Unused receptor capabilities. PubMed: Metabolism of piperonal and piperonyl alcohol in the rat with special reference to the scission of the methylenedioxy group. PubMed: The inhibition of rat nasal cytochrome P-450-dependent mono-oxygenase by the essence heliotropin (piperonal). PubMed: Genotoxicity of safrole-related chemicals in microbial test systems. PubMed: The metabolism of some food additives related to piperonal in the rabbit. PubMed: Quantitative determination of chlorpromazine. HCl in tablets, spansules, injectables, and bulk chemical by nuclear magnetic resonance spectroscopy. PubMed: [The mechanism of centrolobular hepatic necrosis in acute heliotropin poisoning]. PubMed: [Changes in the antigenic composition of the rat liver in acute and chronic heliotropin poisoning]. PubMed: [AUTOANTIGENICITY IN EXPERIMENTAL LIVER DISEASES (ANTIGENIC PROPERTIES OFTHE SERUM IN HELIOTROPIN-INDUCED HEPATITIS)]. PubMed: Correlation of piperonal test values for aromatic compounds with the atmospheric concentration of benzo(A)pyrene. PubMed: [ON THE SYNTHESIS OF PIPERONAL].