pyridaben
3(2H)-pyridazinone, 4-chloro-2-(1,1-dimethylethyl)-5-(((4-(1,1-dimethylethyl)phenyl)methyl)thio)-
Identification
| Name | pyridaben |
| IUPAC | 2-tert-butyl-5-[(4-tert-butylphenyl)methylsulfanyl]-4-chloropyridazin-3-one |
| CAS Number | 96489-71-3 |
| FDA UNII | 2E4JBA5272 |
| Molecular Formula | C19 H25 Cl N2 O S |
| Molecular Weight | 364.93845000 |
| MDL Number | MFCD00274601 |
| Nikkaji Number | J388.265I |
| Beilstein | 7933972 |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Melting Point | 111.50 °C. @ 760.00 mm Hg |
| Boiling Point | 429.90 °C. @ 760.00 mm Hg (est) |
| Vapor Pressure | 1.180000 mmHg @ 1.18 °C. (est) |
| Flash Point | 417.00 °F. TCC ( 213.80 °C. ) (est) |
| logP (o/w) | 6.370 |
| Soluble in | water, 0.012 mg/L @ 20 °C (exp) |
No sensory data available
Safety Information
| Oral/Parenteral Toxicity | oral-mouse LD50 205 mg/kg |
| Dermal Toxicity | skin-rabbit LD50 > 2000 mg/kg |
| Inhalation Toxicity | inhalation-rat LC50 620 mg/m3 |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | herbicides / pesticides |
| Recommendation for pyridaben usage levels up to | not for fragrance use. |
| Recommendation for pyridaben flavor usage levels up to | not for flavor use. |
No supplier data available
Potential Uses
Natural Occurrence
Synonyms
2-tert-
butyl-5-(4-tert-butyl-benzylthio)-4-chloropyridazin-3(2H)-one
2-tert-
butyl-5-[(4-tert-butylphenyl)methylsulfanyl]-4-chloropyridazin-3-one
3(2H)-
pyridazinone, 4-chloro-2-(1,1-dimethylethyl)-5-(((4-(1,1-dimethylethyl)phenyl)methyl)thio)-
sanmite
PubMed:
Worker illness related to newly marketed pesticides--Douglas County, Washington, 2014.
PubMed:
Transfer rates of 19 typical pesticides and the relationship with their physicochemical property.
PubMed:
Synthesis and Bio-Evaluation of New (18) F-Labeled Pyridaben Analogs with Improved Stability for Myocardial Perfusion Imaging in Mice.
PubMed:
Detection of pyridaben residue levels in hot pepper fruit and leaves by liquid chromatography-tandem mass spectrometry: effect of household processes.
PubMed:
Effect of Chinese traditional cooking on eight pesticides residue during cowpea processing.
PubMed:
Determination of 28 pesticides applied on two tomato cultivars with a different surface/weight ratio of the berries, using a multiresidue GC-MS/MS method.
PubMed:
sHsp22.6, an intronless small heat shock protein gene, is involved in stress defence and development in Apis cerana cerana.
PubMed:
Part I: temporal and spatial distribution of multiclass pesticide residues in lake waters of Northern Greece: application of an optimized SPE-UPLC-MS/MS pretreatment and analytical method.
PubMed:
Part II: temporal and spatial distribution of multiclass pesticide residues in lake sediments of northern Greece: application of an optimized MAE-LC-MS/MS pretreatment and analytical method.
PubMed:
Inhibitory effects of respiration inhibitors on aflatoxin production.
PubMed:
The effects of pyridaben pesticide on the DNA integrity of sperms and early in vitro embryonic development in mice.
PubMed:
The effects of pyridaben pesticide on the histomorphometric, hormonal alternations and reproductive functions of BALB/c mice.
PubMed:
Identification and characterization of seven glutathione S-transferase genes from citrus red mite, Panonychus citri (McGregor).
PubMed:
Assessment of pesticide residues in strawberries grown under various treatment regimes.
PubMed:
Residue and risk assessment of pyridaben in cabbage.
PubMed:
Cross-resistance between cyenopyrafen and pyridaben in the twospotted spider mite Tetranychus urticae (Acari: Tetranychidae).
PubMed:
Finding of pesticides in fashionable fruit juices by LC-MS/MS and GC-MS/MS.
PubMed:
Molecular characterization of two carboxylesterase genes of the citrus red mite, Panonychus citri (Acari: Tetranychidae).
PubMed:
[Determination of eight pesticide residues in tea by liquid chromatography-tandem mass spectrometry and its uncertainty evaluation].
PubMed:
Investigation of pesticide residues in vegetables and fruits grown in various regions of Hatay, Turkey.
PubMed:
Simultaneous determination of procymidone, pyridaben and beta-cypermethrin residues in tea solution by GC-ECD.
PubMed:
Protocol for an electrospray ionization tandem mass spectral product ion library: development and application for identification of 240 pesticides in foods.
PubMed:
Transcriptome analysis of the citrus red mite, Panonychus citri, and its gene expression by exposure to insecticide/acaricide.
PubMed:
Concordant signaling pathways produced by pesticide exposure in mice correspond to pathways identified in human Parkinson's disease.
PubMed:
Toxicity assessment of 45 pesticides to the epigeic earthworm Eisenia fetida.
PubMed:
The oxygen free radicals originating from mitochondrial complex I contribute to oxidative brain injury following hypoxia-ischemia in neonatal mice.
PubMed:
Synthesis and preliminary evaluation of 18F-labeled pyridaben analogues for myocardial perfusion imaging with PET.
PubMed:
Pollution level and human health risk assessment of some pesticides and polychlorinated biphenyls in Nantong of Southeast China.
PubMed:
Chemical control of the red palm mite, Raoiella indica (Acari: Tenuipalpidae) in banana and coconut.
PubMed:
Purification and partial characterization of glutathione S-transferases from three field populations of Panonychus citri (Acari: Tetranychidae).
PubMed:
Exploring the boundaries of additivity: mixtures of NADH: quinone oxidoreductase inhibitors.
PubMed:
Fumigant toxicity of lemon eucalyptus oil constituents to acaricide-susceptible and acaricide-resistant Tetranychus urticae.
PubMed:
Contact and fumigant toxicity of plant essential oils and efficacy of spray formulations containing the oils against B- and Q-biotypes of Bemisia tabaci.
PubMed:
Sublethal effects of fenpyroximate and pyridaben on two predatory mite species, Neoseiulus womersleyi and Phytoseiulus persimilis (Acari, Phytoseiidae).
PubMed:
Efficacy of selected pesticides against synanthropic mites under laboratory assay.
PubMed:
DJ-1 deficiency in astrocytes selectively enhances mitochondrial Complex I inhibitor-induced neurotoxicity.
PubMed:
Rate of loss of insecticides during soil solarization and soil biosolarization.
PubMed:
Effects of rotenone and pyridaben on complex I electron transfer and on mitochondrial nitric oxide synthase functional activity.
PubMed:
Toxicity of plant essential oils to acaricide-susceptible and -resistant Tetranychus urticae (Acari: Tetranychidae) and Neoseiulus californicus (Acari: Phytoseiidae).
PubMed:
Monitoring of resistance to spirodiclofen and five other acaricides in Panonychus citri collected from Chinese citrus orchards.
PubMed:
Rapid multiresidue determination for currently used pesticides in agricultural drainage waters and soils using gas chromatography-mass spectrometry.
PubMed:
Preparation and biodistribution of [18F]FP2OP as myocardial perfusion imaging agent for positron emission tomography.
PubMed:
Development of acaricide resistance in Pacific spider mite (Tetranychus pacificus) from California vineyards.
PubMed:
Insecticide resistance status of Bemisia tabaci Q-biotype in south-eastern Spain.
PubMed:
Evaluation of the novel myocardial perfusion positron-emission tomography tracer 18F-BMS-747158-02: comparison to 13N-ammonia and validation with microspheres in a pig model.
PubMed:
Mitochondrial dysfunction contributes to alveolar developmental arrest in hyperoxia-exposed mice.
PubMed:
Acaricides and predatory mites against the begonia mite, Polyphagotarsonemus latus (Acari: Tarsonemidae), on Hedera helix.
PubMed:
Resistance mechanisms to mitochondrial electron transport inhibitors in a field-collected strain of Tetranychus urticae Koch (Acari: Tetranychidae).
PubMed:
Comparison of hollow fiber liquid phase microextraction and dispersive liquid-liquid microextraction for the determination of organosulfur pesticides in environmental and beverage samples by gas chromatography with flame photometric detection.
PubMed:
Susceptibility of Aedes aegypti, Culex quinquefasciatus Say, and Anopheles quadrimaculatus Say to 19 pesticides with different modes of action.
PubMed:
BMS-747158-02: a novel PET myocardial perfusion imaging agent.
PubMed:
Mechanism of uptake and retention of F-18 BMS-747158-02 in cardiomyocytes: a novel PET myocardial imaging agent.
PubMed:
Effects of acaricides, pyrethroids and predator distributions on populations of Tetranychus urticae in apple orchards.
PubMed:
[Resistance of Brevipalpus phoenicis (Geijskes) (Acari: Tenuipalpidae) to acaricides that inhibit cellular respiration in citrus: cross-resistance and fitness cost].
PubMed:
Assessing supercritical fluid extraction for the analysis of fipronil, kresoxim-methyl, acrinathrin, and pyridaben residues in melon.
PubMed:
Safe apples for baby-food production: survey of pesticide treatment regimes leaving minimum residues.
PubMed:
Photocatalytic degradation of pesticide pyridaben. 3. In surfactant/TiO2 aqueous dispersions.
PubMed:
Mechanism of toxicity of pesticides acting at complex I: relevance to environmental etiologies of Parkinson's disease.
PubMed:
Pesticides and impairment of mitochondrial function in relation with the parkinsonian syndrome.
PubMed:
[Compatibility of two fungal biocontrol agents conidia with commercial chemical acaricides].
PubMed:
Multiple resistance and biochemical mechanisms of pyridaben resistance in Tetranychus urticae (Acari: Tetranychidae).
PubMed:
Evaluation of resistance pattern to fenpyroximate and pyridaben in Tetranychus urticae collected from greenhouses and apple orchards using lethal concentration-slope relationship.
PubMed:
Acaricidal activity against Panonychus citri of a ginkgolic acid from the external seed coat of Ginkgo biloba.
PubMed:
Similar patterns of mitochondrial vulnerability and rescue induced by genetic modification of alpha-synuclein, parkin, and DJ-1 in Caenorhabditis elegans.
PubMed:
Evaluation of epidemiologic and animal data associating pesticides with Parkinson's disease.
PubMed:
[Control effects of Mikania micrantha alcohol extract on citrus red mite Panonychus citri].
PubMed:
Effect of household processing and unit-to-unit variability of pyrifenox, pyridaben, and tralomethrin residues in tomatoes.
PubMed:
Acaricide mode of action.
PubMed:
Fenpyroximate resistance in Tetranychus urticae (Acari: Tetranychidae): cross-resistance and biochemical resistance mechanisms.
PubMed:
[Acute toxicity and bio-concentration factor of three pesticides on Brachydanio rerio].
PubMed:
Effects of fungicide residues on the survival, fecundity, and predation of the mites Tetranychus urticae (Acari: Tetranychidae) and Galendromus occidentalis (Acari: Phytoseiidae).
PubMed:
[Inhibitory effect of zinc on beta-hexosaminidase release from RBL-2H3 cells by synthetic chemicals].
PubMed:
Application of liquid chromatography with electrospray tandem mass spectrometry to the determination of a new generation of pesticides in processed fruits and vegetables.
PubMed:
Soil photolysis in a moisture- and temperature-controlled environment. 2. Insecticides.
PubMed:
First detection of chlorfenapyr (Secure) resistance in two-spotted spider mite (Acari: Tetranychidae) from nectarines in an Australian orchard.
PubMed:
Action of major insecticide groups on insect cell lines of the beet armyworm, Spodoptera exigua, compared with larvicidal toxicity.
PubMed:
NADH oxidase activity of rat cardiac sarcoplasmic reticulum regulates calcium-induced calcium release.
PubMed:
An index for selective toxicity of miticides to phytophagous mites and their predators based on orchard trials.
PubMed:
Reversal of Bcl-2-mediated resistance of the EW36 human B-cell lymphoma cell line to arsenite- and pesticide-induced apoptosis by PK11195, a ligand of the mitochondrial benzodiazepine receptor.
PubMed:
Characterization of resistance to clofentezine in populations of European red mite from orchards in Ontario.
PubMed:
Pesticide residue levels in peppers grown in a greenhouse after multiple applications of pyridaben and tralomethrin.
PubMed:
A single-subunit NADH-quinone oxidoreductase renders resistance to mammalian nerve cells against complex I inhibition.
PubMed:
Method development and fate determination of pesticide-treated hops and their subsequent usage in the production of beer.
PubMed:
[Effects of organonitrogen, carbamate pesticides and others on beta-hexosaminidase release from rat basophilic leukemia cells (RBL-2H3)].
PubMed:
Cross-resistance, inheritance, and biochemistry of mitochondrial electron transport inhibitor-acaricide resistance in Tetranychus urticae (Acari: Tetranychidae).
PubMed:
Comparative residual toxicities of pesticides to the predator Agistemus industani (Acari: Stigmaeidae) on citrus in Florida.
PubMed:
The insecticide target in the PSST subunit of complex I.
PubMed:
Acaricide toxicity and resistance in larvae of different strains of Tetranychus urticae and Panonychus ulmi (Acari: Tetranychidae).
PubMed:
Functional coupling of PSST and ND1 subunits in NADH:ubiquinone oxidoreductase established by photoaffinity labeling.
PubMed:
Incidence and inheritance of resistance to METI-acaricides in European strains of the two-spotted spider mite (Tetranychus urticae) (Acari: Tetranychidae).
PubMed:
The use of outdoor freshwater pond microcosms. III. Responses of phytoplankton and periphyton to pyridaben.
PubMed:
Evidence for a quinone binding site close to the interface between NUOD and NUOB subunits of Complex I.
PubMed:
NADH-quinone oxidoreductase: PSST subunit couples electron transfer from iron-sulfur cluster N2 to quinone.
PubMed:
NADH: ubiquinone oxidoreductase inhibitors block induction of ornithine decarboxylase activity in MCF-7 human breast cancer cells.
PubMed:
Anticancer action of cubé insecticide: correlation for rotenoid constituents between inhibition of NADH:ubiquinone oxidoreductase and induced ornithine decarboxylase activities.
PubMed:
A laboratory-based method to measure relative pesticide and spray oil efficacy against broad mite, Polyphagotarsonemus latus (Banks)(Acari: Tarsonemidae).