ammonium perfluorooctanoate

octanoic acid, 2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-pentadecafluoro-, ammonium salt (1:1)

CAS: 3825-26-1 C8 H4 F15 N O2 MW: 431.10132800

Identification

Nameammonium perfluorooctanoate
CAS Number3825-26-1
EINECS223-320-4
FDA UNIIE904OF18PS
Molecular FormulaC8 H4 F15 N O2
Molecular Weight431.10132800
MDL NumberMFCD00042599
Beilstein4286466

Regulatory

DG SANTE Food Contact Materialsperfluorooctanoic acid, ammonium salt

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Soluble in water, 43.34 mg/L @ 25 °C (est)

No sensory data available

Safety Information

Preferred SDSView
Oral/Parenteral Toxicityoral-mouse LD50 457 mg/kg
Dermal Toxicityskin-rabbit LD50 4300 mg/kg
Inhalation Toxicityinhalation-rat LC50 980 mg/m3/4H

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categoryindirect food additives: adhesives and components of coatings
Recommendation for ammonium perfluorooctanoate usage levels up tonot for fragrance use.
Recommendation for ammonium perfluorooctanoate flavor usage levels up tonot for flavor use.

BOC Sciences

Best of Chemicals Supplier

Quality supplier of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecul...

View All Website 1-631-485-4226 account@bocsci.com

TCI AMERICA

Moving Your Chemistry Forward

We continuously strive to advance our technology.

View All Website 1-800-423-8616 Sales-US@TCIchemicals.com;

Potential Uses

None Found

Natural Occurrence

not found in nature

Synonyms

azanium;2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-pentadecafluorooctanoate per fluorooctanoic acid, ammonium salt octanoic acid, 2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-pentadecafluoro-, ammonium salt (1:1) pentadecafluoro-1-octanoic acid, ammonium salt PubMed: Coupling sweeping-micellar electrokinetic chromatography with tandem mass spectrometry for the therapeutic monitoring of benzimidazoles in animal urine by dilute and shoot. PubMed: Enantioselective capillary electrophoresis-mass spectrometry of amino acids in cerebrospinal fluid using a chiral derivatizing agent and volatile surfactant. PubMed: A micellar electrokinetic chromatography-mass spectrometry approach using in-capillary diastereomeric derivatization for fully automatized chiral analysis of amino acids. PubMed: Vortex-assisted surfactant-enhanced emulsification liquid-liquid microextraction for the determination of carbamates in juices by micellar electrokinetic chromatography tandem mass spectrometry. PubMed: New pressure-assisted sweeping on-line preconcentration for highly polar environmentally relevant nitrosamines: Part 2. Cationic and anionic surfactants with zero-flow capillaries. PubMed: Evaluation of the combination of a dispersive liquid-liquid microextraction method with micellar electrokinetic chromatography coupled to mass spectrometry for the determination of estrogenic compounds in milk and yogurt. PubMed: Mortality and cancer incidence in ammonium perfluorooctanoate production workers. PubMed: MEKC-MS/MS method using a volatile surfactant for the simultaneous determination of 12 synthetic cannabinoids. PubMed: Intensification of sonochemical degradation of ammonium perfluorooctanoate by persulfate oxidant. PubMed: Micellar electrokinetic chromatography-electrospray ionization mass spectrometry employing a volatile surfactant for the analysis of amino acids in human urine. PubMed: Perfluorinated compounds in soils from Liaodong Bay with concentrated fluorine industry parks in China. PubMed: Dispersive liquid-liquid microextraction using a low density extraction solvent for the determination of 17 N-methylcarbamates by micellar electrokinetic chromatography-electrospray-mass spectrometry employing a volatile surfactant. PubMed: Chronic dietary toxicity and carcinogenicity study with ammonium perfluorooctanoate in Sprague-Dawley rats. PubMed: Exposure assessment of tetrafluoroethylene and ammonium perfluorooctanoate 1951-2002. PubMed: Perfluorooctanoic acid and ammonium perfluorooctanoate: volatile surfactants for proteome analysis? PubMed: Toxicological evaluation of ammonium perfluorobutyrate in rats: twenty-eight-day and ninety-day oral gavage studies. PubMed: Ammonium perfluorooctanoate may cause testosterone reduction by adversely affecting testis in relation to PPARα. PubMed: Modulation of ammonium perfluorooctanoate-induced hepatic damage by genetically different PPARα in mice. PubMed: Toxicological evaluation of ammonium 4,8-dioxa-3H-perfluorononanoate, a new emulsifier to replace ammonium perfluorooctanoate in fluoropolymer manufacturing. PubMed: Hepatocellular hypertrophy and cell proliferation in Sprague-Dawley rats following dietary exposure to ammonium perfluorooctanoate occurs through increased activation of the xenosensor nuclear receptors PPARα and CAR/PXR. PubMed: Pathology Working Group review and evaluation of proliferative lesions of mammary gland tissues in female rats fed ammonium perfluorooctanoate (APFO) in the diet for 2 years. PubMed: Male reproductive system parameters in a two-generation reproduction study of ammonium perfluorooctanoate in rats and human relevance. PubMed: Role of peroxisome proliferator-activated receptor-alpha in hepatobiliary injury induced by ammonium perfluorooctanoate in mouse liver. PubMed: Ammonium perfluorooctanoate substantially alters phenotype and cytokine secretion of human monocyte-derived dendritic cells in vitro. PubMed: Ammonium perfluorooctanoate production and occupational mortality. PubMed: Microgram-order ammonium perfluorooctanoate may activate mouse peroxisome proliferator-activated receptor alpha, but not human PPARalpha. PubMed: Ischaemic heart disease mortality study among workers with occupational exposure to ammonium perfluorooctanoate. PubMed: Estimation and validation of biomarker-based exposures for historical ammonium perfluorooctanoate. PubMed: Evaluation of the immune system in rats and mice administered linear ammonium perfluorooctanoate. PubMed: Acute and chronic aquatic toxicity of ammonium perfluorooctanoate (APFO) to freshwater organisms. PubMed: Cross-sectional study of lipids and liver enzymes related to a serum biomarker of exposure (ammonium perfluorooctanoate or APFO) as part of a general health survey in a cohort of occupationally exposed workers. PubMed: Longitudinal study of serum lipids and liver enzymes in workers with occupational exposure to ammonium perfluorooctanoate. PubMed: Partitioning and removal of perfluorooctanoate during rain events: the importance of physical-chemical properties. PubMed: Partitioning of hydrogen peroxide between the gas and liquid phases in the presence of surfactant. PubMed: Transport of ammonium perfluorooctanoate in environmental media near a fluoropolymer manufacturing facility. PubMed: Analysis of perfluorocarboxylic acids in air. PubMed: Influence of persistent contaminants and steroid hormones on glioblastoma cell growth. PubMed: Ammonium perfluorooctanoate as a volatile surfactant for the analysis of N-methylcarbamates by MEKC-ESI-MS. PubMed: Age effect on perfluorooctanoate (PFOA) plasma concentration in post-weaning rats following oral gavage with ammonium perfluorooctanoate (APFO). PubMed: Absorption, distribution, and excretion of ammonium perfluorooctanoate (APFO) after oral administration to various species. PubMed: Comparative responses of rats and mice exposed to linear/branched, linear, or branched ammonium perfluorooctanoate (APFO). PubMed: Method for the determination of perfluorooctanoic acid in air samples using liquid chromatography with mass spectrometry. PubMed: Penetration of ammonium perfluorooctanoate through rat and human skin in vitro. PubMed: 13-week dietary toxicity study of ammonium perfluorooctanoate (APFO) in male rats. PubMed: Analytical techniques and method validation for the measurement of selected semivolatile and nonvolatile organofluorochemicals in air. PubMed: Pharmacokinetics of perfluorooctanoate in cynomolgus monkeys. PubMed: Gas-phase NMR technique for studying the thermolysis of materials: thermal decomposition of ammonium perfluorooctanoate. PubMed: The reproductive toxicology of ammonium perfluorooctanoate (APFO) in the rat. PubMed: Fluorinated ionic surfactant microemulsions in hydrofluorocarbon 134a (HFC 134a). PubMed: Toxicity of ammonium perfluorooctanoate in male cynomolgus monkeys after oral dosing for 6 months. PubMed: PAH degradation by UV/H2O2 in perfluorinated surfactant solutions. PubMed: Solubilization of polycyclic aromatic hydrocarbons by perfluorinated surfactant micelles. PubMed: Mechanisms of extrahepatic tumor induction by peroxisome proliferators in male CD rats. PubMed: Plasma cholecystokinin and hepatic enzymes, cholesterol and lipoproteins in ammonium perfluorooctanoate production workers. PubMed: Mechanisms for the pancreatic oncogenic effects of the peroxisome proliferator Wyeth-14,643. PubMed: Effect of the peroxisome proliferator, ammonium perfluorooctanoate (C8), on hepatic aromatase activity in adult male Crl:CD BR (CD) rats. PubMed: The direct effect of hepatic peroxisome proliferators on rat Leydig cell function in vitro. PubMed: Effects of ammonium perfluorooctanoate on Leydig cell function: in vitro, in vivo, and ex vivo studies. PubMed: The potential of fluorinated surfactants in membrane biochemistry. PubMed: Induction of Leydig cell adenomas by ammonium perfluorooctanoate: a possible endocrine-related mechanism. PubMed: Acute inhalation toxicity of ammonium perfluorononanoate. PubMed: Increase in mouse liver weight following feeding of ammonium perfluorooctanoate and related fluorochemicals. PubMed: Biochemical and morphological studies of ammonium perfluorooctanoate-induced hepatomegaly and peroxisome proliferation. PubMed: Inhalation toxicity of ammonium perfluorooctanoate. PubMed: Dermal toxicity of ammonium perfluorooctanoate. PubMed: The embryo-fetal toxicity and teratogenic potential of ammonium perfluorooctanoate (APFO) in the rat. PubMed: Animal toxicity studies with ammonium perfluorooctanoate.