heliotrine

butanoic acid, 2-hydroxy-3-methoxy-2-(1-methylethyl)-, [(1S,7aR)-2,3,5,7a-tetrahydro-1-hydroxy-1H-pyrrolizin-7-yl]methyl ester, (2S,3R)- [(7S,8R)-7- hydroxy-5,6,7,8-tetrahydro-3H-pyrrolizin-1-yl]methyl (2S)-2-hydroxy-2-[(1R)-1-methoxyethyl]-3-methylbutanoate PubMed: Pyrrolizidine alkaloids in food and feed on the Belgian market. PubMed: Utility of an appropriate reporter assay: Heliotrine interferes with GAL4/upstream activation sequence-driven reporter gene systems. PubMed: Disturbance of gene expression in primary human hepatocytes by hepatotoxic pyrrolizidine alkaloids: A whole genome transcriptome analysis. PubMed: Characterization and screening of pyrrolizidine alkaloids and N-oxides from botanicals and dietary supplements using UHPLC-high resolution mass spectrometry. PubMed: An in vitro comparison of the cytotoxic potential of selected dehydropyrrolizidine alkaloids and some N-oxides. PubMed: Heliotropium europaeum poisoning in cattle and analysis of its pyrrolizidine alkaloid profile. PubMed: Reaction of dehydropyrrolizidine alkaloids with valine and hemoglobin. PubMed: Structure-activity relationship in the passage of different pyrrolizidine alkaloids through the gastrointestinal barrier: ABCB1 excretes heliotrine and echimidine. PubMed: Development and validation of a rapid multiplex ELISA for pyrrolizidine alkaloids and their N-oxides in honey and feed. PubMed: Pyrrolizidine alkaloid-derived DNA adducts as a common biological biomarker of pyrrolizidine alkaloid-induced tumorigenicity. PubMed: Pyrrolizidine alkaloids: their occurrence in Spanish honey collected from purple viper's bugloss (Echium spp.). PubMed: Comparison of metabolism-mediated effects of pyrrolizidine alkaloids in a HepG2/C3A cell-S9 co-incubation system and quantification of their glutathione conjugates. PubMed: [Morphologic characteristic of chronic toxic hepatitis for treatment with Neoselen]. PubMed: Pyrrolizidine alkaloids in honey: risk analysis by gas chromatography-mass spectrometry. PubMed: Formation of DHP-derived DNA adducts from metabolic activation of the prototype heliotridine-type pyrrolizidine alkaloid, heliotrine. PubMed: Major components in the hairpencil secretion of a butterfly, Euploea mulciber (Lepidoptera, Danaidae): their origins and male behavioral responses to pyrrolizidine alkaloids. PubMed: Final report of the safety assessment of niacinamide and niacin. PubMed: Differential utilization of pyrrolizidine alkaloids by males of a danaid butterfly, Parantica sita, for the production of danaidone in the alar scent organ. PubMed: [Effect of maternal toxic hepatitis on the functional characteristics of the lactation process]. PubMed: [Experimental and clinical evaluation of the efficacy of ecdysten in the treatment of hepatitis]. PubMed: Evaporative light scattering detection of pyrrolizidine alkaloids. PubMed: [Morphological characteristics of chronic toxic hepatitis treated with neoselen]. PubMed: Taste receptors for pyrrolizidine alkaloids in a monophagous caterpillar. PubMed: Pyrrolizidine alkaloids as oviposition stimulants for the cinnabar moth, Tyria jacobaeae. PubMed: Toxicity of dietary Heliotropium circinatum to rats. PubMed: Biochemical processing of plant acquired pyrrolizidine alkaloids by the neotropical leaf-beetle Platyphora boucardi. PubMed: Metabolism of pyrrolizidine alkaloids by Peptostreptococcus heliotrinreducens and a mixed culture derived from ovine ruminal fluid. PubMed: [Effects of maternal toxic hepatitis on the postnatal development of duodenal morphology of their offspring]. PubMed: [Correction of the lipid composition of the liver plasma membranes during heliotrine intoxication]. PubMed: [Some aspects of the formation of the immune system organs in newborn rats born to females with chronic hepatitis]. PubMed: Toxicity of dietary Heliotropium dolosum seed to mice. PubMed: [The effect of perftoran on the biochemical detoxication parameters in rats with an acute toxic lesion of the liver]. PubMed: [Thymus changes in chronic heliotrine-induced hepatitis]. PubMed: The two facies of pyrrolizidine alkaloids: the role of the tertiary amine and its N-oxide in chemical defense of insects with acquired plant alkaloids. PubMed: [Enzymatic activity of the pancreas and small intestinal mucosa in modelling of toxic hepatitis by administration of heliotrine]. PubMed: Sequestration of pyrrolizidine alkaloids in several arctiid moths (Lepidoptera: Arctiidae). PubMed: Insect pheromone biosynthesis: stereochemical pathway of hydroxydanaidal production from alkaloidal precursors in Creatonotos transiens (Lepidoptera, Arctiidae). PubMed: [Mechanism of the damaging effect of heliotrine on the functional and metabolic parameters of hepatocytes]. PubMed: Micronuclei in adult and foetal mice exposed in vivo to heliotrine, urethane, monocrotaline and benzidine. PubMed: Detection of sulphur-conjugated pyrrolic metabolites in blood and fresh or fixed liver tissue from rats given a variety of toxic pyrrolizidine alkaloids. PubMed: A potential kairomone stimulates pheromone-responsive receptor neurons inUtetheisa ornatrix (Lepidoptera: Arctiidae). PubMed: Chemistry of sulphur-bound pyrrolic metabolites in the blood of rats given different types of pyrrolizidine alkaloid. PubMed: [Change in lipid peroxidation processes and level of individual gangliosides and phospholipids in the liver of rats with toxic experimental hepatitis]. PubMed: Identity of a biliary metabolite formed from monocrotaline in isolated, perfused rat liver. PubMed: Disturbances in oxidative phosphorylation in the liver of rats with heliotrine-induced hepatitis and restoration by phosphatidylcholine and ATP. PubMed: [Reparation of the hepatocyte plasma membrane using phosphatidylcholine liposomes]. PubMed: Model systems for detecting the hepatic toxicity of pyrrolizidine alkaloids and pyrrolizidine alkaloid N-oxides. PubMed: Pyrrolizidine alkaloids from Heliotropium rotundifolium. PubMed: The fetal blood erythrocyte micronucleus assay: classification of RNA-positive erythrocytes into two age populations by RNA aggregation state. PubMed: [Features of protein secretion by the rat liver in various stages of carbon tetrachloride or heliotrine poisoning]. PubMed: Somatic mutation induced by heliotrine in Drosophila. PubMed: [Phosphatidylcholine-induced repair of damaged hepatocyte membranes in heliotrine poisoning]. PubMed: [Phospholipid composition and oxidative phosphorylation in liver mitochondria in hepatitis]. PubMed: [Action of phytoecdysteroids on the bile-secretory function of the normal liver and in experimental hepatitis]. PubMed: [Causes of hyperinsulinemia and decreased sensitivity to insulin in liver damage]. PubMed: Pheromones of two arctiid moths (Creatonotos transiens andC. gangis) : Chiral components from both sexes and achiral female components. PubMed: [Functional state of the hepatocyte cytoplasmic network in heliotrine injury of the rat liver]. PubMed: Induction of SCEs by some pyrrolizidine alkaloids in V79 Chinese hamster cells co-cultured with chick embryo hepatocytes. PubMed: Poisonous plants contaminating edible ones and toxic substances in plant foods. Part 3. Pyrrolizidine alkaloids from Heliotropium digynum Forssk. (= H. luteum, Poir.). PubMed: Stereochemical course of pheromone biosynthesis in the arctiid moth, Creatonotos transiens. PubMed: A Note on "Isolation and Pharmacological Action of Heliotrine, the Major Alkaloid of Heliotropium indicum Seeds". PubMed: [State of oxidizing processes in rat liver in chronic heliotrine hepatitis]. PubMed: [Influence of heliotrin on the rat liver microsomal oxidation system]. PubMed: Isolation and pharmacological action of heliotrine, the major alkaloid of Heliotropium indicum seeds. PubMed: Somatic and teratogenic effects induced by heliotrine in Drosophila. PubMed: [Characteristics of the course of viral hepatitis B in patients with concomitant diseases treated with glucocorticosteroids]. PubMed: Heliotrine poisoning of broiler chickens: an experimental clinicopathologic study of low dose intoxication. PubMed: [Electrolyte effect on heliotrine and lasiocarpine extraction with organic solvents]. PubMed: [On the gas-chromatographical determination of the pyrrolizidine alkaloids of some Senecio-species]. PubMed: Anticancer drug testing in vitro: use of an activating system with the human tumor stem cell assay. PubMed: Comparison of the toxic effects of dehydroheliotridine and heliotrine in pregnant rats and their embryos. PubMed: Chromosomal aberrations and mutation in cultured mammalian cells induced by pyrrolizidine alkaloids. PubMed: Direct quantitative analysis of indicine-N-oxide in cancer patient samples by gas chromatography using the internal standard heliotrine-N-oxide including a mass spectral comparison of their trimethylsilyl derivatives. PubMed: Mutagenicity of pyrrolizidine alkaloids in the Salmonella/mammalian-microsome test. PubMed: Poisoning of chickens and ducks by pyrrolizidine alkaloids of Heliotropium europaeum. PubMed: Relationship of the reductive metabolism of indicine N-oxide to its antitumor activity. PubMed: The gas chromatographic mass spectrometric analysis of the new antitumor drug indicine-N-oxide utilizing a novel reaction accompanying trimethylsilylation. PubMed: An epidemic of veno-occlusive disease of the liver in Afghanistan. Pathologic features. PubMed: Herbal medicines and veno-occlusive disease in India. PubMed: The role of nicotinamide and of certain other modifying factors in diethylnitrosamine carcinogenesis: fusaria mycotoxins and "spontaneous" tumors in animals and man. PubMed: [Interrelationship between the structure, microcirculation and tissue-vascular permeability of the liver after experimental toxic damage]. PubMed: The effects of the pyrrolizidine alkaloid, heliotrine, and nicotinamide on the concentration of plasma insulin and blood glucose in the rat. PubMed: Pancreatic islet-cell and other tumors in rats given heliotrine, a monoester pyrrolizidine alkaloid, and nicotinamide. PubMed: Use of repair-deficient strains of Escherichia coli and liver microsomes to detect and characterise DNA damage caused by pyrrolizidine alkaloids heliotrine and monocrotaline. PubMed: Decreased synthesis of hepatic satellite DNA in pyrrolizidine alkaloidosis of the sheep. PubMed: Proceedings: Pancreatic islet cell and other tumours induced in rats by heliotrine- a mono-ester pyrrolizidine alkaloid; the effects of additional treatment with nicotinamide. PubMed: An analysis of chromosomal sensitivity of HPK1 cells from the marsupial Potorous tridactylus to x-rays and to heliotrine. PubMed: Pyrrolizidine alkaloids: actions on muscarinic receptors in the guinea-pig ileum. PubMed: [Study of the action of oxido-reductive enzymes in the liver of rats with chronic heliotrine poisoning]. PubMed: Comparison of the effects of LSD, heliotrine and x-irradiation on chromosome breakage, and the effects of LSD on the rate of cell division. PubMed: The effect of heliotrine, a pyrrolizidine alkaloid, on human liver cells in culture. PubMed: The mutagenic activity of the pyrrolizidine alkaloid heliotrine in Drosophila melanogaster. II. Chromosome rearrangements. PubMed: Excretion of the pyrrolizidine alkaloid heliotrine in the urine and bile of sheep. PubMed: An electron microscopic study of giant cytosegresomes in acute liver injury due to heliotrine. PubMed: [Hematopoiesis in chronic heliotrine poisoning in Wistar albino rats]. PubMed: An electron-microscope study of liver cell necrosis due to heliotrine. PubMed: [Morphologic signs of the participation of immunologic mechanisms in the pathogenesis of heliotrine liver cirrhosis (experimental-morphologic study)]. PubMed: [Morphologic and histochemical changes in the rat liver after administration of heliotrine]. PubMed: Reduction of heliotrine by a rumen microorganism. PubMed: [Phagocytosis of erythroblasts by bone marrow reticular cells in rats with chronic heliotrine poisoning]. PubMed: Effects of the pyrrolizidine alkaloid heliotrine on cell division and chromosome breakage in cultures of leucocytes from the marsupial Potorous tridactylus. PubMed: Lysosome changes in acute liver injury due to heliotrine. PubMed: The mutagenic activity of heliotrine in Drosophila. I. Complete and mosaic sex-linked lethals. PubMed: THE EFFECT OF CYANIDE AND AZIDE ON THE MUTAGENIC ACTIVITY OF THE PYRROLIZIDINE ALKALOID HELIOTRINE IN DROSOPHILA MELANOGASTER. PubMed: Acute toxic liver injury. nicotinamide-adenine dinucleotide-pyrophosphorylase activity of nuclei isolated from rat liver in heliotrine and in dimethylnitrosamine poisoning. PubMed: Liver damage in acute heliotrine poisoning. 1. The intracellular distribution of pyridine nucleotides. PubMed: Liver damage in acute heliotrine poisioning. 2. The effect of nicotinamide on pyridine nucleotide concentrations. PubMed: Malformations in foetal rats induced by the pyrrolizidine alkaloid, heliotrine. PubMed: Pyridine nucleotide metabolism in heliotrine poisoning. PubMed: The chronic pathological effects on the liver of the rat of the pyrrolizidine alkaloids heliotrine, lasiocarpine, and their N-oxides. PubMed: Mutagenic activity of the alkaloid heliotrine in Drosophila. PubMed: The acute toxic effects of heliotrine and lasiocarpine, and their N-oxides, on the rat. PubMed: Hepatotoxic and pharmacologic properties of heliotrine.