intermedine

butanoic acid, 2,3-dihydroxy-2-(1-methylethyl)-, [(1R,7aR)-2,3,5,7a-tetrahydro-1-hydroxy-1H-pyrrolizin-7-yl]methyl ester, (2S,3R)-

CAS: 10285-06-0 C15 H25 N O5 MW: 299.36725000

Identification

Nameintermedine
CAS Number10285-06-0
FDA UNIIDLC9FEP81A
Molecular FormulaC15 H25 N O5
Molecular Weight299.36725000
Nikkaji NumberJ15.602G

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Soluble in water, 2.092e+004 mg/L @ 25 °C (est)

No sensory data available

Safety Information

Oral/Parenteral ToxicityNot determined
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorynatural substances and extractives
Recommendation for intermedine usage levels up tonot for fragrance use.
Recommendation for intermedine flavor usage levels up tonot for flavor use.

No supplier data available

Potential Uses

None Found

Natural Occurrence

borage leaf borage shoot

Synonyms

butanoic acid, 2,3-dihydroxy-2-(1-methylethyl)-, [(1R,7aR)-2,3,5,7a-tetrahydro-1-hydroxy-1H-pyrrolizin-7-yl]methyl ester, (2S,3R)- [(7R,8R)-7- hydroxy-5,6,7,8-tetrahydro-3H-pyrrolizin-1-yl]methyl (2S)-2-hydroxy-2-[(1R)-1-hydroxyethyl]-3-methylbutanoate intermedinum PubMed: Development and validation of a QuEChERS method coupled to liquid chromatography and high resolution mass spectrometry to determine pyrrolizidine and tropane alkaloids in honey. PubMed: Survey of pyrrolizidine alkaloids in seven varieties of Lappula squarrosa: An alternative source of heart-healthy vegetable oil. PubMed: Pyrrolizidine alkaloids in food and feed on the Belgian market. PubMed: The comparative toxicity of a reduced, crude comfrey (Symphytum officinale) alkaloid extract and the pure, comfrey-derived pyrrolizidine alkaloids, lycopsamine and intermedine in chicks (Gallus gallus domesticus). PubMed: Pro-toxic dehydropyrrolizidine alkaloids in the traditional Andean herbal medicine "asmachilca". PubMed: An in vitro comparison of the cytotoxic potential of selected dehydropyrrolizidine alkaloids and some N-oxides. PubMed: Recognition of pyrrolizidine alkaloid esters in the invasive aquatic plant Gymnocoronis spilanthoides (Asteraceae). PubMed: Semi-automated separation of the epimeric dehydropyrrolizidine alkaloids lycopsamine and intermedine: preparation of their N-oxides and NMR comparison with diastereoisomeric rinderine and echinatine. PubMed: Profiling of dehydropyrrolizidine alkaloids and their N-oxides in herbarium-preserved specimens of amsinckia species using HPLC-esi(+)MS. PubMed: Dehydropyrrolizidine alkaloids in two Cryptantha species: including two new open chain diesters one of which is amphoteric. PubMed: Detection of high levels of pyrrolizidine-N-oxides in the endangered plant Cryptantha crassipes (Terlingua Creek cat's-eye) using HPLC-ESI-MS. PubMed: Metabolism, genotoxicity, and carcinogenicity of comfrey. PubMed: Chiral stationary phases for separation of intermedine and lycopsamine enantiomers from Symphytum uplandicum. PubMed: Major components in the hairpencil secretion of a butterfly, Euploea mulciber (Lepidoptera, Danaidae): their origins and male behavioral responses to pyrrolizidine alkaloids. PubMed: Differential utilization of pyrrolizidine alkaloids by males of a danaid butterfly, Parantica sita, for the production of danaidone in the alar scent organ. PubMed: Sequestration and metabolism of protoxic pyrrolizidine alkaloids by larvae of the leaf beetle Platyphora boucardi and their transfer via pupae into defensive secretions of adults. PubMed: Biochemical processing of plant acquired pyrrolizidine alkaloids by the neotropical leaf-beetle Platyphora boucardi. PubMed: Toxic pyrrolyzidine alkaloids from three mongolian plants. a possible risk for cattle poisoning. PubMed: Pyrrolizidine alkaloids in Pulmonaria obscura. PubMed: Sequestration, metabolism and partial synthesis of tertiary pyrrolizidine alkaloids by the neotropical leaf-beetle Platyphora boucardi. PubMed: Preparative separation of pyrrolizidine alkaloids by high-speed counter-current chromatography. PubMed: Stereochemical inversion of pyrrolizidine alkaloids byMechanitis polymnia (Lepidoptera: Nymphalidae: Ithomiinae): Specificity and evolutionary significance. PubMed: Pyrrolizidine alkaloids in the arctiid mothHyalurga syma. PubMed: Investigation into the Presence of Pyrrolizidine Alkaloids in Eupatorium cannabinum by Means of Positive and Negative Ion Chemical Ionization GC-MS. PubMed: Synthesis of pyrrolizidine alkaloids indicine, intermedine, lycopsamine, and analogues and their N-oxides. Potential antitumor agents. PubMed: Pyrrolizidine alkaloids from Symphytum officinale L. and their percutaneous absorption in rats. PubMed: [Biological determination of intermedine in hypophysis and placenta of human embryos]. PubMed: Inhibition of the secretion of intermedine by D-lysergic acid diethylamide (LSD 25) in the toad, Xenopus laevis. PubMed: The relation between ACTH and intermedine.