trichodesmine
(13alpha,14alpha)-14,19-dihydro-12,13-dihydroxy-19-methylcrotalanan-11,15-dione
Identification
| Name | trichodesmine |
| CAS Number | 548-90-3 |
| FDA UNII | Search |
| Molecular Formula | C18 H27 N O6 |
| Molecular Weight | 353.41539000 |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Soluble in | water, 1.025e+005 mg/L @ 25 °C (est) |
No sensory data available
Safety Information
| Oral/Parenteral Toxicity | Not determined |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | natural substances and extractives |
| Recommendation for trichodesmine usage levels up to | not for fragrance use. |
| Recommendation for trichodesmine flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
(13alpha,14alpha)-14,19-
dihydro-12,13-dihydroxy-19-methylcrotalanan-11,15-dione
PubMed:
Pulmonary and hepatic lesions caused by the dehydropyrrolizidine alkaloid-producing plants Crotalaria juncea and Crotalaria retusa in donkeys.
PubMed:
Dehydropyrrolizidine alkaloids, including monoesters with an unusual esterifying acid, from cultivated Crotalaria juncea (Sunn Hemp cv.'Tropic Sun').
PubMed:
Variability for the presence of pyrrolizidine alkaloids in Crotolaria juncea L.
PubMed:
The relationship between reactivity of metabolites of pyrrolizidine alkaloids and extrahepatic toxicity.
PubMed:
Preparative separation of pyrrolizidine alkaloids by high-speed counter-current chromatography.
PubMed:
Physicochemical and metabolic basis for the differing neurotoxicity of the pyrrolizidine alkaloids, trichodesmine and monocrotaline.
PubMed:
The comparative metabolism of the four pyrrolizidine alkaloids, seneciphylline, retrorsine, monocrotaline, and trichodesmine in the isolated, perfused rat liver.
PubMed:
The effect of the pyrrolizidine alkaloids, monocrotaline and trichodesmine, on tissue pyrrole binding and glutathione metabolism in the rat.
PubMed:
Chemical and toxicity studies of Trichodesma africanum L.
PubMed:
[Isolation of trichodesmine and incanine from biological material].
PubMed:
[Extraction of trichodesmine from aqueous solutions].