flumequine

6,7-dihydro-9-fluoro-5-methyl-1-oxo-1H,5H-quinolizine-2-carboxylic acid

CAS: 42835-25-6 C14 H12 F N O3 MW: 261.25264320

Identification

Nameflumequine
IUPAC9-fluoro-5-methyl-1-oxo-6,7-dihydro-1H,5H-pyrido[3,2,1-ij]quinoline-2-carboxylic acid
CAS Number42835-25-6
EINECS255-962-6
FDA UNIIUVG8VSP2SJ
Molecular FormulaC14 H12 F N O3
Molecular Weight261.25264320
MDL NumberMFCD00079298
Nikkaji NumberJ16.025C
Beilstein0490724

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Soluble in water, 2186 mg/L @ 25 °C (est)

No sensory data available

Safety Information

Preferred SDSView
Oral/Parenteral ToxicityNot determined
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categoryherbicides / pesticides
Recommendation for flumequine usage levels up tonot for fragrance use.
Recommendation for flumequine flavor usage levels up tonot for flavor use.

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Potential Uses

None Found

Natural Occurrence

not found in nature

Synonyms

1H,5H- benzo(ij)quinolizine-2-carboxylic acid, 9-fluoro-6,7-dihydro-5-methyl-1-oxo- 6,7- dihydro-9-fluoro-5-methyl-1-oxo-1H,5H-quinolizine-2-carboxylic acid 9- fluoro-5-methyl-1-oxo-6,7-dihydro-1H,5H-pyrido[3,2,1-ij]quinoline-2-carboxylic acid 9- fluoro-6,7-dihydro-5-methyl-1-oxo-1H,5H-benzo(ij)quinolizine-2-carboxylic acid PubMed: Antimicrobial susceptibility of Riemerella anatipestifer strains isolated from geese and ducks in Hungary. PubMed: Antibiotic use in heavy pigs: Comparison between urine and muscle samples from food chain animals analysed by HPLC-MS/MS. PubMed: Aeromonas Diversity and Antimicrobial Susceptibility in Freshwater-An Attempt to Set Generic Epidemiological Cut-Off Values. PubMed: Phylogenetic analysis of Escherichia coli isolated from broilers with colibacillosis based on gyrA gene sequences. PubMed: Analysis of flumequine enantiomers in rat plasma by UFLC-ESI-MS/MS. PubMed: Provisional epidemiological cutoff values for standard broth microdilution susceptibility testing of Flavobacterium columnare. PubMed: Validation of a Chiral Liquid Chromatographic Method for the Degradation Behavior of Flumequine Enantiomers in Mariculture Pond Water. PubMed: Effect of various storage conditions on the stability of quinolones in raw milk. PubMed: Use of micellar liquid chromatography to analyze oxolinic acid, flumequine, marbofloxacin and enrofloxacin in honey and validation according to the 2002/657/EC decision. PubMed: [Multi-residue determination of veterinary drugs in cheese by QuEChERS and liquid chromatography-tandem mass spectrometry]. PubMed: Determination of selected veterinary antimicrobials in poultry excreta by UHPLC-MS/MS, for application in Salmonella control programs. PubMed: Multiresidue determination of fluoroquinolones in poultry muscle and kidney according to the regulation 2002/657/EC. A systematic comparison of two different approaches: Liquid chromatography coupled to high-resolution mass spectrometry or tandem mass spectrometry. PubMed: Occurrence of veterinary antibiotics and progesterone in broiler manure and agricultural soil in Malaysia. PubMed: Antimicrobial resistance of Campylobacter jejuni and Campylobacter coli from poultry in Italy. PubMed: Chemiluminescence competitive indirect enzyme immunoassay for 20 fluoroquinolone residues in fish and shrimp based on a single-chain variable fragment. PubMed: Flumequine enhances the in vivo mutagenicity of MeIQx in the mouse liver. PubMed: Direct determination of danofloxacin and flumequine in milk by use of fluorescence spectrometry in combination with partial least-squares calibration. PubMed: Degradation of flumequine by the Fenton and photo-Fenton processes: evaluation of residual antimicrobial activity. PubMed: Quality control ranges for testing broth microdilution susceptibility of Flavobacterium columnare and F. psychrophilum to nine antimicrobials. PubMed: Laser diode thermal desorption mass spectrometry for the analysis of quinolone antibiotic residues in aquacultured seafood. PubMed: HPLC confirmatory method development for the determination of seven quinolones in salmon tissue (Salmo salar L.) validated according to the European Union Decision 2002/657/EC. PubMed: Analysis of quinolone antibiotics in eggs: preparation and characterization of a raw material for method validation and quality control. PubMed: Development of an improved method for trace analysis of quinolones in eggs of laying hens and wildlife species using molecularly imprinted polymers. PubMed: Determination of (fluoro)quinolones in eggs by liquid chromatography with fluorescence detection and confirmation by liquid chromatography-tandem mass spectrometry. PubMed: Determination of quinolones of veterinary use in bee products by ultra-high performance liquid chromatography-tandem mass spectrometry using a QuEChERS extraction procedure. PubMed: Multiresidue determination of veterinary drugs in aquaculture fish samples by ultra high performance liquid chromatography coupled to tandem mass spectrometry. PubMed: Impact of antibiotic treatments on the expression of the R plasmid tra genes and on the host innate immune activity during pRAS1 bearing Aeromonas hydrophila infection in zebrafish (Danio rerio). PubMed: Development and validation of a multiclass method for the determination of veterinary drug residues in chicken by ultra high performance liquid chromatography-tandem mass spectrometry. PubMed: DNA gyrase and topoisomerase IV mutations in quinolone-resistant Flavobacterium psychrophilum isolated from diseased salmonids in Norway. PubMed: A sensitive chromatographic strip test for the rapid detection of enrofloxacin in chicken muscle. PubMed: Simultaneous determination of fluoroquinolones in foods of animal origin by a high performance liquid chromatography and a liquid chromatography tandem mass spectrometry with accelerated solvent extraction. PubMed: [Preparation of natural matrix standard sample of minced eel for quality control of flumequine residue]. PubMed: Rapid screening method for quinolone residues in livestock and fishery products using immobilised metal chelate affinity chromatographic clean-up and liquid chromatography-fluorescence detection. PubMed: Determination of quinolone residues in infant and young children powdered milk combining solid-phase extraction and ultra-performance liquid chromatography-tandem mass spectrometry. PubMed: Development of a quantitative multiclass/multiresidue method for 21 veterinary drugs in shrimp. PubMed: Depletion study of three formulations of flumequine in edible tissues and drug transfer into chicken feathers. PubMed: Are antibiotic screening approaches sufficiently adequate? A proficiency test. PubMed: Quantitation of fluoroquinolones in honey using tandem mass spectrometry (LC-MS/MS): nested validation with two mass spectrometers. PubMed: Quinolones control in milk and eggs samples by liquid chromatography using a surfactant-mediated mobile phase. PubMed: Depletion of veterinary drugs used in aquaculture after administration in feed to gilthead seabream (Sparus aurata). PubMed: Simultaneous determination of quinolones in fish by liquid chromatography coupled with fluorescence detection: comparison of sub-2 microm particles and conventional C18 columns. PubMed: Environmental and human health risk assessment of organic micro-pollutants occurring in a Spanish marine fish farm. PubMed: Determination of quinolone residues in tilapias (Orechromis niloticus) by HPLC-FLD and LC-MS/MS QToF. PubMed: Validation of an optical surface plasmon resonance biosensor assay for screening (fluoro)quinolones in egg, fish and poultry. PubMed: Rapid determination of 19 quinolone residues in spiked fish and pig muscle by high-performance liquid chromatography (HPLC) tandem mass spectrometry. PubMed: Evaluation of quinolones for use in detection of determinants of acquired quinolone resistance, including the new transmissible resistance mechanisms qnrA, qnrB, qnrS, and aac(6')Ib-cr, in Escherichia coli and Salmonella enterica and determinations of wild-type distributions. PubMed: Quantitation and identity confirmation of residues of quinolones in tilapia fillets by LC-ESI-MS-MS QToF. PubMed: Assessment of antimicrobial usage and residues in commercial chicken eggs from smallholder poultry keepers in Morogoro municipality, Tanzania. PubMed: [Simultaneous determination of 19 quinolone residues in honey using high performance liquid chromatography-tandem mass spectrometry]. PubMed: Simultaneous determination of (fluoro)quinolones antibacterials residues in bovine milk using ultra performance liquid chromatography-tandem mass spectrometry. PubMed: Developing and optimizing an immunoaffinity cleanup technique for determination of quinolones from chicken muscle. PubMed: Selective sample preparation for the analysis of (fluoro)quinolones in baby food: molecularly imprinted polymers versus anion-exchange resins. PubMed: Development of an optical surface plasmon resonance biosensor assay for (fluoro)quinolones in egg, fish, and poultry meat. PubMed: Development of an immunochromatography strip for the rapid detection of 12 fluoroquinolones in chicken muscle and liver. PubMed: In-line solid-phase extraction preconcentration in capillary electrophoresis-tandem mass spectrometry for the multiresidue detection of quinolones in meat by pressurized liquid extraction. PubMed: [Determination of 16 quinolone residues in animal tissues using high performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry]. PubMed: Oral bioavailability, tissue distribution and depletion of flumequine in the food producing animal, chicken for fattening. PubMed: Simultaneous determination of different classes of antibiotics in fish and livestock by CE-MS. PubMed: Development and validation of an HPLC confirmatory method for residue analysis of ten quinolones in tissues of various food-producing animals, according to the European Union Decision 2002/657/EC. PubMed: Chromatographic determination of flumequine in food samples by post-column derivatisation with terbium(III). PubMed: Determination of quinolone residues in shrimp using liquid chromatography with fluorescence detection and residue confirmation by mass spectrometry. PubMed: Improved microbial screening assay for the detection of quinolone residues in poultry and eggs. PubMed: Development of a monoclonal antibody-based broad-specificity ELISA for fluoroquinolone antibiotics in foods and molecular modeling studies of cross-reactive compounds. PubMed: Multiresidue determination of quinolone and fluoroquinolone antibiotics in fish and shrimp by liquid chromatography/tandem mass spectrometry. PubMed: Simultaneous determination of trace levels of 10 quinolones in swine, chicken, and shrimp muscle tissues using HPLC with programmable fluorescence detection. PubMed: Biosensor immunoassay for flumequine in broiler serum and muscle. PubMed: Stability of frozen stock solutions of beta-lactam antibiotics, cephalosporins, tetracyclines and quinolones used in antibiotic residue screening and antibiotic susceptibility testing. PubMed: Dual biosensor immunoassay-directed identification of fluoroquinolones in chicken muscle by liquid chromatography electrospray time-of-flight mass spectrometry. PubMed: Evaluation of certain veterinary drug residues in food. Sixty-sixth report of the Joint FAO/WHO Expert Committee on Food Additives. PubMed: Microbiological detection of 10 quinolone antibiotic residues and its application to artificially contaminated poultry samples. PubMed: Determination of fluoroquinolones in milk samples by postcolumn derivatization liquid chromatography with luminescence detection. PubMed: Biotransformation of flumequine by the fungus Cunninghamella elegans. PubMed: Multiresidue method for the determination of quinolone antibiotics in bovine raw milk by capillary electrophoresis-tandem mass spectrometry. PubMed: Confirmatory and quantitative analysis using experimental design for the extraction and liquid chromatography-UV, liquid chromatography-mass spectrometry and liquid chromatography-mass spectrometry/mass spectrometry determination of quinolones in turkey muscle. PubMed: Simultaneous determination of (fluoro)quinolone antibiotics in kidney, marine products, eggs, and muscle by enzyme-linked immunosorbent assay (ELISA). PubMed: Evaluation of the Premi Test and comparison with the One-Plate Test for the detection of antimicrobials in kidney. PubMed: Flumequine in the goat: pharmacokinetics after intravenous and intramuscular administration. PubMed: Multiresidue method for simultaneous determination of ten quinolone antibacterial residues in multimatrix/multispecies animal tissues by liquid chromatography with fluorescence detection: single laboratory validation study. PubMed: Standardization of a broth microdilution susceptibility testing method to determine minimum inhibitory concentrations of aquatic bacteria. PubMed: Introduction of the HPLC method for the determination of quinolone residues in various muscle tissues. PubMed: Evaluation of certain veterinary drug residues in food. Sixty-second report of the Joint FAO/WHO Expert Committee on food additives. PubMed: Development of an indirect competitive ELISA for flumequine residues in raw milk using chicken egg yolk antibodies. PubMed: Evaluation of certain veterinary drug residues in food. PubMed: Susceptibility of Listeria monocytogenes isolated from food in Italy to antibiotics. PubMed: Simple and sensitive determination of five quinolones in food by liquid chromatography with fluorescence detection. PubMed: Quantitative LC/MS-MS determination of sulfonamides and some other antibiotics in honey. PubMed: Flumequine in Atlantic salmon Salmo salar: disposition in fish held in sea water versus fresh water. PubMed: Determination of residues of oxolinic acid and flumequine in freeze-dried salmon muscle and skin by HPLC with fluorescence detection. PubMed: Disposition of 14C-flumequine in eel Anguilla anguilla, turbot Scophthalmus maximus and halibut Hippoglossus hippoglossus after oral and intravenous administration. PubMed: Antimicrobial susceptibility of potentially pathogenic halophilic vibrios isolated from seafood. PubMed: Evaluation of certain veterinary drug residues in food. PubMed: Inhibition tests for detection and presumptive identification of tetracyclines, beta-lactam antibiotics and quinolones in poultry meat. PubMed: Comparison of extraction techniques for the recovery of veterinary drug residues from animal tissues. PubMed: Single-dose pharmacokinetics of flumequine in the eel (Anguilla anguilla) after intravascular, oral and bath administration. PubMed: Single-dose pharmacokinetics of flumequine in cod (Gadus morhua) and goldsinny wrasse (Ctenolabrus rupestris). PubMed: [Preliminary results of antibiotic resistance monitoring in the Netherlands]. PubMed: Salmonella infections in finishing pigs in The Netherlands: bacteriological herd prevalence, serogroup and antibiotic resistance of isolates and risk factors for infection. PubMed: Extension of multi-residue methodology to include the determination of quinolones in food. PubMed: Single-dose pharmacokinetics of flumequine in halibut (Hippoglossus hippoglossus) and turbot (Scophthalmus maximus). PubMed: Determination of flumequine in channel catfish by liquid chromatography with fluorescence detection. PubMed: Enumeration and characterization of bacteria in mineral water by improved direct viable count method. PubMed: Excretion of flumequine in free-swimming Atlantic salmon (Salmo salar), determined by cannulation of the dorsal aorta, gall bladder and urethra. PubMed: Evaluation of certain veterinary drug residues in food. Forty-eighth report of the Joint FAO/WHO Expert Committee on Food Additives. PubMed: Liquid chromatographic determination of flumequine, nalidixic acid, oxolinic acid, and piromidic acid residues in catfish (Ictalurus punctatus). PubMed: Determination of residues of flumequine and 7-hydroxyflumequine in edible sheep tissues by liquid chromatography with fluorimetric and ultraviolet detection. PubMed: Evaluation of the dorsal aorta cannulation technique for pharmacokinetic studies in Atlantic salmon (Salmo salar) in sea water. PubMed: Determination and confirmation of identities of flumequine and nalidixic, oxolinic, and piromidic acids in salmon and shrimp. PubMed: Antibiotic susceptibility of campylobacter isolates from sewage and poultry abattoir drain water. PubMed: Comparative single-dose pharmacokinetics of four quinolones, oxolinic acid, flumequine, sarafloxacin, and enrofloxacin, in Atlantic salmon (Salmo salar) held in seawater at 10 degrees C. PubMed: Establishment of a microbiologically acceptable daily intake of antimicrobial drug residues. PubMed: Bioavailability of flumequine after semisimultaneous administration to veal calves. PubMed: Effect of cooking on residues of the quinolones oxolinic acid and flumequine in fish. PubMed: Reservoir of quinolone residues in fish.