ergothioneine

(S)-(1- carboxy-2-(2-mercaptoimidazol-4-yl)ethyl)trimethylammonium hydroxide ergoneine L- ergothioneine ergothionine 1H- imidazole-4-ethanaminium, alpha-carboxy-2,3-dihydro-N,N,N-trimethyl-2-thioxo-, hydroxide, inner salt, (S)- (9CI) (2S)-3-(2- sulfanylidene-1,3-dihydroimidazol-4-yl)-2-(trimethylazaniumyl)propanoate PubMed: Convergent evolution of ergothioneine biosynthesis in Cyanobacteria. PubMed: Ergothioneine and related histidine derivatives in the gas phase: tautomer structures determined by IRMPD spectroscopy and theory. PubMed: Role of Ergothioneine in Microbial Physiology and Pathogenesis. PubMed: Anaerobic Origin of Ergothioneine. PubMed: Physiological Roles of Carnitine/Organic Cation Transporter OCTN1/SLC22A4 in Neural Cells. PubMed: Impairment of the carnitine/organic cation transporter 1-ergothioneine axis is mediated by intestinal transporter dysfunction in chronic kidney disease. PubMed: Carnitine/Organic Cation Transporter OCTN1 Negatively Regulates Activation in Murine Cultured Microglial Cells. PubMed: A bioinspired and biocompatible ortho-sulfiliminyl phenol synthesis. PubMed: Sulfoxide Synthase versus Cysteine Dioxygenase Reactivity in a Nonheme Iron Enzyme. PubMed: Mushrooms: A rich source of the antioxidants ergothioneine and glutathione. PubMed: Effects of ergothioneine-rich mushroom extracts on lipid oxidation and discoloration in salmon muscle stored at low temperatures. PubMed: Mycochemical Changes Induced by Selenium Enrichment in P. ostreatus Fruiting Bodies. PubMed: Ergothioneine Antioxidant Function: From Chemistry to Cardiovascular Therapeutic Potential. PubMed: Ergothioneine products derived by superoxide oxidation in endothelial cells exposed to high-glucose. PubMed: Theoretical Study of the Mechanism of the Nonheme Iron Enzyme EgtB. PubMed: Lack of mycothiol and ergothioneine induces different protective mechanisms in Mycobacterium smegmatis. PubMed: OCTN1 Is a High-Affinity Carrier of Nucleoside Analogues. PubMed: Screening and Characterization of Drugs That Protect Corneal Endothelial Cells Against Unfolded Protein Response and Oxidative Stress. PubMed: The Anti-Oxidant Ergothioneine Augments the Immunomodulatory Function of TLR Agonists by Direct Action on Macrophages. PubMed: Nonvolatile Taste Components and Antioxidant Properties of Fruiting Body and Mycelium with High Ergothioneine Content from the Culinary-Medicinal Golden Oyster Mushroom Pleurotus citrinopileatus (Agaricomycetes). PubMed: Quality of Bread Supplemented with Antrodia
salmonea-Fermented Grains. PubMed: Gastrodia elata Blume Extract Modulates Antioxidant Activity and Ultraviolet A-Irradiated Skin Aging in Human Dermal Fibroblast Cells. PubMed: Go it alone: four-electron oxidations by mononuclear non-heme iron enzymes. PubMed: Short protecting-group-free synthesis of 5-acetylsulfanyl-histidines in water: novel precursors of 5-sulfanyl-histidine and its analogues. PubMed: Ergothioneine Biosynthesis and Functionality in the Opportunistic Fungal Pathogen, Aspergillus fumigatus. PubMed: Identification of the Main Intermediate Precursor of l-Ergothioneine Biosynthesis in Human Biological Specimens. PubMed: Metabolomic profiling of brain from infants who died from Sudden Infant Death Syndrome reveals novel predictive biomarkers. PubMed: Administration of Pure Ergothioneine to Healthy Human Subjects: Uptake, Metabolism, and Effects on Biomarkers of Oxidative Damage and Inflammation. PubMed: Ergothioneine levels in an elderly population decrease with age and incidence of cognitive decline; a risk factor for neurodegeneration? PubMed: Characterizing Blood Metabolomics Profiles Associated with Self-Reported Food Intakes in Female Twins. PubMed: L503F variant of carnitine/organic cation transporter 1 efficiently transports metformin and other biguanides. PubMed: S-nitrosomycothiol reductase and mycothiol are required for survival under aldehyde stress and biofilm formation in Mycobacterium smegmatis. PubMed: A Safety Evaluation of a Nature-Identical l-Ergothioneine in Sprague Dawley Rats. PubMed: Protective Effect of Antioxidant Extracts from Grey Oyster Mushroom, Pleurotus pulmonarius (Agaricomycetes), Against Human Low-Density Lipoprotein Oxidation and Aortic Endothelial Cell Damage. PubMed: A Retrospective Study in Adults with Metabolic Syndrome: Diabetic Risk Factor Response to Daily Consumption of Agaricus bisporus (White Button Mushrooms). PubMed: Food-derived hydrophilic antioxidant ergothioneine is distributed to the brain and exerts antidepressant effect in mice. PubMed: Ergothioneine oxidation in the protection against high-glucose induced endothelial senescence: Involvement of SIRT1 and SIRT6. PubMed: Simultaneous determination of the main amino thiol and thione in human whole blood by CE and LC. PubMed: A mutation in SLC22A4 encoding an organic cation transporter expressed in the cochlea strial endothelium causes human recessive non-syndromic hearing loss DFNB60. PubMed: Localization of Xenobiotic Transporter OCTN1/SLC22A4 in Hepatic Stellate Cells and Its Protective Role in Liver Fibrosis. PubMed: Diverse fission yeast genes required for responding to oxidative and metal stress: Comparative analysis of glutathione-related and other defense gene deletions. PubMed: Wide tolerance to amino acids substitutions in the OCTN1 ergothioneine transporter. PubMed: Validation of a HILIC Method for the Analysis of Ergothioneine in Fermentation Broth. PubMed: The human organic cation transporter OCT1 mediates high affinity uptake of the anticancer drug daunorubicin. PubMed: Ergothioneine Maintains Redox and Bioenergetic Homeostasis Essential for Drug Susceptibility and Virulence of Mycobacterium tuberculosis. PubMed: Ergothioneine, an adaptive antioxidant for the protection of injured tissues? A hypothesis. PubMed: Oxidative-stress detoxification and signalling in cyanobacteria: the crucial glutathione synthesis pathway supports the production of ergothioneine and ophthalmate. PubMed: Plasma protein thiols: an early marker of oxidative stress in asthma and chronic obstructive pulmonary disease. PubMed: Conversion of a non-heme iron-dependent sulfoxide synthase into a thiol dioxygenase by a single point mutation. PubMed: Liver ergothioneine accumulation in a guinea pig model of non-alcoholic fatty liver disease. A possible mechanism of defence? PubMed: Growth and metabolism of Beauveria bassiana spores and mycelia. PubMed: Production of ergothioneine by Methylobacterium species. PubMed: Submerged Cultivation of Mycelium with High Ergothioneine Content from the Culinary-Medicinal Golden Oyster Mushroom, Pleurotus citrinopileatus (Higher Basidiomycetes). PubMed: Chemical Composition and Medicinal Value of Fruiting Bodies and Submerged Cultured Mycelia of Caterpillar Medicinal Fungus Cordyceps militaris CBS-132098 (Ascomycetes). PubMed: L-ergothioneine supplementation during culture improves quality of bovine in vitro-produced embryos. PubMed: The versatile low-molecular-weight thiols: Beyond cell protection. PubMed: Amniotic fluid l-ergothioneine concentrations in pregnant sheep after natural mating and transfer of vitrified/thawed in-vitro produced embryos. PubMed: Dietary modifications in Parkinson's disease: A neuroprotective intervention? PubMed: A mushroom-derived amino acid, ergothioneine, is a potential inhibitor of inflammation-related DNA halogenation. PubMed: Regulation of Ergothioneine Biosynthesis and Its Effect on Mycobacterium tuberculosis Growth and Infectivity. PubMed: Mechanistic studies of a novel C-S lyase in ergothioneine biosynthesis: the involvement of a sulfenic acid intermediate. PubMed: The Physiology and Genetics of Oxidative Stress in Mycobacteria. PubMed: Structure of the Ergothioneine-Biosynthesis Amidohydrolase EgtC. PubMed: Spithioneines A and B, Two New Bohemamine Derivatives Possessing Ergothioneine Moiety from a Marine-Derived Streptomyces spinoverrucosus. PubMed: Dermato-protective properties of ergothioneine through induction of Nrf2/ARE-mediated antioxidant genes in UVA-irradiated Human keratinocytes. PubMed: Organic cation transporter Octn1-mediated uptake of food-derived antioxidant ergothioneine into infiltrating macrophages during intestinal inflammation in mice. PubMed: Effect of UV-B Irradiation on Physiologically Active Substance Content and Antioxidant Properties of the Medicinal Caterpillar Fungus Cordyceps militaris (Ascomycetes). PubMed: Memantine transport by a proton-coupled organic cation antiporter in hCMEC/D3 cells, an in vitro human blood-brain barrier model. PubMed: Identification of novel biomarkers for Parkinson's disease by metabolomic technologies. PubMed: Knockout of the ergothioneine transporter ETT in zebrafish results in increased 8-oxoguanine levels. PubMed: Antioxidant and Anti-Inflammatory Properties of Solid-State Fermented Products from a Medicinal Mushroom, Taiwanofungus salmoneus (Higher Basidiomycetes) from Taiwan. PubMed: Reproductive safety evaluation of L-Ergothioneine. PubMed: Ergothioneine protects Streptomyces coelicolor A3(2) from oxidative stresses. PubMed: Retracted: 'Ergothioneine represses inflammation and dysfunction in human endothelial cells exposed to oxidized low-density lipoprotein' by Lunna Saing, Yu-Chi Wei and Chih-Jen Tseng. PubMed: Biochemistry: Elusive source of sulfur unravelled. PubMed: Metabolic coupling of two small-molecule thiols programs the biosynthesis of lincomycin A. PubMed: Structure of the sulfoxide synthase EgtB from the ergothioneine biosynthetic pathway. PubMed: Ergothioneine produces relaxation in isolated rat aorta by inactivating superoxide anion. PubMed: An uncommon redox behavior sheds light on the cellular antioxidant properties of ergothioneine. PubMed: Improved synthesis of the super antioxidant, ergothioneine, and its biosynthetic pathway intermediates. PubMed: Endogenous ergothioneine is required for wild type levels of conidiogenesis and conidial survival but does not protect against 254 nm UV-induced mutagenesis or kill. PubMed: Ergothioneine biosynthetic methyltransferase EgtD reveals the structural basis of aromatic amino acid betaine biosynthesis. PubMed: Bioinformatic and biochemical characterizations of C-S bond formation and cleavage enzymes in the fungus Neurospora crassa ergothioneine biosynthetic pathway. PubMed: Structural insights into the histidine trimethylation activity of EgtD from Mycobacterium smegmatis. PubMed: Ultra-performance liquid chromatographic determination of L-ergothioneine in commercially available classes of cow milk. PubMed: The evolutionary history of the genes involved in the biosynthesis of the antioxidant ergothioneine. PubMed: Protective effect of trehalose-loaded liposomes against UVB-induced photodamage in human keratinocytes. PubMed: Uptake and protective effects of ergothioneine in human endothelial cells. PubMed: Chemical composition and nutritional and medicinal value of fruit bodies and submerged cultured mycelia of culinary-medicinal higher Basidiomycetes mushrooms. PubMed: Different concentrations of cysteamine and ergothioneine improve microscopic and oxidative parameters in ram semen frozen with a soybean lecithin extender. PubMed: Genetic and metabolomic dissection of the ergothioneine and selenoneine biosynthetic pathway in the fission yeast, S. pombe, and construction of an overproduction system. PubMed: Crystallization and preliminary X-ray analysis of the ergothioneine-biosynthetic methyltransferase EgtD. PubMed: Mushrooms and Health Summit proceedings. PubMed: Physicochemical responses and quality changes of red sea bream (Pagrosomus major) to gum arabic coating enriched with ergothioneine treatment during refrigerated storage. PubMed: Ergothioneine and melatonin attenuate oxidative stress and protect against learning and memory deficits in C57BL/6J mice treated with D-galactose. PubMed: Cysteine oxidation reactions catalyzed by a mononuclear non-heme iron enzyme (OvoA) in ovothiol biosynthesis. PubMed: Antioxidant property of edible mushrooms collected from Ethiopia. PubMed: Effects of UV-B Radiation Levels on Concentrations of Phytosterols, Ergothioneine, and Polyphenolic Compounds in Mushroom Powders Used As Dietary Supplements. PubMed: Organic cation transporter-mediated ergothioneine uptake in mouse neural progenitor cells suppresses proliferation and promotes differentiation into neurons. PubMed: The cell line NCl-H441 is a useful in vitro model for transport studies of human distal lung epithelial barrier. PubMed: Clinical and biochemical correlates of serum L-ergothioneine concentrations in community-dwelling middle-aged and older adults. PubMed: Effect of mushroom diet on pharmacokinetics of gabapentin in healthy Chinese subjects. PubMed: Knockout of a putative ergothioneine transporter in Caenorhabditis elegans decreases lifespan and increases susceptibility to oxidative damage. PubMed: Regioselectivity of the oxidative C-S bond formation in ergothioneine and ovothiol biosyntheses. PubMed: Plasma L-ergothioneine measurement by high-performance liquid chromatography and capillary electrophoresis after a pre-column derivatization with 5-iodoacetamidofluorescein (5-IAF) and fluorescence detection. PubMed: Thiohistidine biosynthesis. PubMed: Metabolic effect of an exogenous gene on transgenic Beauveria bassiana using liquid chromatography-mass spectrometry-based metabolomics. PubMed: Effect of shiitake (Lentinus edodes) extract on antioxidant and inflammatory response to prolonged eccentric exercise. PubMed: In vivo evidence of organic cation transporter-mediated tracheal accumulation of the anticholinergic agent ipratropium in mice. PubMed: Involvement of carnitine/organic cation transporter OCTN1/SLC22A4 in gastrointestinal absorption of metformin. PubMed: Functional analysis of novel variants in the organic cation/ergothioneine transporter 1 identified in Singapore populations. PubMed: Comparative study of contents of several bioactive components in fruiting bodies and mycelia of culinary-medicinal mushrooms. PubMed: Antioxidant properties of fruiting bodies, mycelia, and fermented products of the culinary-medicinal king oyster mushroom, Pleurotus eryngii (higher Basidiomycetes), with high ergothioneine content. PubMed: Ergothioneine is a secreted antioxidant in Mycobacterium smegmatis. PubMed: A density functional theory investigation into the binding of the antioxidants ergothioneine and ovothiol to copper. PubMed: Submerged cultivation of mycelium with high ergothioneine content from the culinary-medicinal king oyster mushroom Pleurotus eryngii (higher Basidiomycetes) and its composition. PubMed: Large-scale neurochemical metabolomics analysis identifies multiple compounds associated with methamphetamine exposure. PubMed: Quantification of L-ergothioneine in human plasma and erythrocytes by liquid chromatography-tandem mass spectrometry. PubMed: Quantification of L-ergothioneine in whole blood by hydrophilic interaction ultra-performance liquid chromatography and UV-detection. PubMed: Metabolomic analysis of fission yeast at the onset of nitrogen starvation. PubMed: Quality of bread supplemented with mushroom mycelia. PubMed: Genotoxic and mutagenic effects of lipid-coated CdSe/ZnS quantum dots. PubMed: Metabolic footprinting of mutant libraries to map metabolite utilization to genotype. PubMed: Glutathione analogs in prokaryotes. PubMed: Characterization of ergothionase from Burkholderia sp. HME13 and its application to enzymatic quantification of ergothioneine. PubMed: Mitochondria-targeted antioxidants and metabolic modulators as pharmacological interventions to slow ageing. PubMed: Pharmacological and dietary antioxidant therapies for chronic obstructive pulmonary disease. PubMed: Functional expression of carnitine/organic cation transporter OCTN1 in mouse brain neurons: possible involvement in neuronal differentiation. PubMed: Ergothioneine protects against neuronal injury induced by β-amyloid in mice. PubMed: The Aspergillus fumigatus protein GliK protects against oxidative stress and is essential for gliotoxin biosynthesis. PubMed: A rapid HPLC post-column reaction analysis for the quantification of ergothioneine in edible mushrooms and in animals fed a diet supplemented with extracts from the processing waste of cultivated mushrooms. PubMed: Functional benefits of ergothioneine and fruit- and vegetable-derived nutraceuticals: overview of the supplemental issue contents. PubMed: Improvement of joint range of motion (ROM) and reduction of chronic pain after consumption of an ergothioneine-containing nutritional supplement. PubMed: Preparation of culinary-medicinal king oyster mushroom Pleurotus eryngii-fermented products with high ergothioneine content and their taste quality. PubMed: The bioavailability of ergothioneine from mushrooms (Agaricus bisporus) and the acute effects on antioxidant capacity and biomarkers of inflammation. PubMed: The Neurospora crassa mutant NcΔEgt-1 identifies an ergothioneine biosynthetic gene and demonstrates that ergothioneine enhances conidial survival and protects against peroxide toxicity during conidial germination. PubMed: Preparation of Chaga medicinal mushroom, Inonotus obliquus-fermented rice using solid-state fermentation and its taste quality and antioxidant property. PubMed: Comparative study of contents of several bioactive components in fruiting bodies and mycelia of culinary-medicinal mushrooms. PubMed: Effect of ergothioneine on acute lung injury and inflammation in cytokine insufflated rats. PubMed: The ergothioneine transporter controls and indicates ergothioneine activity--a review. PubMed: Pharmacological antioxidant strategies as therapeutic interventions for COPD. PubMed: Paramount levels of ergothioneine transporter SLC22A4 mRNA in boar seminal vesicles and cross-species analysis of ergothioneine and glutathione in seminal plasma. PubMed: Kinetics of ergothioneine inhibition of mushroom tyrosinase. PubMed: Ergothioneine; antioxidant potential, physiological function and role in disease. PubMed: Functional characterization of apical transporters expressed in rat proximal tubular cells (PTCs) in primary culture. PubMed: Genotype-phenotype correlation in primary carnitine deficiency. PubMed: Alterations of red blood cell metabolome in overhydrated hereditary stomatocytosis. PubMed: Synthesis, transport and mechanism of a type I prodrug: L-carnitine ester of prednisolone. PubMed: Crohn's disease and genetic hitchhiking at IBD5. PubMed: The effect of ergothioneine on clastogenic potential and mutagenic activity: genotoxicity evaluation. PubMed: Reconstitution in liposomes of the functionally active human OCTN1 (SLC22A4) transporter overexpressed in Escherichia coli. PubMed: Oxaliplatin transport mediated by organic cation/carnitine transporters OCTN1 and OCTN2 in overexpressing human embryonic kidney 293 cells and rat dorsal root ganglion neurons. PubMed: Discovery of the strong antioxidant selenoneine in tuna and selenium redox metabolism. PubMed: Edible mushroom (Flammulina velutipes) extract inhibits melanosis in Kuruma shrimp (Marsupenaeus japonicus). PubMed: Effects of cysteine and ergothioneine on post-thawed Merino ram sperm and biochemical parameters. PubMed: Organic hydroperoxide resistance protein and ergothioneine compensate for loss of mycothiol in Mycobacterium smegmatis mutants. PubMed: Identification in human urine and blood of a novel selenium metabolite, Se-methylselenoneine, a potential biomarker of metabolization in mammals of the naturally occurring selenoneine, by HPLC coupled to electrospray hybrid linear ion trap-orbital ion trap MS. PubMed: Specific biomarkers for stochastic division patterns and starvation-induced quiescence under limited glucose levels in fission yeast. PubMed: Chemical Research in Toxicology. In this issue. PubMed: The bioactive agent ergothioneine, a key component of dietary mushrooms, inhibits monocyte binding to endothelial cells characteristic of early cardiovascular disease. PubMed: Ergothioneine prevents copper-induced oxidative damage to DNA and protein by forming a redox-inactive ergothioneine-copper complex. PubMed: Effectiveness of sulfur-containing antioxidants in delaying skeletal muscle fatigue. PubMed: Ergothioneine protects against neuronal injury induced by cisplatin both in vitro and in vivo. PubMed: Top 10 botanical ingredients in 2010 anti-aging creams. PubMed: Antioxidant defence system of boar cauda epididymidal spermatozoa and reproductive tract fluids. PubMed: Evaluation of the safety of the dietary antioxidant ergothioneine using the bacterial reverse mutation assay. PubMed: Functional expression of carnitine/organic cation transporter OCTN1/SLC22A4 in mouse small intestine and liver. PubMed: Value-added use of mushroom ergothioneine as a colour stabilizer in processed fish meats. PubMed: Involvement of an influx transporter in the blood-brain barrier transport of naloxone. PubMed: In vitro reconstitution of Mycobacterial ergothioneine biosynthesis. PubMed: Identification of a novel selenium-containing compound, selenoneine, as the predominant chemical form of organic selenium in the blood of bluefin tuna. PubMed: Antioxidative activities of hydrophilic extracts prepared from the fruiting body and spent culture medium of Flammulina velutipes. PubMed: Gene knockout and metabolome analysis of carnitine/organic cation transporter OCTN1. PubMed: Effects of ergothioneine from mushrooms (Flammulina velutipes) on melanosis and lipid oxidation of kuruma shrimp (Marsupenaeus japonicus). PubMed: The unusual amino acid L-ergothioneine is a physiologic cytoprotectant. PubMed: Genetic variations of the SLC22A4 gene in Chinese and Indian populations of Singapore. PubMed: Substrate discrimination by ergothioneine transporter SLC22A4 and carnitine transporter SLC22A5: gain-of-function by interchange of selected amino acids. PubMed: Metabonomic characterization of aging and investigation on the anti-aging effects of total flavones of Epimedium. PubMed: Imidazole-based erythrocyte markers of oxidative stress in preeclampsia--an NMR investigation. PubMed: Modulation of palmitic acid-induced cell death by ergothioneine: evidence of an anti-inflammatory action. PubMed: [Studies on chemical constituents of Tylopilus plumbeoviolaceus]. PubMed: Characteristics of antioxidant system in dog semen. PubMed: Skin cells and tissue are capable of using L-ergothioneine as an integral component of their antioxidant defense system. PubMed: Antioxidative activities of mushroom (Flammulina velutipes) extract added to bigeye tuna meat: dose-dependent efficacy and comparison with other biological antioxidants. PubMed: Ergothioneine contents in fruiting bodies and their enhancement in mycelial cultures by the addition of methionine. PubMed: Functional genetic variation in the basal promoter of the organic cation/carnitine transporters OCTN1 (SLC22A4) and OCTN2 (SLC22A5). PubMed: Increased ergothioneine tissue concentrations in carriers of the Crohn's disease risk-associated 503F variant of the organic cation transporter OCTN1. PubMed: The metallothionein/thionein system: an oxidoreductive metabolic zinc link. PubMed: The carnitine transporter SLC22A5 is not a general drug transporter, but it efficiently translocates mildronate. PubMed: Partial oxidation and oxidative polymerization of metallothionein. PubMed: Antioxidative activity and antidiscoloration efficacy of ergothioneine in mushroom (Flammulina velutipes) extract added to beef and fish meats. PubMed: Characterization of a mycothiol ligase mutant of Rhodococcus jostii RHA1. PubMed: Supplementation of methionine enhanced the ergothioneine accumulation in the Ganoderma neo-japonicum mycelia. PubMed: Functional characterization of ergothioneine transport by rat organic cation/carnitine transporter Octn1 (slc22a4). PubMed: Involvement of the pyrilamine transporter, a putative organic cation transporter, in blood-brain barrier transport of oxycodone. PubMed: Genotoxicity of visible light (400-800 nm) and photoprotection assessment of ectoin, L-ergothioneine and mannitol and four sunscreens. PubMed: Antioxidants block proteasome inhibitor function in endometrial carcinoma cells. PubMed: Catalysis of zinc transfer by D-penicillamine to secondary chelators. PubMed: A comparison of the relative antioxidant potency of L-ergothioneine and idebenone. PubMed: Effects of low oxygen levels on the expression and function of transporter OCTN2 in BeWo cells. PubMed: Functional effects of protein sequence polymorphisms in the organic cation/ergothioneine transporter OCTN1 (SLC22A4). PubMed: Dual nanomolar and picomolar Zn(II) binding properties of metallothionein. PubMed: Dietary sources and antioxidant effects of ergothioneine. PubMed: Ergothioneine modulates proinflammatory cytokines and heat shock protein 70 in mesenteric ischemia and reperfusion injury. PubMed: Probing the substrate specificity of the ergothioneine transporter with methimazole, hercynine, and organic cations. PubMed: A hydroquinone formulation with increased stability and decreased potential for irritation. PubMed: Decreased proliferation and erythroid differentiation of K562 cells by siRNA-induced depression of OCTN1 (SLC22A4) transporter gene. PubMed: Different redox states of metallothionein/thionein in biological tissue. PubMed: A scent of therapy: pharmacological implications of natural products containing redox-active sulfur atoms. PubMed: Association of rheumatoid arthritis with ergothioneine levels in red blood cells: a case control study. PubMed: Activity of the dietary antioxidant ergothioneine in a virus gene-based assay for inhibitors of HIV transcription. PubMed: An in vitro study on the free radical scavenging capacity of ergothioneine: comparison with reduced glutathione, uric acid and trolox. PubMed: Zinc-buffering capacity of a eukaryotic cell at physiological pZn. PubMed: Pharmacological characterization of the ergot alkaloid receptor in the salivary gland of the ixodid tick Amblyomma hebraeum. PubMed: Antioxidant therapeutic targets in COPD. PubMed: Thionein can serve as a reducing agent for the methionine sulfoxide reductases. PubMed: Modulation of hydrogen peroxide-induced DNA damage, MAPKs activation and cell death in PC12 by ergothioneine. PubMed: Functional role of the 503F variant of the organic cation transporter OCTN1 in Crohn's disease. PubMed: Phenolics as potential antioxidant therapeutic agents: mechanism and actions. PubMed: Domain-specific fluorescence resonance energy transfer (FRET) sensors of metallothionein/thionein. PubMed: Evaluation of photolyase (Photosome) repair activity in human keratinocytes after a single dose of ultraviolet B irradiation using the comet assay. PubMed: Toxicity and detoxification of lipid-derived aldehydes in cultured retinal pigmented epithelial cells. PubMed: Discovery of the ergothioneine transporter. PubMed: L-Ergothioneine scavenges superoxide and singlet oxygen and suppresses TNF-alpha and MMP-1 expression in UV-irradiated human dermal fibroblasts. PubMed: Biological chemistry of naturally occurring thiols of microbial and marine origin. PubMed: beta-Hydroxyergothioneine, a new ergothioneine derivative from the mushroom Lyophyllum connatum, and its protective activity against carbon tetrachloride-induced injury in primary culture hepatocytes. PubMed: Ab initio studies of the properties of intracellular thiols ergothioneine and ovothiol. PubMed: The interaction of selected natural products with human recombinant glutathione transferases. PubMed: Ergothioneine pretreatment protects the liver from ischemia-reperfusion injury caused by increasing hepatic heat shock protein 70. PubMed: The use of ozone as an oxidizing agent to evaluate antioxidant activities of natural substrates. PubMed: Ergothioneine rescues PC12 cells from beta-amyloid-induced apoptotic death. PubMed: L-ergothioneine modulates oxidative damage in the kidney and liver of rats in vivo: studies upon the profile of polyunsaturated fatty acids. PubMed: Kinetic study on the reaction of cisplatin with metallothionein. PubMed: Cellular zinc and redox states converge in the metallothionein/thionein pair. PubMed: Ergothioneine inhibits oxidative stress- and TNF-alpha-induced NF-kappa B activation and interleukin-8 release in alveolar epithelial cells. PubMed: Effects of ergothioneine on diabetic embryopathy in pregnant rats. PubMed: Doxorubicin-dependent reduction of ferrylmyoglobin and inhibition of lipid peroxidation: implications for cardiotoxicity of anticancer anthracyclines. PubMed: Ergothioneine treatment protects neurons against N-methyl-D-aspartate excitotoxicity in an in vivo rat retinal model. PubMed: Nitric oxide-induced changes in intracellular zinc homeostasis are mediated by metallothionein/thionein. PubMed: Comparative (13)C and (31)P NMR studies of the ligand exchange reactions of auranofin with ergothionine, imidazolidine-2-thione and diazinane-2-thione. PubMed: Novel thiols of prokaryotes. PubMed: Role of ergothioneine on S-nitrosoglutathione catabolism. PubMed: L-ergothioneine level in red blood cells of healthy human males in the Western province of Saudi Arabia. PubMed: Protection against oxidative damage and cell death by the natural antioxidant ergothioneine. PubMed: Intracellular antioxidants: from chemical to biochemical mechanisms. PubMed: Uptake and antioxidant effects of ergothioneine in human erythrocytes. PubMed: Metabolic transformation of neuropeptide carnosine modifies its biological activity. PubMed: Molecular crowding and viscosity as determinants of translational diffusion of metabolites in subcellular organelles. PubMed: Thiols and disulphides can aggravate peroxynitrite-dependent inactivation of alpha1-antiproteinase. PubMed: Ergothioneine distribution in bovine and porcine ocular tissues. PubMed: Quenching of singlet molecular oxygen by carnosine and related antioxidants. Monitoring 1270-nm phosphorescence in aqueous media. PubMed: Antioxidant action of ergothioneine: assessment of its ability to scavenge peroxynitrite. PubMed: One-electron oxidation of ergothioneine and analogues investigated by pulse radiolysis: redox reaction involving ergothioneine and vitamin C. PubMed: In vitro administration of ergothioneine failed to protect isolated ischaemic and reperfused rabbit heart. PubMed: Heterocyclic thiols as antioxidants: why ovothiol C is a better antioxidant than ergothioneine. PubMed: Identification and zinc dependence of the bovine herpesvirus 1 transactivator protein BICP0. PubMed: In vitro ergothioneine administration failed to protect isolated ischaemic and reperfused rabbit heart. PubMed: Stability and nonreactivity of ergothioneine in human erythrocytes studied by 1H NMR. PubMed: Low-molecular-weight thiols in streptomycetes and their potential role as antioxidants. PubMed: UV-radiation protecting efficacy of thiols, studied with UVA-induced binding of 8-MOP and CPZ to rat epidermal biomacromolecules in vivo. PubMed: Thiols as potential UV radiation protectors: an in vitro study. PubMed: Effects of thiols on prostaglandin synthesis in bovine bladder epithelium. PubMed: Direct interception of mutagens and carcinogens by biomolecules. PubMed: Reduction of sperm whale ferrylmyoglobin by endogenous reducing agents: potential reducible loci of ferrylmyoglobin. PubMed: Copper and cobalt complexes of carnosine and anserine: production of active oxygen species and its enhancement by 2-mercaptoimidazoles. PubMed: Possible mechanism of inhibition of nitrite-induced oxidation of oxyhemoglobin by ergothioneine and uric acid. PubMed: Inhibition by thiols of copper(II)-induced oxidation of oxyhemoglobin. PubMed: Stimulation of mucosal uptake of selenium from selenite by some thiols at various sites of rat intestine. PubMed: Effects of various chemical compounds on spontaneous and hydrogen peroxide-induced reversion in strain TA104 of Salmonella typhimurium. PubMed: The 13C NMR study of the binding of gold(I) thiomalate with ergothionine in aqueous solution. PubMed: The reactivity of thiols and disulfides with different redox states of myoglobin. Redox and addition reactions and formation of thiyl radical intermediates. PubMed: Zinc transfer from transcription factor IIIA fingers to thionein clusters. PubMed: Clinical analysis in intact erythrocytes using 1H spin echo NMR. PubMed: Measurement of biological thiols and disulfides by high-performance liquid chromatography and electrochemical detection of silver mercaptide formation. PubMed: The antioxidant action of ergothioneine. PubMed: Activity of thiols as singlet molecular oxygen quenchers. PubMed: Reduction of ferrylmyoglobin in rat diaphragm. PubMed: The reduction of ferryl myoglobin by ergothioneine: a novel function for ergothioneine. PubMed: Scavenging of singlet molecular oxygen by imidazole compounds: high and sustained activities of carboxy terminal histidine dipeptides and exceptional activity of imidazole-4-acetic acid. PubMed: Ergothioneine as antioxidant. PubMed: Detection of ferryl myoglobin in the isolated ischemic rat heart. PubMed: In search of a physiological function for L-ergothioneine--II. PubMed: Photodynamic production of superoxide in vitro by altertoxins in the presence of reducing agents. PubMed: Determination of ergothioneine in red blood cells by high-performance liquid chromatography. PubMed: Study of the ergothioneine concentration in the blood of individuals with diabetes mellitus. PubMed: Cellular response to oxidative stress at sulfhydryl group receptor sites on the erythrocyte membrane. PubMed: Ergothioneine, histidine, and two naturally occurring histidine dipeptides as radioprotectors against gamma-irradiation inactivation of bacteriophages T4 and P22. PubMed: Spin-echo 1H NMR detected response of ergothioneine to oxidative stress in the intact human erythrocyte. PubMed: Control of ram sperm adenylate cyclase by divalent cations. PubMed: Analysis of the physiological processes connected with sexual maturation of stallions. PubMed: Interception of some direct-acting mutagens by ergothioneine. PubMed: Thiol-induced hydroxyl radical formation and scavenger effect of thiocarbamides on hydroxyl radicals. PubMed: Interception of toxic agents/mutagens/carcinogens: some of nature's novel strategies. PubMed: In search of a physiological function for L-ergothioneine. PubMed: Direct observation of the NAD glycohydrolase reaction in human erythrocytes using NMR spectroscopy. PubMed: Characteristics of Mycoplasma strains isolated from stallion semen. PubMed: Occurrence and synthesis of a non-thionein, zinc-binding protein in the rainbow trout (Salmo gairdneri). PubMed: Effect of MPG on glucocorticoid-induced cataract formation in developing chick embryo. PubMed: Assay of biological thiols by a combination of high-performance liquid chromatography and postcolumn reaction with 6,6'-dithiodinicotinic acid. PubMed: Cell volume dependence of 1H spin-echo NMR signals in human erythrocyte suspensions. The influence of in situ field gradients. PubMed: Lithium, red blood cell choline and clinical state. A prospective study in manic-depressive patients. PubMed: The protective role of thiol reducing agents in the in vitro inhibition of rat liver DNA methylase by direct acting carcinogens. PubMed: The role of ergothioneine in the oxidation of reduced nicotinamide adenine dinucleotide by metmyoglobin or methemoglobin. PubMed: Studies on ergothioneine. XI. Inhibitory effect on lipid peroxide formation in mouse liver. PubMed: Studies on ergothioneine. X. Effects of ergothioneine on the hepatic drug metabolizing enzyme system and on experimental hepatic injury in rats. PubMed: Effect of acute stresses on Zn-thionein production in rat liver. PubMed: Proton NMR studies of creatine in human erythrocytes. PubMed: Cysteine as precursor and sulfur donor in the biosynthesis of natural sulfur-containing compounds. PubMed: A proton nuclear magnetic resonance study of the interaction of mercury with intact human erythrocytes. 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