N-methyl alanine

N-methyl-DL-alanine

CAS: 600-21-5 C4 H9 N O2 MW: 103.12113000

Identification

NameN-methyl alanine
CAS Number600-21-5
FDA UNIIFER5I9LLG2
Molecular FormulaC4 H9 N O2
Molecular Weight103.12113000
MDL NumberMFCD00063136
Nikkaji NumberJ325.082B

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Soluble in water, 1.395e+005 mg/L @ 25 °C (est)

No sensory data available

Safety Information

Preferred SDSView
Oral/Parenteral ToxicityNot determined
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categoryinformation only not used for fragrances or flavors
Recommendation for N-methyl alanine usage levels up tonot for fragrance use.
Recommendation for N-methyl alanine flavor usage levels up tonot for flavor use.

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Potential Uses

None Found

Natural Occurrence

not found in nature

Synonyms

DL- alanine, N-methyl- N- methyl-DL-alanine N- methylalanine 2-( methylamino)propanoic acid PubMed: Profiling ephedrine prepared from N-methylalanine via the Akabori-Momotani reaction. PubMed: Metabolomics Analysis Revealed Distinct Cyclic Changes of Metabolites Altered by Chronic Ethanol-Plus-Binge and Shp Deficiency. PubMed: Selective quantitation of the neurotoxin BMAA by use of hydrophilic-interaction liquid chromatography-differential mobility spectrometry-tandem mass spectrometry (HILIC-DMS-MS/MS). PubMed: Application of design of experiments (DoE) optimization to the one-pot synthesis of 4,6-dihydropteridinones. PubMed: Hydrogen-deuterium exchange of α-carbon protons and fragmentation pathways in N-methylated glycine and alanine-containing peptides derivatized by quaternary ammonium salts. PubMed: Insight into the structural and biological relevance of the T/R transition of the N-terminus of the B-chain in human insulin. PubMed: Scalable solution-phase synthesis of the biologically active cyclodepsipeptide destruxin E, a potent negative regulator of osteoclast morphology. PubMed: Dissociation of antimicrobial and hemolytic activities of gramicidin S through N-methylation modification. PubMed: In vitro and in vivo antitumor effects of novel actinomycin D analogs with amino acid substituted in the cyclic depsipeptides. PubMed: Design, synthesis and pharmacological characterization of endomorphin analogues with non-cyclic amino acid residues in position 2. PubMed: Effect of a carboxyl group on the chemiluminescent reaction of tris(2,2'-bipyridine)ruthenium(III) with aliphatic amines. PubMed: Actinomycins with altered threonine units in the beta-peptidolactone. PubMed: Kinetic and crystallographic analysis of mutant Escherichia coli aminopeptidase P: insights into substrate recognition and the mechanism of catalysis. PubMed: Exploration of the P6/P7 region of the peptide-binding site of the human class II major histocompatability complex protein HLA-DR1. PubMed: Novel, potent ORL-1 receptor agonist peptides containing alpha-Helix-promoting conformational constraints. PubMed: Probing host-selective phytotoxicity: synthesis of destruxin B and several natural analogues. PubMed: Synthesis and immunological activity of water-soluble thalidomide prodrugs. PubMed: Analogue-resistant mutants of Azotobacter chroococcum derepressed for nitrogenase activity and early ammonia excretion having potential as inoculants for cereal crops. PubMed: Monomeric sarcosine oxidase: 2. Kinetic studies with sarcosine, alternate substrates, and a substrate analogue. PubMed: Role of the pyrrolidine ring of proline in determining the substrate specificity of cdc2 kinase or cdk5. PubMed: Structural modifications of the N-terminal tetrapeptide segment of [D-Ala2]deltorphin I: effects on opioid receptor affinities and activities in vitro and on antinociceptive potency. PubMed: Fluorescence study of neurohypophyseal hormones and their analogues. Distance distributions in a series of arginine-vasopressin analogues. PubMed: 1H-NMR and 13C-NMR investigation of complexes of Mn2+ with ocytocin analogues in (2H6)dimethylsulfoxide. PubMed: Structure-activity relationships of dermorphin analogues containing N-substituted amino acids in the 2-position of the peptide sequence. PubMed: Uptake and receptor sites for glycine in isolated bovine adrenal medulla chromaffin cells. PubMed: Chemical characterization and toxicity of dihydro derivatives of nodularin and microcystin-LR, potent cyanobacterial cyclic peptide hepatotoxins. PubMed: Isolation and Characterization of Two Novel Nematicidal Depsipeptides from an Imperfect Fungus, Strain D1084. PubMed: Enzymatic synthesis of actinomycin D and analogues containing N-methylalanine from synthetic pentapeptide lactone precursors. PubMed: Inhibition of sodium-dependent L-leucine uptake in rat brain synaptosomes. PubMed: Circular dichroism studies of some arginine-vasopressin analogues. PubMed: Identification of a myometrial oxytocin-receptor protein. PubMed: The importance of residues 2 (arginine) and 6 (histidine) in high-affinity angiotensin II antagonists. PubMed: Iodinated photoreactive vasopressin antagonists: labelling of hepatic vasopressin receptor subunits. PubMed: Vasopressin antagonist analogs modified at position 7. PubMed: A resonance Raman study on the structures of complexes of flavoprotein D-amino acid oxidase. PubMed: [Synthesis and analysis of conformationally restricted analogs of peptide inhibitors of the angiotensin-converting enzyme]. PubMed: Arginine-vasopressin analogues with high antidiuretic/vasopressor selectivity. Synthesis, biological activity, and receptor binding affinity of arginine-vasopressin analogues with substitutions in positions 1, 2, 4, 7, and 8. PubMed: Conformational preferences and binding to neurophysins of oxytocin analogs with sarcosine or N-methylalanine in position 7. PubMed: Interactions of vasopressin agonists and antagonists with membrane receptors. PubMed: Influence of sarcosine or N-methylalanine in position 7 on the antagonistic properties of [1-deaminopenicillamine]- and [1-(beta-mercapto-beta, beta-cyclopentylmethylene-propionic acid)]-vasopressin. PubMed: Synthesis and some pharmacological properties of [4-threonine,7-sarcosine]oxytocin, a peptide with high oxytocic potency, and of [4-threonine,7-N-methylalanine]oxytocin. PubMed: Synthesis and some pharmacological properties of oxytocin and vasopressin analogues with sarcosine or N-methyl-L-alanine in position 7. PubMed: Configuration assignments of the amino acid residues and the presence of N-methyldehydroalanine in toxins from the blue-green alga, Microcystis aeruginosa. PubMed: Transport of L-alanine in cultured human fibroblasts: evidence for two kinetically distinguishable systems. PubMed: Molecular specificity of tubular reabsorption of L-proline. A microperfusion study in rat kidney. PubMed: Characteristics of an amino acid transport system in rat liver for glutamine, asparagine, histidine, and closely related analogs. PubMed: Colchicine-induced resistance to antibiotic and amino-acid analogue in plant cell cultures. PubMed: Formation of amino acids on heating glycine with alumina. PubMed: Solubilization, partial purification and properties of N-methylglutamate dehydrogenase from Pseudomonas aminovorans. PubMed: Placental amino acid uptake. III. Transport systems for neutral amino acids. PubMed: Purification and characterization of N-methylalanine dehydrogenase. PubMed: Quantitative determination of secondary amines: measurement of N-methylalanine. PubMed: Polymerization of optical isomers of phenylalanine N-carboxyanhydride by poly(N-methylalanine) diethylamide. PubMed: Nonprotein amino acids from spark discharges and their comparison with the murchison meteorite amino acids. PubMed: Synthesis of (5-valine,7-N-methylalanine)-angiotensin II, a hypertensive peptide. PubMed: Nonprotein amino acids in the murchison meteorite. PubMed: The enzymatic synthesis of N-methylalanine. PubMed: The synthesis of dl-3:4-dihydroxyphenyl-N-methylalanine. PubMed: A study of the oxidation of 3:4-dihydroxyphenyl-N-methylalanine with reference to its possible function as a precursor of adrenaline.