prunella vulgaris

dried cut herb of the self heal, prunella vulgaris l., labiatae

CAS: 90105-92-3

Identification

Nameprunella vulgaris
IUPACprunella vulgaris l.
CAS Number90105-92-3
FDA UNIISearch

Regulatory

FDA/DG SANTE Petitions, Reviews, NoticesGRN 13

Physical Properties

Food Chemicals Codex Listed No

Cosmetic Information

CosIngcosmetic data
Cosmetic Usesskin conditioning

No sensory data available

Safety Information

Oral/Parenteral Toxicityintraperitoneal-mouse LD50 750 mg/kg
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements', 'VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION']

Safety in Use

Categorycosmetic ingredient for skin conditioning
Recommendation for prunella vulgaris usage levels up tonot for fragrance use.
Recommendation for prunella vulgaris flavor usage levels up tonot for flavor use.

No supplier data available

Potential Uses

None Found

Natural Occurrence

prunella vulgaris

Synonyms

dried cut herb of the self heal, prunella vulgaris l., labiatae heal all heal-all self heal self-heal PubMed: Korean medicine therapy as a substitute for chemotherapy for metastatic breast cancer: a case report. PubMed: Structural characterization and immunomodulatory activity of a new heteropolysaccharide from Prunella vulgaris. PubMed: Bacillus wuyishanensis sp. nov., isolated from rhizosphere soil of a medical plant, Prunella vulgaris, in the Wuyi mountain of China. PubMed: Extracts of endophytic fungus xkc-s03 from Prunella vulgaris L. spica inhibit gastric cancer in vitro and in vivo. PubMed: Characterization, antioxidant and immunomodulatory activities of polysaccharides from Prunella vulgaris Linn. PubMed: [Effects of extracts of Prunella Vulgaris L. on proteome of human lung adenocarcinoma cell line A549]. PubMed: Pentacyclic triterpenoids from spikes of Prunella vulgaris L. inhibit glycogen phosphorylase and improve insulin sensitivity in 3T3-L1 adipocytes. PubMed: Effects of ammonium to nitrate ratio on growth, nitrogen metabolism, photosynthetic efficiency and bioactive phytochemical production of Prunella vulgaris. PubMed: SKI306X inhibition of glycosaminoglycan degradation in human cartilage involves down-regulation of cytokine-induced catabolic genes. PubMed: Optimization of adventitious root culture for production of biomass and secondary metabolites in Prunella vulgaris L. PubMed: Inhibition of estrogen signaling through depletion of estrogen receptor alpha by ursolic acid and betulinic acid from Prunella vulgaris var. lilacina. PubMed: Chemical constituents of Prunella vulgaris. PubMed: Oleanolic acid regulates NF-κB signaling by suppressing MafK expression in RAW 264.7 cells. PubMed: Effects of single and multiple applications of glyphosate or aminopyralid on simple constructed plant communities. PubMed: [Preliminary analysis of bitter substances in spica of Prunella vulgaris]. PubMed: Anti-diabetic effects of the ethanol extract of a functional formula diet in mice fed with a fructose/fat-rich combination diet. PubMed: Vulgarisin A, a new diterpenoid with a rare 5/6/4/5 ring skeleton from the Chinese medicinal plant Prunella vulgaris. PubMed: Molecular cloning and characterization of genes involved in rosmarinic acid biosynthesis from Prunella vulgaris. PubMed: Anxiolytic-like effect of danshensu [(3-(3,4-dihydroxyphenyl)-lactic acid)] in mice. PubMed: [Factor of Prunella vulgaris yield components and morphological characteristics of relationship in different populations]. PubMed: In vitro antioxidant and anticancer effects of solvent fractions from Prunella vulgaris var. lilacina. PubMed: Effects of Prunella vulgaris on the mice immune function. PubMed: NF-κB-targeted anti-inflammatory activity of Prunella vulgaris var. lilacina in macrophages RAW 264.7. PubMed: Anti-Proliferative Effect of an Aqueous Extract of Prunella vulgaris in Vascular Smooth Muscle Cells. PubMed: [Observations of in vitro pollen germination of Prunella vulgaris]. PubMed: The protective effect of Prunella vulgaris ethanol extract against vascular inflammation in TNF-α-stimulated human aortic smooth muscle cells. PubMed: Effects of low levels of herbicides on prairie species of the Willamette Valley, Oregon. PubMed: Optimisation of potassium chloride nutrition for proper growth, physiological development and bioactive component production in Prunella vulgaris L. PubMed: Biochar mitigates negative effects of salt additions on two herbaceous plant species. PubMed: [Preliminary study on breeding system of Prunella vulgaris]. PubMed: Effect of Chinese herbal medicine extracts on cell-mediated immunity in a rat model of tuberculosis induced by multiple drug-resistant bacilli. PubMed: Effects of triterpenic acid from Prunella vulgaris L. on glycemia and pancreas in rat model of streptozotozin diabetes. PubMed: Traditional Chinese medicine syndrome-related herbal prescriptions in treatment of malignant tumors. PubMed: Prunella vulgaris attenuates prepulse inhibition deficit and attention disruption induced by MK-801 in mice. PubMed: [Study on HPLC fingerprint of Prunella vulgaris]. PubMed: Variation in concentrations of major bioactive compounds in Prunella vulgaris L. related to plant parts and phenological stages. PubMed: The inhibitory effect of Prunella vulgaris L. on aldose reductase and protein glycation. PubMed: Arbuscular mycorrhizal fungi reduce the differences in competitiveness between dominant and subordinate plant species. PubMed: Vanadium pentoxide phytotoxicity: effects of species selection and nutrient concentration. PubMed: Prunella vulgaris aqueous extract attenuates IL-1β-induced apoptosis and NF-κB activation in INS-1 cells. PubMed: Soil fertilization leads to a decline in between-samples variability of microbial community δ13C profiles in a grassland fertilization experiment. PubMed: Anti-diabetic atherosclerosis effect of Prunella vulgaris in db/db mice with type 2 diabetes. PubMed: [Experimental study of extract from Prunella vulgaris inducing B, T lymphoma cell apoptosis]. PubMed: [Complex evaluation for influence of hosts on hemipatasite Thesium chinense]. PubMed: [Influence of storage period and grading standards on quality of Prunella vulgaris]. PubMed: The aqueous extract of Prunella vulgaris suppresses cell invasion and migration in human liver cancer cells by attenuating matrix metalloproteinases. PubMed: Changes in bioactive components related to the harvest time from the spicas of Prunella vulgaris. PubMed: A new unusual delta11(12)-oleane triterpene and anti-complementary triterpenes from Prunella vulgaris spikes. PubMed: The effects of glyphosate and aminopyralid on a multi-species plant field trial. PubMed: [Analyze on the component of rosmarinic acid in Prunella vulgaris and its effect on alpha-glycosidase activity]. PubMed: [Study on content and distribution characteristics of mineral elements from cultivated and wild Prunella vulgaris]. PubMed: [Absorption and allocation of nitrogen, phosphorus, potassium in Prunella vulgaris and their relationship to dry matter accumulation]. PubMed: Prunella vulgaris suppresses HG-induced vascular inflammation via Nrf2/HO-1/eNOS activation. PubMed: [Textual research on original plant and dietotherapy history of Prunella vulgaris]. PubMed: [Effect of optimized fertilization on spicas biomass and yield of Prunella vulgaris]. PubMed: Medicinal plants: a public resource for metabolomics and hypothesis development. PubMed: Chemopreventive effect of a mixture of Chinese Herbs (antitumor B) on chemically induced oral carcinogenesis. PubMed: [Effects of light intensity on photosynthetic characteristics and seedling growth of Prunella vulgaris]. PubMed: Ethanol extract of Prunella vulgaris var. lilacina inhibits HMGB1 release by induction of heme oxygenase-1 in LPS-activated RAW 264.7 cells and CLP-induced septic mice. PubMed: A new phenolic glycoside from prunella vulgaris. PubMed: Permeability of rosmarinic acid in Prunella vulgaris and ursolic acid in Salvia officinalis extracts across Caco-2 cell monolayers. PubMed: Variation in the Breeding System of Prunella vulgaris L. PubMed: [Dynamic change of active component content in different parts of Prunella vulgaris]. PubMed: Evaluation of the anti-neuraminidase activity of the traditional Chinese medicines and determination of the anti-influenza A virus effects of the neuraminidase inhibitory TCMs in vitro and in vivo. PubMed: [Influence of nitrogen forms ratio on growth and photosynthetic characteristics in Prunella vulgaris]. PubMed: Oleanolic acid from Prunella Vulgaris L. induces SPC-A-1 cell line apoptosis via regulation of Bax, Bad and Bcl-2 expression. PubMed: Inhibition of HIV-1 infection by aqueous extracts of Prunella vulgaris L. PubMed: Determination of phenolic compounds in Prunella L. by liquid chromatography-diode array detection. PubMed: Apoptogenic activity of 2α,3α-dihydroxyurs-12-ene-28-oic acid from Prunella vulgaris var. lilacina is mediated via mitochondria-dependent activation of caspase cascade regulated by Bcl-2 in human acute leukemia Jurkat T cells. PubMed: Screening of traditional Chinese medicinal plants for quorum-sensing inhibitors activity. PubMed: Chemoprevention by Prunella vulgaris L. extract of non-small cell lung cancer via promoting apoptosis and regulating the cell cycle. PubMed: Antioxidant activities of total phenols of Prunella vulgaris L. in vitro and in tumor-bearing mice. PubMed: [Effect of different water treatments on quality and yield of spadix in Prunella vulgaris]. PubMed: Phytochemical screening of Prunella vulgaris l. - an important medicinal plant of Kashmir. PubMed: Effect of polyacetylenic acids from Prunella vulgaris on various plant pathogens. PubMed: Identification of two polysaccharides from Prunella vulgaris L. and evaluation on their anti-lung adenocarcinoma activity. PubMed: Screening for anti-lipase properties of 37 traditional Chinese medicinal herbs. PubMed: [Research on callus induction and plantlet regeneration of Prunella vulgaris]. PubMed: Steroid-like compounds in Chinese medicines promote blood circulation via inhibition of Na+/K+ -ATPase. PubMed: Anti-invasion effect of rosmarinic acid via the extracellular signal-regulated kinase and oxidation-reduction pathway in Ls174-T cells. PubMed: Prunella vulgaris L. Upregulates eNOS expression in human endothelial cells. PubMed: [Involvement of JNK and caspase-3 in human lymphoma cell apoptosis induced by Prunella vulgaris]. PubMed: [Textual research on change of medicinal parts and herbal medicine of Prunella vulgaris]. PubMed: The ameliorating effect of the extract of the flower of Prunella vulgaris var. lilacina on drug-induced memory impairments in mice. PubMed: Suppression of PMA-induced tumor cell invasion and metastasis by aqueous extract isolated from Prunella vulgaris via the inhibition of NF-kappaB-dependent MMP-9 expression. PubMed: Rosmarinic acid in Prunella vulgaris ethanol extract inhibits lipopolysaccharide-induced prostaglandin E2 and nitric oxide in RAW 264.7 mouse macrophages. PubMed: [Genetic variation, correlation and principle component analysis on morphological characteristics of various germplasm from Prunella vulgaris]. PubMed: [Effect of water stress on physiological and growth charaters of Prunella vulgaris at the vegetative stage]. PubMed: Prunella vulgaris extract and rosmarinic acid prevent UVB-induced DNA damage and oxidative stress in HaCaT keratinocytes. PubMed: [Study on proteomics of Jurkat cells treated with the extracts from Prunella vulgaris]. PubMed: [Effects of seed priming on drought tolerence in Prunella vulgaris]. PubMed: [Effects of seed priming on salt tolerance in Prunella vulgaris seed germination under saline conditions]. PubMed: [Study on seed quality test and quality standard of Prunella vulgaris]. PubMed: [Study on HPLC fingerprint of Prunella vulgaris]. PubMed: Prunella vulgaris extract and rosmarinic acid suppress lipopolysaccharide-induced alteration in human gingival fibroblasts. PubMed: Inhibition of lentivirus replication by aqueous extracts of Prunella vulgaris. PubMed: Triterpenoic acids of Prunella vulgaris var. lilacina and their cytotoxic activities in vitro. PubMed: Immunostimulatory activity of aqueous extract isolated from Prunella vulgaris. PubMed: Enhanced analysis of triterpenes, flavonoids and phenolic compounds in Prunella vulgaris L. by capillary zone electrophoresis with the addition of running buffer modifiers. PubMed: Characterization of antiestrogenic activity of the Chinese herb, prunella vulgaris, using in vitro and in vivo (Mouse Xenograft) models. PubMed: [Study of flavonoids distribution in various populations of Prunella vulgaris]. PubMed: [Effects of seed priming on vigor of Prunella vulgaris seeds]. PubMed: [A novel triterpenoid saponin from Prunella vulgaris]. PubMed: Heme oxygenase-1 inducing constituent of Prunella vulgaris in HepG2 cells. PubMed: [Pharmacognostical studies on Prunella vulgaris and Ajuga decumbens]. PubMed: Induction of glucokinase mRNA by dietary phenolic compounds in rat liver cells in vitro. PubMed: HPLC analysis of rosmarinic acid in feed enriched with aerial parts of Prunella vulgaris and its metabolites in pig plasma using dual-channel coulometric detection. PubMed: Assessment of comparative pain relief and tolerability of SKI306X compared with celecoxib in patients with rheumatoid arthritis: a 6-week, multicenter, randomized, double-blind, double-dummy, phase III, noninferiority clinical trial. PubMed: [Studies on chemical constituents of Prunella vulgaris]. PubMed: Seasonal dynamics of arbuscular mycorrhizal fungal communities in roots in a seminatural grassland. PubMed: Effects of Prunella vulgaris on mast cell-mediated allergic reaction and inflammatory cytokine production. PubMed: Chemical properties, mode of action, and in vivo anti-herpes activities of a lignin-carbohydrate complex from Prunella vulgaris. PubMed: The structure-activity relationship of the series of non-peptide small antagonists for p56lck SH2 domain. PubMed: Antihyperglycemic activity of Prunella vulgaris L. in streptozotocin-induced diabetic mice. PubMed: Ethnoveterinary medicines used for ruminants in British Columbia, Canada. PubMed: [The experimental research about the effect of Prunella vulgaris L. on Raji cells growth and expression of apoptosis related protein]. PubMed: Antiviral effect of aqueous extracts from species of the Lamiaceae family against Herpes simplex virus type 1 and type 2 in vitro. PubMed: [Studies on germination characteristics of Prunella vulgaris seeds]. PubMed: Photoprotective properties of Prunella vulgaris and rosmarinic acid on human keratinocytes. PubMed: Effects of two Prunella species on lymphocyte proliferation and nitric oxide production. PubMed: Parental use of the term "Hot Qi" to describe symptoms in their children in Hong Kong: a cross sectional survey "Hot Qi" in children. PubMed: Immune modulatory effects of Prunella vulgaris L. on monocytes/macrophages. PubMed: Cytoprotectivity of Prunella vulgaris on doxorubicin-treated rat cardiomyocytes. PubMed: Clematis mandshurica protected to apoptosis of rat chondrocytes. PubMed: [Establishment of stably expressed human RANTES gene in prunella vulgaris cell clone]. PubMed: In vitro and in vivo immunosuppressive activity of Spica Prunellae ethanol extract on the immune responses in mice. PubMed: Immune modulatory effects of Prunella vulgaris L. PubMed: Macleya cordata and Prunella vulgaris in oral hygiene products - their efficacy in the control of gingivitis. PubMed: A polysaccharide fraction from medicinal herb Prunella vulgaris downregulates the expression of herpes simplex virus antigen in Vero cells. PubMed: Phenolics-rich extracts from Silybum marianum and Prunella vulgaris reduce a high-sucrose diet induced oxidative stress in hereditary hypertriglyceridemic rats. PubMed: Biological activities of Prunella vulgaris extract. PubMed: Inhibitory effects of rosmarinic acid on Lck SH2 domain binding to a synthetic phosphopeptide. PubMed: Post-dispersal seed fates of four prairie species. PubMed: Rosmarinic acid inhibits TCR-induced T cell activation and proliferation in an Lck-dependent manner. PubMed: Identification of inhibitors of the HIV-1 gp41 six-helix bundle formation from extracts of Chinese medicinal herbs Prunella vulgaris and Rhizoma cibotte. PubMed: Effects of SKI 306X, a new herbal agent, on proteoglycan degradation in cartilage explant culture and collagenase-induced rabbit osteoarthritis model. PubMed: Effect of SKI 306X, a new herbal anti-arthritic agent, in patients with osteoarthritis of the knee: a double-blind placebo controlled study. PubMed: Inhibition of immediate-type allergic reactions by Prunella vulgaris in a murine model. PubMed: A comparison of HIV-1 integrase inhibition by aqueous and methanol extracts of Chinese medicinal herbs. PubMed: A comparison of human immunodeficiency virus type-1 protease inhibition activities by the aqueous and methanol extracts of Chinese medicinal herbs. PubMed: Anti-allergic and anti-inflammatory triterpenes from the herb of Prunella vulgaris. PubMed: Extract of Prunella vulgaris spikes inhibits HIV replication at reverse transcription in vitro and can be absorbed from intestine in vivo. PubMed: The response of arbuscular mycorrhizae to fertilization, mowing, and removal of dominant species in a diverse oligotrophic wet meadow. PubMed: Antioxidative and free radical scavenging activities of selected medicinal herbs. PubMed: Isolation and characterization of an anti-HSV polysaccharide from Prunella vulgaris. PubMed: Anti-HIV-1 activity of herbs in Labiatae. PubMed: [Prunella vulgaris L.--a rediscovered medicinal plant]. PubMed: [Screening test of crude drug extract on anti-HIV activity]. PubMed: [Studies on the medicinal plant in the "Sambutsu-cho" of Higo Province possessed by the Kumamoto clan (II): on the medicina herbs]. PubMed: Mechanism of inhibition of HIV-1 infection in vitro by purified extract of Prunella vulgaris. PubMed: [Medicinal Lamiaceae with antioxidant properties, a potential source of rosmarinic acid]. PubMed: [Anti-HBsAg herbs employing ELISA technique]. PubMed: [Experimental study of 472 herbs with antiviral action against the herpes simplex virus]. PubMed: Isolation, purification, and partial characterization of prunellin, an anti-HIV component from aqueous extracts of Prunella vulgaris. PubMed: The cytotoxic principles of Prunella vulgaris, Psychotria serpens, and Hyptis capitata: ursolic acid and related derivatives. PubMed: Antimutagenic activity of extracts from anticancer drugs in Chinese medicine.