prunella vulgaris
dried cut herb of the self heal, prunella vulgaris l., labiatae
Identification
| Name | prunella vulgaris |
| IUPAC | prunella vulgaris l. |
| CAS Number | 90105-92-3 |
| FDA UNII | Search |
Regulatory
| FDA/DG SANTE Petitions, Reviews, Notices | GRN 13 |
Physical Properties
| Food Chemicals Codex Listed | No |
Cosmetic Information
| CosIng | cosmetic data |
| Cosmetic Uses | skin conditioning |
No sensory data available
Safety Information
| Oral/Parenteral Toxicity | intraperitoneal-mouse LD50 750 mg/kg |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements', 'VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION']
Safety in Use
| Category | cosmetic ingredient for skin conditioning |
| Recommendation for prunella vulgaris usage levels up to | not for fragrance use. |
| Recommendation for prunella vulgaris flavor usage levels up to | not for flavor use. |
No supplier data available
Potential Uses
Natural Occurrence
Synonyms
dried cut herb of the self heal, prunella vulgaris l., labiatae
heal all
heal-all
self heal
self-heal
PubMed:
Korean medicine therapy as a substitute for chemotherapy for metastatic breast cancer: a case report.
PubMed:
Structural characterization and immunomodulatory activity of a new heteropolysaccharide from Prunella vulgaris.
PubMed:
Bacillus wuyishanensis sp. nov., isolated from rhizosphere soil of a medical plant, Prunella vulgaris, in the Wuyi mountain of China.
PubMed:
Extracts of endophytic fungus xkc-s03 from Prunella vulgaris L. spica inhibit gastric cancer in vitro and in vivo.
PubMed:
Characterization, antioxidant and immunomodulatory activities of polysaccharides from Prunella vulgaris Linn.
PubMed:
[Effects of extracts of Prunella Vulgaris L. on proteome of human lung adenocarcinoma cell line A549].
PubMed:
Pentacyclic triterpenoids from spikes of Prunella vulgaris L. inhibit glycogen phosphorylase and improve insulin sensitivity in 3T3-L1 adipocytes.
PubMed:
Effects of ammonium to nitrate ratio on growth, nitrogen metabolism, photosynthetic efficiency and bioactive phytochemical production of Prunella vulgaris.
PubMed:
SKI306X inhibition of glycosaminoglycan degradation in human cartilage involves down-regulation of cytokine-induced catabolic genes.
PubMed:
Optimization of adventitious root culture for production of biomass and secondary metabolites in Prunella vulgaris L.
PubMed:
Inhibition of estrogen signaling through depletion of estrogen receptor alpha by ursolic acid and betulinic acid from Prunella vulgaris var. lilacina.
PubMed:
Chemical constituents of Prunella vulgaris.
PubMed:
Oleanolic acid regulates NF-κB signaling by suppressing MafK expression in RAW 264.7 cells.
PubMed:
Effects of single and multiple applications of glyphosate or aminopyralid on simple constructed plant communities.
PubMed:
[Preliminary analysis of bitter substances in spica of Prunella vulgaris].
PubMed:
Anti-diabetic effects of the ethanol extract of a functional formula diet in mice fed with a fructose/fat-rich combination diet.
PubMed:
Vulgarisin A, a new diterpenoid with a rare 5/6/4/5 ring skeleton from the Chinese medicinal plant Prunella vulgaris.
PubMed:
Molecular cloning and characterization of genes involved in rosmarinic acid biosynthesis from Prunella vulgaris.
PubMed:
Anxiolytic-like effect of danshensu [(3-(3,4-dihydroxyphenyl)-lactic acid)] in mice.
PubMed:
[Factor of Prunella vulgaris yield components and morphological characteristics of relationship in different populations].
PubMed:
In vitro antioxidant and anticancer effects of solvent fractions from Prunella vulgaris var. lilacina.
PubMed:
Effects of Prunella vulgaris on the mice immune function.
PubMed:
NF-κB-targeted anti-inflammatory activity of Prunella vulgaris var. lilacina in macrophages RAW 264.7.
PubMed:
Anti-Proliferative Effect of an Aqueous Extract of Prunella vulgaris in Vascular Smooth Muscle Cells.
PubMed:
[Observations of in vitro pollen germination of Prunella vulgaris].
PubMed:
The protective effect of Prunella vulgaris ethanol extract against vascular inflammation in TNF-α-stimulated human aortic smooth muscle cells.
PubMed:
Effects of low levels of herbicides on prairie species of the Willamette Valley, Oregon.
PubMed:
Optimisation of potassium chloride nutrition for proper growth, physiological development and bioactive component production in Prunella vulgaris L.
PubMed:
Biochar mitigates negative effects of salt additions on two herbaceous plant species.
PubMed:
[Preliminary study on breeding system of Prunella vulgaris].
PubMed:
Effect of Chinese herbal medicine extracts on cell-mediated immunity in a rat model of tuberculosis induced by multiple drug-resistant bacilli.
PubMed:
Effects of triterpenic acid from Prunella vulgaris L. on glycemia and pancreas in rat model of streptozotozin diabetes.
PubMed:
Traditional Chinese medicine syndrome-related herbal prescriptions in treatment of malignant tumors.
PubMed:
Prunella vulgaris attenuates prepulse inhibition deficit and attention disruption induced by MK-801 in mice.
PubMed:
[Study on HPLC fingerprint of Prunella vulgaris].
PubMed:
Variation in concentrations of major bioactive compounds in Prunella vulgaris L. related to plant parts and phenological stages.
PubMed:
The inhibitory effect of Prunella vulgaris L. on aldose reductase and protein glycation.
PubMed:
Arbuscular mycorrhizal fungi reduce the differences in competitiveness between dominant and subordinate plant species.
PubMed:
Vanadium pentoxide phytotoxicity: effects of species selection and nutrient concentration.
PubMed:
Prunella vulgaris aqueous extract attenuates IL-1β-induced apoptosis and NF-κB activation in INS-1 cells.
PubMed:
Soil fertilization leads to a decline in between-samples variability of microbial community δ13C profiles in a grassland fertilization experiment.
PubMed:
Anti-diabetic atherosclerosis effect of Prunella vulgaris in db/db mice with type 2 diabetes.
PubMed:
[Experimental study of extract from Prunella vulgaris inducing B, T lymphoma cell apoptosis].
PubMed:
[Complex evaluation for influence of hosts on hemipatasite Thesium chinense].
PubMed:
[Influence of storage period and grading standards on quality of Prunella vulgaris].
PubMed:
The aqueous extract of Prunella vulgaris suppresses cell invasion and migration in human liver cancer cells by attenuating matrix metalloproteinases.
PubMed:
Changes in bioactive components related to the harvest time from the spicas of Prunella vulgaris.
PubMed:
A new unusual delta11(12)-oleane triterpene and anti-complementary triterpenes from Prunella vulgaris spikes.
PubMed:
The effects of glyphosate and aminopyralid on a multi-species plant field trial.
PubMed:
[Analyze on the component of rosmarinic acid in Prunella vulgaris and its effect on alpha-glycosidase activity].
PubMed:
[Study on content and distribution characteristics of mineral elements from cultivated and wild Prunella vulgaris].
PubMed:
[Absorption and allocation of nitrogen, phosphorus, potassium in Prunella vulgaris and their relationship to dry matter accumulation].
PubMed:
Prunella vulgaris suppresses HG-induced vascular inflammation via Nrf2/HO-1/eNOS activation.
PubMed:
[Textual research on original plant and dietotherapy history of Prunella vulgaris].
PubMed:
[Effect of optimized fertilization on spicas biomass and yield of Prunella vulgaris].
PubMed:
Medicinal plants: a public resource for metabolomics and hypothesis development.
PubMed:
Chemopreventive effect of a mixture of Chinese Herbs (antitumor B) on chemically induced oral carcinogenesis.
PubMed:
[Effects of light intensity on photosynthetic characteristics and seedling growth of Prunella vulgaris].
PubMed:
Ethanol extract of Prunella vulgaris var. lilacina inhibits HMGB1 release by induction of heme oxygenase-1 in LPS-activated RAW 264.7 cells and CLP-induced septic mice.
PubMed:
A new phenolic glycoside from prunella vulgaris.
PubMed:
Permeability of rosmarinic acid in Prunella vulgaris and ursolic acid in Salvia officinalis extracts across Caco-2 cell monolayers.
PubMed:
Variation in the Breeding System of Prunella vulgaris L.
PubMed:
[Dynamic change of active component content in different parts of Prunella vulgaris].
PubMed:
Evaluation of the anti-neuraminidase activity of the traditional Chinese medicines and determination of the anti-influenza A virus effects of the neuraminidase inhibitory TCMs in vitro and in vivo.
PubMed:
[Influence of nitrogen forms ratio on growth and photosynthetic characteristics in Prunella vulgaris].
PubMed:
Oleanolic acid from Prunella Vulgaris L. induces SPC-A-1 cell line apoptosis via regulation of Bax, Bad and Bcl-2 expression.
PubMed:
Inhibition of HIV-1 infection by aqueous extracts of Prunella vulgaris L.
PubMed:
Determination of phenolic compounds in Prunella L. by liquid chromatography-diode array detection.
PubMed:
Apoptogenic activity of 2α,3α-dihydroxyurs-12-ene-28-oic acid from Prunella vulgaris var. lilacina is mediated via mitochondria-dependent activation of caspase cascade regulated by Bcl-2 in human acute leukemia Jurkat T cells.
PubMed:
Screening of traditional Chinese medicinal plants for quorum-sensing inhibitors activity.
PubMed:
Chemoprevention by Prunella vulgaris L. extract of non-small cell lung cancer via promoting apoptosis and regulating the cell cycle.
PubMed:
Antioxidant activities of total phenols of Prunella vulgaris L. in vitro and in tumor-bearing mice.
PubMed:
[Effect of different water treatments on quality and yield of spadix in Prunella vulgaris].
PubMed:
Phytochemical screening of Prunella vulgaris l. - an important medicinal plant of Kashmir.
PubMed:
Effect of polyacetylenic acids from Prunella vulgaris on various plant pathogens.
PubMed:
Identification of two polysaccharides from Prunella vulgaris L. and evaluation on their anti-lung adenocarcinoma activity.
PubMed:
Screening for anti-lipase properties of 37 traditional Chinese medicinal herbs.
PubMed:
[Research on callus induction and plantlet regeneration of Prunella vulgaris].
PubMed:
Steroid-like compounds in Chinese medicines promote blood circulation via inhibition of Na+/K+ -ATPase.
PubMed:
Anti-invasion effect of rosmarinic acid via the extracellular signal-regulated kinase and oxidation-reduction pathway in Ls174-T cells.
PubMed:
Prunella vulgaris L. Upregulates eNOS expression in human endothelial cells.
PubMed:
[Involvement of JNK and caspase-3 in human lymphoma cell apoptosis induced by Prunella vulgaris].
PubMed:
[Textual research on change of medicinal parts and herbal medicine of Prunella vulgaris].
PubMed:
The ameliorating effect of the extract of the flower of Prunella vulgaris var. lilacina on drug-induced memory impairments in mice.
PubMed:
Suppression of PMA-induced tumor cell invasion and metastasis by aqueous extract isolated from Prunella vulgaris via the inhibition of NF-kappaB-dependent MMP-9 expression.
PubMed:
Rosmarinic acid in Prunella vulgaris ethanol extract inhibits lipopolysaccharide-induced prostaglandin E2 and nitric oxide in RAW 264.7 mouse macrophages.
PubMed:
[Genetic variation, correlation and principle component analysis on morphological characteristics of various germplasm from Prunella vulgaris].
PubMed:
[Effect of water stress on physiological and growth charaters of Prunella vulgaris at the vegetative stage].
PubMed:
Prunella vulgaris extract and rosmarinic acid prevent UVB-induced DNA damage and oxidative stress in HaCaT keratinocytes.
PubMed:
[Study on proteomics of Jurkat cells treated with the extracts from Prunella vulgaris].
PubMed:
[Effects of seed priming on drought tolerence in Prunella vulgaris].
PubMed:
[Effects of seed priming on salt tolerance in Prunella vulgaris seed germination under saline conditions].
PubMed:
[Study on seed quality test and quality standard of Prunella vulgaris].
PubMed:
[Study on HPLC fingerprint of Prunella vulgaris].
PubMed:
Prunella vulgaris extract and rosmarinic acid suppress lipopolysaccharide-induced alteration in human gingival fibroblasts.
PubMed:
Inhibition of lentivirus replication by aqueous extracts of Prunella vulgaris.
PubMed:
Triterpenoic acids of Prunella vulgaris var. lilacina and their cytotoxic activities in vitro.
PubMed:
Immunostimulatory activity of aqueous extract isolated from Prunella vulgaris.
PubMed:
Enhanced analysis of triterpenes, flavonoids and phenolic compounds in Prunella vulgaris L. by capillary zone electrophoresis with the addition of running buffer modifiers.
PubMed:
Characterization of antiestrogenic activity of the Chinese herb, prunella vulgaris, using in vitro and in vivo (Mouse Xenograft) models.
PubMed:
[Study of flavonoids distribution in various populations of Prunella vulgaris].
PubMed:
[Effects of seed priming on vigor of Prunella vulgaris seeds].
PubMed:
[A novel triterpenoid saponin from Prunella vulgaris].
PubMed:
Heme oxygenase-1 inducing constituent of Prunella vulgaris in HepG2 cells.
PubMed:
[Pharmacognostical studies on Prunella vulgaris and Ajuga decumbens].
PubMed:
Induction of glucokinase mRNA by dietary phenolic compounds in rat liver cells in vitro.
PubMed:
HPLC analysis of rosmarinic acid in feed enriched with aerial parts of Prunella vulgaris and its metabolites in pig plasma using dual-channel coulometric detection.
PubMed:
Assessment of comparative pain relief and tolerability of SKI306X compared with celecoxib in patients with rheumatoid arthritis: a 6-week, multicenter, randomized, double-blind, double-dummy, phase III, noninferiority clinical trial.
PubMed:
[Studies on chemical constituents of Prunella vulgaris].
PubMed:
Seasonal dynamics of arbuscular mycorrhizal fungal communities in roots in a seminatural grassland.
PubMed:
Effects of Prunella vulgaris on mast cell-mediated allergic reaction and inflammatory cytokine production.
PubMed:
Chemical properties, mode of action, and in vivo anti-herpes activities of a lignin-carbohydrate complex from Prunella vulgaris.
PubMed:
The structure-activity relationship of the series of non-peptide small antagonists for p56lck SH2 domain.
PubMed:
Antihyperglycemic activity of Prunella vulgaris L. in streptozotocin-induced diabetic mice.
PubMed:
Ethnoveterinary medicines used for ruminants in British Columbia, Canada.
PubMed:
[The experimental research about the effect of Prunella vulgaris L. on Raji cells growth and expression of apoptosis related protein].
PubMed:
Antiviral effect of aqueous extracts from species of the Lamiaceae family against Herpes simplex virus type 1 and type 2 in vitro.
PubMed:
[Studies on germination characteristics of Prunella vulgaris seeds].
PubMed:
Photoprotective properties of Prunella vulgaris and rosmarinic acid on human keratinocytes.
PubMed:
Effects of two Prunella species on lymphocyte proliferation and nitric oxide production.
PubMed:
Parental use of the term "Hot Qi" to describe symptoms in their children in Hong Kong: a cross sectional survey "Hot Qi" in children.
PubMed:
Immune modulatory effects of Prunella vulgaris L. on monocytes/macrophages.
PubMed:
Cytoprotectivity of Prunella vulgaris on doxorubicin-treated rat cardiomyocytes.
PubMed:
Clematis mandshurica protected to apoptosis of rat chondrocytes.
PubMed:
[Establishment of stably expressed human RANTES gene in prunella vulgaris cell clone].
PubMed:
In vitro and in vivo immunosuppressive activity of Spica Prunellae ethanol extract on the immune responses in mice.
PubMed:
Immune modulatory effects of Prunella vulgaris L.
PubMed:
Macleya cordata and Prunella vulgaris in oral hygiene products - their efficacy in the control of gingivitis.
PubMed:
A polysaccharide fraction from medicinal herb Prunella vulgaris downregulates the expression of herpes simplex virus antigen in Vero cells.
PubMed:
Phenolics-rich extracts from Silybum marianum and Prunella vulgaris reduce a high-sucrose diet induced oxidative stress in hereditary hypertriglyceridemic rats.
PubMed:
Biological activities of Prunella vulgaris extract.
PubMed:
Inhibitory effects of rosmarinic acid on Lck SH2 domain binding to a synthetic phosphopeptide.
PubMed:
Post-dispersal seed fates of four prairie species.
PubMed:
Rosmarinic acid inhibits TCR-induced T cell activation and proliferation in an Lck-dependent manner.
PubMed:
Identification of inhibitors of the HIV-1 gp41 six-helix bundle formation from extracts of Chinese medicinal herbs Prunella vulgaris and Rhizoma cibotte.
PubMed:
Effects of SKI 306X, a new herbal agent, on proteoglycan degradation in cartilage explant culture and collagenase-induced rabbit osteoarthritis model.
PubMed:
Effect of SKI 306X, a new herbal anti-arthritic agent, in patients with osteoarthritis of the knee: a double-blind placebo controlled study.
PubMed:
Inhibition of immediate-type allergic reactions by Prunella vulgaris in a murine model.
PubMed:
A comparison of HIV-1 integrase inhibition by aqueous and methanol extracts of Chinese medicinal herbs.
PubMed:
A comparison of human immunodeficiency virus type-1 protease inhibition activities by the aqueous and methanol extracts of Chinese medicinal herbs.
PubMed:
Anti-allergic and anti-inflammatory triterpenes from the herb of Prunella vulgaris.
PubMed:
Extract of Prunella vulgaris spikes inhibits HIV replication at reverse transcription in vitro and can be absorbed from intestine in vivo.
PubMed:
The response of arbuscular mycorrhizae to fertilization, mowing, and removal of dominant species in a diverse oligotrophic wet meadow.
PubMed:
Antioxidative and free radical scavenging activities of selected medicinal herbs.
PubMed:
Isolation and characterization of an anti-HSV polysaccharide from Prunella vulgaris.
PubMed:
Anti-HIV-1 activity of herbs in Labiatae.
PubMed:
[Prunella vulgaris L.--a rediscovered medicinal plant].
PubMed:
[Screening test of crude drug extract on anti-HIV activity].
PubMed:
[Studies on the medicinal plant in the "Sambutsu-cho" of Higo Province possessed by the Kumamoto clan (II): on the medicina herbs].
PubMed:
Mechanism of inhibition of HIV-1 infection in vitro by purified extract of Prunella vulgaris.
PubMed:
[Medicinal Lamiaceae with antioxidant properties, a potential source of rosmarinic acid].
PubMed:
[Anti-HBsAg herbs employing ELISA technique].
PubMed:
[Experimental study of 472 herbs with antiviral action against the herpes simplex virus].
PubMed:
Isolation, purification, and partial characterization of prunellin, an anti-HIV component from aqueous extracts of Prunella vulgaris.
PubMed:
The cytotoxic principles of Prunella vulgaris, Psychotria serpens, and Hyptis capitata: ursolic acid and related derivatives.
PubMed:
Antimutagenic activity of extracts from anticancer drugs in Chinese medicine.