piper methysticum extract

extract of the leaves, roots and stems of the kawa-kawa, piper methysticum, piperaceae kava-kava extract kawa extract PubMed: Fatal kavalactone intoxication by suicidal intravenous injection. PubMed: Flavokawains B and C, melanogenesis inhibitors, isolated from the root of Piper methysticum and synthesis of analogs. PubMed: Measuring the chemical and cytotoxic variability of commercially available kava (Piper methysticum G. Forster). PubMed: Plant-based medicines for anxiety disorders, part 2: a review of clinical studies with supporting preclinical evidence. PubMed: Kava in the treatment of generalized anxiety disorder: a double-blind, randomized, placebo-controlled study. PubMed: Does a medicinal dose of kava impair driving? A randomized, placebo-controlled, double-blind study. PubMed: Toxicology and carcinogenesis studies of kava kava extract (CAS No. 9000-38-8) in F344/N rats and B6C3F1 mice (Gavage Studies). PubMed: [Medicinal plants for the treatment of generalized anxiety disorder: a review of controlled clinical studies]. PubMed: Regulatory causality evaluation methods applied in kava hepatotoxicity: are they appropriate? PubMed: Re-introduction of kava (Piper methysticum) to the EU: is there a way forward? PubMed: Flavokawain B, the hepatotoxic constituent from kava root, induces GSH-sensitive oxidative stress through modulation of IKK/NF-kappaB and MAPK signaling pathways. PubMed: Kava hepatotoxicity: pathogenetic aspects and prospective considerations. PubMed: Cyclodextrins as carriers for kavalactones in aqueous media: spectroscopic characterization of (S)-7,8-dihydrokavain and beta-cyclodextrin inclusion complex. PubMed: Final report on the safety assessment of Piper methysticum leaf/root/stem extract and Piper methysticum root extract. PubMed: The Kava Anxiety Depression Spectrum Study (KADSS): a randomized, placebo-controlled crossover trial using an aqueous extract of Piper methysticum. PubMed: Kava Anxiety Depression Spectrum Study (KADSS): a mixed methods RCT using an aqueous extract of Piper methysticum. PubMed: Discriminative-stimulus and time-course effects of kava-kava (Piper methysticum) in rats. PubMed: Efficacy of extracting solvents to chemical components of kava (Piper methysticum) roots. PubMed: Clinical assessment of CYP2D6-mediated herb-drug interactions in humans: effects of milk thistle, black cohosh, goldenseal, kava kava, St. John's wort, and Echinacea. PubMed: Identification of C-glycoside flavonoids as potential mutagenic compounds in kava. PubMed: Immunohistochemical analysis of expressions of hepatic cytochrome P450 in F344 rats following oral treatment with kava extract. PubMed: Safety of ethanolic kava extract: Results of a study of chronic toxicity in rats. PubMed: Melanogenesis stimulation in murine B16 melanoma cells by Kava (Piper methysticum) rhizome extract and kavalactones. PubMed: Herbicidal and Fungicidal Activities of Lactones in Kava (Piper methysticum). PubMed: HPLC analysis of flavokavins and kavapyrones from Piper methysticum Forst. PubMed: Extracts and kavalactones of Piper methysticum G. Forst (kava-kava) inhibit P-glycoprotein in vitro. PubMed: Determination of six kavalactones in dietary supplements and selected functional foods containing Piper methysticum by isocratic liquid chromatography with internal standard. PubMed: Pharmacokinetic and pharmacodynamic drug interactions with Kava (Piper methysticum Forst. f.). PubMed: Effects of kava (Kava-kava, 'Awa, Yaqona, Piper methysticum) on c-DNA-expressed cytochrome P450 enzymes and human cryopreserved hepatocytes. PubMed: Enhanced cognitive performance and cheerful mood by standardized extracts of Piper methysticum (Kava-kava). PubMed: Kava does not display metabolic toxicity in a homogeneous cellular assay. PubMed: Saccade and cognitive impairment associated with kava intoxication. PubMed: Quantitative elimination of Flavokavines A and B from Kava Kava (Piper methysticum G. Forst) by isoelectric focused adsorptive bubble separation. PubMed: Extracts of kava (Piper methysticum) induce acute anxiolytic-like behavioral changes in mice. PubMed: Isolation and synthesis of TNF-alpha release inhibitors from Fijian kawa (Piper methysticum). PubMed: Identification of novel electrophilic metabolites of piper methysticum Forst (Kava). PubMed: Anxiolytic properties of Piper methysticum extract samples and fractions in the chick social-separation-stress procedure. PubMed: Kava-Kava administration reduces anxiety in perimenopausal women. PubMed: Saccade and cognitive function in chronic kava users. PubMed: Kava extract for treating anxiety. PubMed: Inhibition of cytochrome P450 3A4 by extracts and kavalactones of Piper methysticum (Kava-Kava). PubMed: Anxiolytic-like effects of kava-kava in the elevated plus maze test--a comparison with diazepam. PubMed: Densitometric analysis of kawain in kava-kava root extracts. PubMed: Kava extract for treating anxiety. PubMed: A systematic review of the safety of kava extract in the treatment of anxiety. PubMed: Cyclooxygenase enzyme inhibitory compounds with antioxidant activities from Piper methysticum (kava kava) roots. PubMed: Novel compounds from Piper methysticum Forst (Kava Kava) roots and their effect on cyclooxygenase enzyme. PubMed: Synergy and other interactions in phytomedicines. PubMed: Kava extract for treating anxiety. PubMed: Kava pyrones exert effects on neuronal transmission and transmembraneous cation currents similar to established mood stabilizers--a review. PubMed: Anxiolytic effects of kava extract and kavalactones in the chick social separation-stress paradigm. PubMed: Efficacy of kava extract for treating anxiety: systematic review and meta-analysis. PubMed: Inhibition of platelet MAO-B by kava pyrone-enriched extract from Piper methysticum Forster (kava-kava). PubMed: [Kava-kava preparations--alternative anxiolytics]. PubMed: Electrospray high performance liquid chromatography-mass spectrometry in phytochemical analysis of kava (Piper methysticum) extract. PubMed: Efficacy of a special Kava extract (Piper methysticum) in patients with states of anxiety, tension and excitedness of non-mental origin - A double-blind placebo-controlled study of four weeks treatment. PubMed: Kavapyrone enriched extract from Piper methysticum as modulator of the GABA binding site in different regions of rat brain. PubMed: Effects of oxazepam and an extract of kava roots (Piper methysticum) on event-related potentials in a word recognition task. PubMed: Extract of kava (Piper methysticum) and its methysticin constituents protect brain tissue against ischemic damage in rodents. PubMed: Effect of aqueous and lipid-soluble extracts of kava on the conditioned avoidance response in rats. PubMed: Comparison of the central nervous system activity of the aqueous and lipid extract of kava (Piper methysticum).