sanguinaria canadensis rhizome/root extract

extract of the rhizomes and roots of the blood root, sanguinaria canadensis l., papaveraceae

CAS: 84929-48-6

Identification

Namesanguinaria canadensis rhizome/root extract
IUPACsanguinaria canadensis rhizome/root extract
CAS Number84929-48-6
FDA UNIISearch

Regulatory

Physical Properties

Food Chemicals Codex Listed No

Cosmetic Information

CosIngcosmetic data
Cosmetic Usescleansing agents

No sensory data available

Safety Information

Oral/Parenteral ToxicityNot determined
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorycosmetic agents
Recommendation for sanguinaria canadensis rhizome/root extract usage levels up tonot for fragrance use.
Recommendation for sanguinaria canadensis rhizome/root extract flavor usage levels up tonot for flavor use.

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Potential Uses

cleansing agents refreshing agents skin conditioning FL tonic

Natural Occurrence

sanguinaria canadensis

Synonyms

blood rhizome/root extract bloodroot rhizome/root extract extract of the rhizomes and roots of the blood root, sanguinaria canadensis l., papaveraceae red- puccoon rhizome/root extract sanguinaria australis rhizome/root extract sanguinaria canadensis var. rotundifolia rhizome/root extract sanguinaria dilleniana rhizome/root extract sanguinaria rhizome/root extract PubMed: Bloodroot associated eschar. PubMed: In vitro screening of forty medicinal plant extracts from the United States Northern Great Plains for anthelmintic activity against Haemonchus contortus. PubMed: A review of topical corrosive black salve. PubMed: Hybrid poplar plantations are suitable habitat for reintroduced forest herbs with conservation status. PubMed: Signals can trump rewards in attracting seed-dispersing ants. PubMed: Rapid human melanoma cell death induced by sanguinarine through oxidative stress. PubMed: Bloodroot. PubMed: Efficacy of a non-hormonal treatment, BRN-01, on menopausal hot flashes: a multicenter, randomized, double-blind, placebo-controlled trial. PubMed: Rise and fall of oral health products with Canadian bloodroot extract. PubMed: Sanguinarine induces apoptosis of HT-29 human colon cancer cells via the regulation of Bax/Bcl-2 ratio and caspase-9-dependent pathway. PubMed: Consequences of intratumoral injection of a herbal preparation containing blood root (Sanguinaria canadensis) extract in two dogs. PubMed: The mechanism of action of sanguinarine against methicillin-resistant Staphylococcus aureus. PubMed: An Internet misadventure: bloodroot salve toxicity. PubMed: Bloodroot (Sanguinaria canadensis L., Papaveraceae) Enhances Proliferation and Cytokine Production by Human Peripheral Blood Mononuclear Cells in an In Vitro Model. PubMed: Sanguinarine sensitizes human gastric adenocarcinoma AGS cells to TRAIL-mediated apoptosis via down-regulation of AKT and activation of caspase-3. PubMed: Human blood mononuclear cell in vitro cytokine response before and after two different strenuous exercise bouts in the presence of bloodroot and Echinacea extracts. PubMed: In vitro screening for the tumoricidal properties of international medicinal herbs. PubMed: Sanguinarine-induced apoptosis in human leukemia U937 cells via Bcl-2 downregulation and caspase-3 activation. PubMed: Histopathologic findings and diagnostic difficulties posed with use of escharotic agents for treatment of skin lesions: a case report and review of the literature. PubMed: Treating hot flushes in menopausal women with homeopathic treatment--results of an observational study. PubMed: Sanguinarine-induced apoptosis: generation of ROS, down-regulation of Bcl-2, c-FLIP, and synergy with TRAIL. PubMed: Effects of aqueous extracts from five species of the family Papaveraceae on selected aquatic organisms. PubMed: Induction of apoptosis by sanguinarine in C6 rat glioblastoma cells is associated with the modulation of the Bcl-2 family and activation of caspases through downregulation of extracellular signal-regulated kinase and Akt. PubMed: Sanguinarine inhibits VEGF-induced angiogenesis in a fibrin gel matrix. PubMed: Sanguinarine inhibits VEGF-induced Akt phosphorylation. PubMed: HPLC quantification of seven quaternary benzo[c]phenanthridine alkaloids in six species of the family Papaveraceae. PubMed: The plant alkaloid sanguinarine is a potential inhibitor of follicular angiogenesis. PubMed: Variability in the yield of benzophenanthridine alkaloids in wildcrafted vs cultivated bloodroot (Sanguinaria canadensis L.). PubMed: Induction of necrosis and apoptosis to KB cancer cells by sanguinarine is associated with reactive oxygen species production and mitochondrial membrane depolarization. PubMed: Antiplatelet effect of sanguinarine is correlated to calcium mobilization, thromboxane and cAMP production. PubMed: Sanguinarine causes cell cycle blockade and apoptosis of human prostate carcinoma cells via modulation of cyclin kinase inhibitor-cyclin-cyclin-dependent kinase machinery. PubMed: Suppression of angiogenesis by the plant alkaloid, sanguinarine. PubMed: Dual inhibition of 5-lipoxygenase/cyclooxygenase by a reconstituted homeopathic remedy; possible explanation for clinical efficacy and favourable gastrointestinal tolerability. PubMed: Forest edges and fire ants alter the seed shadow of an ant-dispersed plant. PubMed: Activation of prodeath Bcl-2 family proteins and mitochondrial apoptosis pathway by sanguinarine in immortalized human HaCaT keratinocytes. PubMed: In vitro susceptibility of Helicobacter pylori to isoquinoline alkaloids from Sanguinaria canadensis and Hydrastis canadensis. PubMed: Consequences of using escharotic agents as primary treatment for nonmelanoma skin cancer. PubMed: Capillary electrophoresis of phytochemical substances. PubMed: The evaluation of forty-three plant species for in vitro antimycobacterial activities; isolation of active constituents from Psoralea corylifolia and Sanguinaria canadensis. PubMed: Environmental and genotypic influences on isoquinoline alkaloid content in Sanguinaria canadensis. PubMed: Elevational trends in defense chemistry, vegetation, and reproduction in Sanguinaria canadensis. PubMed: Sanguinarine induces K+ outflow from yeast cells expressing mammalian sodium pumps. PubMed: Involvement of protein kinase and G proteins in the signal transduction of benzophenanthridine alkaloid biosynthesis. PubMed: Immunoblot analyses of the elicited Sanguinaria canadensis enzyme, dihydrobenzophenanthridine oxidase: evidence for resolution from a polyphenol oxidase isozyme. PubMed: Elicitation of dihydrobenzophenanthridine oxidase in Sanguinaria canadensis cell cultures. PubMed: Quercetin-induced benzophenanthridine alkaloid production in suspension cell cultures of Sanguinaria canadensis. PubMed: Isolation and Characterization of S-Adenosyl-L-Methionine:Tetrahydroberberine-cis-N-Methyltransferase from Suspension Cultures of Sanguinaria canadensis L. PubMed: Differential enhancement of benzophenanthridine alkaloid content in cell suspension cultures of Sanguinaria canadensis under conditions of combined hormonal deprivation and fungal elicitation. PubMed: Purification and characterization of dihydrobenzophenanthridine oxidase from elicited Sanguinaria canadensis cell cultures. PubMed: Growth characteristics of Sanguinaria canadensis L. cell suspensions and immobilized cultures for production of benzophenanthridine alkaloids. PubMed: Characterization of Sanguinaria canadensis L. fluid extract by FAB mass spectrometry. PubMed: The history, chemistry and pharmacokinetics of Sanguinaria extract. PubMed: Antimicrobial action of sanguinarine. PubMed: Short-term toxicity studies of sanguinarine and of two alkaloid extracts of Sanguinaria canadensis L. PubMed: Plant tyrosine decarboxylase can be strongly inhibited by L-α-aminooxy-β-phenylpropionate. PubMed: Sanguinarine: a positive inotropic alkaloid which inhibits cardiac Na+,K+-ATPase. PubMed: Biological and phytochemical evaluation of plants. 8. Isolation of a new alkaloid from Sanguinaria canadensis. PubMed: [Separation of sanguinarine and chelerythrine and additional plant bases of Sanguinaria canadensis]. PubMed: ALKALOIDS FROM SANGUINARIA CANADENSIS AND THEIR INFLUENCE ON GROWTH OF PHYMATOTRICHUM OMNIVORUM.