butenafine hydrochloride
N-4-tert-butylbenzyl-N-methyl-1-naphthalenemethylamine hydrochloride
Identification
| Name | butenafine hydrochloride |
| IUPAC | 1-(4-tert-butylphenyl)-N-methyl-N-(naphthalen-1-ylmethyl)methanamine;hydrochloride |
| CAS Number | 101827-46-7 |
| FDA UNII | R8XA2029ZI |
| Molecular Formula | C23 H28 Cl N |
| Molecular Weight | 353.93516000 |
| MDL Number | MFCD00917064 |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Flash Point | 32.00 °F. TCC ( 0.00 °C. ) (est) |
No sensory data available
Safety Information
| Preferred SDS | View |
| Oral/Parenteral Toxicity | oral-dog LD50 > 5000 mg/kg |
| Dermal Toxicity | skin-dog LD50 > 100 mg/kg |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | pharmaceuticals / chemical synthisis |
| Recommendation for butenafine hydrochloride usage levels up to | not for fragrance use. |
| Recommendation for butenafine hydrochloride flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
butenafine HCl
N-4-tert-
butylbenzyl-N-methyl-1-naphthalenemethylamine hydrochloride
N-(p-tert-
butylbenzyl)-N-methyl-1-naphthalenemethylamine hydrochloride
1-(4-tert-
butylphenyl)-N-methyl-N-(naphthalen-1-ylmethyl)methanamine;hydrochloride
N-((4-(1,1-
dimethylethyl)phenyl)methyl)-N-methyl-1-naphthalenemethanamine hydrochloride
KP-363
mentax
mentax-TC
1-
naphthalenemethanamine, N-((4-(1,1-dimethylethyl)phenyl)methyl)-N-methyl-, hydrochloride
PubMed:
Tinea nigra presenting speckled or "salt and pepper" pattern.
PubMed:
Influence of penetration enhancers and molecular weight in antifungals permeation through bovine hoof membranes and prediction of efficacy in human nails.
PubMed:
Efficacy of topical antifungals in the treatment of dermatophytosis: a mixed-treatment comparison meta-analysis involving 14 treatments.
PubMed:
Determination of butenafine hydrochloride in human plasma by liquid chromatography electrospray ionization-mass spectrometry following its topical administration in human subjects.
PubMed:
Stability-indicating LC assay for butenafine hydrochloride in creams using an experimental design for robustness evaluation and photodegradation kinetics study.
PubMed:
RP-HPLC method for simultaneous determination of butenafine hydrochloride and betamethasone dipropionate in a cream formulation.
PubMed:
A simple and rapid method to assess butenafine hydrochloride in skin samples and a comparative cutaneous retention study of two marketed formulations.
PubMed:
Simultaneous HPLC determination of butenafine hydrochloride and betamethasone in a cream formulation.
PubMed:
Butenafine and superficial mycoses: current status.
PubMed:
A Japanese case of tinea corporis caused by Arthroderma benhamiae.
PubMed:
Butenafine hydrochloride (Mentax) cream for the treatment of hyperkeratotic type tinea pedis and its transfer into the horny layer, with or without concomitant application of 20% urea ointment (Keratinamin).
PubMed:
Comparison of in vitro antifungal activities of topical antimycotics launched in 1990s in Japan.
PubMed:
Butenafine hydrochloride: for the treatment of interdigital tinea pedis.
PubMed:
Treatment of toenail onychomycosis with 2% butenafine and 5% Melaleuca alternifolia (tea tree) oil in cream.
PubMed:
Management of toenail onychomycosis with 2% butenafine and 20% urea cream: a placebo-controlled, double-blind study.
PubMed:
A randomized trial to assess once-daily topical treatment of tinea corporis with butenafine, a new antifungal agent.
PubMed:
Butenafine 1% cream in the treatment of tinea cruris: a multicenter, vehicle-controlled, double-blind trial.
PubMed:
One-week therapy with twice-daily butenafine 1% cream versus vehicle in the treatment of tinea pedis: a multicenter, double-blind trial.
PubMed:
Treatment of interdigital tinea pedis with a 4-week once-daily regimen of butenafine hydrochloride 1% cream.
PubMed:
Two mechanisms of butenafine action in Candida albicans.
PubMed:
[Synthesis and antifungal activity of butenafine hydrochloride (KP-363), a new benzylamine antifungal agent].
PubMed:
Effects of butenafine hydrochloride, a new benzylamine derivative, on experimental tinea pedis in guinea pigs.
PubMed:
Effects of butenafine hydrochloride, a new benzylamine derivative, on experimental dermatophytosis in guinea pigs.