nordazepam

2H-1,4- benzodiazepin-2-one, 1,3-dihydro-7-chloro-5-phenyl- 2H-1,4- benzodiazepin-2-one, 7-chloro-1,3-dihydro-5-phenyl- calmday 7- chlor-2,3-dihydro-5-phenyl-1H-1,4-benzodiazepin-2-on chlordesmethyldiazepam 7- chloro-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-one 7- chloro-5-phenyl-1,3-dihydro-1,4-benzodiazepin-2-one dealkylprazepam demadar 1- demethyldiazepam N- demethyldiazepam N- deoxydemoxapam N- deoxydemoxepam desalkylprazepam N- descyclopropylmethylprazepam desmethyldiazepam N- desmethyldiazepam N1- desmethyldiazepam DMDZ lomax madar nordazepamum nordiazepam norprazepam sopax stilny vegesan PubMed: Quantification of five compounds with heterogeneous physicochemical properties (morphine, 6-monoacetylmorphine, cyamemazine, meprobamate and caffeine) in 11 fluids and tissues, using automated solid-phase extraction and gas chromatography-tandem mass spectrometry. PubMed: Urinary diazepam metabolite distribution in a chronic pain population. PubMed: Direct determination of diazepam and its glucuronide metabolites in human whole blood by μElution solid-phase extraction and liquid chromatography-tandem mass spectrometry. PubMed: Diazepam and its metabolites in the mothers' and newborns' hair as a biomarker of prenatal exposure. PubMed: An air-tolerant approach to the carbonylative Suzuki-Miyaura coupling: applications in isotope labeling. PubMed: Concentrations of drugs determined in blood samples collected from suspected drugged drivers in England and Wales. PubMed: The potential of forensic analysis on human bones found in riverine environment. PubMed: Evaluation of plasma diazepam and nordiazepam concentrations following administration of diazepam intravenously or via suppository per rectum in dogs. PubMed: Blood drug concentrations of benzodiazepines correlate poorly with actual driving impairment. PubMed: Sensitive UPLC-MS-MS assay for 21 benzodiazepine drugs and metabolites, zolpidem and zopiclone in serum or plasma. PubMed: Concentrations of diazepam and nordiazepam in 1,000 blood samples from apprehended drivers--therapeutic use or abuse of anxiolytics? PubMed: Muscle relaxants for pain management in rheumatoid arthritis. PubMed: Combined occlusal and pharmacological therapy in the treatment of temporo-mandibular disorders. PubMed: Gas chromatography-tandem mass spectrometry assay for the quantification of four benzodiazepines and citalopram in eleven postmortem rabbit fluids and tissues, with application to animal and human samples. PubMed: Detection and validated quantification of 21 benzodiazepines and 3 "z-drugs" in human hair by LC-MS/MS. PubMed: Pharmacokinetics of diazepam administered intramuscularly by autoinjector versus rectal gel in healthy subjects: a phase I, randomized, open-label, single-dose, crossover, single-centre study. PubMed: Comparison by means of bispectral index score, between anxiolysis induced by diazepam and sedation induced by midazolam. PubMed: Pharmacokinetics of the cytochrome P-450 substrates phenytoin, theophylline, and diazepam in healthy Greyhound dogs. PubMed: Folie à deux: double case-report of shared delusions with a fatal outcome. PubMed: Reduction of temazepam to diazepam and lorazepam to delorazepam during enzymatic hydrolysis. PubMed: Diazepam pharmacokinetics after nasal drop and atomized nasal administration in dogs. PubMed: Biotransformation of diazepam in a clinically relevant flat membrane bioreactor model using primary porcine hepatocytes. PubMed: A novel reductive transformation of oxazepam to nordiazepam observed during enzymatic hydrolysis. PubMed: Electronic properties of neuroleptics: ionization energies of benzodiazepines. PubMed: Simultaneous determination and quantification of 12 benzodiazepines in serum or whole blood using UPLC/MS/MS. PubMed: LC-MS/MS analysis of 13 benzodiazepines and metabolites in urine, serum, plasma, and meconium. PubMed: Quantitation of benzodiazepines in blood and urine using gas chromatography-mass spectrometry (GC-MS). PubMed: Measurement of benzodiazepines in urine by liquid chromatography-tandem mass spectrometry: confirmation of samples screened by immunoassay. PubMed: Effects of organic solvents on the time-dependent inhibition of CYP3A4 by diazepam. PubMed: Simultaneous analysis of diazepam and its metabolites in rat plasma and brain tissue by HPLC-UV and SPE. PubMed: [Mechanisms of opioid-induced overdose: experimental approach to clinical concerns]. PubMed: Quantification of chlordesmethyldiazepam by liquid chromatography-tandem mass spectrometry: application to a cloxazolam bioequivalence study. PubMed: Cardiac and peripheral blood similarities in the comparison of nordiazepam and bromazepam blood concentrations. PubMed: Alleged breaches of "standards of medical care" in a patient overdose death possibly related to chronic opioid analgesic therapy, application of the controlled substances model guidelines: case report. PubMed: Two compartment model of diazepam biotransformation in an organotypical culture of primary human hepatocytes. PubMed: Determination of diazepam and its metabolites in human urine by liquid chromatography/tandem mass spectrometry using a hydrophilic polymer column. PubMed: Fatal intoxication with milnacipran. PubMed: New high-performance liquid chromatographic method for serum analysis of oxazepam: application to bioequivalence and pharmacokinetic study. PubMed: Fatal intoxication with labetalol (Trandate). PubMed: Thiodicarb and methomyl tissue distribution in a fatal multiple compounds poisoning. PubMed: Bioavailability and dose proportionality of intramuscular diazepam administered by autoinjector. PubMed: Massive intoxication involving unusual high concentration of amitriptyline. PubMed: Voriconazole and fluconazole increase the exposure to oral diazepam. PubMed: Concentrations of scheduled prescription drugs in blood of impaired drivers: considerations for interpreting the results. PubMed: LC-MS-MS analysis of 2,4-dinitrophenol and its phase I and II metabolites in a case of fatal poisoning. PubMed: Highlights on new food research. PubMed: A sensitive and selective method for the detection of diazepam and its main metabolites in urine by gas chromatography-tandem mass spectrometry. PubMed: Optimized determination of lorazepam in human serum by extraction and high-performance liquid chromatographic analysis. PubMed: Medicolegal aspects of tetrazepam metabolism. PubMed: Liquid chromatographic-electrospray ionization mass spectrometric quantitative analysis of buprenorphine, norbuprenorphine, nordiazepam and oxazepam in rat plasma. PubMed: Fast in vivo microextraction: a new tool for clinical analysis. PubMed: Date-rape drugs scene in Poland. PubMed: Quantification of benzodiazepines in whole blood and serum. PubMed: Papain: a novel urine adulterant. PubMed: Hair analysis by liquid chromatography-tandem mass spectrometry in toxicological investigation of drug-facilitated crimes: report of 128 cases over the period June 2003-May 2004 in metropolitan Paris. PubMed: Fast, simple, and validated gas chromatographic-mass spectrometric assay for quantification of drugs relevant to diagnosis of brain death in human blood plasma samples. PubMed: Development and validation of a liquid chromatographic/electrospray ionization mass spectrometric method for the quantitation of prazepam and its main metabolites in human plasma. PubMed: High concentrations of diazepam and nordiazepam in blood of impaired drivers: association with age, gender and spectrum of other drugs present. PubMed: Screening, library-assisted identification and validated quantification of 23 benzodiazepines, flumazenil, zaleplone, zolpidem and zopiclone in plasma by liquid chromatography/mass spectrometry with atmospheric pressure chemical ionization. PubMed: Combined sedation with oral chlordemethyldiazepam and midazolam by nasal route in third molar surgery. PubMed: Distribution of diazepam and nordiazepam between plasma and whole blood and the influence of hematocrit. PubMed: Toxicological data and growth characteristics of single post-feeding larvae and puparia of Calliphora vicina (Diptera: Calliphoridae) obtained from a controlled nordiazepam study. PubMed: Coexistence and concentrations of ethanol and diazepam in postmortem blood specimens: risk for enhanced toxicity? PubMed: Buprenorphine in drug-facilitated sexual abuse: a fatal case involving a 14-year-old boy. PubMed: Ximelagatran, an oral direct thrombin inhibitor, has a low potential for cytochrome P450-mediated drug-drug interactions. PubMed: Effects of diazepam and its metabolites on nocturnal melatonin secretion in the rat pineal and Harderian glands. A comparative in vivo and in vitro study. PubMed: Evaluation of the novel antiepileptic drug, AWD 131-138, for benzodiazepine-like discriminative stimulus and reinforcing effects in squirrel monkeys. PubMed: Fatal accident caused by isoflurane abuse. PubMed: Interpretations of the TDxFLx calibration data of the abused drugs. PubMed: Quantitation using GC-TOF-MS: example of bromazepam. PubMed: Bio-compatible in-tube solid-phase microextraction capillary for the direct extraction and high-performance liquid chromatographic determination of drugs in human serum. PubMed: Alcohol and benzodiazepines in fatal poisonings. PubMed: SPME-LC with UV detection to study delorazepam-serum albumin interactions. PubMed: Sensitive method for the detection of 22 benzodiazepines by gas chromatography-ion trap tandem mass spectrometry. PubMed: [Fatal outcome of poisoning with the benzodiazepines flunitrazepam and diazepam]. PubMed: Determination of delorazepam in urine by solid-phase microextraction coupled to high performance liquid chromatography. PubMed: Direct determination of benzodiazepines in biological fluids by restricted-access solid-phase microextraction. PubMed: Binding of [3H]CB 34, a selective ligand for peripheral benzodiazepine receptors, to rat brain membranes. PubMed: Direct LC analysis of five benzodiazepines in human urine and plasma using an ADS restricted access extraction column. PubMed: A contemporaneous finding of fenproporex in a polydrug suicide. PubMed: The simultaneous determination of diazepam and its three metabolites in dog plasma by high-performance liquid chromatography with mass spectroscopy detection. PubMed: Urinary excretion of diazepam metabolites in healthy volunteers and drug users. PubMed: Diazepam poisoning with one-month monitoring of diazepam and nordiazepam blood levels. PubMed: Screening, identification and quantitation of benzodiazepines in serum by solid phase extraction on a cyanopropyl phase using high performance liquid chromatography and photodiode array detection. PubMed: Liquid-phase microextraction as a sample preparation technique prior to capillary gas chromatographic-determination of benzodiazepines in biological matrices. PubMed: Fatal intoxication with melperone. PubMed: A modified simple and rapid reversed phase liquid chromatographic method for quantification of diazepam and nordiazepam in plasma. PubMed: Influence of bleaching on stability of benzodiazepines in hair. PubMed: Benzodiazepines and postoperative cognitive dysfunction in the elderly. ISPOCD Group. International Study of Postoperative Cognitive Dysfunction. PubMed: Prolonged sedation requiring mechanical ventilation and continuous flumazenil infusion after routine doses of clorazepam for alcohol withdrawal syndrome. PubMed: Effect of the gene dosage of CgammaP2C19 on diazepam metabolism in Chinese subjects. PubMed: Effect of dipotassium clorazepate on amygdaloid-kindling and comparison between amygdaloid- and hippocampal-kindled seizures in rats. PubMed: Distribution of topiramate in a medical examiner's case. PubMed: Sigmoidal kinetic model for two co-operative substrate-binding sites in a cytochrome P450 3A4 active site: an example of the metabolism of diazepam and its derivatives. PubMed: The urinary elimination profiles of diazepam and its metabolites, nordiazepam, temazepam, and oxazepam, in the equine after a 10-mg intramuscular dose. PubMed: Determination of benzodiazepines in human urine and plasma with solvent modified solid phase micro extraction and gas chromatography; rationalisation of method development using experimental design strategies. PubMed: [Possibilities for toxicologic evidence in adipocere formation and postmortem interval of several years]. PubMed: Benzodiazepines: toxic serum concentrations in positive enzyme immunoassay responses. PubMed: Rapid and simple chromatographic method for the determination of diazepam and its major metabolites in human plasma and urine. PubMed: Peripheral benzodiazepine receptor messenger RNA is decreased in lymphocytes of generalized anxiety disorder patients. PubMed: The effect of chronic benzodiazepines exposure on body weight in rats. PubMed: Role of cDNA-expressed human cytochromes P450 in the metabolism of diazepam. PubMed: Pilot investigation of thyrotropin-releasing hormone-induced thyrotropin and prolactin release in anxious patients treated with diazepam. PubMed: Comparison of single- and repeated-dose pharmacokinetics of diazepam. PubMed: Benzodiazepine-like compounds in the plasma of patients with fulminant hepatic failure. PubMed: Naltrexone effects on diazepam intoxication and pharmacokinetics in humans. PubMed: Diagnostic performance of the EMIT-tox benzodiazepine immunoassay, FPIA serum benzodiazepine immunoassay, and radioreceptor assay in suspected acute poisoning. PubMed: Application of microdialysis to study the in vitro metabolism of drugs in liver microsomes. PubMed: A fatality due to moclobemide. PubMed: Age-related changes in the pharmacokinetic disposition of diazepam in foals. PubMed: Paroxetine efficacy in the treatment of generalized anxiety disorder. PubMed: Detection of benzodiazepines and other psychotropic drugs in human hair by GC/MS. PubMed: Abnormal ventricular repolarization mimicking myocardial infarction after heterocyclic antidepressant overdose. PubMed: Effect of sertraline on the pharmacokinetics and protein binding of diazepam in healthy volunteers. PubMed: Benzodiazepine misuse by drug addicts. PubMed: Evidence against oppositional and pharmacokinetic mechanisms of tolerance to diazepam's sedative effects. PubMed: Automation of toxicological screenings on a Hewlett Packard Chemstation GC-MS system. PubMed: Extraction of selected drugs from serum using microwave irradiation. PubMed: Assessment of diazepam loading dose therapy of delirium tremens. PubMed: Reduction of oxazepam to desmethyldiazepam by human intestinal bacteria. PubMed: Hair analysis for nordiazepam and oxazepam by gas chromatography--negative-ion chemical ionization mass spectrometry. PubMed: [Benzodiazepines in geriatrics--a case report on prolonged action]. PubMed: [Detection of nordiazepam in the hair of drug addicts]. PubMed: Lymphatic bioavailability of diazepam and desmethyldiazepam in the rat. PubMed: [Determination of diazepam concentration in maternal and fetal serum after intravenous administration during active phase of labor and its effects on neonates]. PubMed: Absorption of diazepam after its rectal administration in dogs. PubMed: Flumazenil, diazepam, nordiazepam and oxazepam interactions on plasma protein binding. PubMed: Comparison of the interaction potential of a new proton pump inhibitor, E3810, versus omeprazole with diazepam in extensive and poor metabolizers of S-mephenytoin 4'-hydroxylation. PubMed: Interethnic difference in omeprazole's inhibition of diazepam metabolism. PubMed: Flunitrazepam and nordiazepam slowly released from silastic capsules induce physical dependence in rat. PubMed: Development and preliminary application of high-performance liquid chromatographic assay of urinary metabolites of diazepam in humans. PubMed: Acid-base equilibria of 1,4-benzodiazepine 4-oxides by spectrophotometry. PubMed: Premedication with chlordemethyldiazepam and anxiolytic effect of diazepeam in implantology. PubMed: [Determination of N-demethyldiazepam and its metabolite oxazepam in plasma by HPLC and their pharmacokinetics in rats]. PubMed: [Comparison of the effectiveness of orally administered clorazepate dipotassium and nordiazepam on preoperative anxiety]. PubMed: Behavioral and metabolic consequences of neonatal exposure to diazepam in rat pups. PubMed: Effects of liver disease on the pharmacokinetics of intravenous and oral chlordesmethyldiazepam. PubMed: Lack of low Km diazepam N-demethylase in livers of poor metabolizers for S-mephenytoin 4'-hydroxylation. PubMed: Inhibition of diazepam metabolism by fluvoxamine: a pharmacokinetic study in normal volunteers. PubMed: Metabolic and subjective responses to oral diazepam and midazolam. PubMed: Diazepam metabolism by human liver microsomes is mediated by both S-mephenytoin hydroxylase and CYP3A isoforms. PubMed: [Electroencephalographic demonstration of central nervous system effects of different premedication regimens]. PubMed: [Preanesthesia in elderly patients undergoing subarachnoid anesthesia: chlordesmethyldiazepam versus diazepam]. PubMed: Radioiodinated nordiazepam analog for in vivo assessment of benzodiazepine receptors by single photon emission tomography. PubMed: Relationship between plasma benzodiazepine receptor ligand concentrations and severity of hepatic encephalopathy. PubMed: Mesolimbic dopamine turnover effects of benzodiazepines do not correlate with sedative and muscle-relaxant potencies. PubMed: Pharmacokinetic differences of desmethyldiazepam in three outbred Wistar strains related to differences in liver enzyme activities. PubMed: Immunoassay detection of nordiazepam, triazolam, lorazepam, and alprazolam in blood. PubMed: Analysis of oxazepam in urine using solid-phase extraction and high-performance liquid chromatography with fluorescence detection by post-column derivatization. PubMed: Determination of plasma diazepam and desmethyldiazepam by solid-phase extraction and reversed-phase high-performance liquid chromatography. PubMed: Effects of a 44-day administration of phenobarbital on disposition of clorazepate in dogs. PubMed: Kinetics of sequential metabolism. II. Formation and metabolism of nordiazepam and oxazepam from diazepam in the perfused murine liver. PubMed: Kinetics of sequential metabolism. I. Formation and metabolism of oxazepam from nordiazepam and temazepam in the perfused murine liver. PubMed: Pharmacokinetics of nordiazepam in physical dependence and precipitated abstinence in dogs. PubMed: Solid-phase extraction of 1,4-benzodiazepines from biological fluids. PubMed: Inhibitory effect of diltiazem on diazepam metabolism in the mouse hepatic microsomes. PubMed: Subjective and behavioral effects of diazepam depend on its rate of onset. PubMed: Studies of "endogenous" benzodiazepine in human hepatic encephalopathy. PubMed: Studies on the excretion of diazepam and nordazepam into milk for the prediction of milk-to-plasma drug concentration ratios. PubMed: Quantitation by gas chromatography with selected-ion monitoring mass spectrometry of "natural" diazepam, N-desmethyldiazepam and oxazepam in normal human serum. PubMed: Incidence of S-mephenytoin hydroxylation deficiency in a Korean population and the interphenotypic differences in diazepam pharmacokinetics. PubMed: Determination of nonderivatized para-hydroxylated metabolites of diazepam in biological fluids with a GC Megabore column system. PubMed: Diazepam metabolism by rat and human liver in vitro: inhibition by mephenytoin. PubMed: The effects of felodipine on the pharmacokinetics of diazepam. PubMed: Comparative metabolism of clinically important precursors of N-desmethyldiazepam using phenobarbitone-pretreated rat liver microsomes. PubMed: Benzodiazepine metabolism in ethanol-treated male rats: use of pair-fed and age-matched controls. PubMed: Niaprazine vs chlordesmethyldiazepam in sleep disturbances in pediatric outpatients. PubMed: Effect of benzodiazepines on tryptophan binding to rat hepatic nuclei. PubMed: Serum disposition of oral clorazepate from regular-release and sustained-delivery tablets in dogs. PubMed: [Monitoring of diazepam treatment: comparison of the results of gas chromatography and radioreceptor methods]. PubMed: Pharmacokinetics of diazepam intramuscularly administered to rhesus monkeys. PubMed: Chronic administration of and dependence on halazepam, diazepam, and nordiazepam in the dog. PubMed: Elevated brain concentrations of 1,4-benzodiazepines in fulminant hepatic failure. PubMed: Effect of orally administered misoprostol and cimetidine on the steady state pharmacokinetics of diazepam and nordiazepam in human volunteers. PubMed: Amnestic effects of intravenous diazepam in healthy young men. PubMed: Differences in the duration of sedative and anxiolytic effects of desmethyldiazepam in two outbred Wistar strains. PubMed: Determination of diazepam and nordazepam in milk and plasma in the presence of oxazepam and temazepam. PubMed: Characterization by saturation studies of the in vivo binding of [3H]flunitrazepam in mouse brain. PubMed: Pharmacokinetic profiles of prazepam and 14C-prazepam in rat. PubMed: Pharmacokinetics of intravenous and oral chlordesmethyldiazepam in patients on regular haemodialysis. PubMed: Distribution of diazepam, nordiazepam, and oxazepam between brain extraneuronal space, brain tissue, plasma, and cerebrospinal fluid in diazepam and nordiazepam dependent dogs. PubMed: Disposition of clorazepate in dogs after single- and multiple-dose oral administration. PubMed: A death due to self-administered fentanyl. PubMed: Benzodiazepine-induced antagonism of opioid antinociception may be abolished by spinalization or blockade of the benzodiazepine receptor. PubMed: Ciprofloxacin does not impair the elimination of diazepam in humans. PubMed: Depressive stupor and chlordesmethyldiazepam. PubMed: [Antagonism with flumazenil of sedation by benzodiazepine during loco-regional anesthesia]. PubMed: Liquid chromatographic assay and pharmacokinetics of halazepam and its metabolite in humans. PubMed: Diazepam loading in alcohol withdrawal: clinical pharmacokinetics. PubMed: Cytochrome P450IIIA enzymes in rat liver microsomes: involvement in C3-hydroxylation of diazepam and nordazepam but not N-dealkylation of diazepam and temazepam. PubMed: Depressive stupor treated with intramuscular chlordesmethyldiazepam. PubMed: Effect of omeprazole and cimetidine on plasma diazepam levels. PubMed: Effects of single doses of alprazolam and diazepam, alone and in combination with ethanol, on psychomotor and cognitive performance and on autonomic nervous system reactivity in healthy volunteers. PubMed: Effect of chronic oral delorazepam on in vitro and in vivo hepatic drug-metabolizing enzyme activities in the rat. PubMed: Excretion of diazepam and its metabolites in human milk during withdrawal from combination high dose diazepam and oxazepam. PubMed: Effect of omeprazole treatment on diazepam plasma levels in slow versus normal rapid metabolizers of omeprazole. PubMed: Determination of pharmacodynamics of diazepam by quantitative pharmaco-EEG. PubMed: Bioinequivalence of a generic brand of diazepam. PubMed: A large-sample study of diazepam pharmacokinetics. PubMed: [Control of the side effects of ketamine: chlordemethyldiazepam vs diazepam in pre-anesthesia]. PubMed: In vitro drug metabolism and pharmacokinetics of diazepam in cynomolgus monkey hepatocytes during culture for six days. PubMed: Effect of the benzodiazepines diazepam, des-N-methyldiazepam and midazolam on corticosteroid biosynthesis in bovine adrenocortical cells in vitro; location of site of action. PubMed: Detection of desmethyldiazepam and diazepam in brain of different species and plants. PubMed: Physical dependence on diazepam in the dog: precipitation of different abstinence syndromes by the benzodiazepine receptor antagonists Ro 15-1788 and ZK 93426. PubMed: Importance of genetic factors in the regulation of diazepam metabolism: relationship to S-mephenytoin, but not debrisoquin, hydroxylation phenotype. PubMed: A rapid HPLC procedure for the simultaneous determination of chloroquine, monodesethylchloroquine, diazepam, and nordiazepam in blood. PubMed: Efficacy of flumazenil in COPD patient with therapeutic diazepam levels. PubMed: [Chlordesmethyldiazepam and prolactinemia during surgical stress]. PubMed: Placental transfer and distribution of pinazepam and its metabolite N-desmethyldiazepam in the maternal and fetal rabbit: effect of the stage of gestation. PubMed: Double-blind placebo cross-over study of long-acting (chlordesmethyldiazepam) versus short-acting (lorazepam) benzodiazepines in generalized anxiety disorders. PubMed: Toxicity in a case of acute and massive overdose of chlordiazepoxide and its correlation to blood concentration. PubMed: Radioreceptor assay of clonazepam and diazepam in blood for therapeutic drug monitoring. PubMed: Benzodiazepines: are they of natural origin? PubMed: Clorazepate, correlation between metabolism and anticonvulsant activity. PubMed: [A ketamine-chlordemethyldiazepam combination in celioscopy]. PubMed: Studies of cyclodextrin inclusion complexes: II--Inclusion complexes between alpha-cyclodextrin and N-desmethyldiazepam and chlordiazepoxide. PubMed: Sensitive determination of diazepam and N-desmethyldiazepam in human material using capillary gas chromatography-mass spectrometry. PubMed: [Screening of the new benzodiazepine derivative, pinazepan, and its major metabolites]. PubMed: Comparative single-dose kinetics and dynamics of lorazepam, alprazolam, prazepam, and placebo. PubMed: [Use of a chlordemethyldiazepam-fentanyl combination in invasive neuroradiologic examinations]. PubMed: Desmethyldiazepam pharmacokinetics: studies following intravenous and oral desmethyldiazepam, oral clorazepate, and intravenous diazepam. PubMed: Metabolism of diazepam in vitro by human liver. Independent variability of N-demethylation and C3-hydroxylation. PubMed: Kinetics of drug action in disease states. XXV. Effect of experimental hypovolemia on the pharmacodynamics and pharmacokinetics of desmethyldiazepam. PubMed: Effects of HOE 760 (histamine H2-receptor antagonist) on diazepam pharmacokinetics. PubMed: [Potentiating drugs in postoperative pain control with opiates for patient controlled analgesia]. PubMed: Precipitation of abstinence in nordiazepam- and diazepam-dependent dogs. PubMed: The effect of fluoxetine on the pharmacokinetics and psychomotor responses of diazepam. PubMed: Effect of food on absorption of chlordemethyldiazepam. PubMed: Kinetics of drug action in disease states. XXIV. Pharmacodynamics of diazepam and its active metabolites in rats. PubMed: Endogenous benzodiazepines in brain: right or wrong? PubMed: Improved method for the determination of diazepam and N-desmethyldiazepam in plasma using capillary gas chromatography and nitrogen-phosphorus detection. PubMed: [Effects of chlordemethyldiazepam on blood cortisol during surgical stress]. PubMed: Pharmacokinetics and bioavailability of intravenous and oral chlordesmethyldiazepam in humans. PubMed: Comparison of sublingual and oral prazepam in normal subjects. II. Pharmacokinetic and pharmacodynamic data. PubMed: Imipramine treatment alters the pharmacokinetics and pharmacodynamics of diazepam. PubMed: Identification and differentiation of benzodiazepines and their metabolites in urine by computerized gas chromatography-mass spectrometry. PubMed: Simultaneous determination of diazepam and its active metabolites in rat serum, brain and cerebrospinal fluid by high-performance liquid chromatography. PubMed: Analysis of chlorodesmethyldiazepam and its metabolites in plasma and urine. PubMed: The effect of diazepam on nociception in mice. PubMed: Placental and blood-CSF transfer of orally administered diazepam in the same person. PubMed: Validation of a radioreceptor assay technique for monitoring pharmacological active material during intensive diazepam tetanus therapy. PubMed: Effects of propranolol, atenolol, and chlordesmethyldiazepam on response to mental stress in patients with recent myocardial infarction. PubMed: Diazepam and desmethyldiazepam differ in their affinities and efficacies at 'central' and 'peripheral' benzodiazepine receptors. PubMed: Microsample determination of diazepam and its three metabolites in serum by reversed-phase high-performance liquid chromatography. PubMed: [Premedication for endoscopic examinations with intravenous administration of chlordesmethyldiazepam. A controlled double-blind study with diazepam and placebo]. PubMed: Nocturnal doses of ranitidine and nizatidine do not affect the disposition of diazepam. PubMed: Apparent lesser physical dependence potential of nor-diazepam compared to diazepam in the rat. PubMed: Differences in diazepam pharmacokinetics in Chinese and white Caucasians--relation to body lipid stores. PubMed: Diazepam and N-desmethyldiazepam are found in rat brain and adrenal and may be of plant origin. PubMed: [Chlordesmethyldiazepam as an anesthesia-inducing agent: time of loss of consciousness. Statistical analysis in man]. PubMed: Purification of a benzodiazepine from bovine brain and detection of benzodiazepine-like immunoreactivity in human brain. PubMed: Influence of propranolol coadministration or cigarette smoking on the kinetics of desmethyldiazepam following intravenous clorazepate. PubMed: Diazepam and methadone blood levels following concurrent administration of diazepam and methadone. PubMed: [Determination of diazepam and its metabolites in the blood by microcolumn high-performance liquid chromatography]. PubMed: Serum concentrations of diazepam and its metabolite desmethyldiazepam in epileptic patients after chronic diazepam treatment. PubMed: Potencies of diazepam metabolites in rats trained to discriminate diazepam. PubMed: Pharmacokinetics of chlordesmethyldiazepam after single-dose oral administration in humans. PubMed: P-450 activity in monolayer cultures of hepatocytes seeded in polystyrene tissue culture dishes. PubMed: [Epilepsy induced by penicillin in rabbits: comparative study of the anticonvulsant effects of diazepam and chlordesmethyldiazepam]. PubMed: The effect of diazepam on indices of 5-HT function in man. PubMed: Aging: changes in distribution of diazepam and metabolites in the rat. PubMed: Interaction of diazepam with famotidine and cimetidine, two H2-receptor antagonists. PubMed: The pharmacological profile of chlordesmethyldiazepam and other benzodiazepines. PubMed: Acute tolerance to diazepam in mice: pharmacokinetic considerations. PubMed: Premedication with oral and rectal diazepam. PubMed: Screening and quantification of hypnotic sedatives in serum by capillary gas chromatography with a nitrogen-phosphorus detector, and confirmation by capillary gas chromatography-mass spectrometry. PubMed: Diazepam metabolism in the guinea pig materno-fetal model: effects of cigarette smoke. PubMed: The pharmacokinetics of diazepam and desmethyldiazepam in rat brain and plasma. PubMed: Preliminary study of the pharmacokinetics of desmethyldiazepam administered as drops or tablets. PubMed: Age-related multiple-dose pharmacokinetics and anxiolytic effects of delorazepam (chlordesmethyldiazepam). PubMed: Disruption of schedule-controlled behavior by Ro 15-1788 one day after acute treatment with benzodiazepines. PubMed: Omeprazole inhibits oxidative drug metabolism. Studies with diazepam and phenytoin in vivo and 7-ethoxycoumarin in vitro. PubMed: [Effects of intravenous administration of chlordesmethyldiazepam on paroxysmal intercritical activity in various electroclinical forms of infantile epilepsy]. PubMed: Tissue distribution of diazepam and its metabolite desmethyldiazepam: a human autopsy study. PubMed: N-desmethyldiazepam physical dependence in dogs. PubMed: Development of tolerance to the anticonvulsant effect of diazepam in amygdala-kindled rats. PubMed: Discriminative-stimulus effects of midazolam in squirrel monkeys: comparison with other drugs and antagonism by Ro 15-1788. PubMed: Severe withdrawal syndrome after substitution of a short-acting benzodiazepine for a long-acting benzodiazepine. PubMed: Liquid-chromatographic assay of diazepam and its major metabolites in serum, and application to pharmacokinetic study of high doses of diazepam in schizophrenics. PubMed: [Efficacy and kinetics of chlorazepate administered to anxious patients in a single daily dose]. PubMed: Responsiveness to oral diazepam in the elderly: relationship to total and free plasma concentrations. PubMed: Effects of caffeine and chlor-desmethyldiazepam on fighting behavior of mice with different reactivity baselines. PubMed: [Effect of sodium valproate on brain levels of diazepam and N-desmethyldiazepam in the rat]. PubMed: Effect of clorazepate in spasticity and rigidity: a quantitative study of reflexes and plasma concentrations. PubMed: Plasma concentrations of diazepam and N-desmethyldiazepam in Asian children after an intravenous or rectal dose of diazepam. PubMed: Long-lasting anticonvulsant effects of diazepam in different mouse strains: correlations with brain concentrations and receptor occupancy. PubMed: Diazepam and desmethyldiazepam in breast milk. PubMed: Inhibition of diazepam metabolism in microsomal- and perfused liver preparations of the rat by desmethyldiazepam, N-methyloxazepam and oxazepam. PubMed: Implications of dosing tricyclic antidepressants and benzodiazepines in geriatrics. PubMed: Withdrawal responses to abrupt discontinuation of desmethyldiazepam. PubMed: Diazepam tapering in detoxification for high-dose benzodiazepine abuse. PubMed: Propranolol interactions with diazepam, lorazepam, and alprazolam. PubMed: In vitro interaction of diazepam and oxazepam with pancuronium and suxamethonium. PubMed: Comparative single-dose kinetics of oxazolam, prazepam, and clorazepate: three precursors of desmethyldiazepam. PubMed: Plasma concentrations and clinical effects after single oral doses of prazepam, clorazepate, and diazepam. PubMed: Development of tolerance to the anticonvulsant effect of diazepam in dogs. PubMed: Value of serum diazepam and nordiazepam measurements in anxious patients. PubMed: Clinical importance of the interaction of diazepam and cimetidine. PubMed: Multiple-dose halazepam kinetics. PubMed: Diazepam and desmethyldiazepam plasma concentrations in chronic anxious outpatients. PubMed: Pharmacokinetics of diazepam and nordiazepam in the cat. PubMed: Cimetidine interaction with dipotassium clorazepate disposition in the anesthetized dog. PubMed: The contribution of the active metabolites to the tolerance developing to diazepam in man: relationship to bioassayed serum benzodiazepine levels. 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