mefenamic acid
anthranilic acid, N-2,3-xylyl-
Identification
| Name | mefenamic acid |
| IUPAC | 2-(2,3-dimethylanilino)benzoic acid |
| CAS Number | 61-68-7 |
| EINECS | 200-513-1 |
| FDA UNII | 367589PJ2C |
| Molecular Formula | C15 H15 N O2 |
| Molecular Weight | 241.28995000 |
| MDL Number | MFCD00051721 |
| Nikkaji Number | J2.344B |
| Beilstein | 2216243 |
| XlogP3 | 5.10 (est) |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Melting Point | 230.00 °C. @ 760.00 mm Hg |
| Boiling Point | 398.80 °C. @ 760.00 mm Hg (est) |
| Flash Point | 383.00 °F. TCC ( 195.00 °C. ) (est) |
| logP (o/w) | 5.120 |
| Soluble in | water, 20 mg/L @ 30 °C (exp) |
No sensory data available
Safety Information
| Preferred SDS | View |
| Oral/Parenteral Toxicity | intravenous-cat LD50 100 mg/kg |
| Dermal Toxicity | subcutaneous-mouse LDLo > 2000 mg/kg |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements', 'BEHAVIORAL: ATAXIA\nBEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)\nLUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION']
Safety in Use
| Category | pharmaceuticals / chemical synthisis |
| Recommendation for mefenamic acid usage levels up to | not for fragrance use. |
| Recommendation for mefenamic acid flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
acidum mefenamicum
anthranilic acid, N-(2,3-xylyl)-
anthranilic acid, N-2,3-xylyl-
bafameritin-M
bafhameritin-M
benzoic acid, 2-((2,3-dimethylphenyl)amino)-
benzoic acid, 2-(2,3-dimethylphenyl)amino-
bonabol
CI-473
CL 473
CN 35355
CN-35355
coslan
2-(2,3-
dimethylanilino)benzoic acid
2-((2,3-
dimethylphenyl)amino)benzoic acid
N-(2,3-
dimethylphenyl)anthranilic acid
2-
diphenylaminecarboxylic acid, 2',3'-dimethyl-
fenamin
lysalgo
mefacit
mefedolo
mefenamate
mephenamic acid
mephenaminic acid
methenamic acid
mycasaal
namphen
parkemed
ponalar
ponstan
ponstan forte
ponstel
rolan
tanston
vialidon
N-(2,3-
xylyl)-2-aminobenzoic acid
N-2,3-
xylylanthranilic acid
PubMed:
Synthesis, structure and biological activity of nickel(II) complexes with mefenamato and nitrogen-donor ligands.
PubMed:
Multi-residue analytical methodology-based liquid chromatography-time-of-flight-mass spectrometry for the analysis of pharmaceutical residues in surface water and effluents from sewage treatment plants and hospitals.
PubMed:
The determination of pharmaceutical residues in cooked and uncooked marine bivalves using pressurised liquid extraction, solid-phase extraction and liquid chromatographyâtandem mass spectrometry.
PubMed:
Validation of a liquid chromatography method for the simultaneous determination of several nonsteroidal anti-inflammatory drugs in human plasma for therapeutic drug monitoring.
PubMed:
The determination of pharmaceutical residues in cooked and uncooked marine bivalves using pressurised liquid extraction, solid-phase extraction and liquid chromatography-tandem mass spectrometry.
PubMed:
Development and validation of a confirmatory method for the determination of 12 non steroidal anti-inflammatory drugs in milk using liquid chromatography-tandem mass spectrometry.
PubMed:
Simultaneous determination of 20 pharmacologically active substances in cow's milk, goat's milk, and human breast milk by gas chromatography-mass spectrometry.
PubMed:
A wild blueberry-enriched diet (Vaccinium angustifolium) improves vascular tone in the adult spontaneously hypertensive rat.
PubMed:
Confirmatory analysis of non-steroidal anti-inflammatory drugs in bovine milk by high-performance liquid chromatography with fluorescence detection.
PubMed:
Dietary enrichment with wild blueberries (Vaccinium angustifolium) affects the vascular reactivity in the aorta of young spontaneously hypertensive rats.
PubMed:
Confirmatory identification of sixteen non-steroidal anti-inflammatory drug residues in raw milk by liquid chromatography coupled with ion trap mass spectrometry.
PubMed:
Inhibition of sulfotransferases by xenobiotics.
PubMed:
Determination of glabridin in human plasma by solid-phase extraction and LC-MS/MS.
PubMed:
The "high solubility" definition of the current FDA Guidance on Biopharmaceutical Classification System may be too strict for acidic drugs.
PubMed:
[Variance of bioavailability of pharmaceutical preparations and analysis of factors affecting it].
PubMed:
In vivo selectivity of nonsteroidal antiinflammatory drugs and gastrointestinal ulcers in rats.
PubMed:
[In vivo selectivity of nonsteroidal anti-inflammatory drugs on COX-1-COX-2 and gastrointestinal ulcers, in rats].
PubMed:
Experimental renal papillary necrosis in the Syrian hamster.
PubMed:
Thromboxane synthesis inhibitors and postprandial jejunal capillary exchange capacity.
PubMed:
Effects of food on absorption of mefenamic acid from two commercial capsules differing in bioavailability under the fasting state.
PubMed:
Bioavailability of mefenamic acid: influence of food and water intake.
PubMed:
The effects of mefenamic acid on postprandial intestinal carbohydrate metabolism.
PubMed:
Prostaglandin synthesis inhibition and postprandial intestinal hyperemia.