ortho-salicylic acid

2-hydroxybenzoic acid

CAS: 69-72-7 C7 H6 O3 MW: 138.12242000 nutty

Identification

Nameortho-salicylic acid
IUPAC2-hydroxybenzoic acid
CAS Number69-72-7
EINECS200-712-3
FDA UNIIO414PZ4LPZ
Molecular FormulaC7 H6 O3
Molecular Weight138.12242000
MDL NumberMFCD00002439
Nikkaji NumberJ2.370A
Beilstein0774890
CoE Number10165
XlogP32.30 (est)

Regulatory

JECFA Food Flavoring958 2-hydroxybenzoic acid
DG SANTE Food Flavourings08.112 o-salicylic acid
DG SANTE Food Contact Materialso-salicylic acid
FEMA Number3985
FDANo longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm (SATF)69-72-7 ; SALICYLIC ACID
FDA RegulationFDA PART 175 -- INDIRECT FOOD ADDITIVES: ADHESIVES AND COMPONENTS OF COATINGS

Physical Properties

Appearance white powder (est)
Assay 99.00 to 100.00
Food Chemicals Codex Listed No
Melting Point 158.00 to 161.00 °C. @ 760.00 mm Hg
Boiling Point 211.00 °C. @ 20.00 mm Hg, 336.00 to 337.00 °C. @ 760.00 mm Hg
Vapor Pressure 1.000000 mmHg @ 114.00 °C.
Vapor Density 4.8 ( Air = 1 )
Flash Point > 212.00 °F. TCC ( > 100.00 °C. )
logP (o/w) 2.260
Soluble in alcohol

Cosmetic Information

CosIngcosmetic data
Cosmetic Usesantidandruff agents

Organoleptic Properties

Odor Description at 100.00 %.

Safety Information

Preferred SDSView
European informationMost important hazard(s):
Oral/Parenteral Toxicityoral-rat LD50 891 mg/kg
Dermal Toxicityskin-rabbit LD50 > 10000 mg/kg
Inhalation Toxicityinhalation-rat LC50 > 900 mg/m3/1H

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorystabilizing agents
Recommendation for ortho-salicylic acid usage levels up tonot for fragrance use.
Maximised Survey-derived Daily Intakes (MSDI-EU)0.024 (μg/capita/day)
Maximised Survey-derived Daily Intakes (MSDI-USA)0.03 (μg/capita/day)
Structure ClassI
baked goods-
beverages(nonalcoholic)5.00000
beverages(alcoholic)10.00000
breakfast cereal-
cheese-
chewing gum-
condiments / relishes-
confectionery froastings-
egg products-
fats / oils-
fish products-
frozen dairy10.00000
fruit ices10.00000
gelatins / puddings-
granulated sugar-
gravies-
hard candy-
imitation dairy-
instant coffee / tea-
jams / jellies10.00000
meat products-
milk products5.00000
nut products-
other grains-
poultry-
processed fruits-
processed vegetables-
reconstituted vegetables-
seasonings / flavors-
snack foods-
soft candy-
soups-
sugar substitutes-
sweet sauces-

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Potential Uses

antidandruff agents bacteriostatic FR castoreum fungicide hair conditioning keratolytics preservatives skin conditioning

Natural Occurrence

anise seed barley shoot beet root bilberry leaf broccoli asparagus broccoli leaf cashew fruit cassia plant chamomile sweet false chamomile plant cotton root currant red currant fruit evening-primrose plant garlic bulb grape hull husk grape leaf grape root meadow sweet pea plant peanut seed pennyroyal raspberry red raspberry fruit raspberry red raspberry plant sage plant soybean seed sunflower seed tarragon leaf tea leaf wheat seed ylang ylang

Synonyms

acidum salicylicum amiperfect amipreserve benzoic acid, 2-hydroxy- benzoic acid, o-hydroxy- 2- carboxyphenol o- carboxyphenol ortho- carboxyphenol compound W domerine duofilm duoplant fostex freezone 2- hydroxy-benzoic acid 2- hydroxybenzene carboxylic acid 2- hydroxybenzenecarboxylic acid 2- hydroxybenzoic acid o- hydroxybenzoic acid ortho- hydroxybenzoic acid phenol-2-carboxylic acid retarder W 2- salicylic acid o- salicylic acid salicylic acid crystalline/powder salicylic acid natural salicylic acid USP crystal salicylic acid USP powder saligel salonil sebucare verrugon PubMed: Effects of salicylic acid and putrescine on storability, quality attributes and antioxidant activity of plum cv. 'Santa Rosa'. J-Stage: Cellulase Applied to the Leaves of Sweet Pepper (Capsicum annuum L. var. grossum) Upregulates the Production of Salicylic and Azelaic Acids PubMed: Effects of postharvest salicylic acid dipping on Alternaria rot and disease resistance of jujube fruit during storage. PubMed: After-ripening induced transcriptional changes of hormonal genes in wheat seeds: the cases of brassinosteroids, ethylene, cytokinin and salicylic acid. PubMed: Evaluation of the pharmacological properties of salicylic acid-derivative organoselenium: 2-hydroxy-5-selenocyanatobenzoic acid as an anti-inflammatory and antinociceptive compound. PubMed: Toxicology of isoproturon to the food crop wheat as affected by salicylic acid. PubMed: Eugenol enhances the resistance of tomato against tomato yellow leaf curl virus. PubMed: Reciprocal crosstalk between jasmonate and salicylate defence-signalling pathways modulates plant volatile emission and herbivore host-selection behaviour. PubMed: Application of Tb(4)O(7) nanoparticles for lasalocid and salicylate determination in food analysis. PubMed: A systemic response of geophytes is demonstrated by patterns of protein expression and the accumulation of signal molecules in Zantedeschia aethiopica. PubMed: Biotic elicitors effectively increase the glucosinolates content in Brassicaceae sprouts. PubMed: Opening of Iris flowers is regulated by endogenous auxins. PubMed: The effects of host defence elicitors on betacyanin accumulation in Amaranthus mangostanus seedlings. PubMed: Two centrosymmetric dinuclear phenanthroline-copper(II) complexes with 3,5-dichloro-2-hydroxybenzoic acid and 5-chloro-2-hydroxybenzoic acid. PubMed: Influence of elicitation with H₂O₂ on phenolics content, antioxidant potential and nutritional quality of Lens culinaris sprouts. PubMed: Novel interrelationship between salicylic acid, abscisic acid, and PIP2-specific phospholipase C in heat acclimation-induced thermotolerance in pea leaves. PubMed: [Changes in H2O2 and salicylic acid contents as well as plasma membrane H+-ATPase activity and their relations in pea leaves during thermotolerance induction]. PubMed: Phenolic Compounds from Halimodendron halodendron (Pall.) Voss and Their Antimicrobial and Antioxidant Activities. PubMed: Hydrogen peroxide scavenging, antioxidant and anti-radical activity of some phenolic acids. PubMed: Nematicidal activity of mint aqueous extracts against the root-knot nematode Meloidogyne incognita. PubMed: Anti-inflammatory drugs selectively target sporangium development in Mucor. PubMed: New CE-ESI-MS analytical method for the separation, identification and quantification of seven phenolic acids including three isomer compounds in virgin olive oil. PubMed: Effect of chemical systemic acquired resistance elicitors on avenanthramide biosynthesis in oat (Avena sativa). PubMed: Determination of the antioxidant capacity of active food packagings by in situ gas-phase hydroxyl radical generation and high-performance liquid chromatography-fluorescence detection. PubMed: Effect of external stress on density and size of glandular trichomes in full-grown Artemisia annua, the source of anti-malarial artemisinin. PubMed: Pleiotropic changes in Arabidopsis f5h and sct mutants revealed by large-scale gene expression and metabolite analysis. PubMed: Aspirin inhibits secretagogue-stimulated and postprandial pancreatic exocrine secretion in conscious rats. PubMed: Multi-substrate flavonol O-glucosyltransferases from strawberry (Fragaria x ananassa) achene and receptacle. PubMed: Benzothiadiazole induces the accumulation of phenolics and improves resistance to powdery mildew in strawberries. PubMed: Phenolic acid profiles in some small berries. PubMed: Salicylate activity. 3. Structure relationship to systemic acquired resistance. PubMed: Chemical marker for ALS-inhibitor herbicides: 2-aminobutyric acid proportional in sub-lethal applications. PubMed: Development of a yeast bio-assay to screen anti-mitochondrial drugs. PubMed: Inhibition of pancreatic lipase by phenolic acids--examination in vitro. PubMed: Valine pathway is more crucial than phenyl propanoid pathway in regulating capsaicin biosynthesis in Capsicum frutescens mill. PubMed: Metabolic profiling of root exudates of Arabidopsis thaliana. PubMed: Adsorption and Chemical Modification of Phenols on a Silver Surface. PubMed: Is there a role for dietary salicylates in health?