Identification

Nameacetamide
IUPACacetamide
CAS Number60-35-5
EINECS200-473-5
FDA UNII8XOE1JSO29
Molecular FormulaC2 H5 N O
Molecular Weight59.06805000
MDL NumberMFCD00008023
Nikkaji NumberJ2.339F
Beilstein1071207

Regulatory

FEMA Number4251-VOID
FDANo longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm (SATF)60-35-5 ; ACETAMIDE--NLFG

Physical Properties

Appearance white to pale yellow crystalline powder (est)
Assay 99.00 to 100.00
Food Chemicals Codex Listed No
Melting Point 79.00 to 81.00 °C. @ 760.00 mm Hg
Boiling Point 221.00 to 222.00 °C. @ 760.00 mm Hg
Vapor Pressure 1.000000 mmHg @ 65.00 °C.
Flash Point > 212.00 °F. TCC ( > 100.00 °C. )
logP (o/w) -1.260
Soluble in alcohol
Similar Items note

Cosmetic Information

CosIngcosmetic data
Cosmetic Usesnot used anymore

Organoleptic Properties

Odor Description bland

Safety Information

Preferred SDSView
European informationMost important hazard(s):
Oral/Parenteral Toxicityoral-rat LD50 7000 mg/kg
Dermal Toxicitysubcutaneous-rat LD50 10000 mg/kg
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements', 'LUNGS, THORAX, OR RESPIRATION: DYSPNEA\nBEHAVIORAL: MUSCLE WEAKNESS\nBEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)', 'SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE\nPERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE', 'PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE\nSENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE', 'SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE\nPERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE', 'PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE\nSENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE', 'AUTONOMIC NERVOUS SYSTEM: "SMOOTH MUSCLE RELAXANT (MECHANISM UNDEFINED, SPASMOLYTIC)"\nPERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE)\nCARDIAC: CHANGE IN RATE', 'AUTONOMIC NERVOUS SYSTEM: "SMOOTH MUSCLE RELAXANT (MECHANISM UNDEFINED, SPASMOLYTIC)"\nCARDIAC: CHANGE IN RATE\nPERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE)']

Safety in Use

Categoryfood contact closures with sealing gaskets for food containers
Recommendation for acetamide usage levels up tonot for fragrance use.
baked goods1.00000
beverages(nonalcoholic)-
beverages(alcoholic)-
breakfast cereal0.20000
cheese0.40000
chewing gum-
condiments / relishes0.10000
confectionery froastings1.00000
egg products-
fats / oils0.10000
fish products0.20000
frozen dairy0.40000
fruit ices0.40000
gelatins / puddings-
granulated sugar-
gravies-
hard candy-
imitation dairy-
instant coffee / tea-
jams / jellies-
meat products0.20000
milk products0.40000
nut products-
other grains0.20000
poultry0.20000
processed fruits0.40000
processed vegetables-
reconstituted vegetables-
seasonings / flavors0.10000
snack foods1.00000
soft candy-
soups0.10000
sugar substitutes-
sweet sauces-

BOC Sciences

Best of Chemicals Supplier

Quality supplier of research chemicals and biochemicals including inhibitors, building blocks, GMP Products, impurities and metabolites, APIs for Veterinary, Natural Compounds, ADCs, Stem Cell Molecul...

View All Website 1-631-485-4226 account@bocsci.com

Glentham Life Sciences Ltd

The Chemical, Biochemical & Research Essentials Supplier

Glentham Life Sciences is a supplier of fine chemicals and raw materials with warehousing, laboratories and packaging facilities in the UK.

View All Website +44 (0) 1225 667798 info@glentham.com

Penta International Corporation

Chemistry innovation

At Penta, our products and services help businesses do business better.

View All Website (973) 740-2300 lisaa@pentamfg.com

TCI AMERICA

Moving Your Chemistry Forward

We continuously strive to advance our technology.

View All Website 1-800-423-8616 Sales-US@TCIchemicals.com;

Potential Uses

FL cereal FL cheese FL dairy FL fish FR fruit FL meat

Natural Occurrence

beet root not found in nature

Synonyms

acetic acid amide ethanamide formamide, methyl- methane carboxamide methanimidic acid, methyl- methylcarbylamine mono methylformamide methylimidoformic acid PubMed: Pellet cryopreservation for chicken semen: effects of sperm working concentration, cryoprotectant concentration, and equilibration time during in vitro processing. PubMed: The postprandial plasma rye fingerprint includes benzoxazinoid-derived phenylacetamide sulfates. PubMed: Inhibition of β-N-acetylglucosaminidase by acetamide affects sperm motility and fertilization success of rainbow trout (Oncorhynchus mykiss) and Siberian sturgeon (Acipenser baerii). PubMed: The TRPA1 agonist, methyl syringate suppresses food intake and gastric emptying. PubMed: Ammoxidation of lignocellulosic materials: formation of nonheterocyclic nitrogenous compounds from monosaccharides. PubMed: Can the unauthorised use of ceftiofur be detected in poultry? PubMed: Synthesis and anticonvulsant and antidepressant activity of 2-(5-bromo-2,3-dioxoindolin)-N-substituted phenylacetamide derivatives. PubMed: Comparative analysis of flagellin glycans among pathovars of phytopathogenic Pseudomonas syringae. PubMed: Hydroxylated phenylacetamides derived from bioactive benzoxazinoids are bioavailable in humans after habitual consumption of whole grain sourdough rye bread. PubMed: Molecular and behavioral pharmacology of two novel orally-active 5HT2 modulators: potential utility as antipsychotic medications. PubMed: SEPALLATA1/2-suppressed mature apples have low ethylene, high auxin and reduced transcription of ripening-related genes. PubMed: Biodegradation of butachlor by Rhodococcus sp. strain B1 and purification of its hydrolase (ChlH) responsible for N-dealkylation of chloroacetamide herbicides. PubMed: Inclusion of 1-naphthylacetic acid and 2-(1-naphthyl)acetamide into three typical multiresidue methods for LC/MS/MS analysis of tomatoes and zucchini. PubMed: New nitrogen-containing bromophenols from the marine red alga Rhodomela confervoides and their radical scavenging activity. PubMed: Isolation, identification and characterization of human intestinal bacteria with the ability to utilize chloramphenicol as the sole source of carbon and energy. PubMed: Radiation dosimetry and biodistribution of the TSPO ligand 11C-DPA-713 in humans. PubMed: Forced degradation study of thiocolchicoside: characterization of its degradation products. PubMed: Assessment of liquid chromatography-tandem mass spectrometry approaches for the analysis of ceftiofur metabolites in poultry muscle. PubMed: Activity of meadowfoam (Limnanthes alba) seed meal glucolimnanthin degradation products against soilborne pathogens. PubMed: Discriminating multiple impacts of biogas residues amendment in selectively decontaminating chloroacetanilide herbicides. PubMed: Biodegradation of chloroacetamide herbicides by Paracoccus sp. FLY-8 in vitro. PubMed: Fate and efficacy of metolachlor granular and emulsifiable concentrate formulations in a conservation tillage system. PubMed: T-type calcium channel antagonism decreases motivation for nicotine and blocks nicotine- and cue-induced reinstatement for a response previously reinforced with nicotine. PubMed: A concise synthesis of 1,4-dihydro-[1,4]diazepine-5,7-dione, a novel 7-TM receptor ligand core structure with melanocortin receptor agonist activity. PubMed: Antagonist selective modulation of adenosine A1 and A3 receptor pharmacology by the food dye Brilliant Black BN: evidence for allosteric interactions. PubMed: Identification of Pseudomonas aeruginosa in water-bottling plants on the basis of procedures included in ISO 16266:2006. PubMed: Reduction in metolachlor and degradate concentrations in shallow groundwater through cover crop use. PubMed: Reactivity of 1-deoxy-D-erythro-hexo-2,3-diulose: a key intermediate in the maillard chemistry of hexoses. PubMed: 2-[(2,3-dihydro-1H-indol-1-yl)methyl]melatonin analogues: a novel class of MT2-selective melatonin receptor antagonists. PubMed: Runoff and leaching of metolachlor from Mississippi River alluvial soil during seasons of average and below-average rainfall. PubMed: 2-Chloro-N,N-diphenyl-acetamide. PubMed: Characterization of metabolites of fungicidal cymoxanil in a sensitive strain of Botrytis cinerea. PubMed: A dose-ranging study of the pharmacokinetics and pharmacodynamics of the selective apoptotic antineoplastic drug (SAAND), OSI-461, in patients with advanced cancer, in the fasted and fed state. PubMed: The conversion of chicken manure to bio-oil by fast pyrolysis. III. Analyses of chicken manure, bio-oils and char by Py-FIMS and Py-FDMS. PubMed: Suitability of two laboratory testing methods to evaluate the side effects of pesticides on Typhlodromus pyri Scheuten (Acari: Phytoseiidae). PubMed: Synthesis and antimicrobial activity of some derivatives of (7-hydroxy-2-oxo-2H-chromen-4-yl)-acetic acid hydrazide. PubMed: Detection of Pseudomonas aeruginosa in water samples using a novel synthetic medium and impedimetric technology. PubMed: Cytotoxicity of chloroacetanilide herbicide alachlor in HepG2 cells independent of CYP3A4 and CYP3A7. PubMed: Effects of atypical anxiolytic N-phenyl-2-[1-[3-(2-pyridinylethynyl)benzoyl]-4-piperidine]acetamide (JNJ-5234801) on alcohol intake in alcohol-preferring P rats. PubMed: Identification of metabolites produced from N-phenylpiperazine by Mycobacterium spp. PubMed: One-pot synthesis of macrocycles by a tandem three-component reaction and intramolecular [3+2] cycloaddition. PubMed: Felinine stability in the presence of selected urine compounds. PubMed: Degradation of chloroacetanilide herbicides by anodic fenton treatment. PubMed: QSAR models for Daphnia magna toxicity prediction of benzoxazinone allelochemicals and their transformation products. PubMed: Joint action of benzoxazinone derivatives and phenolic acids. PubMed: Degradation of alachlor in natural and sludge-amended soils, studied by gas and liquid chromatography coupled to mass spectrometry (GC-MS and HPLC-MS). PubMed: Synthesis of new benzoxazinone derivatives as neuropeptide Y5 antagonists for the treatment of obesity. PubMed: Effect of processing on Celecoxib and its solvates. PubMed: [Modafinil and fatigue in multiple sclerosis]. PubMed: Application of micellar electrokinetic capillary chromatography to the analysis of uncharged pesticides of environmental impact. PubMed: Kinetic evidence related to substrate-assisted catalysis of family 18 chitinases. PubMed: Kinetics and mechanism of the nucleophilic displacement reactions of chloroacetanilide herbicides: investigation of alpha-substituent effects. PubMed: Kinetics and mechanism of cymoxanil degradation in buffer solutions. PubMed: Reaction mechanism of chitobiose phosphorylase from Vibrio proteolyticus: identification of family 36 glycosyltransferase in Vibrio. PubMed: Indole derivatives produced by the fungus Colletotrichum acutatum causing lime anthracnose and postbloom fruit drop of citrus. PubMed: Multilaboratory trial for determination of ceftiofur residues in bovine and swine kidney and muscle, and bovine milk. PubMed: Determination of triazine and chloroacetanilide herbicides in soils by microwave-assisted extraction (MAE) coupled to gas chromatographic analysis with either GC-NPD or GC-MS. PubMed: Analysis and detection of the herbicides dimethenamid and flufenacet and their sulfonic and oxanilic acid degradates in natural water. PubMed: Runoff and drainage losses of atrazine, metribuzin, and metolachlor in three water management systems. PubMed: NMR and MS analysis of decomposition compounds produced from N-acetyl-L-glutamine at low pH. PubMed: Comparison of enzyme-linked immunosorbent assay and gas chromatography procedures for the detection of cyanazine and metolachlor in surface water samples. PubMed: Tillage, intercrop, and controlled drainage-subirrigation influence atrazine, metribuzin, and metolachlor loss. PubMed: Development of a gas chromatographic method for fungicide cymoxanil analysis in dried hops. PubMed: Prediction of interindividual variation in drug plasma levels in vivo from individual enzyme kinetic data and physiologically based pharmacokinetic modeling. PubMed: Structural influences in relative sorptivity of chloroacetanilide herbicides on soil. PubMed: Pressurized fluid extraction for quantitative recovery of chloroacetanilide and nitrogen heterocyclic herbicides in soil. PubMed: Photodegradation of metolachlor: isolation, identification, and quantification of monochloroacetic acid. PubMed: Methylene group modifications of the N-(Isothiazol-5-yl)phenylacetamides. Synthesis and insecticidal activity. PubMed: Identification of the major urinary and fecal metabolites of 3,5-dinitrobenzamide in chickens and rats. PubMed: A novel, selective synthetic acetamide containing culture medium for isolating Pseudomonas aeruginosa from milk. PubMed: Metabolism of metolachlor by the fungus Cunninghamella elegans. PubMed: Effects of anticonvulsants in a novel operant learning paradigm in rats: comparison of remacemide hydrochloride and FPL 15896AR to other anticonvulsant agents. PubMed: Determination of ephedrine, pseudoephedrine, and norephedrine in mixtures (bulk and dosage forms) by proton nuclear magnetic resonance spectroscopy. PubMed: Friedländer synthesis of the food carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine. PubMed: Purification and characterization of an amidase from an acrylamide-degrading Rhodococcus sp. PubMed: Oncogenicity studies of the cognition-enhancing agent nefiracetam in mice and rats. PubMed: Drug dependence study of the new cognition-enhancing agent nefiracetam in rats. PubMed: Reproductive toxicity studies of the new cognition-enhancing agent nefiracetam in rats and rabbits. PubMed: Thirteen-week oral toxicity study of the new cognition-enhancing agent nefiracetam in dogs. PubMed: Evaluation of neuroprotection and behavioral recovery by the kappa-opioid, PD117302 following transient forebrain ischemia. PubMed: Enhancement of the prophagic but not of the antidipsogenic effect of U-50, 488H after chronic amphetamine. PubMed: An analytical study of antibacterial residues in meat: the simultaneous determination of 23 antibiotics and 13 drugs using gas chromatography. PubMed: Single- and multiple-dose pharmacokinetics of nefiracetam, a new nootropic agent, in healthy volunteers. PubMed: Metabolism of acrylonitrile by Klebsiella pneumoniae. PubMed: Rapid and uniform electromagnetic heating of aqueous cryoprotectant solutions from cryogenic temperatures. PubMed: A synthetic, selective culture medium for Pseudomonas aeruginosa. PubMed: Inhibition of spontaneous growth and induced differentiation of murine erythroleukaemia cells by paraquat and atrazine. PubMed: Orally administered kappa but not mu opiate agonists enhance gastric emptying of a solid canned food meal in dogs. PubMed: Discriminative stimulus properties of physostigmine in rats. PubMed: The kappa agonists PD117302 and U50488 produce a biphasic effect on 24 hour food intake in the rat. PubMed: Simultaneous gas chromatographic determination of carboxylic acids in soft drinks and jams. PubMed: Pharmacokinetics of acetohydroxamic acid in patients with staghorn renal calculi. PubMed: Metabolism of AC 206,784 herbicide [2-chloro-N-(2,3-dimethylphenyl)-N-(1-methylethyl)acetamide] in soybean plants. PubMed: Residues of the plant growth regulator mefluidide [N-[2,4]dimethy-5-[[(trifluoromethyl)sulfonyl]amino]phenyl]acetamide] in the milk and tissues of lactating dairy cows: a 28-day feeding study. PubMed: Fate of the plant growth regulator mefluidide [N-[2,4-dimethyl-5-[[(trifluoromethyl)sulfonyl]amino]phenyl]acetamide] in a cow and sheep. PubMed: 2-Cyano-N-[(ethylamino)carbonyl]-2-(methoxyimino)acetamide, a new fungicide. PubMed: Gas-liquid chromatographic/mass spectrometric screening method for T-2 toxin in milk. PubMed: Excretion and metabolism of 3,4,5-tribromo-N,N,alpha-trimethyl-1H-pyrazole-1-acetamide in the rat. PubMed: Gas-liquid chromatographic determination of vinyl chloride in vinyl chloride polymers, food-simulating solvents, and other samples. PubMed: Gas-liquid chromatographic determination of diethylstilbestrol in molasses-based liquid feed supplements.