calcium gluconate

calcium di-D-gluconate monohydrate

CAS: 299-28-5 C12 H22 Ca O14 MW: 430.37414000

Identification

Namecalcium gluconate
IUPACcalcium (2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoate
CAS Number299-28-5
EINECS206-075-8
FDA UNIISQE6VB453K
Molecular FormulaC12 H22 Ca O14
Molecular Weight430.37414000
MDL NumberMFCD00064209
Nikkaji NumberJ2.984J

Regulatory

FDA/DG SANTE Petitions, Reviews, Notices184.1199
JECFA Food AdditiveCalcium Gluconate
GSFA CodexCalcium gluconate (578)
DG SANTE Food Additivescalcium gluconate
FDA Mainterm (SATF)299-28-5 ; CALCIUM GLUCONATE
FDA RegulationFDA PART 150 -- FRUIT BUTTERS, JELLIES, PRESERVES, AND RELATED PRODUCTS

Physical Properties

Appearance white crystalline powder (est)
Assay 98.00 to 100.00
Food Chemicals Codex Listed No
Melting Point 195.00 °C. @ 760.00 mm Hg
Boiling Point 673.00 to 674.00 °C. @ 760.00 mm Hg
Flash Point 707.00 °F. TCC ( 375.00 °C. )
logP (o/w) -3.175 (est)
Soluble in water, 3.33E+04 mg/L @ 25 °C (exp)
Insoluble in alcohol

Cosmetic Information

CosIngcosmetic data
Cosmetic Useshumectants

Organoleptic Properties

Odor Description at 100.00 %.

Safety Information

Preferred SDSView
Oral/Parenteral Toxicityintravenous-dog LDLo 1987 mg/kg
Dermal Toxicitysubcutaneous-mouse LD50 2890 mg/kg
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categoryacidity regulators, firming agents, sequestrants, nutrient supplements, flavor enhancer
Recommendation for calcium gluconate usage levels up tonot for fragrance use.

American International Chemical, Inc.

Consistent sources

North American supplier for globally sourced ingredients.

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BOC Sciences

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Charkit Chemical Corporation

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Penta International Corporation

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TCI AMERICA

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Potential Uses

additives

Natural Occurrence

not found in nature

Synonyms

calcicol calciofon calcipur calcium (2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoate calcium bis(D-gluconate) calcium bis[(2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoate] calcium di-D-gluconate monohydrate calcium di-dextro-gluconate monohydrate calcium di(D-gluconate) calcium gluconate anhydrous calcium gluconate anhydrous USP FCC powder calcium gluconate monohydrate USP FCC fine granular calcium gluconate monohydrate USP FCC granular calcium gluconate monohydrate USP FCC powder calcium gluconate, anhydrous USP calcium gluconate, monohydrate USP calcium hexagluconate calciumgluconate calglucol dragocal ebucin glucal glucobiogen gluconic acid calcium salt D- gluconic acid calcium salt D- gluconic acid calcium salt (2:1) dextro- gluconic acid calcium salt (2:1) D- gluconic acid, calcium salt (2:1) kalpren novocal PubMed: Aluminum Contamination in Parenteral Nutrition Admixtures for Low-Birth-Weight Preterm Infants in Mexico. J-Stage: Evaluation of the Suppressive Effect on Bitter Taste of Gluconate PubMed: Postprandial metabolic responses of serum calcium, parathyroid hormone and C-telopeptide of type I collagen to three doses of calcium delivered in milk. PubMed: Spontaneous supersaturation of calcium D-gluconate during isothermal dissolution of calcium L-lactate in aqueous sodium D-gluconate. PubMed: Enhanced glucagon-like peptide-1 secretion in a patient with glucagonoma: implications for glucagon-like peptide-1 secretion from pancreatic α cells in vivo. PubMed: Aqueous solubility of calcium L-lactate, calcium D-gluconate, and calcium D-lactobionate: importance of complex formation for solubility increase by hydroxycarboxylate mixtures. PubMed: Effect of calcium on the kinetics of free fatty acid release during in vitro lipid digestion in model emulsions. PubMed: Safety and efficacy of polycalcium for improving biomarkers of bone metabolism: a 4-week open-label clinical study. PubMed: A single-dose study of denosumab in patients with various degrees of renal impairment. PubMed: Amlodipine fatality in an infant with postmortem blood levels. PubMed: Feasibility of using dialysis for determining calcium ion concentration and pH in calcium-fortified soymilk at high temperature. PubMed: Drug shortage. PubMed: Aluminium exposure from parenteral nutrition in preterm infants and later health outcomes during childhood and adolescence. PubMed: Hormone replacement after thyroid and parathyroid surgery. PubMed: Calcium and phosphate compatibility in low-osmolarity parenteral nutrition admixtures intended for peripheral vein administration. PubMed: Intravenous ceftriaxone and calcium in the neonate: assessing the risk for cardiopulmonary adverse events. PubMed: High altitude induced anorexia: effect of changes in leptin and oxidative stress levels. PubMed: Silicate release from glass for pharmaceutical preparations. PubMed: Primary periodic paralyses. PubMed: [Zinc and copper content in individual components used to prepare pediatric total nutrition mixtures]. PubMed: Calcium supplementation in clinical practice: a review of forms, doses, and indications. PubMed: The role of oxalate in star fruit neurotoxicity of five-sixths nephrectomized rats. PubMed: Reaction on D-glucal by an inverting phosphorylase to synthesize derivatives of 2-deoxy-beta-D-arabino-hexopyranosyl-(1-->4)-D-glucose (2II-deoxycellobiose). PubMed: Arsenic species in solutions for parenteral nutrition. PubMed: [A case of intraoperative hyperkalemia induced with administration of an angiotensin II receptor antagonist (AIIA) and intake of dried persimmons]. PubMed: Incorporation of a high concentration of mineral or vitamin into chitosan-based films. PubMed: Fluid and electrolyte therapy in ruminants. PubMed: A fortifier comprising protein, vitamins, and calcium-glycerophosphate for preterm human milk. PubMed: [The evaluation of the efficiency of biological prophylaxis of lead poisoning (experimental study)]. PubMed: Acute effects of calcium sodium citrate supplementation of a test meal on mineral homeostasis, oxalate, and calcium oxalate crystallization in the urine of healthy humans--preliminary results in patients with idiopathic calcium urolithiasis. PubMed: Anything else to add? PubMed: Parenteral calcium gluconate supplementation: efficacious or potentially disastrous? PubMed: The study of a physiological significance of prolactin in the regulation of calcium metabolism during pregnancy and lactation in rats. PubMed: Chromium and zinc contamination of parenteral nutrient solution components commonly used in infants and children. PubMed: Calcium and phosphate solubility curves for parenteral nutrient solutions containing Vaminolact. PubMed: Evaluation of four animal models of intrarenal calcium deposition and assessment of the influence of dietary supplementation with essential fatty acids on calcification. PubMed: Effects of meal on the pharmacokinetics of fluoride from oral monofluorophosphate. PubMed: Influence of dietary calcium and vitamin D on colon epithelial cell proliferation and 1,2-dimethylhydrazine-induced colon carcinogenesis in rats fed high fat diets. PubMed: Hypocalcemia and pregnancy-induced hypertension produced by maternal fasting. PubMed: Glycero- vs glucose-phosphate in parenteral nutrition of premature infants: a comparative in vitro evaluation of calcium/phosphorus compatibility. PubMed: Effect of dietary calcium on colon carcinogenesis induced by a single injection of 1,2-dimethylhydrazine in rats. PubMed: Secondary copper deficiency in cattle caused by molybdenum contamination of fodder: a case history. PubMed: Parturient paresis and hypocalcemia in ruminant livestock. PubMed: Gastrointestinal absorption of calcium from milk and calcium salts. PubMed: The effect of long-term enrichment of diet with selenium, vitamin E and B15 on the activity of certain enzymes in rat brain. PubMed: Calcium and phosphate solubility in neonatal parenteral nutrient solutions containing Aminosyn PF. PubMed: Calcium and phosphate solubility in neonatal parenteral nutrient solutions containing TrophAmine. PubMed: The effect of vitamin and mineral supplements and health foods on physical endurance and performance. PubMed: Hydrofluoric acid skin treatment not approved by FDA. PubMed: Effect of long-term diet enrichment with selenium, vitamin E and vitamin B15 on the degree of fatty infiltration of the liver. PubMed: Calcium and phosphorus in neonatal parenteral nutrition solutions. PubMed: The early diagnosis of gastrinoma. PubMed: Nutritional rickets due to food fadism. PubMed: [Effect of methionine and vitamins B12 and B15 on the content and distribution of proteins, glycogen and lipids in the hepatic lobules of chickens]. PubMed: FDA's hands loosely tied. PubMed: Vitamin B15--whatever it is, it won't help. PubMed: From those wonderful people who brought you laetrile. PubMed: [Dynamic aspects of blood gastrin after antral stimulation].