choline chloride

2-hydroxyethyl(trimethyl)azanium chloride

CAS: 67-48-1 C5 H14 Cl N O MW: 139.62478000

Identification

Namecholine chloride
IUPAC2-hydroxyethyl(trimethyl)azanium chloride
CAS Number67-48-1
EINECS200-655-4
FDA UNII45I14D8O27
Molecular FormulaC5 H14 Cl N O
Molecular Weight139.62478000
MDL NumberMFCD00011721
Beilstein3563126

Regulatory

FDA/DG SANTE Petitions, Reviews, Notices182.8252
JECFA Food Flavoring2003 choline chloride
FEMA Number4500
FDANo longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm (SATF)67-48-1 ; CHOLINE CHLORIDE
FDA RegulationFDA PART 182 -- SUBSTANCES GENERALLY RECOGNIZED AS SAFE

Physical Properties

Appearance white crystalline powder (est)
Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Melting Point 302.00 to 305.00 °C. @ 760.00 mm Hg
Flash Point 32.00 °F. TCC ( 0.00 °C. ) (est)
logP (o/w) -3.700 (est)
Soluble in alcohol

Cosmetic Information

CosIngcosmetic data
Cosmetic Usesnot used anymore

No sensory data available

Safety Information

Preferred SDSView
European informationMost important hazard(s):
Oral/Parenteral Toxicityoral-rat LD50 3400 mg/kg
Dermal Toxicitysubcutaneous-mouse LDLo 735 mg/kg
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorynutrient supplements
Recommendation for choline chloride usage levels up tonot for fragrance use.
Structure ClassI
baked goods4000.00000
beverages(nonalcoholic)-
beverages(alcoholic)-
breakfast cereal4000.00000
cheese-
chewing gum-
condiments / relishes-
confectionery froastings-
egg products-
fats / oils-
fish products600.00000
frozen dairy-
fruit ices-
gelatins / puddings-
granulated sugar-
gravies4000.00000
hard candy-
imitation dairy-
instant coffee / tea-
jams / jellies-
meat products4000.00000
milk products-
nut products-
other grains-
poultry4000.00000
processed fruits-
processed vegetables-
reconstituted vegetables-
seasonings / flavors4000.00000
snack foods4000.00000
soft candy-
soups2500.00000
sugar substitutes-
sweet sauces-

American International Chemical, Inc.

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Potential Uses

None Found

Natural Occurrence

found in nature

Synonyms

biocolina cholinchloride choline chloride 2 silica conditioned choline chloride FCC choline chloride USP FCC cholinium chloride (2- hydroxy-ethyl)-trimethyl-ammonium 2- hydroxy-N,N,N-trimethylethanaminium chloride 2- hydroxyethyl(trimethyl)azanium chloride (2- hydroxyethyl)trimethyl-ammonium chloride (2- hydroxyethyl)trimethylammonium chloride (beta- hydroxyethyl)trimethylammonium chloride (2- hydroxyethyl)trimethylazanium chloride luridin chloride 2-( trimethylamino)ethan-1-ol, chloride PubMed: A novel digestion method based on a choline chloride-oxalic acid deep eutectic solvent for determining Cu, Fe, and Zn in fish samples. PubMed: Construction of Au nanoparticles on choline chloride modified glassy carbon electrode for sensitive detection of nitrite. PubMed: Enhancement of salt intake by choline chloride. PubMed: Simple electrochemical sensor for caffeine based on carbon and Nafion-modified carbon electrodes. PubMed: An episode of dioxin contamination in feedingstuff: the choline chloride case. PubMed: [Lipid metabolism in the gastrointestinal tract of lactating cows during the duodenal infusion of choline chloride and methionine]. PubMed: Enzymatic production of pyrimidine nucleotides using Corynebacterium ammoniagenes cells and recombinant Escherichia coli cells: enzymatic production of CDP-choline from orotic acid and choline chloride (Part I). PubMed: Acute toxicity assessment of choline by inhalation, intraperitoneal and oral routes in Balb/c mice. PubMed: Dioxin contamination of food in Italy: an overview of the situation 1999-2000. PubMed: Dipsogenic and feeding influences of intraventricularly infused anionic choline solutions. PubMed: Growth of the skeletal units of the rat mandible in acute renal failure experimental model. PubMed: Evaluation of PCDD/Fs characterization in animal feed and feed additives. PubMed: Choline distribution and metabolism in pregnant rats and fetuses are influenced by the choline content of the maternal diet. PubMed: The effects of manganese, biotin, and choline on hexosamine and hydroxyproline content as related to leg weakness. PubMed: Dietary S-methylmethionine, a component of foods, has choline-sparing activity in chickens. PubMed: Effect of supplementary choline on the performance of broiler breeders fed on different energy sources. PubMed: Lung surfactant phospholipids as related to hydration and choline status of fasted rats. PubMed: Lack of effect of choline and narcotic antagonists upon apomorphine discrimination. PubMed: Prolonged survival of female AKR mice fed diets supplemented with methionine and choline. PubMed: Effects of cationic species on visual color formation in model Maillard reactions of pentose sugars and amino acids. PubMed: A choline-rich diet improves survival in a rat model of endotoxin shock. PubMed: The folic acid requirements of starting broiler chicks fed diets based on practical ingredients. 1. Interrelationships with dietary choline. PubMed: [Studies on the vitamin requirement and vitamin supply in fattening turkeys. 2. Checking the vitamin supplements to state-approved mixed animal feed for fattening turkeys]. PubMed: Construction of a plasmid carrying both CTP synthetase and a fused gene formed from cholinephosphate cytidylyltransferase and choline kinase genes and its application to industrial CDP-choline production: enzymatic production of CDP-choline from orotic acid (Part II). PubMed: Rumen-protected choline and vitamin E supplementation in periparturient dairy goats: effects on milk production and folate, vitamin B12 and vitamin E status. PubMed: Solid-state fermentation for production of griseofulvin on rice bran using Penicillium griseofulvum. PubMed: Rumen-protected choline administration to transition cows: effects on milk production and vitamin E status. PubMed: Dietary choline requirements of juvenile hybrid tilapia, Oreochromis niloticus x O. aureus. PubMed: Effects of Ionic and Osmotic Strength on the Glucosyltransferase of Rhizobium meliloti Responsible for Cyclic beta-(1,2)-Glucan Biosynthesis.