climbazole

1-(4-clorophenoxy)-3,3-dimethyl-1-(imidazole-1-yl)-2-butanone

CAS: 38083-17-9 C15 H17 Cl N2 O2 MW: 292.76489000

Identification

Nameclimbazole
CAS Number38083-17-9
EINECS253-775-4
FDA UNII9N42CW7I54
Molecular FormulaC15 H17 Cl N2 O2
Molecular Weight292.76489000
MDL NumberMFCD00055505
Nikkaji NumberJ19.421B
Beilstein0618020

Regulatory

Physical Properties

Appearance white crystalline powder (est)
Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Boiling Point 447.00 to 448.00 °C. @ 760.00 mm Hg (est)
Flash Point 436.00 °F. TCC ( 224.40 °C. ) (est)
logP (o/w) 3.486 (est)

Cosmetic Information

CosIngcosmetic data
Cosmetic Usesantimicrobial agents

No sensory data available

Safety Information

Preferred SDSView
European informationMost important hazard(s):
Oral/Parenteral Toxicityoral-rat LD50 400 mg/kg
Dermal Toxicityskin-rat LD50 > 5000 mg/kg
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categoryantimicrobial preservatives
Recommendation for climbazole usage levels up tonot for fragrance use.
Recommendation for climbazole flavor usage levels up tonot for flavor use.

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Potential Uses

preservatives

Natural Occurrence

not found in nature

Synonyms

baypival baysan 2- butanone, 1-(4-chlorophenoxy)-1-(1H-imidazol-1-yl)-3,3-dimethyl- 2- butanone, 1-(p-chlorophenoxy)-3,3-dimethyl-1-(1-imidazolyl)- 1-(4- chlorophenoxy)-1-(1H-imidazol-1-yl)-3,3-dimethyl-2-butanone 1-(4- chlorophenoxy)-1-(1H-imidazol-1-yl)-3,3-dimethylbutan-2-one 1-(4- chlorophenoxy)-1-(1H-imidazolyl)-3,3-dimethyl-2-butanone 1-(4- chlorophenoxy)-1-(imidazol-1-yl)-3,3-dimethyl butanone 1-(4- chlorophenoxy)-1-(imidazol-1-yl)-3,3-dimethylbutanone 1-(p- chlorophenoxy)-1-imidazol-1-yl-3,3-dimethyl-2-butanone 1-(4- chlorophenoxy)-1-imidazolyl-3,3-dimethylbutan-2-one 1-(p- chlorophenoxy)-3,3-dimethyl-1-(1-imidazolyl)-2-butanone 1-(4- clorophenoxy)-3,3-dimethyl-1-(imidazole-1-yl)-2-butanone crinipan AD (Symrise) PubMed: Triclosan as a surrogate for household biocides: An investigation into biocides in aquatic environments of a highly urbanized region. PubMed: Selective determination of antimycotic drugs in environmental water samples by mixed-mode solid-phase extraction and liquid chromatography quadrupole time-of-flight mass spectrometry. PubMed: Sucrose ester stabilized solid lipid nanoparticles and nanostructured lipid carriers. II. Evaluation of the imidazole antifungal drug-loaded nanoparticle dispersions and their gel formulations. PubMed: Protease activity, localization and inhibition in the human hair follicle. PubMed: Ecotoxicity of climbazole, a fungicide contained in antidandruff shampoo. PubMed: Ultra-high-performance liquid chromatography-tandem mass spectrometry measurement of climbazole deposition from hair care products onto artificial skin and human scalp. PubMed: Typical azole biocides in biosolid-amended soils and plants following biosolid applications. PubMed: Therapeutic efficacy of anti-dandruff shampoos: a randomized clinical trial comparing products based on potentiated zinc pyrithione and zinc pyrithione/climbazole. PubMed: Occurrence and dissipation of three azole biocides climbazole, clotrimazole and miconazole in biosolid-amended soils. PubMed: Determination of biocides in different environmental matrices by use of ultra-high-performance liquid chromatography-tandem mass spectrometry. PubMed: Enhanced efficacy and sensory properties of an anti-dandruff shampoo containing zinc pyrithione and climbazole. PubMed: Efficacy of a piroctone olamine/climbazol shampoo in comparison with a zinc pyrithione shampoo in subjects with moderate to severe dandruff. PubMed: Comparison of electrospray ionization and atmospheric pressure chemical ionization for multi-residue analysis of biocides, UV-filters and benzothiazoles in aqueous matrices and activated sludge by liquid chromatography-tandem mass spectrometry. PubMed: Evaluation of the genotoxicity of the imidazole antifungal climbazole: comparison to published results for other azole compounds. PubMed: Simultaneous determination of four anti-dandruff agents including octopirox in shampoo products by reversed-phase liquid chromatography. PubMed: Rheology of Dead Sea shampoo containing the antidandruff climbazole. PubMed: [Determination of antidangdruff agent salicylic acid, zinc pyrithione, octopirox, climbazole and ketoconazole in shampoo by high performance liquid chromatography]. PubMed: The hair strand test - a new method for testing antifungal effects of antidandruff preparations. PubMed: Induction and inhibition of cytochrome P450 and drug-metabolizing enzymes by climbazole. PubMed: Climbazole is a new potent inducer of rat hepatic cytochrome P450. PubMed: [Clinical effectiveness and tolerance of climbazole containing dandruff shampoo in patients with seborrheic scalp eczema]. PubMed: [Comparison of the thermostability of natural (sulfoprolamine and sodium usnate) and synthetic (climbazole and piroctone olamine) antidandruff agents]. PubMed: In vitro activity of climbazole, clotrimazole and silver-sulphadiazine against isolates of Malassezia pachydermatis. PubMed: In vitro susceptibility of Malassezia furfur against azole compounds. PubMed: In vitro susceptibility of Malassezia furfur.