2-phenyl phenol

2-phenylphenol

CAS: 90-43-7 C12 H10 O MW: 170.21090000

Identification

Name2-phenyl phenol
CAS Number90-43-7
EINECS201-993-5
FDA UNIID343Z75HT8
Molecular FormulaC12 H10 O
Molecular Weight170.21090000
MDL NumberMFCD00002208
Nikkaji NumberJ3.555F
Beilstein0606907
XlogP33.10 (est)

Regulatory

JECFA Food Flavoring735 2-phenylphenol
JECFA Food Additiveo-Phenylphenol
GSFA Codexortho-Phenylphenol (231)
FEMA Number3959
FDANo longer provide for the use of these seven synthetic flavoring substances
FDA Mainterm (SATF)90-43-7 ; O-PHENYLPHENOL
FDA RegulationFDA PART 175 -- INDIRECT FOOD ADDITIVES: ADHESIVES AND COMPONENTS OF COATINGS

Physical Properties

Appearance white to pale purple crystalline powder (est)
Assay 99.00 to 100.00
Food Chemicals Codex Listed No
Melting Point 57.00 to 59.00 °C. @ 760.00 mm Hg
Boiling Point 282.00 to 285.00 °C. @ 760.00 mm Hg
Vapor Pressure 0.002020 mmHg @ 25.00 °C. (est)
Flash Point 255.00 °F. TCC ( 123.89 °C. )
logP (o/w) 3.090
Shelf Life 24.00 month(s) or longer if stored properly.
Storage store in cool, dry place in tightly sealed containers, protected from heat and light.
Soluble in alcohol
Insoluble in water

Cosmetic Information

CosIngcosmetic data
Cosmetic Usespreservatives

No sensory data available

Safety Information

Preferred SDSView
European informationMost important hazard(s):
Oral/Parenteral Toxicityintraperitoneal-mouse LD50 50 mg/kg
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categoryantioxidants and preservatives for fragrance and flavor
Recommendation for 2-phenyl phenol usage levels up tonot for fragrance use.
baked goods-
beverages(nonalcoholic)-
beverages(alcoholic)-
breakfast cereal-
cheese-
chewing gum-
condiments / relishes-
confectionery froastings-
egg products-
fats / oils-
fish products-
frozen dairy-
fruit ices-
gelatins / puddings-
granulated sugar-
gravies-
hard candy-
imitation dairy-
instant coffee / tea-
jams / jellies-
meat products-
milk products-
nut products-
other grains-
poultry-
processed fruits-
processed vegetables-
reconstituted vegetables-
seasonings / flavors1.00000
snack foods-
soft candy-
soups-
sugar substitutes-
sweet sauces-

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Potential Uses

preservatives

Natural Occurrence

lemon oil mandarin

Synonyms

anthrapole 73 biphenyl-2-ol 2- biphenylol dowicide 1 2- hydroxy-1,1'-biphenyl 2- hydroxybiphenyl o- hydroxybiphenyl ortho- hydroxybiphenyl 2- phenyl phenol o- phenyl phenol ortho- phenyl phenol 2- phenylphenol o- phenylphenol ortho- phenylphenol torsite xenol PubMed: The protective effects of hydroxytyrosol against ortho-phenylphenol-induced DNA damage in HepG2 cells. PubMed: Automated on-line column-switching HPLC-MS/MS method with peak focusing for measuring parabens, triclosan, and other environmental phenols in human milk. PubMed: Plastic components affect the activation of the aryl hydrocarbon and the androgen receptor. PubMed: Problems of positive list system revealed by survey of pesticide residue in food. PubMed: Efflux pump activity in fluoroquinolone and tetracycline resistant Salmonella and E. coli implicated in reduced susceptibility to household antimicrobial cleaning agents. PubMed: Simple and sensitive determination of o-phenylphenol in citrus fruits using gas chromatography with atomic emission or mass spectrometric detection. PubMed: Determination and levels of the biocide ortho-phenylphenol in canned beers from different countries. PubMed: Micronuclei and cell proliferation as early biological markers of ortho-phenylphenol-induced changes in the bladder of male F344 rats. PubMed: Combination of analyte protectants to overcome matrix effects in routine GC analysis of pesticide residues in food matrixes. PubMed: [Inhibitory effect of zinc on beta-hexosaminidase release from RBL-2H3 cells by synthetic chemicals]. PubMed: Complexation of several fungicides with beta-cyclodextrin: determination of the association constants and isolation of the solid complexes. PubMed: [Studies on estrogenic activities of food additives with human breast cancer MCF-7 cells and mechanism of estrogenicity by BHA and OPP]. PubMed: Off-line solid-phase microextraction and capillary electrophoresis mass spectrometry to determine acidic pesticides in fruits. PubMed: Simple and rapid determination of thiabendazole, imazalil, and o-phenylphenol in citrus fruit using flow-injection electrospray ionization tandem mass spectrometry. PubMed: The comet assay with 8 mouse organs: results with 39 currently used food additives. PubMed: Monitoring of five postharvest fungicides in fruit and vegetables by matrix solid-phase dispersion and liquid chromatography/mass spectrometry. PubMed: Comparative in vitro-in vivo percutaneous penetration of the fungicide ortho-phenylphenol. PubMed: Detection and characterization of DNA adducts formed from metabolites of the fungicide ortho-phenylphenol. PubMed: Estimation of concentrations of antifungal agents allowed as food additives in foods and their daily intake based on official inspection results in Japan in fiscal year 1998. PubMed: Dose- and time-response studies of sodium o-phenylphenate urinary bladder carcinogenicity in rats. PubMed: Determination of phenolic disinfectant agents in commercial formulations by liquid chromatography. PubMed: Orthophenylphenol and phenylhydroquinone residues in citrus fruit and processed citrus products after postharvest fungicidal treatments with sodium orthophenylphenate in California and Florida. PubMed: Dietary effects of ortho-phenylphenol and sodium ortho-phenylphenate on rat urothelium. PubMed: Action against Vibrio cholerae O1 Tox+ of chemical products used in the lemon production. PubMed: An analysis of the possibility for health implications of joint actions and interactions between food additives. PubMed: Determination of benomyl, diphenyl, o-phenylphenol, thiabendazole, chlorpyrifos, methidathion, and methyl parathion in oranges by solid-phase extraction, liquid chromatography, and gas chromatography. PubMed: Human semen quality in relation to dietary pesticide exposure and organic diet. PubMed: Toxicological profile for o-phenylphenol and its sodium salt. PubMed: Urinary physiologic and chemical metabolic effects on the urothelial cytotoxicity and potential DNA adducts of o-phenylphenol in male rats. PubMed: Cytotoxicity of food preservatives in cultured rat hepatocytes loaded with linolenic acid. PubMed: Determination of o-phenylphenol, diphenylamine, and propargite pesticide residues in selected fruits and vegetables by gas chromatography/mass spectrometry. PubMed: Laboratory evaluation of chemical control of aflatoxin production in unshelled peanuts (Arachis hypogaea L.). PubMed: Mycological evaluation of chemically-treated unshelled peanuts. PubMed: In vitro comparison of the effectiveness of three surface disinfectants. PubMed: The effect of home processing on postharvest fungicide residues in citrus fruit: residues of imazalil, 2-phenylphenol and thiabendazole in 'home-made' marmalade, prepared from late Valencia oranges. PubMed: Determination of pesticides in indoor air and dust. PubMed: Synergistic effect of fungicides on resistant strains of Penicillium italicum and Penicillium digitatum. PubMed: Effects of pH on the carcinogenicity of o-phenylphenol and sodium o-phenylphenate in the rat urinary bladder. PubMed: Enhancing effect of thiabendazole on urinary bladder carcinogenesis induced by sodium o-phenylphenate in F344 rats. PubMed: Urinary excretion of orally administered oxalic acid in saccharin and o-phenylphenol-fed NMRI mice. PubMed: Induction of tumours of the urinary bladder in F344 rats by dietary administration of o-phenylphenol. PubMed: Long-term toxicity and carcinogenicity study of sodium o-phenylphenate in B6C3F1 mice. PubMed: Induction of chromosome aberrations and sister-chromatid exchanges in CHO-K1 cells by o-phenylphenol. PubMed: The sensitizing potential of metalworking fluid biocides (phenolic and thiazole compounds) in the guinea-pig maximization test in relation to patch-test reactivity in eczema patients. PubMed: Changes in enzyme activities in the urine and tissues of rats fed sodium o-phenylphenate. PubMed: Altered levels of cyclic nucleotides in F344 rats fed sodium o-phenylphenate. PubMed: Mechanism of orthophenylphenol toxicity. PubMed: Drugs, food additives and natural products as promoters in rat urinary bladder carcinogenesis. PubMed: [Determination of o-phenylphenol (OPP) in marmalade and juice]. PubMed: The metabolic profile of sodium o-phenylphenate after subchronic oral administration to rats. PubMed: [Application of isotachophoresis technic in the metabolic study of food additives: separation and determination of hydroxybiphenyl conjugates]. PubMed: Induction of tumours of the urinary system in F344 rats by dietary administration of sodium o-phenylphenate. PubMed: Contents of diphenyl (DP), o-phenylphenol (OPP) and thiabendazole (TB) in imported citrus fruits and citrus fruit products. PubMed: Survey of o-phenylphenol residues found in marketable citrus fruit.