2-phenyl phenol
2-phenylphenol
Identification
| Name | 2-phenyl phenol |
| CAS Number | 90-43-7 |
| EINECS | 201-993-5 |
| FDA UNII | D343Z75HT8 |
| Molecular Formula | C12 H10 O |
| Molecular Weight | 170.21090000 |
| MDL Number | MFCD00002208 |
| Nikkaji Number | J3.555F |
| Beilstein | 0606907 |
| XlogP3 | 3.10 (est) |
Regulatory
| JECFA Food Flavoring | 735 2-phenylphenol |
| JECFA Food Additive | o-Phenylphenol |
| GSFA Codex | ortho-Phenylphenol (231) |
| FEMA Number | 3959 |
| FDA | No longer provide for the use of these seven synthetic flavoring substances |
| FDA Mainterm (SATF) | 90-43-7 ; O-PHENYLPHENOL |
| FDA Regulation | FDA PART 175 -- INDIRECT FOOD ADDITIVES: ADHESIVES AND COMPONENTS OF COATINGS |
Physical Properties
| Appearance | white to pale purple crystalline powder (est) |
| Assay | 99.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Melting Point | 57.00 to 59.00 °C. @ 760.00 mm Hg |
| Boiling Point | 282.00 to 285.00 °C. @ 760.00 mm Hg |
| Vapor Pressure | 0.002020 mmHg @ 25.00 °C. (est) |
| Flash Point | 255.00 °F. TCC ( 123.89 °C. ) |
| logP (o/w) | 3.090 |
| Shelf Life | 24.00 month(s) or longer if stored properly. |
| Storage | store in cool, dry place in tightly sealed containers, protected from heat and light. |
| Soluble in | alcohol |
| Insoluble in | water |
Cosmetic Information
| CosIng | cosmetic data |
| Cosmetic Uses | preservatives |
No sensory data available
Safety Information
| Preferred SDS | View |
| European information | Most important hazard(s): |
| Oral/Parenteral Toxicity | intraperitoneal-mouse LD50 50 mg/kg |
| Dermal Toxicity | Not determined |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | antioxidants and preservatives for fragrance and flavor |
| Recommendation for 2-phenyl phenol usage levels up to | not for fragrance use. |
| baked goods | - |
| beverages(nonalcoholic) | - |
| beverages(alcoholic) | - |
| breakfast cereal | - |
| cheese | - |
| chewing gum | - |
| condiments / relishes | - |
| confectionery froastings | - |
| egg products | - |
| fats / oils | - |
| fish products | - |
| frozen dairy | - |
| fruit ices | - |
| gelatins / puddings | - |
| granulated sugar | - |
| gravies | - |
| hard candy | - |
| imitation dairy | - |
| instant coffee / tea | - |
| jams / jellies | - |
| meat products | - |
| milk products | - |
| nut products | - |
| other grains | - |
| poultry | - |
| processed fruits | - |
| processed vegetables | - |
| reconstituted vegetables | - |
| seasonings / flavors | 1.00000 |
| snack foods | - |
| soft candy | - |
| soups | - |
| sugar substitutes | - |
| sweet sauces | - |
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Potential Uses
Natural Occurrence
Synonyms
anthrapole 73
biphenyl-2-ol
2-
biphenylol
dowicide 1
2-
hydroxy-1,1'-biphenyl
2-
hydroxybiphenyl
o-
hydroxybiphenyl
ortho-
hydroxybiphenyl
2-
phenyl phenol
o-
phenyl phenol
ortho-
phenyl phenol
2-
phenylphenol
o-
phenylphenol
ortho-
phenylphenol
torsite
xenol
PubMed:
The protective effects of hydroxytyrosol against ortho-phenylphenol-induced DNA damage in HepG2 cells.
PubMed:
Automated on-line column-switching HPLC-MS/MS method with peak focusing for measuring parabens, triclosan, and other environmental phenols in human milk.
PubMed:
Plastic components affect the activation of the aryl hydrocarbon and the androgen receptor.
PubMed:
Problems of positive list system revealed by survey of pesticide residue in food.
PubMed:
Efflux pump activity in fluoroquinolone and tetracycline resistant Salmonella and E. coli implicated in reduced susceptibility to household antimicrobial cleaning agents.
PubMed:
Simple and sensitive determination of o-phenylphenol in citrus fruits using gas chromatography with atomic emission or mass spectrometric detection.
PubMed:
Determination and levels of the biocide ortho-phenylphenol in canned beers from different countries.
PubMed:
Micronuclei and cell proliferation as early biological markers of ortho-phenylphenol-induced changes in the bladder of male F344 rats.
PubMed:
Combination of analyte protectants to overcome matrix effects in routine GC analysis of pesticide residues in food matrixes.
PubMed:
[Inhibitory effect of zinc on beta-hexosaminidase release from RBL-2H3 cells by synthetic chemicals].
PubMed:
Complexation of several fungicides with beta-cyclodextrin: determination of the association constants and isolation of the solid complexes.
PubMed:
[Studies on estrogenic activities of food additives with human breast cancer MCF-7 cells and mechanism of estrogenicity by BHA and OPP].
PubMed:
Off-line solid-phase microextraction and capillary electrophoresis mass spectrometry to determine acidic pesticides in fruits.
PubMed:
Simple and rapid determination of thiabendazole, imazalil, and o-phenylphenol in citrus fruit using flow-injection electrospray ionization tandem mass spectrometry.
PubMed:
The comet assay with 8 mouse organs: results with 39 currently used food additives.
PubMed:
Monitoring of five postharvest fungicides in fruit and vegetables by matrix solid-phase dispersion and liquid chromatography/mass spectrometry.
PubMed:
Comparative in vitro-in vivo percutaneous penetration of the fungicide ortho-phenylphenol.
PubMed:
Detection and characterization of DNA adducts formed from metabolites of the fungicide ortho-phenylphenol.
PubMed:
Estimation of concentrations of antifungal agents allowed as food additives in foods and their daily intake based on official inspection results in Japan in fiscal year 1998.
PubMed:
Dose- and time-response studies of sodium o-phenylphenate urinary bladder carcinogenicity in rats.
PubMed:
Determination of phenolic disinfectant agents in commercial formulations by liquid chromatography.
PubMed:
Orthophenylphenol and phenylhydroquinone residues in citrus fruit and processed citrus products after postharvest fungicidal treatments with sodium orthophenylphenate in California and Florida.
PubMed:
Dietary effects of ortho-phenylphenol and sodium ortho-phenylphenate on rat urothelium.
PubMed:
Action against Vibrio cholerae O1 Tox+ of chemical products used in the lemon production.
PubMed:
An analysis of the possibility for health implications of joint actions and interactions between food additives.
PubMed:
Determination of benomyl, diphenyl, o-phenylphenol, thiabendazole, chlorpyrifos, methidathion, and methyl parathion in oranges by solid-phase extraction, liquid chromatography, and gas chromatography.
PubMed:
Human semen quality in relation to dietary pesticide exposure and organic diet.
PubMed:
Toxicological profile for o-phenylphenol and its sodium salt.
PubMed:
Urinary physiologic and chemical metabolic effects on the urothelial cytotoxicity and potential DNA adducts of o-phenylphenol in male rats.
PubMed:
Cytotoxicity of food preservatives in cultured rat hepatocytes loaded with linolenic acid.
PubMed:
Determination of o-phenylphenol, diphenylamine, and propargite pesticide residues in selected fruits and vegetables by gas chromatography/mass spectrometry.
PubMed:
Laboratory evaluation of chemical control of aflatoxin production in unshelled peanuts (Arachis hypogaea L.).
PubMed:
Mycological evaluation of chemically-treated unshelled peanuts.
PubMed:
In vitro comparison of the effectiveness of three surface disinfectants.
PubMed:
The effect of home processing on postharvest fungicide residues in citrus fruit: residues of imazalil, 2-phenylphenol and thiabendazole in 'home-made' marmalade, prepared from late Valencia oranges.
PubMed:
Determination of pesticides in indoor air and dust.
PubMed:
Synergistic effect of fungicides on resistant strains of Penicillium italicum and Penicillium digitatum.
PubMed:
Effects of pH on the carcinogenicity of o-phenylphenol and sodium o-phenylphenate in the rat urinary bladder.
PubMed:
Enhancing effect of thiabendazole on urinary bladder carcinogenesis induced by sodium o-phenylphenate in F344 rats.
PubMed:
Urinary excretion of orally administered oxalic acid in saccharin and o-phenylphenol-fed NMRI mice.
PubMed:
Induction of tumours of the urinary bladder in F344 rats by dietary administration of o-phenylphenol.
PubMed:
Long-term toxicity and carcinogenicity study of sodium o-phenylphenate in B6C3F1 mice.
PubMed:
Induction of chromosome aberrations and sister-chromatid exchanges in CHO-K1 cells by o-phenylphenol.
PubMed:
The sensitizing potential of metalworking fluid biocides (phenolic and thiazole compounds) in the guinea-pig maximization test in relation to patch-test reactivity in eczema patients.
PubMed:
Changes in enzyme activities in the urine and tissues of rats fed sodium o-phenylphenate.
PubMed:
Altered levels of cyclic nucleotides in F344 rats fed sodium o-phenylphenate.
PubMed:
Mechanism of orthophenylphenol toxicity.
PubMed:
Drugs, food additives and natural products as promoters in rat urinary bladder carcinogenesis.
PubMed:
[Determination of o-phenylphenol (OPP) in marmalade and juice].
PubMed:
The metabolic profile of sodium o-phenylphenate after subchronic oral administration to rats.
PubMed:
[Application of isotachophoresis technic in the metabolic study of food additives: separation and determination of hydroxybiphenyl conjugates].
PubMed:
Induction of tumours of the urinary system in F344 rats by dietary administration of sodium o-phenylphenate.
PubMed:
Contents of diphenyl (DP), o-phenylphenol (OPP) and thiabendazole (TB) in imported citrus fruits and citrus fruit products.
PubMed:
Survey of o-phenylphenol residues found in marketable citrus fruit.