potassium orotate

4-pyrimidinecarboxylic acid, 1,2,3,6-tetrahydro-2,6-dioxo-, potassium salt (1:1)

CAS: 24598-73-0 C5 H4 N2 O4.K MW: 195.19590000

Identification

Namepotassium orotate
CAS Number24598-73-0
EINECS246-341-0
FDA UNII6ZDN9W1C9W
Molecular FormulaC5 H4 N2 O4.K
Molecular Weight195.19590000
MDL NumberMFCD00039118

Regulatory

Physical Properties

Assay 95.00 to 100.00
Food Chemicals Codex Listed No
Flash Point 32.00 °F. TCC ( 0.00 °C. ) (est)
logP (o/w) -0.928 (est)
Soluble in water, 1e+006 mg/L @ 25 °C (est)

No sensory data available

Safety Information

Preferred SDSView
Oral/Parenteral Toxicityoral-rat LD50 10900 mg/kg
Dermal ToxicityNot determined
Inhalation ToxicityNot determined

GHS Classification

['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']

Safety in Use

Categorynutrient supplements, EFSA concludes: use is of safety concern.
Recommendation for potassium orotate usage levels up tonot for fragrance use.
Recommendation for potassium orotate flavor usage levels up tonot for flavor use.

American International Chemical, Inc.

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Potential Uses

None Found

Natural Occurrence

not found in nature

Synonyms

2,6- dioxo-1,3-dihydropyrimidine-4-carboxylic acid, potassium salt etrahydro-2,6-dioxo-4-pyrimidinecarboxylic acid monopotassium salt, 1,2,3,6-t orotic acid potassium salt orotic acid, monopotassium salt potassium 1,2,3,6-tetrahydro-2,6-dioxopyrimidine-4-carboxylate potassium 2,4-dioxo-1H-pyrimidine-6-carboxylate potassium 2,6-dioxo-1,2,3,6-tetrahydro-4-pyrimidinecarboxylate potassium 2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylate potassium orotate anhydrous potassiumorotate 4- pyrimidinecarboxylic acid, 1,2,3,6-tetrahydro-2,6-dioxo-, monopotassium salt 4- pyrimidinecarboxylic acid, 1,2,3,6-tetrahydro-2,6-dioxo-, potassium salt (1:1) 1,2,3,6- tetrahydro-2,6-dioxo-4-pyrimidinecarboxylic acid monopotassium salt PubMed: [New derivatives of triazino- and imidazoindole with hepatoprotective activity]. PubMed: [Psychophysiological effects of combined administration of pantogam and potassium orotate in patients with neurotic disorders]. PubMed: [Effectiveness of treating periodontitis in patients with thyroid dysfunction]. PubMed: [Effects of bemethyl, ethomersol, and yakton on the liver regeneration after partial hepatectomy]. PubMed: [Effect of potassium orotate on the reversibility of cirrhotic changes and regeneration of the rat liver]. PubMed: [Content of components of the renin-angiotensin-aldosterone system and prostaglandins series E, F in various organs after suturing of peripheral nerves during treatment with dehydrating agents]. PubMed: Metabolic effect of orotic acid in calves. PubMed: [The carbohydrate-resistant mechanism of the action of caries-prophylactic agents on the oral fluid in children]. PubMed: [The treatment results in patients with gouty nephropathy]. PubMed: [Structure of the liver after correction of experimental chronic hepatitis with benzonal and potassium orotate]. PubMed: [Mud treatment of patients with rheumatoid arthritis with an immunologic deficiency]. PubMed: [The glycolytic status of peripheral blood phagocytes and its therapeutic correction in patients with foot mycoses]. PubMed: [Effect of quinazopyrine on the process of reparative regeneration]. PubMed: [Mechanism of the action of potassium orotate on sodium excretion from the body]. PubMed: [Use of neurotropic drugs and potassium orotate in the complex treatment of patients with chronic salpingo-oophoritis with marked pain syndrome]. PubMed: [Pharmacological correction of central nervous system function in exposure to Coriolis acceleration]. PubMed: [Quantitative evaluation of the anxiolytic and nootropic effects of potassium orotate in a wide range of doses]. PubMed: [Effect of pyridoxine, riboflavin, potassium orotate, folic and glutamic acids on the recovery of work capacity in sexually immature rats]. PubMed: [Comparative study of the indices of the antidepressive activity of potassium orotate and piracetam]. PubMed: [The action of potassium orotate in prophylactic and therapeutic administration to irradiated rats]. PubMed: [Reparative regeneration of the liver as a model for the preclinical study of the hepatotropism of anti-alcohol agents]. PubMed: [Various principles of therapeutic tactics in epilepsy patients during pregnancy]. PubMed: [Electron-radioautographic study of the effect of potassium orotate on RNA and protein synthesis in fibroblasts during experimental wound healing]. PubMed: [Anxiolytic effect of potassium orotate]. PubMed: [Effect of potassium orotate on the metabolism of various vitamins in patients with long bone fractures]. PubMed: The enzymatic status of circulating lymphocytes as an index of the regenerative process in the lungs under stimulation with pyrimidine and purine derivatives. A clinical experimental study. PubMed: The status of the lymphoid system under conditions of lung regeneration stimulation. PubMed: [Potassium orotate and polyvitamins in the treatment of fractures]. PubMed: [Effect of potassium orotate and the sodium salt of uridine monophosphate on the development of experimental adrenaline myocardial dystrophy]. PubMed: [Morphologic and biochemical study of stimulated collagenogenesis]. PubMed: [Oxidative phosphorylation in cardiac muscle mitochondria during combined treatment of experimental myocardial infarct with potassium orotate and hyperbaric oxygenation]. PubMed: [Therapeutic effect of indomethacin and potassium orotate in experimental nephritis in rats]. PubMed: [Dependence of calcium absorption in the chicken small intestine on its Ca2+-binding protein content and the effect of exogenous nucleotide precursors on this process]. PubMed: [Effect of anabolic substances on the state of the individual components of the glutathione-ascorbic acid system]. PubMed: [Comparative evaluation of the effectiveness of 2 drug combinations (strophanthin and potassium orotate, strophanthin and methyluracil) in circulatory insufficiency]. PubMed: [Action of potassium orotate, hyperbaric oxygenation and their combination on the course of experimental microfocal myocardial infarct]. PubMed: [Autoradiographic analysis of the effect of potassium orotate on the intensity of uridine-5 3H and proline-3H incorporation into wound fibroblasts]. PubMed: [Effect of potassium orotate and guanine on calcium uptake in small intestine of chickens with different amounts of vitamin D3]. PubMed: [Autoradiographic study of stimulation of RNA synthesis in fibroblasts]. PubMed: [Effect of potassium orotate on metabolism in chickens under different provision with vitamin D3]. PubMed: [DNA synthesis by granulation tissue fibroblasts under conditions of stimulation of the wound process]. PubMed: [Differential spectrophotometric method of determining potassium orotate]. PubMed: [Strophanthin sensitivity in disorders of cardiac blood supply, altered immunologic reactivity and under the influence of several pharmacologic agents]. PubMed: [Effect of complex treatment using potassium orotate on the non-specific immunologic reactivity of children with viral hepatitis]. PubMed: [Autoradiographic study of the rate of collagen synthesis under conditions of stimulation of the wound process]. PubMed: [An autoradiographic and electron microscopic study of fibroblasts under conditions of stimulation of the wound process]. PubMed: [Changes in hemodynamics in acute myocardial infarct following administration of potassium orotate]. PubMed: [Stimulation of fibrillogenesis in granulation tissue]. PubMed: [Effect of potassium orotate on the clinical laboratory indices of viral hepatitis in children]. PubMed: [Effect of potassium orotate on compensatory hypertrophy of the remaining lung after left-side pneumonectomy]. PubMed: [Mechanisms of the effect of orotic acid on the growth and development of young rats]. PubMed: [Effect of potassium orotate on the contractile function of the myocardium in patients with coronary aterosclerosis]. PubMed: [Effect of potassium orotate on the indicators of rheohepatogram in patients with coronary arteriosclerosis]. PubMed: [Effect of potassium orotate and nerobol on the nucleic acid metabolism in patients with pulmonary tuberculosis]. PubMed: Effect of potassium orotate on the transport of organic substances in the kidneys. PubMed: [Prevention of experimental adrenaline damage to the myocardium with potassium orotate]. PubMed: [The effect of potassium orotate on the ultrastructure of cardiac muscle cells in experimental myocardial infarct]. PubMed: [Some results of treatment of chronic hepatitis with potassium orotate (first preliminary report)]. PubMed: [Effect of potassium orotate on the bile-secretion function of the liver in normal state and in experimental hepatitis]. PubMed: [Use of potassium orotate in patients with diabetes mellitus]. PubMed: [Effect of potassium orotate on the course of myocardial infarct]. PubMed: [Therapeutic use of potassium orotate]. PubMed: [Experiences with potassium orotate in hyperuricemic subjects]. PubMed: [Behavior of bloodketones in chronic decompensated liver diseases, in the course of treatment with potassium orotate and alpha-tocopherol]. PubMed: [Influence of potassium orotate on hydrosaline metabolism in patients of liver disease]. PubMed: [Orotic acid (Potassium orotate): Its use in dermatology (Preliminary communication)]. PubMed: [Effects of potassium orotate on various pentose fractions in the blood of normal individuals]. PubMed: [First experience with potassium orotate therapy of chronic liver diseases]. PubMed: [Notes on a case of edematigenous complex deficiency syndrome in a gastrectomized subject; combined potassium orotate and vitamin E therapy]. PubMed: [Behavior of blood ketones in chronic decompensated liver diseases during treatment with potassium orotate & alpha-tocopherol].