conessine
N,N-dimethylcon-5-enin-3-amine
Identification
| Name | conessine |
| CAS Number | 546-06-5 |
| EINECS | 208-897-2 |
| FDA UNII | EZ38J9BBDF |
| Molecular Formula | C24 H40 N2 |
| Molecular Weight | 356.59680000 |
| MDL Number | MFCD00016752 |
| Nikkaji Number | J6.427K |
| Beilstein | 4702160 |
Regulatory
Physical Properties
| Assay | 95.00 to 100.00 |
| Food Chemicals Codex Listed | No |
| Melting Point | 125.50 °C. @ 760.00 mm Hg |
| Boiling Point | 450.43 °C. @ 760.00 mm Hg (est) |
| Flash Point | 391.00 °F. TCC ( 199.60 °C. ) (est) |
| logP (o/w) | 6.060 (est) |
| Soluble in | water, 2.352 mg/L @ 25 °C (est) |
No sensory data available
Safety Information
| Preferred SDS | View |
| Oral/Parenteral Toxicity | intraperitoneal-mouse LDLo 208 mg/kg |
| Dermal Toxicity | subcutaneous-guinea pig LDLo 138 mg/kg |
| Inhalation Toxicity | Not determined |
GHS Classification
['GHS Classification in accordance with 29 CFR 1910 (OSHA HCS)', 'GHS Label elements, including precautionary statements']
Safety in Use
| Category | natural substances and extractives |
| Recommendation for conessine usage levels up to | not for fragrance use. |
| Recommendation for conessine flavor usage levels up to | not for flavor use. |
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Potential Uses
Natural Occurrence
Synonyms
conessin
connessine
N,N-
dimethylcon-5-enin-3-amine
konessin
neriine
roquessine
wrightine
PubMed:
Holarrhena antidysenterica Extract and Its Steroidal Alkaloid, Conessine, as Resistance-Modifying Agents Against Extensively Drug-Resistant Acinetobacter baumannii.
PubMed:
Anti-malarial property of steroidal alkaloid conessine isolated from the bark of Holarrhena antidysenterica.
PubMed:
Steroidal alkaloids from Holarrhena antidysenterica as acetylcholinesterase inhibitors and the investigation for structure-activity relationships.
PubMed:
Cloning, expression, characterization and inhibition studies on trypanothione synthetase, a drug target enzyme, from Leishmania donovani.
PubMed:
Antimicrobial activity of the methanolic bark extract of Holarrhena pubescens (Buch. Ham), its fractions and the pure compound conessine.
PubMed:
Design of a new histamine H3 receptor antagonist chemotype: (3aR,6aR)-5-alkyl-1-aryl-octahydropyrrolo[3,4-b]pyrroles, synthesis, and structure-activity relationships.
PubMed:
The alkaloid conessine and analogues as potent histamine H3 receptor antagonists.
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Novel H3 receptor antagonists with improved pharmacokinetic profiles.
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Development and validation of a visible absorption densitometry method for quantitation of conessine in Holarrhena antidysenterica (Kurchi).
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Chromatographic analysis of Kutajarista--an ayurvedic polyherbal formulation.
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A new family of H3 receptor antagonists based on the natural product Conessine.
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High-performance thin layer chromatography method for estimation of conessine in herbal extract and pharmaceutical dosage formulations.
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A new family of histamine H3 receptor antagonists based on a natural product: discovery, SAR, and properties of the series.
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Steroidal alkaloids from Holarrhena antidysenterica (L.) WALL.
PubMed:
Antibacterial activities of the extracts and conessine from Holarrhena floribunda G. Don. (Apocynaceae).
PubMed:
Isolation, characterization and antiplasmodial activity of steroidal alkaloids from Funtumia elastica (Preuss) Stapf.
PubMed:
Highly enantioselective construction of fused pyrrolidine systems that contain a quaternary stereocenter: concise formal synthesis of (+)-conessine.
PubMed:
Alkaloid production by plant cell cultures of Holarrhena antidysenterica: II. Effect of precursor feeding and cultivation in stirred tank bioreactor.
PubMed:
Alkaloid production by plant cell suspension cultures of Holarrhena antidysenterica: I. Effect of major nutrients.
PubMed:
Alkaloids in the tissue culture of Holarrhena antidysenterica.
PubMed:
[Changes in conessine in stem bark of Holarrhena floribunda in Burkina Faso].
PubMed:
Antiamoebic activity of chonemorphine, a steroidal alkaloid, in experimental models.
PubMed:
[Steroidal alkaloids 98. Chemical constitution of the seeds of Holarrhena floribunda (G. Don) Dur. and Schiz: cycloartenol, nor-31 lanosterol, dehydro-24 lophenol, desmosterol and steroidal alkaloids: conessine, isoconessimine, conamine and conarrhimine].
PubMed:
[Steroid alkaloids. LXXXIV. (25). Synthesis of 18-hydroxyprogesterone and 18-nor-13 beta hydroxyprogesterone from conessine].
PubMed:
[On biosynthesis of steroid derivatives in the plant kingdom. 9. Biosynthesis of conessine from pregnenolone].
PubMed:
[Steroidal alkaloids. LXX. Acid rearrangements of conessine: neoconessine and novoconessine].
PubMed:
[Steroidal alkaloids. 58. Westphalen rearrangement of conessine derivatives. Alloconessine].
PubMed:
[Steroidal alkaloids. LXIX. Acid catalyzed rearrangements of conessine. Structure of isoconessine].
PubMed:
Microbiological transformation of conessine. II.
PubMed:
[Steroid alkaloids. 53. Synthesis of dihydro-4,5 hydroxy-18 progesterone and nor-18 hydroxy-13 dihydro-4,5 progesterone starting with conessine].
PubMed:
The microbiological oxidation of conessine.
PubMed:
[Effects of isoconessine and neoconessine on Endamoeba histolytica in vitro, as compared with conessine and emetine].
PubMed:
[Two recent cases of psychic manifestation caused by conessine].
PubMed:
[Conessine (hydrobromide) conessini hydrobromidum: bibromhydrate of conessine].
PubMed:
[Aminohydroxyconessine dihydrobromide in therapy of intestinal or hepatic amebiasis; results obtained].
PubMed:
[New orientation and new therapeutic weapons in the therapy of intestinal amebiasis].
PubMed:
[Dibromhydr Amino-oxyconessine dibromhydrate in the treatment of intestinal or hepatic amebiasis; results].
PubMed:
[New therapy of intestinal amebiasis].
PubMed:
[On a new acquisition in phytotherapy: Holarrhena floribunda and its principal alkaloid: conessine].
PubMed:
[Emetine resistant amebiasis, a major indication for conessine].
PubMed:
[Further notes on the Congress of Amebiasis].
PubMed:
[Conessine in therapy of intestinal amebiasis].
PubMed:
[Considerations of the slowness of urinary elimination of conessine].
PubMed:
[Conessine in the treatment of vaginitis due to Trichomonas].
PubMed:
[Experimental studies on conessine. VI. Comparison of experimental and clinical results of emetine and conessine].
PubMed:
[Experimental studies on conessine. V. Action of hydrochlorides of conessine or emetine on cultures of Entamoeba dysenteriae].
PubMed:
[Experimental studies of conessine. Cultures of dysenteric amoeba in mediums to which chlorhydrates of conessine or emetine were previously added].
PubMed:
[Experimental studies of conessine. Comparative study of the culture medium of dysenteric amoeba after addition of chlorhydrates of conessine or emetine].
PubMed:
[Distribution and fixation time of conessine in the organs of the monkey].
PubMed:
[Experimental studies on conessine. II. Elimination of conessine in man during treatment of amebic dysentery].
PubMed:
[Two cases of amebic hepatitis treated by conessine chlorhydrate].
PubMed:
[Practical therapeutic experiments with conessine].
PubMed:
[Psychic disturbances observed during treatment with conessine].
PubMed:
[Conessine bromohydrate].
PubMed:
[Treatment of amebiasis with conessine].
PubMed:
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PubMed:
A comparison of the irritant action of conessine, isoconessine, and neoconessine.
PubMed:
The pharmacological properties of conessine, isoconessine and neoconessine.
PubMed:
Constitution of conessine.
PubMed:
[Not Available].
PubMed:
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PubMed:
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PubMed:
Observations on the Amoebicidal Action of Conessine.